{"id":61070,"date":"2024-02-28T07:23:11","date_gmt":"2024-02-28T07:23:11","guid":{"rendered":"https:\/\/medsname.com\/encorate-chrono\/"},"modified":"2026-05-01T10:49:16","modified_gmt":"2026-05-01T10:49:16","slug":"encorate-chrono","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/encorate-chrono\/","title":{"rendered":"Encorate Chrono"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Encorate Chrono?<\/h3>\n<p style=\"margin:0;\"><strong>Encorate Chrono<\/strong> este un <strong>200 \/ 300 \/ 400 \/ 500 \/ 600 mg valproat de sodiu \/ acid valproic cu eliberare prelungit\u0103 (chrono \/ CR) \u00een comprimate<\/strong> de la Sun Pharma \u2014 un antiepileptic \/ stabilizator de dispozi\u021bie \/ preventiv pentru migrene. \u00cen preven\u021bia migrenelor, este utilizat la <strong>500-1.500 mg o dat\u0103 pe zi<\/strong> ca m\u0103sur\u0103 preventiv\u0103 de linia a treia sau a patra dup\u0103 propranolol, topiramat \u0219i amitriptilin\u0103. <strong>Contraindica\u021bie absolut\u0103 \u00een timpul sarcinii \u0219i la femeile \u00een v\u00e2rst\u0103 fertil\u0103 f\u0103r\u0103 program de prevenire a sarcinii<\/strong> \u2014 valproatul prezint\u0103 un risc de 10% pentru malforma\u021bii congenitale majore (defecte ale tubului neural, craniofaciale, cardiace, ale membrelor, urogenitale) \u0219i un risc de 30-40% pentru tulbur\u0103ri de dezvoltare neurologic\u0103 (sc\u0103dere a IQ-ului cu 7-10 puncte, spectru autist). EMA \u0219i MHRA au emis restric\u021bii progresiv mai stricte de prescrip\u021bie din 2014. Alte efecte adverse importante: hepatotoxicitate (idiosincratic\u0103; grav\u0103, rareori fatal\u0103), pancreatit\u0103, trombocitopenie, hiperamonemie, cre\u0219tere \u00een greutate, pierdere de p\u0103r, tremor \u0219i sindromul ovarelor polichistice la femei.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<h2 class=\"wp-block-heading\">Encorate Chrono este un comprimat cu eliberare prelungit\u0103 (chrono \/ CR) oral de<\/h2>\n<p>valproat de sodiu \/ acid valproic 200 \/ 300 \/ 400 \/ 500 \/ 600 mg <strong>valproat de sodiu \/ acid valproic 200 \/ 300 \/ 400 \/ 500 \/ 600 mg<\/strong> de la Sun Pharma, furnizat \u00een cutii de 30-180 comprimate. Valproatul este un acid gras cu lan\u021b scurt ramificat, utilizat ini\u021bial ca solvent \u00een chimia farmaceutic\u0103, ulterior descoperit \u00eent\u00e2mpl\u0103tor c\u0103 are activitate antiepileptic\u0103. A devenit un anticonvulsivant de prim\u0103 linie pentru epilepsia generalizat\u0103 \u0219i par\u021bial\u0103 din anii 1970 \u0219i al treilea medicament aprobat de FDA SUA pentru profilaxia migrenei \u00een 1996 (dup\u0103 propranolol \u0219i timolol).<\/p>\n<p>Numele <strong>Formulare Chrono \/ CR cu eliberare prelungit\u0103<\/strong> permite administrarea o dat\u0103 pe zi cu niveluri plasmatice mai stabile dec\u00e2t formula\u021bia cu eliberare imediat\u0103 \u2014 tolerabilitate mai bun\u0103 (mai pu\u021bine grea\u021b\u0103 \u0219i tremururi legate de v\u00e2rf) \u0219i respectare mai bun\u0103 a tratamentului.<\/p>\n<h2 class=\"wp-block-heading\">Cum Valproatul previne migrenele<\/h2>\n<p>Valproate ac\u021bioneaz\u0103 prin mai multe mecanisme relevante pentru migren\u0103:<\/p>\n<ul>\n<li><strong>\u2014 cre\u0219te sinteza GABA \u0219i reduce degradarea acesteia, sporind tonul inhibitor \u00een nucleul caudal trigeminal \u0219i cortex.<\/strong> \u2014 increases GABA synthesis and reduces its degradation, enhancing inhibitory tone in the trigeminal nucleus caudalis and cortex<\/li>\n<li><strong>Suprimarea depresiei corticale de r\u0103sp\u00e2ndire<\/strong> \u2014 unda patologic\u0103 care st\u0103 la baza aurei migrenoase<\/li>\n<li><strong>Blocarea canalelor de sodiu dependente de tensiune<\/strong> \u2014 reduce hiperexcitabilitatea neuronal\u0103<\/li>\n<li><strong>Inhibi\u021bia transmisiei NMDA-glutamat<\/strong><\/li>\n<\/ul>\n<p>\u00cen studiile de preven\u021bie a migrenei (Jensen 1994, Mathew 1995, Klapper 1997), valproatul 500-1.500 mg\/zi a redus frecven\u021ba migrenelor lunare cu ~50% la aproximativ jum\u0103tate dintre pacien\u021bii trata\u021bi.<\/p>\n<h2 class=\"wp-block-heading\">Utiliz\u0103ri aprobate<\/h2>\n<ul>\n<li><strong>Profilaxia migrenei la adul\u021bi<\/strong> \u2014 aprobat de FDA \u00een 1996<\/li>\n<li><strong>Epilepsie generalizat\u0103<\/strong> \u2014 absen\u021be, crize mioclonice, crize tonico-clonice (linia \u00eent\u00e2i)<\/li>\n<li><strong>Epilepsie focal\u0103<\/strong> (crize par\u021biale) \u2014 alternativ\u0103 la carbamazepin\u0103<\/li>\n<li><strong>Tulburare bipolar\u0103<\/strong> \u2014 manie acut\u0103 \u0219i tratament de \u00eentre\u021binere<\/li>\n<li><strong>Statu epileptic<\/strong> (formulare IV)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza Encorate Chrono pentru prevenirea migrenei<\/h2>\n<p>Valproatul este <strong>titrat progresiv<\/strong> pe parcursul a 2-4 s\u0103pt\u0103m\u00e2ni pentru a minimiza grea\u021ba:<\/p>\n<ul>\n<li><strong>S\u0103pt\u0103m\u00e2na 1:<\/strong> 500 mg o dat\u0103 pe zi la masa de sear\u0103<\/li>\n<li><strong>S\u0103pt\u0103m\u00e2na 2:<\/strong> 750 mg o dat\u0103 pe zi<\/li>\n<li><strong>S\u0103pt\u0103m\u00e2na 3+:<\/strong> 1.000 mg o dat\u0103 pe zi (\u021bint\u0103; ajusta\u021bi \u00eentre 500-1.500 mg \u00een func\u021bie de r\u0103spuns \u0219i toleran\u021b\u0103)<\/li>\n<li><strong>Evalua\u021bi beneficiul la 8-12 s\u0103pt\u0103m\u00e2ni.<\/strong> \u021aine\u021bi un jurnal al migrenelor pentru a cuantifica modific\u0103rile.<\/li>\n<li><strong>Nivelurile terapeutice plasmatice<\/strong> sunt de 50-100 \u03bcg\/mL pentru controlul crizelor; pentru migrene, nivelurile nu sunt de obicei necesare \u2014 doza se stabile\u0219te \u00een func\u021bie de r\u0103spunsul clinic.<\/li>\n<\/ul>\n<p><strong>Monitorizare:<\/strong><\/p>\n<ul>\n<li>De baz\u0103: teste hepatice (AST, ALT, bilirubin), hemogram\u0103 complet\u0103 (num\u0103r de trombocite), amilaz\u0103, test de sarcin\u0103 (femei \u00een v\u00e2rst\u0103 fertil\u0103), nivel de amoniac (de baz\u0103)<\/li>\n<li>Luna 1, 3, 6, apoi la fiecare 6 luni: teste hepatice, hemogram\u0103 complet\u0103<\/li>\n<li>Verifica\u021bi amoniac dac\u0103 apar confuzie sau simptome cognitive noi<\/li>\n<\/ul>\n<p><strong>\u00centrerupere:<\/strong> reducere progresiv\u0103 pe 2-4 s\u0103pt\u0103m\u00e2ni la \u00eentrerupere. La pacien\u021bii cu epilepsie concomitent\u0103, nu \u00eentrerupe\u021bi valproatul f\u0103r\u0103 consult neurologic (risc de crize).<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:18px 0;border-radius:4px;\">\n<strong>\u26a0\ufe0f AVERTIZARE SARCIN\u0102.<\/strong> Valproatul este unul dintre cele mai teratogene medicamente din uzul clinic obi\u0219nuit. Expunerea \u00een primul trimestru poart\u0103 un <strong>risc de ~10% de malforma\u021bii congenitale majore<\/strong> (defecte ale tubului neural, defecte cardiace, fisuri labio-palatine, defecte ale membrelor, anomalii urogenitale) \u0219i un <strong>risc de 30-40% de tulbur\u0103ri de dezvoltare neurologic\u0103<\/strong> (sc\u0103dere a IQ-ului copilului cu 7-10 puncte, risc crescut de spectru autist de 5 ori). <strong>Valproatul NU trebuie utilizat \u00een sarcin\u0103 sau la femeile \u00een v\u00e2rst\u0103 fertil\u0103, dec\u00e2t dac\u0103 alte op\u021biuni au e\u0219uat \u0219i exist\u0103 un program formal de prevenire a sarcinii.<\/strong> Pentru prevenirea migrenei, trece\u021bi la <a href=\"https:\/\/medsbase.com\/ro\/inderal\/\">propranolol<\/a>, amitriptilin\u0103 sau un antagonist CGRP \u00eenainte de planificarea sarcinii.\n<\/div>\n<h2 class=\"wp-block-heading\">Efecte Secundare<\/h2>\n<p><strong>Foarte frecvent (&gt;10%):<\/strong> gre\u021buri, dispepsie, somnolen\u021b\u0103, tremor, cre\u0219tere \u00een greutate, sub\u021bierea p\u0103rului \/ c\u0103derea p\u0103rului, alopecie (de obicei tranzitorie; p\u0103rul se regenereaz\u0103 dup\u0103 reducerea dozei sau \u00eentrerupere).<\/p>\n<p><strong>Frecvente (1-10%):<\/strong> ataxie, ame\u021beli, cefalee, cre\u0219tere tranzitorie a enzimelor hepatice, trombocitopenie (de obicei u\u0219oar\u0103 \u0219i dependent\u0103 de doz\u0103), amenoree sau menstrua\u021bii neregulate, sindromul ovarelor polichistice (la femeile tinere), sc\u0103derea libidoului, edem periferic.<\/p>\n<p><strong>Pu\u021bin frecvente, dar grave:<\/strong><\/p>\n<ul>\n<li><strong>Hepatotoxicitate<\/strong> \u2014 idiosincratic; de obicei \u00een primele 6 luni; riscul este mai mare la copiii sub 2 ani, la pacien\u021bii cu tulbur\u0103ri mitocondriale (muta\u021biile POLG sunt o contraindica\u021bie absolut\u0103) \u0219i la politerapie. Se manifest\u0103 prin gre\u021buri, v\u0103rs\u0103turi, oboseal\u0103, icter. Necesit\u0103 teste hepatice urgente + \u00eentrerupere.<\/li>\n<li><strong>Pancreatit\u0103<\/strong> \u2014 rar dar poten\u021bial fatal; se manifest\u0103 prin dureri abdominale, gre\u021buri, v\u0103rs\u0103turi, lipaz\u0103 crescut\u0103<\/li>\n<li><strong>Encefalopatie hiperamonemic\u0103<\/strong> \u2014 poate ap\u0103rea cu teste hepatice normale; se manifest\u0103 prin confuzie, letargie, simptome cognitive noi<\/li>\n<li><strong>Trombocitopenie, leucopenie<\/strong> \u2014 dependent de doz\u0103; forme severe rare<\/li>\n<li><strong>Sindromul Stevens-Johnson\/TEN<\/strong> \u2014 rar; \u00eentrerupe\u021bi imediat \u0219i c\u0103uta\u021bi \u00eengrijire urgent\u0103<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindica\u021bii<\/h2>\n<ul>\n<li><strong>Sarcin\u0103 (contraindica\u021bie absolut\u0103)<\/strong> \u0219i femei \u00een v\u00e2rst\u0103 fertil\u0103 f\u0103r\u0103 program de prevenire a sarcinii<\/li>\n<li><strong>Boal\u0103 mitocondrial\u0103 POLG cunoscut\u0103 sau suspectat\u0103<\/strong> (\u0219i copii sub 2 ani \u00een cazul \u00een care POLG nu poate fi exclus) \u2014 risc de hepatotoxicitate fatal\u0103<\/li>\n<li>Insuficien\u021b\u0103 hepatic\u0103 sever\u0103 sau antecedente familiale de disfunc\u021bie hepatic\u0103 sever\u0103<\/li>\n<li>Porfirie acut\u0103<\/li>\n<li>Pancreatit\u0103 (antecedente personale)<\/li>\n<li>Tulbur\u0103ri ale ciclului ureic<\/li>\n<li>Hipersensibilitate la valproat<\/li>\n<\/ul>\n<p><strong>Al\u0103ptarea:<\/strong> valproatul trece \u00een lapte \u00een cantit\u0103\u021bi mici (raport lapte\/plasm\u0103 ~0,02). \u00cen general, este considerat acceptabil \u00een timpul al\u0103pt\u0103rii dac\u0103 medicamentul este necesar; monitoriza\u021bi copilul pentru letargie neobi\u0219nuit\u0103 sau alimenta\u021bie deficitar\u0103.<\/p>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Lamotrigin\u0103<\/strong> \u2014 valproatul dubleaz\u0103 nivelurile de lamotrigin\u0103; doza de lamotrigin\u0103 trebuie s\u0103 fie jum\u0103tate din doza ini\u021bial\u0103 obi\u0219nuit\u0103<\/li>\n<li><strong>Antibiotice carbapenemice<\/strong> (meropenem, imipenem, ertapenem) \u2014 reduc dramatic nivelurile de valproat \u2014 risc de convulsii \u00een epilepsie; evita\u021bi combina\u021bia<\/li>\n<li><strong>Warfarin<\/strong> \u2014 valproatul \u00eenlocuie\u0219te warfarina de pe albumin\u0103; monitoriza\u021bi INR<\/li>\n<li><strong>Aspirin<\/strong> \u2014 \u00eenlocuie\u0219te valproatul de pe albumin\u0103; cre\u0219te concentra\u021bia liber\u0103 de valproat<\/li>\n<li><strong>Fenitoin\u0103, carbamazepin\u0103<\/strong> \u2014 reduc nivelurile de valproat prin induc\u021bie CYP<\/li>\n<li><strong>Alte depresante ale SNC<\/strong> (benzodiazepine, alcool, opioide) \u2014 sedare aditiv\u0103<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Depozitare<\/h2>\n<p>P\u0103stra\u021bi la temperaturi sub 25\u00b0C \u00een blisterul original. Proteja\u021bi de umiditate. P\u0103stra\u021bi departe de copii.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">C\u00e2t timp dureaz\u0103 p\u00e2n\u0103 \u00eencepe Encorate Chrono s\u0103 previn\u0103 migrenele?<\/h3>\n<p>Permite\u021bi 8-12 s\u0103pt\u0103m\u00e2ni la doza \u021bint\u0103 pentru efectul complet. \u021aine\u021bi un jurnal de migrene \u00een care s\u0103 \u00eenregistra\u021bi zilele pe lun\u0103 la \u00eenceput \u0219i la s\u0103pt\u0103m\u00e2na 12. Un r\u0103spuns clinic semnificativ este o reducere cu 50% a zilelor de migren\u0103 pe lun\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Este Encorate Chrono sigur dac\u0103 planific sarcin\u0103?<\/h3>\n<p><strong>Nu.<\/strong> Valproatul este unul dintre cele mai teratogene medicamente din uz clinic (~10% risc de malforma\u021bii, 30-40% risc de tulbur\u0103ri de dezvoltare neurologic\u0103). Femeile \u00een v\u00e2rst\u0103 fertil\u0103 ar trebui s\u0103 fie trecute la un medicament preventiv mai sigur (<a href=\"https:\/\/medsbase.com\/ro\/inderal\/\">propranolol<\/a> este preferat \u00een sarcin\u0103) \u00eenainte de concep\u021bie. De obicei, se recomand\u0103 o perioad\u0103 de eliminare de 3 luni \u00eenainte de a \u00eencerca s\u0103 concepe\u021bi. Valproatul nu ar trebui utilizat la femeile care planific\u0103 sau pot deveni \u00eens\u0103rcinate f\u0103r\u0103 un program formal de prevenire a sarcinii.<\/p>\n<h3 class=\"wp-block-heading\">De ce este forma cu eliberare prelungit\u0103 diferit\u0103 de Encorate IR?<\/h3>\n<p>Aceea\u0219i molecul\u0103 (valproat de sodiu \/ acid valproic), dar cu un profil de eliberare diferit. Encorate Chrono are eliberare prelungit\u0103 pentru administrare o dat\u0103 pe zi, cu niveluri plasmatice mai stabile. Mai bun\u0103 tolerabilitate, mai bun\u0103 conformitate. <a href=\"https:\/\/medsbase.com\/ro\/encorate\/\">Encorate IR<\/a> necesit\u0103 administrare de dou\u0103 ori pe zi.<\/p>\n<h3 class=\"wp-block-heading\">Encorate Chrono m\u0103 va face s\u0103 iau \u00een greutate?<\/h3>\n<p>Da \u2014 cre\u0219terea \u00een greutate este unul dintre cele mai frecvente efecte adverse (\u00een medie 3-5 kg \u00een 6-12 luni, mai mult la unii). Mecanismul include cre\u0219terea apetitului \u0219i posibil modificarea metabolismului glucozei. Dac\u0103 cre\u0219terea \u00een greutate este problematic\u0103, lua\u021bi \u00een considerare trecerea la <a href=\"https:\/\/medsbase.com\/ro\/topicon\/\">topiramate<\/a> (care provoac\u0103 pierdere \u00een greutate) sau <a href=\"https:\/\/medsbase.com\/ro\/inderal\/\">propranolol<\/a> (neutru din punct de vedere al greut\u0103\u021bii).<\/p>\n<h3 class=\"wp-block-heading\">De ce am nevoie de analize de s\u00e2nge la Encorate Chrono?<\/h3>\n<p>Valproatul poate provoca hepatotoxicitate, pancreatit\u0103, trombocitopenie \u0219i hiperamonemie. Analizele hepatice ini\u021biale \u0219i periodice, hemoleucograma complet\u0103 \u0219i monitorizarea clinic\u0103 detecteaz\u0103 problemele devreme. Monitorizarea terapeutic\u0103 a medicamentului (niveluri 50-100 \u03bcg\/mL) nu este necesar\u0103 \u00een mod obi\u0219nuit pentru prevenirea migrenei \u2014 doza se stabile\u0219te \u00een func\u021bie de r\u0103spunsul clinic.<\/p>\n<h3 class=\"wp-block-heading\">Pot consuma alcool \u00een timp ce iau Encorate Chrono?<\/h3>\n<p>Evita\u021bi consumul regulat sau excesiv de alcool. Alcoolul are efect sedativ aditiv cu valproatul \u0219i cre\u0219te stresul hepatic. Cantit\u0103\u021bi mici ocazionale nu sunt absolut contraindicate, dar consumul regulat cre\u0219te riscul de hepatotoxicitate. Alcoolul este, de asemenea, un factor declan\u0219ator frecvent al migrenei; reducerea consumului \u00eembun\u0103t\u0103\u021be\u0219te adesea migrena independent de valproat.<\/p>\n<h3 class=\"wp-block-heading\">Pot \u00eentrerupe brusc tratamentul cu Encorate Chrono?<\/h3>\n<p>Nu \u2014 reduce\u021bi treptat doza \u00een 2-4 s\u0103pt\u0103m\u00e2ni. \u00centreruperea brusc\u0103 poate declan\u0219a migren\u0103 de rebound \u0219i, la pacien\u021bii cu predispozi\u021bie la convulsii, poate provoca crize epileptice.<\/p>\n<h3 class=\"wp-block-heading\">Unde pot cump\u0103ra Encorate Chrono online?<\/h3>\n<p>Pute\u021bi achizi\u021biona Encorate Chrono (valproat de sodiu 200 \/ 300 \/ 400 \/ 500 \/ 600 mg comprimate cu eliberare prelungit\u0103 (chrono \/ CR), cutii de 30-180 comprimate) de la MedsBase cu ambalaj discret \u0219i livrare la nivel mondial.<\/p>\n<h2 class=\"wp-block-heading\">Tratamente pentru Migren\u0103 Asem\u0103n\u0103toare pe MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/zolmist-nasal-spray\/\">Zolmist Spray Nazal \u2014 Zolmitriptan 5 mg (ac\u021biune rapid\u0103)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/zolitas-ods\/\">Zolitas ODS \u2014 Zolmitriptan 2,5\/5 mg orodispersibil<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/maxtan\/\">Maxtan \u2014 Rizatriptan 5\/10 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rizatop\/\">Rizatop \u2014 Rizatriptan 10 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rizact\/\">Rizact \u2014 Rizatriptan (Cipla)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/sumitop\/\">Sumitop \u2014 Sumatriptan 25\/50\/100 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/anti-migraine\/\"><strong>R\u0103sfoi\u021bi toate tratamentele anti-migren\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are doar scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui profesionist calificat din domeniul s\u0103n\u0103t\u0103\u021bii. Consulta\u021bi \u00eentotdeauna medicul \u00eenainte de a \u00eencepe, modifica sau \u00eentrerupe orice tratament pentru migren\u0103.<\/div>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Afec\u021biuni cronice<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/carvego\/\">Carvego<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/hepcinat-lp\/\">Hepcinat LP<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/glucobay\/\">Glucobay<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/synaptol\/\">Synaptol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tenvir-af\/\">Tenvir AF<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Encorate Chrono este valproat de sodiu 200 \/ 300 \/ 400 \/ 500 \/ 600 mg cu eliberare prelungit\u0103 (chrono \/ CR) de la Sun Pharma \u2014 dozare o dat\u0103 pe zi, cu niveluri plasmatice mai stabile dec\u00e2t Encorate cu eliberare imediat\u0103. Pentru preven\u021bia migrenelor: \u00eencepe\u021bi cu 500 mg noaptea, titra\u021bi p\u00e2n\u0103 la 1.000 mg noaptea (interval 500-1.500 mg). Acelea\u0219i restric\u021bii de sarcin\u0103 \u0219i monitorizare ca pentru toate produsele cu valproat.<\/p>","protected":false},"featured_media":61071,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3553,3141,3223,3342,3554],"product_tag":[4973,4677,4898],"class_list":{"0":"post-61070","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-migraine","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-general-health","10":"product_cat-migraine-treatment","11":"product_tag-encorate-chrono","12":"product_tag-sodium-valproate","13":"product_tag-valproic-acid","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/61070","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=61070"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/61071"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=61070"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=61070"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=61070"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=61070"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}