{"id":61432,"date":"2024-02-28T07:40:41","date_gmt":"2024-02-28T07:40:41","guid":{"rendered":"https:\/\/medsname.com\/mefque\/"},"modified":"2026-04-30T10:23:35","modified_gmt":"2026-04-30T10:23:35","slug":"mefque","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/mefque\/","title":{"rendered":"Mefque"},"content":{"rendered":"

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R\u0103spuns rapid<\/h3>\n

Mefque<\/strong> con\u021bine mefloquine 250 mg<\/strong> (Cipla). Este o op\u021biune de chimioprofilaxie s\u0103pt\u0103m\u00e2nal\u0103 pentru malaria rezistent\u0103 la clorochin\u0103<\/strong> \u00een Africa subsaharian\u0103, India, Asia de Sud-Est (cu excep\u021bia frontierelor Thailanda-Cambodgia \/ Thailanda-Myanmar) \u0219i Amazonia. Doza pentru adul\u021bi: 250 mg o dat\u0103 pe s\u0103pt\u0103m\u00e2n\u0103, \u00eenceput\u0103 cu 2\u20133 s\u0103pt\u0103m\u00e2ni \u00eenainte de c\u0103l\u0103torie<\/strong> (pentru a identifica intoleran\u021ba \u0219i a atinge starea de echilibru), continuat \u00een timpul c\u0103l\u0103toriei \u0219i continuat 4 s\u0103pt\u0103m\u00e2ni dup\u0103 \u00eentoarcere<\/strong>. Se administreaz\u0103 cu o mas\u0103 complet\u0103 \u0219i ap\u0103. Doza de test obligatorie \u00eenainte de c\u0103l\u0103torie cu 3 s\u0103pt\u0103m\u00e2ni \u00eenainte de plecare<\/strong> \u2014 dac\u0103 apar efecte adverse neuropsihiatrice, trece\u021bi la doxiciclin\u0103 sau atovaquon-proguanil \u00eenainte de zbor. Contraindicat la pacien\u021bii cu depresie actual\u0103 sau trecut\u0103, tulburare de anxietate generalizat\u0103, psihoz\u0103, schizofrenie, tulburare bipolar\u0103, tulbur\u0103ri de convulsii sau anomalie semnificativ\u0103 de conducere cardiac\u0103.<\/p>\n<\/div>\n

\ud83c\udfed Produc\u0103tor certificat WHO-GMP<\/strong>  \u00b7  \ud83d\udce6 Ambalaj discret<\/strong>  \u00b7  \ud83c\udf0d Livrare \u00een toat\u0103 lumea<\/strong>  \u00b7  \u2b50 Peste 1.400 de recenzii ale clien\u021bilor<\/a><\/strong><\/div>\n

\ud83d\udee1\ufe0f Fiecare comand\u0103 este acoperit\u0103 de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 if your parcel does not arrive within 20 business days we ship a free replacement on EMS or ITPS courier.<\/p>\n

De ce s\u0103 comanzi de la MedsBase<\/h3>\n

Mefque este procurat de la un produc\u0103tor certificat WHO-GMP \u0219i expediat \u00een toat\u0103 lumea \u00een ambalaje discrete. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u0219i sprijinit\u0103 de Peste 1.400 de recenzii ale clien\u021bilor<\/a>. Livrare worldwide f\u0103r\u0103 documenta\u021bie medical\u0103.<\/p>\n

Despre Mefque<\/h2>\n

Mefque este un comprimat de 250 mg de meflochin\u0103 hidroclorur\u0103 fabricat de Cipla \u00een condi\u021bii certificate WHO-GMP. Meflochina a fost dezvoltat\u0103 de US Walter Reed Army Institute of Research \u00een anii 1970 \u0219i r\u0103m\u00e2ne una dintre cele trei op\u021biuni moderne (al\u0103turi de doxiciclin\u0103 \u0219i atovaquon-proguanil) pentru profilaxia \u00een zonele rezistente la clorochin\u0103. Semivia\u021ba sa lung\u0103 permite administrarea o dat\u0103 pe s\u0103pt\u0103m\u00e2n\u0103 \u2014 convenabil pentru c\u0103l\u0103torii lungi.<\/p>\n

Cum func\u021bioneaz\u0103 meflochina<\/h2>\n

Meflochina este un antimalaric din clasa 4-quinolinemethanol. La fel ca clorochina, interfereaz\u0103 cu detoxifierea hemului parazitului \u00een vacuola alimentar\u0103, dar este activ\u0103 \u00eempotriva multor tulpini rezistente la clorochin\u0103 deoarece nu depinde de acela\u0219i mecanism de transport al parazitului. Are \u0219i activitate \u00eempotriva stadiului sanguin al P. falciparum, P. vivax, P. ovale \u0219i P. malariae. Meflochina are penetrare substan\u021bial\u0103 \u00een SNC \u2014 dezirabil\u0103 pentru eficacitatea parasitologic\u0103, dar sursa profilului s\u0103u de efecte adverse neuropsihiatrice.<\/p>\n

Semivia\u021ba este de ~ 2\u20133 s\u0103pt\u0103m\u00e2ni. Administrarea o dat\u0103 pe s\u0103pt\u0103m\u00e2n\u0103 atinge starea de echilibru p\u00e2n\u0103 \u00een s\u0103pt\u0103m\u00e2nile 7\u20139; de aceea majoritatea autorit\u0103\u021bilor recomand\u0103 \u00eenceperea cu 2\u20133 s\u0103pt\u0103m\u00e2ni \u00eenainte de c\u0103l\u0103torie.<\/p>\n

Indica\u021bii \u0219i dozaj<\/h2>\n
\n\n\n\n\n\n\n\n\n
Indica\u021bie<\/th>\nDoza<\/th>\nProgram<\/th>\n<\/tr>\n<\/thead>\n
Chimioprofilaxie, adul\u021bi<\/td>\n250 mg o dat\u0103 pe s\u0103pt\u0103m\u00e2n\u0103<\/td>\n\u00cencepe\u021bi cu 2\u20133 s\u0103pt\u0103m\u00e2ni \u00eenainte de a intra \u00een zona de malarie; continua\u021bi s\u0103pt\u0103m\u00e2nal \u00een timpul expunerii; continua\u021bi 4 s\u0103pt\u0103m\u00e2ni dup\u0103 \u00eentoarcere.<\/td>\n<\/tr>\n
Chimioprofilaxie pediatric\u0103 (\u2265 5 kg)<\/td>\n5 mg\/kg o dat\u0103 pe s\u0103pt\u0103m\u00e2n\u0103 (maxim 250 mg)<\/td>\nAcela\u0219i program de \u00eencepere\/continuare\/oprire. Jum\u0103tate de tablet\u0103 pentru copiii mai mici \u2014 doza exact\u0103 \u00een mg\/kg conteaz\u0103.<\/td>\n<\/tr>\n
Malarie acut\u0103 necomplicat\u0103 cu P. falciparum rezistent la clorochin\u0103, adul\u021bi<\/td>\n750 mg doz\u0103 unic\u0103, urmat\u0103 de 500 mg dup\u0103 6\u201312 ore (total 1250 mg)<\/td>\nDozele terapeutice provoac\u0103 semnificativ mai multe efecte adverse dec\u00e2t cele profilactice. Preferin\u021ba actual\u0103 a WHO este terapia combinat\u0103 cu artemisinin\u0103 acolo unde este disponibil\u0103.<\/td>\n<\/tr>\n
Tratament de urgen\u021b\u0103 pentru malarie presupus\u0103<\/td>\n750 mg + 500 mg conform schemei de mai sus<\/td>\nPentru c\u0103l\u0103torii \u00een zone f\u0103r\u0103 acces rapid la \u00eengrijiri medicale care dezvolt\u0103 o afec\u021biune febril\u0103 compatibil\u0103 cu malaria. Nu \u00eenlocuie\u0219te evaluarea medical\u0103.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
Avertisment neuropsihiatric \u00een caset\u0103 ro\u0219ie \u2014 citi\u021bi \u00eenainte de cump\u0103rare.<\/strong> Meflochina este asociat\u0103 cu anxietate, vise vii, co\u0219maruri, insomnie, modific\u0103ri de stare, depresie, g\u00e2nduri suicidare, paranoia, halucina\u021bii \u0219i rareori convulsii. Majoritatea reac\u021biilor apar \u00een primele 3 doze. Unii pacien\u021bi descriu simptome persistente (\u201csindrom post-meflochin\u0103\u201d) dup\u0103 \u00eentreruperea medicamentului. Contraindica\u021bii:<\/strong> depresie curent\u0103 sau trecut\u0103, tulburare de anxietate generalizat\u0103, psihoz\u0103, schizofrenie, tulburare bipolar\u0103, tulburare de convulsii, anomalie sever\u0103 de conduc\u021bie cardiac\u0103, traumatism cranian recent, istoric de boal\u0103 psihiatric\u0103 sever\u0103 \u00een familie apropiat\u0103. Efectua\u021bi \u00eentotdeauna un test doz\u0103 de 3 s\u0103pt\u0103m\u00e2ni \u00eenainte de c\u0103l\u0103torie<\/strong>: dac\u0103 apar anxietate, disforie, vise vii sau tulbur\u0103ri de somn, trece\u021bi la doxiciclin\u0103 sau atovaquon-proguanil \u00eenainte de zbor.<\/div>\n
Not\u0103 cardiac\u0103.<\/strong> Mefloquina prelunge\u0219te intervalul PR \u0219i prelunge\u0219te moderat QTc. Evita\u021bi combina\u021bia cu alte medicamente care prelungesc QT (azitromicin\u0103, ondansetron, fluoroquinolone, antipsihotice, SSRI \/ TCA la doze mari). Evita\u021bi la pacien\u021bii cu bradicardie, bloc AV sau dependen\u021b\u0103 de stimulator cardiac f\u0103r\u0103 consult cardiologic.<\/div>\n

Efecte secundare<\/h2>\n