{"id":61476,"date":"2024-02-28T07:42:25","date_gmt":"2024-02-28T07:42:25","guid":{"rendered":"https:\/\/medsname.com\/seretra\/"},"modified":"2026-04-30T10:23:34","modified_gmt":"2026-04-30T10:23:34","slug":"seretra","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/seretra\/","title":{"rendered":"Seretra"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Quick Answer \u2014 What is Seretra?<\/h3>\n<p><strong>Seretra<\/strong> con\u021bine <strong>seratrodast 80 mg<\/strong>, un <strong>selective thromboxane A2 (TXA2) receptor antagonist<\/strong> used as preventer therapy for asthma and allergic rhinitis. Seratrodast blocks the TXA2 receptor on bronchial smooth muscle, eosinophils, and platelets \u2014 preventing TXA2-mediated bronchoconstriction, eosinophil recruitment, and airway hyperresponsiveness. It was developed and is mainly used in Japan; less widely available outside Asia. Used as add-on preventer alongside ICS in patients with persistent asthma. Onset of preventer benefit takes <strong>1\u20132 s\u0103pt\u0103m\u00e2ni<\/strong> of daily dosing.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 Checkout criptat<\/strong> \u00b7 <strong>\ud83d\udcb3 Procesator Verificat<\/strong> \u00b7 <strong>\ud83d\ude9a Livrare Worldwide<\/strong> \u00b7 <strong>\u2b50 4,9\/5 de la peste 1.400 de clien\u021bi<\/strong>\n<\/div>\n<h2>What Is Seretra?<\/h2>\n<p>Seretra contains seratrodast \u2014 a niche anti-asthma agent introduced in Japan in 1995. Seratrodast targets the thromboxane A2 (TXA2) receptor \u2014 a contrast to leukotriene receptor antagonists (montelukast) which target the cysteinyl leukotriene receptor. Both TXA2 and leukotrienes are inflammatory mediators released during the allergic cascade.<\/p>\n<h2>How Does Seratrodast Work?<\/h2>\n<ul>\n<li><strong>TXA2 receptor blockade<\/strong> on bronchial smooth muscle prevents TXA2-mediated bronchoconstriction<\/li>\n<li><strong>Reduces eosinophil recruitment<\/strong> to airways<\/li>\n<li><strong>Decreases airway hyperresponsiveness<\/strong> over 1\u20132 weeks of dosing<\/li>\n<li><strong>Mild platelet inhibition<\/strong> \u2014 TXA2 is a potent platelet aggregator; this effect is rarely clinically significant<\/li>\n<\/ul>\n<h2>Utiliz\u0103ri \u0219i indica\u021bii<\/h2>\n<ul>\n<li><strong>Astm persistent<\/strong> \u2014 add-on preventer when ICS alone is inadequate<\/li>\n<li><strong>Rinit\u0103 alergic\u0103<\/strong> \u2014 adjunct<\/li>\n<li><strong>Astm cu tuse variant\u0103<\/strong><\/li>\n<li><strong>Aspirin-exacerbated respiratory disease<\/strong> (AERD) \u2014 niche use<\/li>\n<\/ul>\n<h2>Seretra Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Pacient<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Doza<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Frecven\u021b\u0103<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Adul\u021bi<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>80 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Once daily after dinner<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Insuficien\u021b\u0103 hepatic\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce\u021bi doza cu 50%<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">O dat\u0103 pe zi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Side Effects of Seretra<\/h2>\n<ul>\n<li>Nausea, dyspepsia<\/li>\n<li>Dureri de cap<\/li>\n<li>Mild dizziness<\/li>\n<li>Cre\u0219tere u\u0219oar\u0103 a enzimelor hepatice<\/li>\n<li>Rarely: rash, fatigue<\/li>\n<\/ul>\n<p><strong>Severe \u2014 \u00eentrerupe\u021bi \u0219i c\u0103uta\u021bi ajutor medical:<\/strong><\/p>\n<ul>\n<li>Hepatitis (jaundice, dark urine, RUQ pain)<\/li>\n<li>Reac\u021bie alergic\u0103 sever\u0103<\/li>\n<li>V\u0103rs\u0103turi severe persistente<\/li>\n<\/ul>\n<h2>Avertismente \u0219i precau\u021bii<\/h2>\n<ul>\n<li><strong>Monitorizarea func\u021biei hepatice:<\/strong> baseline LFTs and periodic monitoring during long-term use.<\/li>\n<li><strong>Continua\u021bi terapia cu ICS<\/strong> if previously prescribed; seratrodast is add-on, not replacement.<\/li>\n<li><strong>Nu este un medicament de salvare.<\/strong> Use SABA (Asthalin, Levolin) for acute attacks.<\/li>\n<li><strong>Sarcin\u0103 \u0219i al\u0103ptare:<\/strong> date limitate; evita\u021bi, cu excep\u021bia cazurilor \u00een care beneficiul este clar.<\/li>\n<li><strong>Bleeding disorders:<\/strong> mild TXA2 inhibition could theoretically prolong bleeding; rarely clinically significant.<\/li>\n<\/ul>\n<h2>Contraindica\u021bii<\/h2>\n<ul>\n<li>Hypersensitivity to seratrodast<\/li>\n<li>Insuficien\u021b\u0103 hepatic\u0103 sever\u0103<\/li>\n<li>Active hepatitis<\/li>\n<\/ul>\n<h2>Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li>Aspirin and other antiplatelet agents \u2014 additive bleeding risk (rarely clinically significant)<\/li>\n<li>Warfarin \u2014 monitor INR<\/li>\n<li>Other hepatotoxic drugs \u2014 monitor LFTs<\/li>\n<\/ul>\n<h2>Depozitare<\/h2>\n<ul>\n<li>Depozita\u021bi la temperaturi sub <strong>25\u00b0C<\/strong> \u00eentr-un loc r\u0103coros \u0219i uscat, departe de lumina direct\u0103 a soarelui.<\/li>\n<li>P\u0103stra\u021bi \u00een ambalajul original p\u00e2n\u0103 la utilizare pentru a proteja de umiditate \u0219i lumin\u0103.<\/li>\n<li>Nu utiliza\u021bi dup\u0103 data de expirare tip\u0103rit\u0103 pe blister.<\/li>\n<li>P\u0103stra\u021bi la distan\u021b\u0103 de copii.<\/li>\n<\/ul>\n<h2>Alternative conexe pe MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/asthalin-inhaler\/\"><strong>Asthalin Inhaler \u2014 salbutamol pentru ameliorarea simptomelor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 budesonide ICS pentru preven\u021bie<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 budesonide + formoterol ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/montair\/\"><strong>Montair \u2014 comprimat montelukast LTRA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tiova-inhaler\/\"><strong>Tiova Inhaler \u2014 tiotropium LAMA pentru BPOC<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>How is seratrodast different from montelukast?<\/h3>\n<p>Both block specific allergic mediators. Montelukast (Montair) blocks the cysteinyl leukotriene CysLT1 receptor. Seratrodast blocks the thromboxane A2 receptor. Different mediators, different targets, similar add-on niche. Montelukast has more global use and a stronger evidence base; seratrodast is mainly used in Japan and parts of Asia.<\/p>\n<h3>Can I take Seretra alongside montelukast?<\/h3>\n<p>Combination is not standard. Discuss with your prescriber \u2014 there is no established additional benefit over ICS-LABA + LTRA.<\/p>\n<h3>How long until Seretra works?<\/h3>\n<p>1\u20132 weeks for noticeable improvement; 4\u20138 weeks for full preventer effect on exacerbation rate.<\/p>\n<h3>Is Seretra a rescue inhaler?<\/h3>\n<p>No \u2014 onset is far too slow. Use a SABA (Asthalin, Levolin) for acute attacks.<\/p>\n<h3>Why monitor liver function?<\/h3>\n<p>Mild liver enzyme elevation is a known side effect. Baseline LFTs and periodic monitoring are recommended.<\/p>\n<h3>Will Seretra replace my inhaler?<\/h3>\n<p>No \u2014 seratrodast is an oral add-on. Continue ICS or ICS-LABA inhaler therapy.<\/p>\n<h3>Is Seretra evidence-based?<\/h3>\n<p>Yes, but mainly through Japanese trials. Evidence base is smaller than for montelukast or ICS-LABA combinations. Reasonable as add-on in selected patients.<\/p>\n<h3>Can children take Seretra?<\/h3>\n<p>Limited paediatric data; specialist supervision required.<\/p>\n<h3>Is Seretra safe in pregnancy?<\/h3>\n<p>Limited data; avoid unless benefit clear.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Avertizare medical\u0103:<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical profesionist. Consult\u0103 \u00eentotdeauna un profesionist calificat \u00een s\u0103n\u0103tate \u00eenainte de a \u00eencepe, \u00eentrerupe sau schimba orice inhalator sau medicament respirator, mai ales dac\u0103 ai alte afec\u021biuni medicale, iei alte re\u021bete, e\u0219ti gravid\u0103 sau al\u0103ptezi, sau ai peste 65 de ani.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Afec\u021biuni cronice<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tenof-em\/\">Tenof EM<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/headset\/\">Casc\u0103<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/maxiflo-rotacaps\/\">Maxiflo Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/neomercazole\/\">Neomercazole<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tridon\/\">Tridon<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Reduce inflama\u021bia c\u0103ilor respiratorii<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te func\u021bia pulmonar\u0103<br \/>\n\u2705 Amelioreaz\u0103 simptomele astmului<br \/>\n\u2705 Prevents bronchoconstriction<br \/>\n\u2705 Enhances respiratory health<\/p>\n<p>Seretra contains Seratrodast.<\/p>","protected":false},"featured_media":61477,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[5040,5041],"class_list":{"0":"post-61476","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-seratrodast","10":"product_tag-seretra","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/61476","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=61476"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/61477"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=61476"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=61476"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=61476"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=61476"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}