{"id":64534,"date":"2024-10-02T06:03:04","date_gmt":"2024-10-02T06:03:04","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=64534"},"modified":"2026-05-08T09:15:21","modified_gmt":"2026-05-08T09:15:21","slug":"biciphage-1000-sr","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/biciphage-1000-sr\/","title":{"rendered":"Biciphage 1000 SR"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Biciphage 1000 SR?<\/h3>\n<p style=\"margin:0;\"><strong>Biciphage 1000 SR<\/strong> este o marc\u0103 a <strong>metformin hidroclorur\u0103<\/strong> (1000 mg SR), a first-line oral medicine for <strong>diabetului de tip 2<\/strong>. Ac\u021bioneaz\u0103 prin reducerea produc\u021biei de glucoz\u0103 \u00een ficat \u0219i \u00eembun\u0103t\u0103\u021birea r\u0103spunsului organismului la insulin\u0103 \u2014 <strong>nu provoac\u0103 hipoglicemie de la sine<\/strong> \u0219i este neutru din punct de vedere al greut\u0103\u021bii sau reduce u\u0219or greutatea. Metformina este cel mai prescris antidiabetic la nivel mondial, recomandat\u0103 ca terapie de prim\u0103 linie de c\u0103tre ADA, EASD, NICE \u0219i IDF. Utilizat\u0103 off-label \u0219i pentru sindromul ovarelor polichistice (PCOS), prediabet \u0219i diabet gesta\u021bional. Se administreaz\u0103 cu m\u00e2ncare pentru a reduce tulbur\u0103rile gastrointestinale. Cele mai frecvente efecte secundare: diaree, grea\u021b\u0103, gust metalic \u2014 de obicei se \u00eembun\u0103t\u0103\u021besc dup\u0103 1\u20132 s\u0103pt\u0103m\u00e2ni sau la trecerea la SR. <strong>Evita\u021bi la eGFR &lt; 30 mL\/min\/1,73 m\u00b2<\/strong>; reduce\u021bi doza dac\u0103 eGFR 30\u201345. Sigur pe termen lung; monitoriza\u021bi vitamina B12 anual.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<h2 class=\"wp-block-heading\">What Is Biciphage 1000 SR?<\/h2>\n<p>Biciphage 1000 SR is an oral antidiabetic medicine containing <strong>metformin hidroclorur\u0103<\/strong> (1000 mg SR), manufactured by WHO-GMP certified manufacturer. Sustained-release (SR) formulation &mdash; releases metformin gradually over 8&ndash;10 hours, reducing GI side effects and allowing once-daily dosing. It is prescribed for adults and children 10&nbsp;years and older with type&nbsp;2 diabetes mellitus, typically alongside diet and exercise. Available in packs of 30, 60, 90 or 180 tablets.<\/p>\n<p>Metformina apar\u021bine clasei <strong>biguanidelor<\/strong> \u0219i este utilizat\u0103 \u00een clinic\u0103 din 1957. Este cel mai prescris medicament pentru diabet din lume \u0219i se afl\u0103 pe Lista Medicamentelor Esen\u021biale a OMS.<\/p>\n<h2 class=\"wp-block-heading\">How Does Biciphage 1000 SR Work?<\/h2>\n<p>Metformina are trei mecanisme suprapuse care, \u00eempreun\u0103, reduc nivelul glucozei din s\u00e2nge f\u0103r\u0103 a provoca hipoglicemie \u00een st\u0103ri non-diabetice:<\/p>\n<ul>\n<li><strong>Reduce produc\u021bia hepatic\u0103 de glucoz\u0103<\/strong> \u2014 activeaz\u0103 proteina kinaz\u0103 activat\u0103 de AMP (AMPK) \u00een ficat \u0219i inhib\u0103 glicerofosfat dehidrogenaza mitochondrial\u0103, reduc\u00e2nd gliconeogeneza cu aproximativ o treime.<\/li>\n<li><strong>\u00cembun\u0103t\u0103\u021be\u0219te sensibilitatea la insulin\u0103<\/strong> \u2014 spore\u0219te absorb\u021bia periferic\u0103 de glucoz\u0103 \u00een \u021besutul muscular \u0219i adipos, permi\u021b\u00e2nd organismului s\u0103 utilizeze propria insulin\u0103 mai eficient.<\/li>\n<li><strong>\u00cencetine\u0219te absorb\u021bia intestinal\u0103 de glucoz\u0103<\/strong> \u2014 reduce moderat v\u00e2rful de glucoz\u0103 postprandial\u0103 \u0219i poate influen\u021ba favorabil microbiota intestinal\u0103.<\/li>\n<\/ul>\n<p>Metformina reduce de obicei HbA1c cu <strong>1,0\u20131,5 puncte procentuale<\/strong> ca monoterapie. Este neutr\u0103 din punct de vedere al greut\u0103\u021bii sau duce la o sc\u0103dere modest\u0103 a greut\u0103\u021bii (\u00een medie 2\u20133 kg) \u0219i are rezultate cardiovasculare favorabile (UKPDS, urm\u0103rire pe termen lung).<\/p>\n<h2 class=\"wp-block-heading\">Doza \u0219i administrare<\/h2>\n<p><strong>Doza de Metformin SR:<\/strong> Usual starting dose is 500 mg once daily with the evening meal. Titrate up in 500 mg increments weekly if tolerated. Maximum dose is 2,000 mg once daily (or split into two doses of 1,000 mg twice daily if GI upset). Always take Biciphage 1000 SR <strong>\u00een timpul mesei sau imediat dup\u0103 aceasta<\/strong> \u2014 acest lucru reduce semnificativ riscul de grea\u021b\u0103 \u0219i diaree.<\/p>\n<ul>\n<li><strong>\u00cencepe\u021bi cu doze mici, titra\u021bi \u00eencet.<\/strong> Cel mai important factor de predic\u021bie al tolerabilit\u0103\u021bii pe termen lung este o cre\u0219tere gradual\u0103 a dozei pe parcursul a 4\u20136 s\u0103pt\u0103m\u00e2ni.<\/li>\n<li><strong>A\u021bi omis o doz\u0103?<\/strong> S\u0103ri\u021bi doza respectiv\u0103 \u0219i lua\u021bi urm\u0103toarea doz\u0103 la ora obi\u0219nuit\u0103 \u2014 nu lua\u021bi o doz\u0103 dubl\u0103.<\/li>\n<li><strong>Doza renal\u0103.<\/strong> eGFR &gt; 60: doz\u0103 complet\u0103. eGFR 45\u201360: monitoriza\u021bi func\u021bia renal\u0103 la 3\u20136 luni. eGFR 30\u201345: \u00eenjum\u0103t\u0103\u021bi\u021bi doza. <strong>eGFR &lt; 30: \u00eentrerupe\u021bi metformina.<\/strong><\/li>\n<li><strong>\u00cenainte de investiga\u021bii cu substan\u021b\u0103 de contrast sau interven\u021bii chirurgicale.<\/strong> Suspend\u0103 administrarea metforminei \u00een ziua administr\u0103rii contrastului IV iodinat dac\u0103 FG &lt; 60 \u0219i pentru 48 de ore dup\u0103 aceea, relu\u00e2nd administrarea odat\u0103 ce func\u021bia renal\u0103 se stabilizeaz\u0103.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Efecte Secundare<\/h2>\n<p>Metformina este \u00een general bine tolerat\u0103. Cele mai frecvente efecte adverse (care afecteaz\u0103 10\u201325% dintre utilizatori, de obicei \u00een primele 2 s\u0103pt\u0103m\u00e2ni) sunt:<\/p>\n<ul>\n<li>Diaree, grea\u021b\u0103, crampe abdominale<\/li>\n<li>Gust metalic \u00een gur\u0103<\/li>\n<li>Pierderea apetitului<\/li>\n<li>Flatulen\u021b\u0103<\/li>\n<\/ul>\n<p>Acestea sunt de obicei u\u0219oare \u0219i autolimitante. Trecerea la o formul\u0103 cu eliberare prelungit\u0103 sau administrarea \u00een timpul meselor mai mari rezolv\u0103 simptomele gastrointestinale \u00een majoritatea cazurilor.<\/p>\n<p><strong>Pu\u021bin frecvente, dar importante:<\/strong><\/p>\n<ul>\n<li><strong>Deficit de vitamina B12<\/strong> \u2014 utilizarea pe termen lung a metforminei (&gt; 4 ani) reduce absorb\u021bia vitaminei B12 la 6\u201330% dintre utilizatori. Verifica\u021bi nivelul seric de B12 anual \u0219i suplimenta\u021bi dac\u0103 este sc\u0103zut.<\/li>\n<li><strong>Acidoz\u0103 lactic\u0103<\/strong> \u2014 extrem de rar\u0103 (&lt; 10 cazuri la 100.000 de ani-pacient), dar poten\u021bial fatal\u0103. Aproape \u00eentotdeauna apare \u00een contextul leziunii renale acute, septicemiei, deshidrat\u0103rii severe sau hipoxiei. <strong>Suspend\u0103 administrarea metforminei \u00een timpul oric\u0103rei boli acute cu deshidratare, v\u0103rs\u0103turi sau aport redus.<\/strong><\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Mediu de contrast IV iodinat<\/strong> \u2014 suspenda\u021bi metformina \u00eenainte \u0219i dup\u0103 procedur\u0103 dac\u0103 FG &lt; 60.<\/li>\n<li><strong>Alcool<\/strong> \u2014 consumul excesiv de alcool cre\u0219te riscul de acidoz\u0103 lactic\u0103. Consumul moderat de alcool este \u00een general sigur.<\/li>\n<li><strong>Medicamente cationice<\/strong> (cimetidina, dolutegravir, ranolazina) \u2014 concureaz\u0103 pentru secre\u021bia tubular\u0103 renal\u0103 \u0219i cresc nivelurile de metformin\u0103.<\/li>\n<li><strong>Inhibitori ai anhidrazei carbonice<\/strong> (acetazolamida, topiramatul) \u2014 risc adi\u021bional de acidoz\u0103 metabolic\u0103.<\/li>\n<li><strong>Insulin\u0103 \u0219i sulfoniluree<\/strong> \u2014 efect adi\u021bional de sc\u0103dere a glicemiei; hipoglicemia devine o problem\u0103 atunci c\u00e2nd sunt combinate.<\/li>\n<li><strong>Corticosteroizi, diuretice, beta-2 agonisti<\/strong> \u2014 pot cre\u0219te glicemia; este necesar un monitorizare mai atent\u0103.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Who Should Not Take Biciphage 1000 SR?<\/h2>\n<ul>\n<li>Insuficien\u021b\u0103 renal\u0103 sever\u0103 (TFG &lt; 30 mL\/min\/1,73 m\u00b2)<\/li>\n<li>Insuficien\u021b\u0103 cardiac\u0103 acut\u0103 sau decompensat\u0103 care necesit\u0103 spitalizare<\/li>\n<li>Insuficien\u021b\u0103 hepatic\u0103 sever\u0103<\/li>\n<li>Acidoz\u0103 metabolic\u0103 acut\u0103, inclusiv cetoacidoz\u0103 diabetic\u0103<\/li>\n<li>Boal\u0103 acut\u0103 sever\u0103 cu risc de hipoxie tisular\u0103 (seps\u0103, insuficien\u021b\u0103 respiratorie, infarct miocardic recent)<\/li>\n<li>Hipersensibilitate cunoscut\u0103 la metformin<\/li>\n<\/ul>\n<p>\u00cen <strong>sarcina<\/strong>, metformin este utilizat pe scar\u0103 larg\u0103 pentru diabetul gesta\u021bional \u0219i PCOS \u0219i are un profil de siguran\u021b\u0103 bun; discuta\u021bi cu obstetricianul dumneavoastr\u0103. Trece \u00een laptele matern \u00een cantit\u0103\u021bi mici \u0219i este \u00een general considerat compatibil cu al\u0103ptarea.<\/p>\n<h2 class=\"wp-block-heading\">Depozitare<\/h2>\n<p>Store Biciphage 1000 SR below 25&deg;C in a dry place, in the original blister. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Is Biciphage 1000 SR the same as metformin?<\/h3>\n<p>Yes. Biciphage 1000 SR contains the same active ingredient (metformin hydrochloride) as the originator brand Glucophage and every other metformin generic. Bioequivalence is required by regulatory authorities, so clinical effect is the same at the same dose.<\/p>\n<h3 class=\"wp-block-heading\">Will Biciphage 1000 SR help me lose weight?<\/h3>\n<p>Metforminul produce o sc\u0103dere modest\u0103 \u00een greutate (de obicei 2\u20133 kg pe parcursul a 6\u201312 luni) la persoanele cu diabet de tip 2 sau rezisten\u021b\u0103 la insulin\u0103. Nu este un medicament pentru sl\u0103bit la adul\u021bii non-diabetici \u2014 efectele sunt mici \u0219i majoritatea studiilor arat\u0103 pierdere \u00een greutate doar la cei cu niveluri ridicate de insulin\u0103 sau PCOS.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Biciphage 1000 SR for PCOS?<\/h3>\n<p>Da \u2014 metforminul este utilizat pe scar\u0103 larg\u0103 off-label pentru sindromul ovarelor polichistice pentru a \u00eembun\u0103t\u0103\u021bi sensibilitatea la insulin\u0103, a restabili ovula\u021bia \u0219i a reduce simptomele androgenice. Doza tipic\u0103 este de 1.500\u20132.000 mg\/zi.<\/p>\n<h3 class=\"wp-block-heading\">Does Biciphage 1000 SR cause hypoglycaemia (low blood sugar)?<\/h3>\n<p>Nu singur. Metforminul nu stimuleaz\u0103 eliberarea de insulin\u0103, deci nu provoac\u0103 hipoglicemie ca monoterapie. Glicemia sc\u0103zut\u0103 devine o problem\u0103 doar atunci c\u00e2nd metforminul este combinat cu o sulfoniluree, meglitinid\u0103 sau insulin\u0103.<\/p>\n<h3 class=\"wp-block-heading\">How long does Biciphage 1000 SR take to work?<\/h3>\n<p>Glicemia la stomacul gol scade de obicei \u00een 1\u20132 s\u0103pt\u0103m\u00e2ni. Efectul maxim asupra HbA1c se observ\u0103 la 2\u20133 luni. Dac\u0103 HbA1c nu a sc\u0103zut cu 0,5% sau mai mult dup\u0103 3 luni la doza maxim\u0103 tolerat\u0103, se adaug\u0103 de obicei o terapie suplimentar\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol while taking Biciphage 1000 SR?<\/h3>\n<p>Alcoolul moderat (1\u20132 b\u0103uturi pe zi) este \u00een general sigur. Consumul excesiv sau episodic de alcool trebuie evitat \u2014 cre\u0219te riscul de acidoz\u0103 lactic\u0103 \u0219i poate provoca hipoglicemie, mai ales f\u0103r\u0103 m\u00e2ncare.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Biciphage 1000 SR online?<\/h3>\n<p>You can order Biciphage 1000 SR (1000 mg SR) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide, with discreet packaging and genuine WHO-GMP certified manufacturer stock.<\/p>\n<p class=\"medsbase-bundle-link-2026-05-01\" data-marker=\"mb-bundle-link-diabetes-starter-pack\">Biciphage 1000 SR users often add a sulfonylurea step-up tablet once metformin monotherapy is no longer controlling HbA1c; for the bundled first-line + step-up regimen see our <a href='\/ro\/diabetes-starter-pack\/'>Pachetul de Start pentru Diabet (Glycomet SR 1000 mg + Glycomet-GP)<\/a> with both tiers shipped together.<\/p>\n<p class=\"medsbase-link-boost-2026-05-08\" data-marker=\"mb-link-boost-glycomet-sr\">Patients managed on <a href=\"https:\/\/medsbase.com\/ro\/biciphage-1000-sr\/\">Biciphage 1000 SR<\/a> who require flexible SR dosing \u2014 including 250&nbsp;mg, 500&nbsp;mg, or 850&nbsp;mg strengths \u2014 may consider <a href=\"https:\/\/medsbase.com\/ro\/glycomet-sr\/\">Glycomet SR (clorhidrat de metformin 250\u20131000 mg SR)<\/a> as a WHO-GMP-certified alternative offering the same extended-release metformin backbone across a broader strength range.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2 class=\"wp-block-heading\">Medicamente \u00eenrudite pentru Diabet<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/glycomet-sr\/\">Glycomet SR \u2014 Metformin SR 250\/500\/850\/1000 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/glycomet-gp\/\">Glycomet-GP \u2014 combina\u021bie de Metformin + Glimepiride<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/januvia\/\">Januvia \u2014 Sitagliptin\u0103 (inhibitor DPP-4)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/jardiance-empagliflozin\/\">Jardiance \u2014 Empagliflozin\u0103 (inhibitor SGLT-2)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/forxiga-dapagliflozin\/\">Forxiga \u2014 Dapagliflozin (inhibitor SGLT-2)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/amaryl\/\">Amaryl \u2014 Glimepirid\u0103 (sulfoniluree)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/diabetes-medication\/\"><strong>Vizualiza\u021bi toate Medicamentele pentru Diabet<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are doar scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui profesionist calificat \u00een domeniul s\u0103n\u0103t\u0103\u021bii. Diabetul de tip 2 necesit\u0103 monitorizare \u0219i individualizare a dozei de c\u0103tre un medic \u2014 utiliza\u021bi \u00eentotdeauna metformin sub \u00eendrumare medical\u0103, \u00een special dac\u0103 ave\u021bi probleme renale sau hepatice, sunte\u021bi gravid\u0103 sau al\u0103pta\u021bi, sau lua\u021bi alte medicamente.<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 Lowers blood sugar<br \/>\n\u2705 Gestioneaz\u0103 diabetul de tip 2<br \/>\n\u2705 Sprijin\u0103 managementul greut\u0103\u021bii<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te sensibilitatea la insulin\u0103<br \/>\n\u2705 Reduces risk of complications<\/p>\n<p>Biciphage 1000 SR contains <strong>Metformin\u0103<\/strong>.<\/p>","protected":false},"featured_media":64535,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[3230,3231],"product_tag":[5310,3255],"class_list":{"0":"post-64534","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-diabetes","7":"product_cat-diabetes-medication","8":"product_tag-biciphage","9":"product_tag-metformin","11":"first","12":"instock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/64534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=64534"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/64535"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=64534"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=64534"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=64534"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=64534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}