{"id":69013,"date":"2026-03-13T11:58:53","date_gmt":"2026-03-13T11:58:53","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=69013"},"modified":"2026-05-21T07:14:11","modified_gmt":"2026-05-21T07:14:11","slug":"kpv-lysine-proline-valine","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/kpv-lysine-proline-valine\/","title":{"rendered":"KPV (Lizin\u0103-Prolin\u0103-Valin\u0103)"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">R\u0103spuns rapid \u2014 Ce este KPV?<\/h3>\n<p style=\"margin: 0;\"><strong>KPV<\/strong> este tripeptida Lys-Pro-Val \u2014 fragmentul C-terminal antiinflamator al hormonului melanocit-stimulant alfa (\u03b1-MSH). Spre deosebire de analogii melanocortinici mai largi, KPV are <strong>nicio activitate de pigmentare<\/strong>; semnalul s\u0103u de cercetare este pur antiinflamator prin inhibarea NFkB \u0219i stabilizarea mastocitelor. Studiat pentru IBD, inflama\u021bie alergic\u0103 \u0219i cercet\u0103ri privind inflama\u021bia pielii. Furnizat \u00een flacoane liofilizate de 5 mg \u0219i 10 mg, exclusiv pentru uz de laborator.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Peptide liofilizate pentru cercetare \u00b7 puritate HPLC \u226599% (certificat de analiz\u0103 la cerere) \u00b7 Ambalaj discret stabil la temperatur\u0103 \u00b7 Curierat worldwide de peptide \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">Specifica\u021bii<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">Detaliu<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Num\u0103r CAS<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">67727-97-3<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Formula molecular\u0103<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>16<\/sub>H<sub>30<\/sub>N<sub>4<\/sub>O<sub>4<\/sub><\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Greutate molecular\u0103<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">342.43 Da<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Secven\u021b\u0103<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lys-Pro-Val (\u03b1-MSH 11\u201313)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Form\u0103<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Pulbere liofilizat\u0103 (sau a\u0219a cum este furnizat)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Puritate<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226599% (verificat prin HPLC, COA la cerere)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Depozitare<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Liofilizat: 2\u20138\u00b0C (frigider) pentru stocul de lucru; \u221220\u00b0C pentru depozitarea pe termen lung a vialelor nefolosite. Reconstituit: 2\u20138\u00b0C, utilizat \u00een ~30 de zile. Proteja\u021bi de lumin\u0103. Nu \u00eenghe\u021ba\u021bi-decongela\u021bi solu\u021bia reconstituit\u0103.<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Solubilitate<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Ap\u0103 bacteriostatic\u0103 (recomandat\u0103) sau ap\u0103 steril\u0103 pentru perioade mai scurte de utilizare<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Utilizare \u00een cercetare<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Doar pentru utilizare \u00een cercetare de laborator. Nu este destinat pentru uz diagnostic sau terapeutic uman sau veterinar.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>Ce este KPV?<\/h2>\n<p><strong>KPV<\/strong> este abrevierea \u00een cod de trei litere\/una liter\u0103 pentru <strong>tripeptidul Lys-Pro-Val<\/strong> \u2014 cele trei aminoacizi C-terminali (pozi\u021biile 11\u201313) ai hormonului alfa-melanocit stimulator (\u03b1-MSH). \u00cen anii 1980\u20131990, mai multe grupuri de cercetare au observat c\u0103 molecula complet\u0103 de \u03b1-MSH producea dou\u0103 efecte func\u021bional separate: activitatea cunoscut\u0103 de pigmentare\/excitare prin receptorul MC N-terminal \u0219i o <strong>antiinflamatoare<\/strong> activitate C-terminal\u0103. C\u00e2nd tripeptidul KPV C-terminal a fost sintetizat \u0219i testat izolat, a reprodus efectele antiinflamatoare f\u0103r\u0103 efectele secundare de pigmentare.<\/p>\n<p>Greutate molecular\u0103 aproximativ\u0103 342,4 Da. KPV este unul dintre cei mai mici peptizi din familia melanocortinelor \u0219i unul dintre tripeptizii antiinflamatori cei mai studia\u021bi \u00een cercetare. Este furnizat sub form\u0103 de pulbere liofilizat\u0103 de \u00eenalt\u0103 puritate. KPV este <strong>destinat doar pentru cercetare de laborator<\/strong> \u0219i nu este destinat pentru diagnostic sau terapie uman\u0103 sau veterinar\u0103. Pentru mecanism, istoricul cercet\u0103rilor \u00een IBD \u0219i contextul de combinare, consulta\u021bi <a href=\"https:\/\/medsbase.com\/ro\/kpv-peptide-anti-inflammatory-guide\/\">ghidul nostru de cercetare KPV<\/a>.<\/p>\n<h2>Mecanism de ac\u021biune \u2014 Trei c\u0103i antiinflamatoare<\/h2>\n<p>Activitatea antiinflamatoare a KPV ac\u021bioneaz\u0103 prin cel pu\u021bin trei c\u0103i complementare, toate converg\u00e2nd spre reducerea semnaliz\u0103rii inflamatorii f\u0103r\u0103 a afecta alte func\u021bii ale melanocortinei:<\/p>\n<ul>\n<li><strong>Inhibarea NFkB<\/strong> \u2014 KPV blocheaz\u0103 translocarea NFkB \u00een nucleu, prevenind transcrierea citokinelor pro-inflamatoare, inclusiv TNF-alfa, IL-6, IL-1\u03b2 \u0219i IL-8. NFkB este regulatorul principal al expresiei genelor inflamatorii, astfel c\u0103 blocarea activ\u0103rii sale produce un efect antiinflamator larg \u0219i upstream.<\/li>\n<li><strong>Stabilizarea mastocitelor<\/strong> \u2014 KPV reduce degranularea mastocitelor \u0219i eliberarea de histamin\u0103 \u00een modelele de cercetare. Acesta este un mecanism distinct de inhibarea NFkB \u0219i este deosebit de relevant pentru cercetarea inflama\u021biei alergice \u0219i modelele de inflama\u021bie cutanat\u0103 topic\u0103.<\/li>\n<li><strong>Separarea peptid-vs-MSH<\/strong> \u2014 deoarece KPV este doar fragmentul C-terminal, acesta <strong>nu activeaz\u0103 MC1R<\/strong> (receptorul de pigmentare) sau MC4R (receptorul de excita\u021bie\/alimenta\u021bie). Acest lucru separ\u0103 mecanic activitatea antiinflamatoare de celelalte efecte ale \u03b1-MSH \u2014 distinct de analogii MC mai largi, cum ar fi <a href=\"https:\/\/medsbase.com\/ro\/melanotan-ii\/\">Melanotan II<\/a> sau <a href=\"https:\/\/medsbase.com\/ro\/pt-141\/\">PT-141<\/a>.<\/li>\n<\/ul>\n<p>Implica\u021bia practic\u0103 \u00een cercetare: KPV este un instrument de cercetare antiinflamator \u201ccurat\u201d care produce semnalul antiinflamator \u03b1-MSH f\u0103r\u0103 efectele de bronzare, excita\u021bie sau modulare a apetitului care complic\u0103 interpretarea cercet\u0103rilor utiliz\u00e2nd agonisti MC cu lan\u021b \u00eentreg.<\/p>\n<h2>Aplica\u021bii de Cercetare Publicate<\/h2>\n<p>KPV este utilizat \u00een contexte de cercetare de laborator care investigheaz\u0103:<\/p>\n<ul>\n<li><strong>Cercetarea IBD \u0219i colitei<\/strong> \u2014 modele de boal\u0103 inflamatorie intestinal\u0103 la roz\u0103toare; KPV este activ at\u00e2t pe cale subcutanat\u0103, c\u00e2t \u0219i oral\u0103, f\u0103c\u00e2ndu-l deosebit de flexibil pentru cercetarea inflama\u021biei gastrointestinale (Brzoska et al., Endocr Rev 2008)<\/li>\n<li><strong>Inflama\u021bie alergic\u0103<\/strong> \u2014 cercet\u0103ri privind stabilizarea mastocitelor \u0219i eliberarea histaminei \u00een modelele de alergie \u0219i atopie<\/li>\n<li><strong>Inflama\u021bia pielii<\/strong> \u2014 modele de cercetare pentru eczem\u0103, psoriazis \u0219i dermatit\u0103 de contact; unele protocoale de cercetare includ formul\u0103ri topice<\/li>\n<li><strong>Cicatrizarea<\/strong> \u2014 faza antiinflamatorie a cercet\u0103rilor privind vindecarea r\u0103nilor, adesea asociat\u0103 cu <a href=\"https:\/\/medsbase.com\/ro\/bpc-157\/\">BPC-157<\/a> pentru acoperire combinat\u0103 antiinflamatoare \u0219i a factorilor de cre\u0219tere<\/li>\n<li><strong>Inflama\u021bia articular\u0103<\/strong> \u2014 modele de cercetare pe roz\u0103toare pentru artrit\u0103 \u0219i inflama\u021bie articular\u0103<\/li>\n<li><strong>Cercet\u0103ri privind combinarea<\/strong> \u2014 adesea asociat cu <a href=\"https:\/\/medsbase.com\/ro\/bpc-157\/\">BPC-157<\/a> \u00een cercet\u0103rile gastrointestinale \u0219i ale \u021besutului conjunctiv unde este necesar\u0103 acoperire antiinflamatoare \u0219i de reparare tisular\u0103<\/li>\n<li><strong>Cercet\u0103ri comparative ale melanocortinelor<\/strong> \u2014 \u00een paralel cu <a href=\"https:\/\/medsbase.com\/ro\/melanotan-ii\/\">Melanotan II<\/a> \u0219i <a href=\"https:\/\/medsbase.com\/ro\/pt-141\/\">PT-141<\/a> pentru a izola efectele pur antiinflamatoare vs cele ale receptorilor MC<\/li>\n<\/ul>\n<p>Pentru un context mai larg privind peptidele antiinflamatoare \u0219i de vindecare, consulta\u021bi <a href=\"https:\/\/medsbase.com\/ro\/peptides\/\">de peptide de cercetare<\/a>.<\/p>\n<h2>Concentra\u021bii \u0219i doze disponibile<\/h2>\n<p>MedsBase stocheaz\u0103 KPV \u00een urm\u0103toarele dimensiuni de flacoane liofilizate:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Putere flacon<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Caz de utilizare tipic<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Dimensiuni pachet<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>5\u00a0mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Protocoale scurte de cercetare, dozare pilot \u2014 suport\u0103 ~10 administr\u0103ri la 500 mcg<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10, 20 sau 30 de flacoane<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>10 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Putere standard de cercetare \u2014 suport\u0103 ~20 administr\u0103ri la 500 mcg<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10, 20 sau 30 de flacoane<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Protocoalele de cercetare KPV acoper\u0103 o gam\u0103 variabil\u0103 \u00een func\u021bie de sistemul model \u2014 200\u2013500 mcg SC zilnic pentru cercet\u0103ri antiinflamatoare sistematice, sau rute topice\/orale pentru contexte de cercetare gastrointestinale \u0219i cutanate. Toate concentra\u021biile sunt furnizate sub form\u0103 de pulbere liofilizat\u0103 cu puritate HPLC de 99%+.<\/p>\n<h2>Cum se compar\u0103 \u2014 KPV vs Alte Peptide Antiinflamatoare\/Melanocortin<\/h2>\n<p>KPV este una dintre cele mai precise peptide antiinflamatoare utilizate \u00een cercetare datorit\u0103 activit\u0103\u021bii sale foarte \u00eenguste. Comparativ cu compu\u0219ii \u00eenrudi\u021bi:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Criteriu<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">KPV<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">BPC-157<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Melanotan II<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Lungime<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">3 aminoacizi<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">15 aminoacizi<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">7 aminoacizi (ciclici)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Activitate principal\u0103<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Doar antiinflamator<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Antiinflamator + reparare \u021besut + receptor GH<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Agonist MC larg (MC1-5)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Activitate receptor MC<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Nimic (doar C-terminal)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Niciuna<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">MC1, MC3, MC4, MC5<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Efectul asupra pigment\u0103rii<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Niciuna<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Niciuna<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Puternic (semnal primar)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Aplica\u021bii de cercetare<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Boal\u0103 inflamatorie intestinal\u0103 (IBD), alergie, inflama\u021bie cutanat\u0103<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Recuperare tendon, intestin, mu\u0219chi<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Melanogenez\u0103, fotoprotec\u021bie<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Pentru cercetarea inflama\u021biei gastrointestinale, combina\u021bia KPV + BPC-157 este una deosebit de frecvent\u0103, deoarece KPV asigur\u0103 semnalizare antiinflamatoare upstream, \u00een timp ce BPC-157 ofer\u0103 activitate de factor de cre\u0219tere pentru repararea \u021besuturilor. Acest aspect este acoperit \u00een <a href=\"https:\/\/medsbase.com\/ro\/bpc-157-peptide-healing-recovery-guide\/\">BPC-157 research guide<\/a>.<\/p>\n<h2>Depozitare \u0219i reconstituire<\/h2>\n<p><strong>\u00cenainte de reconstituire:<\/strong> p\u0103stra\u021bi flacoanele liofilizate la frigider la 2\u20138\u00b0C \u00een ambalajul original, stabile p\u00e2n\u0103 la 36 de luni. Evita\u021bi ciclurile de \u00eenghe\u021b-dezghe\u021b pe pulbere.<\/p>\n<p><strong>Procedura de reconstituire:<\/strong> injecta\u021bi ap\u0103 bacteriostatic\u0103 pe peretele lateral al flaconului de peptid\u0103 conform graficului de mai sus. \u00cenv\u00e2rti\u021bi u\u0219or \u2014 nu <strong>prime\u0219te,<\/strong> zg\u00e2l\u021b\u00e2i\u021bi \u2014 \u0219i a\u0219tepta\u021bi 5\u201310 minute pentru dizolvare complet\u0103. Solu\u021bia trebuie s\u0103 fie clar\u0103 \u0219i incolor\u0103.<\/p>\n<p><strong>Dup\u0103 reconstituire:<\/strong> p\u0103stra\u021bi la frigider la 2\u20138 \u00b0C \u0219i utiliza\u021bi \u00een termen de 30 de zile. Nu \u00eenghe\u021ba\u021bi solu\u021bia reconstituit\u0103.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>Pentru ce este utilizat KPV \u00een cercetare?<\/h3>\n<p>KPV este utilizat \u00een cercetarea de laborator care investigheaz\u0103 biologia antiinflamatoare, boala inflamatorie intestinal\u0103 (IBD) \u0219i colita, inflama\u021bia alergic\u0103, inflama\u021bia cutanat\u0103 (modele de eczem\u0103\/psoriazis), faza inflamatorie a cicatriz\u0103rii, inflama\u021bia articular\u0103 \u0219i farmacologia comparativ\u0103 a melanocortinelor. Acesta este <strong>prime\u0219te,<\/strong> aprobat de FDA \u0219i este v\u00e2ndut aici strict pentru uz \u00een cercetare de laborator.<\/p>\n<h3>Cum difer\u0103 KPV de Melanotan II sau PT-141?<\/h3>\n<p>KPV este doar fragmentul C-terminal de trei aminoacizi al alfa-MSH, \u00een timp ce Melanotan II \u0219i PT-141 sunt analogi MSH ciclici completi sau aproape completi. Aceasta \u00eenseamn\u0103 c\u0103 KPV are <strong>nicio activitate la receptorii de melanocortin\u0103<\/strong> \u0219i, prin urmare, nu are efecte de pigmentare (MC1R), excita\u021bie (MC4R) sau apetit (MC4R) \u2014 doar activitate antiinflamatoare prin c\u0103ile NFkB \u0219i celulele mast.<\/p>\n<h3>Care este doza tipic\u0103 de KPV pentru cercetare?<\/h3>\n<p>Protocoalele preclinice publicate utilizeaz\u0103 \u00een mod tipic 200\u2013500 mcg subcutan zilnic pentru cercetarea antiinflamatoare sistemic\u0103. Unele cercet\u0103ri privind IBD \u0219i inflama\u021bia cutanat\u0103 utilizeaz\u0103 administrare oral\u0103 sau topic\u0103. Un flacon de 10 mg reconstituit cu 2,0 mL ap\u0103 bacteriostatic\u0103 ofer\u0103 5 mg\/mL \u2014 10 diviziuni pe o sering\u0103 subcutanat\u0103 U-100 furnizeaz\u0103 500 mcg.<\/p>\n<h3>Este KPV aprobat de FDA?<\/h3>\n<p>Nu. KPV nu a primit aprobare de la FDA, EMA sau orice alt organism de reglementare. Peptidul complet alpha-MSH \u0219i cercet\u0103rile legate de KPV au contribuit la dezvoltarea general\u0103 a medicamentelor melanocortine, dar KPV \u00een sine r\u0103m\u00e2ne destinat doar cercet\u0103rii. Tot KPV v\u00e2ndut de furnizorii de peptide pentru cercetare este destinat exclusiv investiga\u021biilor de laborator.<\/p>\n<h3>Poate fi KPV administrat oral pentru cercet\u0103ri \u00een IBD?<\/h3>\n<p>Da. Spre deosebire de majoritatea peptidelor care sunt degradate de enzimele gastrice, KPV p\u0103streaz\u0103 o anumit\u0103 activitate antiinflamatorie prin administrare oral\u0103 \u00een cercet\u0103rile publicate despre IBD \u0219i colit\u0103. Acest lucru \u00eel face deosebit de flexibil pentru cercet\u0103rile privind inflama\u021bia GI, unde administrarea oral\u0103 \u021binte\u0219te direct tractul gastrointestinal. Protocoalele de cercetare variaz\u0103 \u00een func\u021bie de model \u2014 administrarea subcutanat\u0103 r\u0103m\u00e2ne calea dominant\u0103 sistemic\u0103.<\/p>\n<h3>Cum trebuie depozitat KPV?<\/h3>\n<p>Viale liofilizate: p\u0103strate la frigider la 2\u20138 \u00b0C \u00een ambalajul original, stabile p\u00e2n\u0103 la 36 de luni. Solu\u021bie reconstituit\u0103: p\u0103strat\u0103 la frigider la 2\u20138 \u00b0C, de utilizat \u00een 30 de zile. Nu \u00eenghe\u021ba\u021bi solu\u021bia reconstituit\u0103.<\/p>\n<h3>Cum trebuie reconstituit KPV?<\/h3>\n<p>Urma\u021bi graficul de reconstituire de mai sus. Ad\u0103uga\u021bi ap\u0103 bacteriostatic\u0103 pe peretele lateral al flaconului, amesteca\u021bi u\u0219or \u0219i l\u0103sa\u021bi 5\u201310 minute pentru dizolvare complet\u0103. Nu <strong>prime\u0219te,<\/strong> agita\u021bi.<\/p>\n<h3>Pot fi KPV \u0219i BPC-157 combinate \u00een cercetare?<\/h3>\n<p>Da \u2014 aceasta este una dintre cele mai comune combina\u021bii de cercetare pentru inflama\u021bia GI \u0219i a \u021besutului conjunctiv. KPV ofer\u0103 semnalizare antiinflamatoare pe calea NFkB; <a href=\"https:\/\/medsbase.com\/ro\/bpc-157\/\">BPC-157<\/a> ofer\u0103 activitate de reparare a \u021besutului \u0219i factori de cre\u0219tere pe calea VEGF. Mecanismele sunt complementare, nu suprapuse.<\/p>\n<h3>Ce doze stocheaz\u0103 MedsBase?<\/h3>\n<p>MedsBase comercializeaz\u0103 KPV \u00een flacoane liofilizate de 5 mg \u0219i 10 mg. Fiecare concentra\u021bie este disponibil\u0103 \u00een pachete de 10, 20 sau 30 de flacoane. Toate flacoanele sunt furnizate cu o puritate HPLC de 99%+ \u0219i un certificat de analiz\u0103 la cerere.<\/p>\n<h3>Provoac\u0103 KPV efecte secundare \u00een cercetare?<\/h3>\n<p>Cercet\u0103rile preclinice publicate au raportat un profil de siguran\u021b\u0103 remarcabil de bun. Deoarece KPV nu are activitate la receptorii de melanocortin\u0103, efectele de pigmentare, excitare \u0219i tensiune arterial\u0103 observate ocazional cu agonii\u0219ti comple\u021bi ai MC nu apar cu KPV. Nu au fost identificate semnale semnificative de ac\u021biuni nedorite la dozele tipice de cercetare. Datele privind siguran\u021ba pe termen lung la om nu sunt disponibile.<\/p>\n<h3>Care este timpul de \u00eenjum\u0103t\u0103\u021bire al KPV?<\/h3>\n<p>KPV (Lys-Pro-Val) este un tripeptid cu un timp de \u00eenjum\u0103t\u0103\u021bire plasmatic scurt, consistent cu cel al peptidelor mici nemodificate \u2014 estimat la sub 30 de minute. Aplica\u021bia sa principal\u0103 \u00een cercetare este gastrointestinal\u0103, unde studiile de administrare local\u0103 arat\u0103 efecte asupra celulelor epiteliale intestinale \u0219i a popula\u021biilor de celule imune care persist\u0103 dincolo de detectarea plasmatic\u0103, atribuite interac\u021biunii directe cu receptorii de la nivelul mucoasei intestinale.<\/p>\n<h3>Cum reduce KPV inflama\u021bia \u00een modelele de cercetare?<\/h3>\n<p>KPV este tripeptidul C-terminal al \u03b1-MSH (hormonului alfa-melanocit stimulant) \u0219i p\u0103streaz\u0103 o mare parte din activitatea antiinflamatorie a peptidei p\u0103rinte prin activarea MC1R. \u00cen modelele de colit\u0103 \u0219i leziuni intestinale, KPV reduce semnalizarea NF-\u03baB, scade produc\u021bia de citokine proinflamatorii (IL-1\u03b2, IL-6, TNF-\u03b1) \u0219i promoveaz\u0103 integritatea barierii epiteliale intestinale. Dimensiunea sa mic\u0103 faciliteaz\u0103 absorb\u021bia direct\u0103 de c\u0103tre celulele epiteliale, independent de proteinele purt\u0103toare.<\/p>\n<h3>Pot comanda KPV pentru livrare interna\u021bional\u0103?<\/h3>\n<p>Da. MedsBase expediaz\u0103 KPV \u00een \u00eentreaga lume prin re\u021beaua noastr\u0103 dedicat\u0103 de livrare a peptidelor. Comenzile care con\u021bin doar peptide se calific\u0103 pentru serviciul nostru separat de livrare a peptidelor. Comenzile sunt expediate \u00een ambalaje cu control termic \u0219i cu urm\u0103rire complet\u0103.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte peptide pentru cercetare \u00een recuperare \u0219i performan\u021b\u0103<\/h2>\n<ul>\n<li><a href=\"\/ro\/bpc-157\/\"><strong>BPC-157<\/strong><\/a> \u2014 Compus de protec\u021bie corporal\u0103 \u2014 cercetare \u00een recuperarea tendonilor, ligamentelor \u0219i intestinului<\/li>\n<li><a href=\"\/ro\/tb-500\/\"><strong>TB-500<\/strong><\/a> \u2014 Fragment de Thymosin Beta-4 \u2014 cercetare \u00een recuperarea \u021besuturilor moi \u0219i vasculare<\/li>\n<li><a href=\"\/ro\/ipamorelin\/\"><strong>Ipamorelin<\/strong><\/a> \u2014 Agonist selectiv de ghrelin\u0103 \u2014 puls de hormon de cre\u0219tere f\u0103r\u0103 cortizol\/prolactin\u0103<\/li>\n<li><a href=\"\/ro\/cjc-1295-with-dac\/\"><strong>CJC-1295 cu DAC<\/strong><\/a> \u2014 Analog GHRH cu timp de \u00eenjum\u0103t\u0103\u021bire prelungit<\/li>\n<li><a href=\"\/ro\/ghk-cu\/\"><strong>GHK-Cu<\/strong><\/a> \u2014 Peptid de cupru \u2014 cercetare \u00een regenerarea pielii \u0219i a \u021besutului conjunctiv<\/li>\n<\/ul>\n<p><!-- medsbase-peptide-guide-cta --><\/p>\n<h2>Lectur\u0103 suplimentar\u0103<\/h2>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<p style=\"margin: 0 0 8px 0;\"><strong>\ud83d\udcd6 Afla\u021bi cercetarea din spatele acestui peptid<\/strong><\/p>\n<p style=\"margin: 0;\">Cititi ghidul nostru complet bazat pe dovezi: <a href=\"https:\/\/medsbase.com\/ro\/kpv-peptide-anti-inflammatory-guide\/\"><strong>KPV \u2014 fragmentul C-terminal al alpha-MSH pentru cercetarea antiinflamatorie<\/strong><\/a>. Acoper\u0103 farmacologia NFkB, stabilizarea mastocitelor, istoricul cercet\u0103rilor \u00een IBD, protocoale orale \u0219i subcutanate, \u0219i combinarea cu BPC-157.<\/p>\n<\/div>\n<p><!-- pep-seo-v1 --><\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 Sus\u021bine repararea \u021besuturilor<br \/>\n\u2705 Reduce stresul oxidativ<br \/>\n\u2705 Moduleaz\u0103 r\u0103spunsul imun<br \/>\n\u2705 Promoveaz\u0103 rezisten\u021ba celular\u0103<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te integritatea epitelial\u0103<\/p>\n<p><strong>KPV<\/strong> con\u021bine compus peptidic sintetic.<\/p>","protected":false},"featured_media":70964,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[5472,5473],"class_list":{"0":"post-69013","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-kpv","8":"product_tag-lysine-proline-valine","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/69013","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=69013"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/70964"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=69013"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=69013"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=69013"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=69013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}