{"id":71505,"date":"2026-05-20T10:30:00","date_gmt":"2026-05-20T10:30:00","guid":{"rendered":"https:\/\/medsbase.com\/vip-vasoactive-intestinal-peptide\/"},"modified":"2026-05-21T07:14:08","modified_gmt":"2026-05-21T07:14:08","slug":"vip-vasoactive-intestinal-peptide","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/vip-vasoactive-intestinal-peptide\/","title":{"rendered":"VIP (Peptid Intestinal Vasoactiv) \u2014 Grad de Cercetare"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">R\u0103spuns rapid \u2014 Ce este VIP (Peptidul Intestinal Vasoactiv)?<\/h3>\n<p style=\"margin: 0;\"><strong>VIP<\/strong> (Peptid Intestinal Vasoactiv; CAS 40077-57-4, MW 3.325,79 g\/mol) este un neuropeptid sintetic de 28 de aminoacizi identic cu VIP uman nativ. Secven\u021b\u0103: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH<sub>2<\/sub> (amid\u0103 C-terminal\u0103). Membru al <strong>superfamiliei VIP\/PACAP \/ secretin\u0103-glucagon<\/strong>. VIP ac\u021bioneaz\u0103 la <strong>receptorii VPAC1 \u0219i VPAC2<\/strong> (GPCRs cuplate la Gs) produc\u00e2nd o gam\u0103 larg\u0103 de efecte fiziologice: vasodilata\u021bie, relaxare a mu\u0219chilor netezi intestinali, secre\u021bie exocrin\u0103, modulare neurotransmi\u021b\u0103toare, reglare somn\/circadian\u0103 \u0219i efecte <strong>activitate antiinflamatoare \/ imunomodulatoare<\/strong>. Cercet\u0103rile publicate se concentreaz\u0103 pe rolul VIP \u00een imunomodularea polarizat\u0103 Th2, farmacologia bolilor autoimune (modele de AR, SM, IBD) \u0219i neuroprotec\u021bie. Pentru uz exclusiv \u00een cercetare de laborator.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Liofilizat \u226599% verificat prin HPLC \u00b7 COA disponibil la cerere \u00b7 Ambalaj discret stabil la temperatur\u0103 \u00b7 Curier mondial de aprovizionare pentru cercetare \u00b7 Peste 1.400 de verific\u0103ri <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px;\">Specifica\u021bii<\/th>\n<th style=\"padding: 8px 12px;\">Detaliu<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Clas\u0103 de compu\u0219i<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Neuropeptid sintetic de 28-aa; agonist al receptorilor VPAC1 \/ VPAC2; membru al superfamiliei secretine-glucagon<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Num\u0103r CAS<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">40077-57-4 (VIP uman)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Secven\u021b\u0103<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH<sub>2<\/sub> (HSDAVFTDNYTRLRKQMAVKKYLNSILN-NH<sub>2<\/sub>; 28 aa; amid\u0103 C-terminal\u0103)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Greutate molecular\u0103<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">3.325,79 g\/mol<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Formula molecular\u0103<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>147<\/sub>H<sub>237<\/sub>N<sub>43<\/sub>O<sub>43<\/sub>S; MM 3326,78 g\/mol (neuropeptid liber de 28-aa cu amid\u0103).<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Mecanism de ac\u021biune<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Se leag\u0103 de <strong>VPAC1<\/strong> (distribu\u021bie larg\u0103: pl\u0103m\u00e2ni, tract GI, celule T, creier, ficat) \u0219i <strong>VPAC2<\/strong> (mu\u0219chi neted, celule mast, SNC) cu afinitate similar\u0103 (K \u00een gama nanomolar\u0103)<sub>D<\/sub>). Ambii receptori sunt cupla\u021bi Gs \u2014 cre\u0219te cAMP intracelular, activeaz\u0103 PKA, determin\u0103 efecte specifice \u021besuturilor \u00een aval. De asemenea, are o legare cu afinitate mai mic\u0103 a receptorului PAC1 (receptorul preferat de PACAP).<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Form\u0103 \/ Puritate \/ Depozitare<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Pudr\u0103 liofilizat\u0103 alb\u0103 p\u00e2n\u0103 la alb-g\u0103lbuie, \u226599% HPLC. Depozitare 2\u20138 \u00b0C pe termen scurt, \u221220 \u00b0C pe termen lung (\u226536 luni). Reconstituit: 2\u20138 \u00b0C, utilizare \u00een termen de 30 de zile.<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Utilizare \u00een cercetare<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Doar pentru utilizare \u00een cercet\u0103ri de laborator. Nu se afl\u0103 pe Lista Interzis\u0103 WADA. Aviptadil (formulare sintetic\u0103 de VIP) a avut cercet\u0103ri \u00een Faza III pe cale de inhalare pentru SDRA COVID-19, dar nu a ob\u021binut aprobare regulatorie.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>Mecanism de ac\u021biune \u2014 Farmacologie VPAC1 \/ VPAC2<\/h2>\n<ul>\n<li><strong>Agonism dual VPAC1 + VPAC2<\/strong> \u2014 VIP se leag\u0103 de ambii receptori cu afinitate similar\u0103. Distribu\u021bia VPAC1 este larg\u0103 (pl\u0103m\u00e2ni, tract gastrointestinal, celule T, hepatocite, creier). VPAC2 este concentrat pe mu\u0219chi neted, celule mastocitare, SNC \u0219i popula\u021bii selectate de celule imune.<\/li>\n<li><strong>Cascad\u0103 cAMP-PKA<\/strong> \u2014 Ambii receptori VPAC sunt cupla\u021bi Gs, stimuleaz\u0103 adenilat ciclaza, cresc cAMP \u0219i activeaz\u0103 PKA. Efectele specifice \u021besuturilor \u00een aval depind de disponibilitatea substratelor PKA.<\/li>\n<li><strong>Relaxare a mu\u0219chiului neted<\/strong> \u2014 Cre\u0219terea cAMP mediat\u0103 de VPAC2 \u00een mu\u0219chiul neted al c\u0103ilor respiratorii determin\u0103 bronhodilata\u021bie; \u00een mu\u0219chiul neted gastrointestinal determin\u0103 relaxare intestinal\u0103; \u00een mu\u0219chiul neted vascular determin\u0103 vasodilata\u021bie.<\/li>\n<li><strong>Modulare imun\u0103 polarizat\u0103 Th2<\/strong> \u2014 Activarea VPAC1 pe celulele T induce polarizarea Th2, suprim\u0103 produc\u021bia de citokine Th1 (IFN-\u03b3, IL-12), reduce produc\u021bia inflamatoare de TNF-\u03b1 \/ IL-6 \u0219i cre\u0219te citokinele regulate IL-10 \/ TGF-\u03b2. Efectul net este antiinflamator \u00een modelele de boli autoimune (artrit\u0103 reumatoid\u0103, scleroz\u0103 multipl\u0103, boal\u0103 inflamatorie intestinal\u0103, septicemie).<\/li>\n<li><strong>Modulare a celulelor mastocitare<\/strong> \u2014 VIP elibereaz\u0103 histamin\u0103 din celulele mastocitare la concentra\u021bii mari, dar poate \u0219i s\u0103 stabilizeze eliberarea granulelor mastocitare \u00een anumite contexte (\u00een func\u021bie de concentra\u021bie \u0219i \u021besut).<\/li>\n<li><strong>Neuroprotec\u021bie<\/strong> \u2014 VPAC2 pe neuronii SNC activeaz\u0103 semnalizarea pro-supravie\u021buire PKA-CREB; cercet\u0103rile publicate \u00een modelele de accident vascular cerebral ischemic, boala Parkinson \u0219i neurodegenerare au documentat efecte neuroprotectoare.<\/li>\n<li><strong>Reglare circadian\u0103<\/strong> \u2014 VIP este principalul neurotransmi\u021b\u0103tor de cuplare al nucleului suprahiasmatic (SCN), sincroniz\u00e2nd neuronii SCN individuali \u00een ceasul principal coordonat care regleaz\u0103 ritmul circadian.<\/li>\n<\/ul>\n<h2>Aplica\u021bii de Cercetare Publicate<\/h2>\n<ul>\n<li><strong>Farmacologia receptorilor VPAC<\/strong> \u2014 compusul de referin\u021b\u0103 canonic pentru cercetarea VPAC1\/VPAC2<\/li>\n<li><strong>Cercetare \u00een boli autoimune<\/strong> \u2014 efecte antiinflamatoare publicate \u00een modelele de AR, SM, BII, septicemie<\/li>\n<li><strong>Cercetare pulmonar\u0103<\/strong> \u2014 Aviptadil (VIP sintetic inhalator) studiat pentru sarcoidoz\u0103, fibroz\u0103 pulmonar\u0103, SDRA COVID-19<\/li>\n<li><strong>Farmacologie vasodilatatoare<\/strong> \u2014 cercet\u0103ri istorice privind func\u021bia vascular\u0103 \u0219i erectil\u0103 mediat\u0103 de VIP<\/li>\n<li><strong>Cercetare privind ritmul circadian<\/strong> \u2014 farmacologia cupl\u0103rii re\u021belei SCN<\/li>\n<li><strong>Cercetare privind polarizarea Th1\/Th2<\/strong> \u2014 VIP este peptidul canonic de polarizare Th2 al\u0103turi de IL-4<\/li>\n<li><strong>Cercetare privind neuroprotec\u021bia \/ neurodegenerarea<\/strong> \u2014 modele de accident vascular cerebral ischemic, Parkinson, Alzheimer<\/li>\n<\/ul>\n<p>Pentru peptide de cercetare \u00eenrudite, consulta\u021bi <a href=\"https:\/\/medsbase.com\/ro\/oxytocin-acetate\/\">Oxitocin\u0103 Acetat<\/a> (peptid nonapeptidic din hipofiza posterioar\u0103), <a href=\"https:\/\/medsbase.com\/ro\/selank\/\">Selank<\/a> (peptid neuropeptidic dezvoltat \u00een Rusia), <a href=\"https:\/\/medsbase.com\/ro\/semax\/\">Semax<\/a> (peptid nootrop), <a href=\"https:\/\/medsbase.com\/ro\/dsip\/\">DSIP<\/a> (peptid inductor de somn delta), <a href=\"https:\/\/medsbase.com\/ro\/thymosin-alpha-1\/\">Timozin\u0103 Alfa-1<\/a> (modulator imun). R\u0103sfoi\u021bi \u00eentregul <a href=\"https:\/\/medsbase.com\/ro\/peptides\/\">catalog de cercetare peptidic\u0103<\/a>.<\/p>\n<h2>Concentra\u021bii disponibile<\/h2>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px;\">Putere flacon<\/th>\n<th style=\"padding: 10px;\">Dimensiuni pachet<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>5 mg<\/strong> \u2014 concentra\u021bie standard pentru cercetare<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 sau 20 flacoane<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>10 mg<\/strong> \u2014 protocoale extinse, cost redus pe mg<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 sau 20 flacoane<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 14px 18px; margin: 18px 0;\"><strong class=\"mb-bac-water-callout\">\ud83d\udca7 Ave\u021bi nevoie de ap\u0103 BAC?<\/strong> Reconstituirea oric\u0103rui flacon liofilizat necesit\u0103 ap\u0103 bacteriostatic\u0103 steril\u0103. Combina\u021bi acest produs cu <a href=\"\/ro\/bac-water\/\"><strong>Ap\u0103 BAC (Ap\u0103 bacteriostatic\u0103)<\/strong><\/a> \u2014 flacon multidoz\u0103 de 30 mL, conservat cu 0,9% alcool benzilic, grad USP.<\/div>\n<h2>Depozitare \u0219i reconstituire<\/h2>\n<p>Liofilizat 2\u20138 \u00b0C pe termen scurt, \u221220 \u00b0C pe termen lung. Reconstitui\u021bi cu ap\u0103 bacteriostatic\u0103 (1,0 mL per flacon de 5\/10 mg \u2192 5 \/ 10 mg\/mL). Evita\u021bi ciclurile de \u00eenghe\u021bare-dezghe\u021bare. VIP este sensibil la oxidare la nivelul reziduului Met-17 \u2014 proteja\u021bi solu\u021biile reconstituite de expunerea prelungit\u0103 la aer.<\/p>\n<h2>\u00centreb\u0103ri frecvente<\/h2>\n<h3>Este VIP acela\u0219i lucru cu PACAP?<\/h3>\n<p>Nu \u2014 sunt peptide \u00eenrudite (aceea\u0219i superfamilie) dar distincte. PACAP-38 \u0219i PACAP-27 sunt ligan\u021bi alternativi ai acelora\u0219i receptori VPAC1\/VPAC2 (cu selectivitate PAC1 care nu este \u00eemp\u0103rt\u0103\u0219it\u0103 de VIP). VIP \u0219i PACAP au o identitate de secven\u021b\u0103 de ~68%.<\/p>\n<h3>Ce game de doze sunt utilizate \u00een cercetare?<\/h3>\n<p>Protocoalele in-vivo pe roz\u0103toare folosesc de obicei 1\u201310 nmol\/kg SC sau IP. Lucr\u0103rile in-vitro folosesc concentra\u021bii nanomolare. Dozarea prin inhalare \u00een studii clinice cu Aviptadil a fost de 100 \u00b5g de 3 ori pe zi \u00een cercet\u0103rile COVID-19.<\/p>\n<h3>De ce este timpul de \u00eenjum\u0103t\u0103\u021bire plasmatic al VIP scurt?<\/h3>\n<p>VIP este rapid degradat de endopeptidaza neutr\u0103 (NEP) \u0219i alte peptidaze, cu un timp de \u00eenjum\u0103t\u0103\u021bire plasmatic de aproximativ 2 minute. Acest lucru face ca administrarea SC\/IP s\u0103 fie ruta standard de cercetare; administrarea prin inhalare (Aviptadil) evit\u0103 eliminarea plasmatic\u0103 de prim\u0103 trecere pentru indica\u021biile pulmonare.<\/p>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 20px 0 8px; border-radius: 4px; font-size: 14px;\"><strong>De ce s\u0103 comanzi compu\u0219i de cercetare de la MedsBase:<\/strong> Peptide \u0219i compu\u0219i liofiliza\u021bi HPLC \u226599% \u00b7 COA disponibil la cerere \u00b7 Ambalaj discret stabil la temperatur\u0103 \u00b7 Curierat worldwide \u00b7 <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance<\/a> la fiecare comand\u0103 \u00b7 Peste 1.400 de <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a><\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte Peptide de Cercetare \u00een Neuropeptide\/Imunitate<\/h2>\n<ul>\n<li><a href=\"\/ro\/oxytocin-acetate\/\"><strong>Oxitocin\u0103 Acetat<\/strong><\/a> \u2014 Nonapeptid hipofizar posterior<\/li>\n<li><a href=\"\/ro\/selank\/\"><strong>Selank<\/strong><\/a> \u2014 Neuropeptid anxiolitic rus<\/li>\n<li><a href=\"\/ro\/dsip\/\"><strong>DSIP<\/strong><\/a> \u2014 Peptid inductiv de somn delta<\/li>\n<li><a href=\"\/ro\/thymosin-alpha-1\/\"><strong>Timozin\u0103 Alfa-1<\/strong><\/a> \u2014 Peptid imunomodulator (polarizare Th1; complementar)<\/li>\n<li><a href=\"\/ro\/ll-37-cathelicidin-antimicrobial-peptide\/\"><strong>LL-37 (Cathelicidin\u0103)<\/strong><\/a> \u2014 Peptid antimicrobian al imunit\u0103\u021bii innase<\/li>\n<li><a href=\"\/ro\/bac-water\/\"><strong>Ap\u0103 BAC (Ap\u0103 bacteriostatic\u0103)<\/strong><\/a> \u2014 Necesar pentru reconstituirea oric\u0103rui flacon liofilizat \u2014 diluent steril, conservat cu 0,9% alcool benzilic<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Peptid neuropeptidic uman sintetic de 28-aa (familia VIP\/PACAP, superfamilia secretin-glucagon)<br \/>\n\u2705 Agonist al receptorilor VPAC1 + VPAC2 (GPCRs cuplat la Gs) \u2192 cascad\u0103 cAMP-PKA<br \/>\n\u2705 Vasodilata\u021bie, relaxare a mu\u0219chilor netezi, modulare imun\u0103 polarizat\u0103 Th2<br \/>\n\u2705 Neurotransmi\u021b\u0103tor principal de cuplare al ritmului circadian al nucleului suprahiasmatic<br \/>\n\u2705 CAS 40077-57-4; MW 3.325,79; C-terminal amida<\/p>\n<p><strong>VIP (Peptid Intestinal Vasoactiv)<\/strong> con\u021bine neuropeptid sintetic uman de 28-aa.<\/p>","protected":false},"featured_media":71532,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[6557,6494,6558,6554,6553,6555,6556],"class_list":{"0":"post-71505","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-neuropeptide","8":"product_tag-research-peptide","9":"product_tag-th2-immune-modulator","10":"product_tag-vasoactive-intestinal-peptide","11":"product_tag-vip","12":"product_tag-vpac1-agonist","13":"product_tag-vpac2-agonist","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/71505","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=71505"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/71532"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=71505"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=71505"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=71505"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=71505"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}