{"id":71510,"date":"2026-05-20T10:35:00","date_gmt":"2026-05-20T10:35:00","guid":{"rendered":"https:\/\/medsbase.com\/b7-33\/"},"modified":"2026-05-21T07:14:08","modified_gmt":"2026-05-21T07:14:08","slug":"b7-33","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/b7-33\/","title":{"rendered":"B7-33 (Biased RXFP1 Relaxin B-Chain Analogue)"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">R\u0103spuns rapid \u2014 Ce este B7-33?<\/h3>\n<p style=\"margin: 0;\"><strong>B7-33<\/strong> este un analog sintetic de 33-aminoacizi <strong>al lan\u021bului B de relaxin\u0103 cu lan\u021b unic<\/strong> dezvoltat de Hossain, Howe \u0219i colegii de la Institutul Florey (Melbourne, Australia) \u0219i publicat \u00een <em>Nature Communications<\/em> (2017). \u00cen timp ce relaxina-2 nativ\u0103 (hormonul canonic de tratare a fibrozei, clinic cunoscut sub denumirea de Serelaxin) este un peptid cu dou\u0103 lan\u021buri A\/B legate prin disulfuri care activeaz\u0103 at\u00e2t receptorul RXFP1 (anti-fibrotic) c\u00e2t \u0219i RXFP2 (pro-supravie\u021buire a celulelor canceroase), B7-33 este un <strong>agonist polarizat RXFP1<\/strong> \u2014 design cu un singur lan\u021b B care activeaz\u0103 selectiv semnalizarea anti-fibrotic\u0103 a RXFP1 (calea ERK1\/2 \u2192 upregulare MMP-2 \u2192 degradare ECM) evit\u00e2nd semnalizarea pro-cancer prin cAMP care a contribuit la \u00eentreruperea utiliz\u0103rii Serelaxin. Aplica\u021bii de cercetare publicate: insuficien\u021b\u0103 cardiac\u0103, fibroz\u0103 hepatic\u0103\/renal\u0103\/pulmonar\u0103\/cardiac\u0103, pre-eclampsie. <em>Doar pentru uz \u00een cercetare de laborator.<\/em><\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Liofilizat \u226599% verificat prin HPLC \u00b7 COA disponibil la cerere \u00b7 Ambalaj discret stabil la temperatur\u0103 \u00b7 Curier mondial de aprovizionare pentru cercetare \u00b7 Peste 1.400 de <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px;\">Specifica\u021bii<\/th>\n<th style=\"padding: 8px 12px;\">Detaliu<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Clas\u0103 de compu\u0219i<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Analog sintetic cu un singur lan\u021b al lan\u021bului B al relaxinei de 33-aa; agonist polarizat al receptorului RXFP1 (cale anti-fibrotic\u0103 ERK, cu semnalizare redus\u0103 pro-supravie\u021buire prin cAMP)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Denumire chimic\u0103<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">B7-33 (analog al lan\u021bului B al relaxinei 7-33 cu modific\u0103ri stabilizatoare; Hossain et al. 2017 Nat Commun)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Num\u0103r CAS<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Peptid de grad de cercetare \u2014 nu are un CAS unic \u00eenregistrat pe scar\u0103 larg\u0103; identificare prin secven\u021b\u0103 publicat\u0103 \u0219i COA furnizor<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Formula molecular\u0103<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Analog cu un singur lan\u021b de 33 de reziduuri al lan\u021bului B \u2014 MF aproximativ derivat din secven\u021b\u0103 C<sub>164<\/sub>H<sub>252<\/sub>N<sub>50<\/sub>O<sub>45<\/sub>S<sub>2<\/sub>; publicat MW ~3,728 Da (Hossain &amp; Bathgate 2015, J Med Chem).<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Lungimea secven\u021bei \/ MW<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">33 de aminoacizi deriva\u021bi din lan\u021bul B al H2-relaxinei cu modific\u0103ri N- \u0219i C-terminale pentru solubilitate\/stabilitate; MW ~3,800 Da<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Mecanism de ac\u021biune<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Agonist RXFP1 p\u0103rtinitor<\/strong>. Activeaz\u0103 selectiv ERK1\/2 \u2192 upregulare MMP-2\/MMP-9 \u2192 cale de degradare a colagenului\/remodelare a matricei extracelulare (bra\u021bul antifibrotic al semnaliz\u0103rii RXFP1), prezent\u00e2nd o activare redus\u0103 a semnaliz\u0103rii RXFP1 mediate de cAMP (calea implicat\u0103 \u00een semnalele adverse cardiace ale Serelaxinei \u0219i efectul pro-supravie\u021buire al celulelor canceroase care a complicat dezvoltarea clinic\u0103 a relaxinei).<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Form\u0103 \/ Puritate \/ Depozitare<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Pudr\u0103 liofilizat\u0103 alb\u0103 p\u00e2n\u0103 la alb-g\u0103lbuie, \u226599% HPLC. Depozitare 2\u20138 \u00b0C pe termen scurt, \u221220 \u00b0C pe termen lung (\u226536 luni). Reconstituit: 2\u20138 \u00b0C, utilizare \u00een termen de 30 de zile.<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>Utilizare \u00een cercetare<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Doar pentru uz \u00een cercetare de laborator. Nu se afl\u0103 pe Lista interzis\u0103 WADA. Compus de cercetare preclinic\u0103.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>Mecanism de ac\u021biune \u2014 Agonism RXFP1 p\u0103rtinitor (ERK f\u0103r\u0103 cAMP)<\/h2>\n<p>B7-33 a fost proiectat de grupul Hossain\/Howe\/Bathgate de la Institutul Florey ca r\u0103spuns la \u201cproblema Serelaxinei\u201d. Serelaxina (relaxin\u0103-2 uman\u0103 recombinant\u0103) a finalizat studii de faz\u0103 III pentru insuficien\u021b\u0103 cardiac\u0103 acut\u0103, dar nu a ob\u021binut aprobarea FDA \u2014 par\u021bial din cauza semnalelor mixte de siguran\u021b\u0103 cardiovascular\u0103 atribuite semnaliz\u0103rii duale RXFP1 (calea antifibrotic\u0103 ERK benefic\u0103; calea cAMP poten\u021bial pro-aritmic\u0103 \u0219i pro-supravie\u021buire a celulelor canceroase).<\/p>\n<p>Ipoteza de proiectare a B7-33: lan\u021bul B al relaxinei singur <strong>(lan\u021bul care mediaz\u0103 legarea RXFP1) poate fi inginerizat \u00eentr-un peptid stabil cu un singur lan\u021b care activeaz\u0103 doar bra\u021bul antifibrotic ERK1\/2\/upregulare MMP al semnaliz\u0103rii RXFP1, evit\u00e2nd bra\u021bul pro-cancer\/pro-aritmic mediat de cAMP. Lucrarea publicat\u0103 \u00een 2017 \u00een Nature Communications a confirmat acest lucru: B7-33 produce activare m\u0103surabil\u0103 RXFP1-ERK1\/2 dar o elevare minim\u0103 a cAMP \u2014 definind agonismul p\u0103rtinitor. \u00cen modelele publicate de fibroz\u0103 cardiac\u0103, fibroz\u0103 renal\u0103 \u0219i pre-eclampsie la \u0219oareci, B7-33 a produs eficacitate antifibrotic\u0103 echivalent\u0103 sau superioar\u0103 relaxinei native f\u0103r\u0103 complica\u021biile mediate de cAMP.<\/strong> Farmacologie agonist\u0103 p\u0103rtinitoare RXFP1.<\/p>\n<h2>Aplica\u021bii de Cercetare Publicate<\/h2>\n<ul>\n<li><strong>\u2014 exemplu canonic de polarizare a c\u0103ii receptorului \u00een literatura publicat\u0103 de inginerie peptidic\u0103<\/strong> Cercetare fibroz\u0103 cardiac\u0103<\/li>\n<li><strong>\u2014 modele de cardiomiopatie ischemic\u0103 \u0219i hipertensiv\u0103; citire depunere colagen \u0219i remodelare ECM<\/strong> \u2014 ischaemic and hypertensive cardiomyopathy models; collagen-deposition and ECM-remodelling readouts<\/li>\n<li><strong>Cercetare pe fibroz\u0103 renal\u0103\/hepatic\u0103\/pulmonar\u0103<\/strong> \u2014 upregulare MMP-2\/9 \u0219i degradare ECM \u00een modele cronice de fibroz\u0103<\/li>\n<li><strong>Cercetare pe pre-eclampsie<\/strong> \u2014 publicat \u00een modele de soareci gravizi; axa relaxinei este implicat\u0103 central \u00een adaptarea hemodinamic\u0103 a sarcinii normale<\/li>\n<li><strong>Cercetare preclinic\u0103 pe insuficien\u021b\u0103 cardiac\u0103<\/strong> \u2014 alternativ\u0103 la Serelaxin pentru cercetare translacional\u0103 clinic\u0103 unde profilul de semnalizare polarizat\u0103 este mai favorabil<\/li>\n<li><strong>Cercetare pe leziune renal\u0103 acut\u0103<\/strong> \u2014 studii de protec\u021bie tubular\u0103 renal\u0103 mediat\u0103 de RXFP1<\/li>\n<\/ul>\n<p>Pentru un context mai larg, consulta\u021bi peptidele de cercetare conexe: <a href=\"https:\/\/medsbase.com\/ro\/bpc-157\/\">BPC-157<\/a> (reparare tisular\u0103), <a href=\"https:\/\/medsbase.com\/ro\/tb-500\/\">TB-500<\/a> (recuperare), <a href=\"https:\/\/medsbase.com\/ro\/ghk-cu\/\">GHK-Cu<\/a> (remodelare a pielii \u0219i a \u021besutului conjunctiv). R\u0103sfoi\u021bi \u00eentregul <a href=\"https:\/\/medsbase.com\/ro\/peptides\/\">catalog de cercetare peptidic\u0103<\/a>.<\/p>\n<h2>Concentra\u021bii disponibile<\/h2>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px;\">Putere flacon<\/th>\n<th style=\"padding: 10px;\">Dimensiuni pachet<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>2 mg<\/strong> \u2014 standard de protocol de cercetare pentru farmacologia RXFP1 in vitro \u0219i lucr\u0103ri in vivo cu ciclu scurt<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 sau 20 flacoane<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>10 mg<\/strong> \u2014 modele extinse de fibroz\u0103 cu dozare cronic\u0103, dimensiuni ale e\u0219antioanelor multi-cohorte; cel mai mic cost pe mg<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 sau 20 flacoane<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 14px 18px; margin: 18px 0;\"><strong class=\"mb-bac-water-callout\">\ud83d\udca7 Ave\u021bi nevoie de ap\u0103 BAC?<\/strong> Reconstituirea oric\u0103rui flacon liofilizat necesit\u0103 ap\u0103 bacteriostatic\u0103 steril\u0103. Combina\u021bi acest produs cu <a href=\"\/ro\/bac-water\/\"><strong>Ap\u0103 BAC (Ap\u0103 bacteriostatic\u0103)<\/strong><\/a> \u2014 flacon multidoz\u0103 de 30 mL, conservat cu 0,9% alcool benzilic, grad USP.<\/div>\n<h2>Depozitare \u0219i reconstituire<\/h2>\n<p>Liofilizat 2\u20138 \u00b0C pe termen scurt, \u221220 \u00b0C pe termen lung. Se reconstituie cu ap\u0103 bacteriostatic\u0103 (1,0 mL per flacon de 2 mg \u2192 2 mg\/mL; 1,0 mL per flacon de 10 mg \u2192 10 mg\/mL). Evita\u021bi ciclurile de \u00eenghe\u021bare-dezghe\u021bare.<\/p>\n<h2>\u00centreb\u0103ri frecvente<\/h2>\n<h3>Cum difer\u0103 B7-33 de Serelaxin \/ relaxina-2 natural\u0103?<\/h3>\n<p>Relaxina-2 natural\u0103 este un peptid cu dou\u0103 lan\u021buri (A + B) legate prin disulfuri, care activeaz\u0103 ambele c\u0103i descendente ale RXFP1 \u2014 ramura antifibrotic\u0103 ERK \u0219i ramura pro-supravie\u021buire cAMP. Serelaxin este relaxina-2 natural\u0103 recombinat\u0103; a e\u0219uat \u00een Faza III pentru insuficien\u021b\u0103 cardiac\u0103 acut\u0103, par\u021bial din cauza semnalelor adverse pe calea cAMP. B7-33 este un analog cu un singur lan\u021b B care activeaz\u0103 selectiv ramura antifibrotic\u0103 ERK f\u0103r\u0103 semnalul pe calea cAMP.<\/p>\n<h3>B7-33 a fost testat \u00een studii clinice?<\/h3>\n<p>B7-33 r\u0103m\u00e2ne un compus de cercetare preclinic\u0103; p\u00e2n\u0103 \u00een prezent, nu au fost finalizate studii clinice umane formale de Faza I\/II.<\/p>\n<h3>Ce game de doze sunt utilizate \u00een cercetare?<\/h3>\n<p>Protocoalele publicate pe modele murine in-vivo folosesc 25\u201350 \u00b5g\/kg subcutan zilnic timp de 2\u20134 s\u0103pt\u0103m\u00e2ni. Lucr\u0103rile in-vitro pe culturi celulare folosesc concentra\u021bii nanomolare.<\/p>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 20px 0 8px; border-radius: 4px; font-size: 14px;\"><strong>De ce s\u0103 comanzi compu\u0219i de cercetare de la MedsBase:<\/strong> Peptide \u0219i compu\u0219i liofiliza\u021bi HPLC \u226599% \u00b7 COA disponibil la cerere \u00b7 Ambalaj discret stabil la temperatur\u0103 \u00b7 Curierat worldwide \u00b7 <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance<\/a> la fiecare comand\u0103 \u00b7 Peste 1.400 de <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a><\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte Peptide de Cercetare pentru Repararea \u021aesuturilor \/ Antifibrotice<\/h2>\n<ul>\n<li><a href=\"\/ro\/bpc-157\/\"><strong>BPC-157<\/strong><\/a> \u2014 Compus de cercetare pentadecapeptidic pentru repararea \u021besuturilor<\/li>\n<li><a href=\"\/ro\/tb-500\/\"><strong>TB-500<\/strong><\/a> \u2014 Fragment de Timozin\u0103 Beta-4, recuperare<\/li>\n<li><a href=\"\/ro\/ghk-cu\/\"><strong>GHK-Cu<\/strong><\/a> \u2014 Tripeptid legat de cupru, remodelare a pielii \/ \u021besutului conjunctiv<\/li>\n<li><a href=\"\/ro\/glow-blend\/\"><strong>Amestec GLOW<\/strong><\/a> \u2014 Stiv\u0103 BPC-157 + GHK-Cu + TB-500<\/li>\n<li><a href=\"\/ro\/peptide-healing-stack-bpc-157-tb-500-bac-water\/\"><strong>Stiv\u0103 de peptide curative<\/strong><\/a> \u2014 Pachet BPC-157 + TB-500<\/li>\n<li><a href=\"\/ro\/bac-water\/\"><strong>Ap\u0103 BAC (Ap\u0103 bacteriostatic\u0103)<\/strong><\/a> \u2014 Necesar pentru reconstituirea oric\u0103rui flacon liofilizat \u2014 diluent steril, conservat cu 0,9% alcool benzilic<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Analog sintetic de 33-aa cu lan\u021b unic al lan\u021bului B de relaxin\u0103<br \/>\n\u2705 Agonist polarizat RXFP1 \u2014 efect anti-fibrotic ERK1\/2 f\u0103r\u0103 semnalizare pro-cancer cAMP<br \/>\n\u2705 Alternativ\u0103 inginerizat\u0103 la Serelaxin (Hossain\/Howe, Institutul Florey 2017 Nat Commun)<br \/>\n\u2705 Cercetare \u00een fibroz\u0103 cardiac\u0103\/renal\u0103\/hepatic\u0103\/pulmonar\u0103; modele de pre-eclampsie<br \/>\n\u2705 ~MW 3.800 Da; dozaj publicat 25-50 \u00b5g\/kg\/zi SC la \u0219oareci<\/p>\n<p><strong>B7-33<\/strong> con\u021bine peptid de cercetare analog sintetic de 33-aa al lan\u021bului B de relaxin\u0103.<\/p>","protected":false},"featured_media":71533,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[6562,6559,6563,6560,6494,6561],"class_list":{"0":"post-71510","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-anti-fibrotic-peptide","8":"product_tag-b7-33","9":"product_tag-cardiac-fibrosis-research","10":"product_tag-relaxin-analogue","11":"product_tag-research-peptide","12":"product_tag-rxfp1-biased-agonist","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/71510","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=71510"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/71533"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=71510"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=71510"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=71510"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=71510"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}