{"id":3519,"count":15,"description":"Terapia hormonal\u0103 substitutiv\u0103 (THS) \u00eenlocuie\u0219te estrogenul ovarian \u00een sc\u0103dere \u2014 \u0219i adaug\u0103 progestogen pentru femeile cu uter intact pentru a proteja endometrul \u2014 pentru a gestiona simptomele menopauzei (furnic\u0103turi, transpira\u021bii nocturne, atrofie vaginal\u0103, dispozi\u021bie, somn) \u0219i pentru a reduce pierderea pe termen lung a densit\u0103\u021bii osoase care urmeaz\u0103 menopauzei. Ghidurile moderne sus\u021bin utilizarea THS \u00een termen de 10 ani de la menopauz\u0103 pentru femeile simptomatice f\u0103r\u0103 contraindica\u021bii. Catalogul THS de la MedsBase include op\u021biuni orale, topice \u0219i cu progestogen exclusiv furnizate de produc\u0103tori certifica\u021bi WHO-GMP<\/strong>.\n\nEstrogeni conjuga\u021bi ecvini orali.<\/strong> Premarin (the original conjugated oestrogen extracted from pregnant mare's urine \u2014 the most-studied HRT preparation) is stocked as Premarin<\/a> comprimate orale \u0219i Premarin Cream<\/a> pentru atrofie vaginal\u0103. Premarin ac\u021bioneaz\u0103 pe multiple subtipuri de receptori de estrogen; preparatul oral necesit\u0103 combinarea cu progestogen la femeile cu uter intact.\n\nValerat de estradiol.<\/strong> Estradiol pur (bioidentic cu estrogenul natural) la 1 mg sau 2 mg zilnic oral, disponibil \u0219i sub form\u0103 de gel transdermal \u0219i plasture. Valeratul de estradiol oral ca Progynova<\/a>. Op\u021biunile transdermale (Oestrogel) ocolesc metabolismul hepatic de prim\u0103 trecere \u2014 preferate pentru femeile cu hipertrigliceridemie, boli ale vezicii biliare sau migren\u0103 cu aur\u0103 unde estrogenul oral este contraindicated.\n\nTibolone \u2014 alternativ\u0103 sub form\u0103 de comprimat unic.<\/strong> Tibolone 2.5 mg este un steroid sintetic cu activitate estrogenic\u0103, progestogenic\u0103 \u0219i androgenic\u0103 slab\u0103 \u00eentr-un singur comprimat zilnic \u2014 util pentru femeile postmenopauzale care doresc controlul simptomelor f\u0103r\u0103 progestogen separat \u0219i poate \u00eembun\u0103t\u0103\u021bi libidoul prin efectul s\u0103u androgen. Disponibil sub form\u0103 de Livial<\/a> \u0219i Tibofem<\/a>.\n\nProgesteron \u0219i progestogene \u2014 pentru protec\u021bie endometrial\u0103 sau ca supliment la THS.<\/strong> Progesteronul micronizat natural este progestogenul preferat \u00een terapia hormonal\u0103 substitutiv\u0103 modern\u0103 (profil de efecte adverse mai favorabil \u0219i semnal cardiovascular mai bun dec\u00e2t progestogenele sintetice vechi). Disponibil sub form\u0103 de Susten Capsule<\/a> \u0219i Endogest<\/a>. Progestogenele sintetice pentru THS combinat ciclic sau continuu includ dydrogesteron (Gestoford<\/a>, Gestheal<\/a>) \u0219i medroxiprogesteron (Meprate).\n\nModulator selectiv al receptorului de estrogen (SERM).<\/strong> Raloxifen 60 mg (cu efect estrogenic asupra osului \u0219i antiestrogen asupra s\u00e2nului \u0219i endometrului) este alternativa pentru prevenirea osteoporozei postmenopauzale la femeile care nu pot sau nu doresc terapie hormonal\u0103 substitutiv\u0103 complet\u0103 \u2014 \u0219i reduce inciden\u021ba cancerului de s\u00e2n invaziv \u00een studiile MORE\/STAR. Disponibil sub form\u0103 de Raloxiheal<\/a>. Prezint\u0103 avertisment similar pentru TEV ca estrogenul.\n\nTratamente adjunctive.<\/strong> Cabergoline (agonist dopaminergic, folosit ocazional pentru simptomele menopauzei mediate de prolactin\u0103) ca Cabgolin<\/a>. Shatavari (Asparagus racemosus \u2014 adjuvant Ayurvedic pentru simptomele menopauzei) ca Shatavari<\/a>.\n\nCum s\u0103 alegi.<\/strong> Vase de s\u00e2nge\/nop\u021bi transpirate\/atrofie vaginal\u0103 cu uter \u2192 terapie combinat\u0103 estrogen + progestogen ciclic\u0103 sau continu\u0103. Histerectomie \u2192 monoterapie cu estrogen. Atrofie vaginal\u0103 izolat\u0103 \u2192 estrogen vaginal\/topic (Premarin Cream, Oestrogel). Preferin\u021b\u0103 pentru efect androgen adi\u021bional \u00eentr-un singur comprimat \u2192 tibolon\u0103. Contraindicat estrogen dar necesar\u0103 protec\u021bie osoas\u0103 \u2192 raloxifen\u0103. Migren\u0103 cu aur\u0103, hipertrigliceridemie, boli ale vezicii biliare \u2192 estrogen transdermal \u00een loc de oral.\n\nImportant.<\/strong> HRT contraindications: history of breast or endometrial cancer, undiagnosed vaginal bleeding, active VTE, severe liver disease, recent stroke or MI, pregnancy. Risk discussion with your GP or menopause specialist is essential \u2014 current evidence supports HRT use as net-benefit for symptomatic women starting within 10 years of menopause, with risk-benefit reassessment annually. Breast cancer risk is small in absolute terms (around 1 extra case per 1,000 women per year on combined HRT for < 5 years).\n\nAll MedsBase HRT products ship from produc\u0103tori certifica\u021bi WHO-GMP<\/strong> cu ambalaj discret \u0219i sunt acoperite de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a>.","link":"https:\/\/medsbase.com\/ro\/hormone-replacement-therapy-hrt-medication-for-menopause\/","name":"Terapie hormonal\u0103 substitu\u021biv\u0103 (THS) pentru menopauz\u0103","slug":"hormone-replacement-therapy-hrt-medication-for-menopause","taxonomy":"product_cat","parent":3502,"meta":[],"menu_order":0,"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat\/3519","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/taxonomies\/product_cat"}],"up":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat\/3502"}],"wp:post_type":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product?product_cat=3519"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}