{"id":52562,"date":"2023-09-20T09:34:47","date_gmt":"2023-09-20T09:34:47","guid":{"rendered":"https:\/\/medsname.com\/g-cin\/"},"modified":"2026-04-30T10:18:11","modified_gmt":"2026-04-30T10:18:11","slug":"g-cin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/g-cin\/","title":{"rendered":"G-Cin"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fffbe6;border-left:4px solid #f5a623;padding:14px 18px;margin:14px 0 22px;border-radius:6px;font-size:15px;line-height:1.55;\">\n<h3 style=\"margin:0 0 6px;font-size:17px;color:#8a6d3b;\">\u26a1 Quick Answer \u2014 What is G-Cin?<\/h3>\n<p style=\"margin:0;\">G-Cin is a <strong>gemifloxacin tablet (320 mg, Glenmark)<\/strong> \u2014 a fourth-generation respiratory fluoroquinolone with very strong S. pneumoniae and atypical cover. Used for acute exacerbations of chronic bronchitis and mild\u2013moderate community-acquired pneumonia. Higher rash incidence than other fluoroquinolones, particularly in young women.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f6f7fb;border:1px solid #e3e5ee;border-radius:8px;padding:14px 18px;margin:18px 0;font-size:14px;line-height:1.55;\"><strong style=\"color:#1f3661;\">Why order from MedsBase?<\/strong> Sourced from a WHO-GMP certified manufacturer \u00b7 Discreet packaging \u00b7 Worldwide Shipping \u00b7 <a href=\"\/reviews\/\" rel=\"noopener\">1,400+ verified customer reviews<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Every order is covered by our <a href=\"https:\/\/medsbase.com\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 if your parcel does not arrive within 20 business days, we reship it.<\/p>\n<h3>Why order from MedsBase<\/h3>\n<p>Our generic medications are sourced from WHO-GMP certified manufacturers and shipped worldwide in discreet, plain packaging \u2014 no medication name on the parcel exterior. Card payments are routed through a regulated processor (statement descriptors include a regulated card-payment processor \u2014 never &ldquo;MedsBase&rdquo; or any medication name). Crypto and SEPA bank transfer are also accepted. Every order is backed by our Reshipment Assurance Policy.<\/p>\n<h2 id=\"mechanism\">How G-Cin works<\/h2>\n<p>G-Cin contains <strong>Gemifloxacin<\/strong>, a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV \u2014 the enzymes that supercoil and decatenate bacterial DNA during replication. Without functional gyrase \/ topoisomerase, the bacterial chromosome fragments and the cell dies. Fluoroquinolones are bactericidal and exhibit concentration-dependent killing with a long post-antibiotic effect, supporting once-daily dosing in many indications.<\/p>\n<p>Gemifloxacin is a fourth-generation respiratory fluoroquinolone with very strong Streptococcus pneumoniae activity, atypical pathogen cover, and good Gram-negative activity. It is used primarily for CAP and acute exacerbations of chronic bronchitis. It carries a higher rate of skin rash than other fluoroquinolones, especially in young women.<\/p>\n<h2 id=\"indications\">Indications &amp; dosing<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:14px;\">\n<caption style=\"text-align:left;font-weight:bold;margin-bottom:6px;\">Adult dosing<\/caption>\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Indication<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Dose<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Duration<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Acute exacerbation of chronic bronchitis<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">320 mg once daily<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">5 days<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Mild\u2013moderate community-acquired pneumonia<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">320 mg once daily<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">5\u20137 days<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Renal dose adjustment:<\/strong> all fluoroquinolones except moxifloxacin require dose extension below CrCl 50. Moxifloxacin is hepatically cleared and does not need renal adjustment.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:6px;\"><strong style=\"color:#a94442;\">\u26a0 FDA black-box: tendinopathy, peripheral neuropathy, CNS effects, aortic events<\/strong><\/p>\n<div style=\"margin-top:6px;font-size:14px;line-height:1.55;\">\n<p style=\"margin:0;\">Fluoroquinolones carry FDA black-box warnings for: <strong>tendinitis and tendon rupture<\/strong> (Achilles most commonly; risk increased with age &gt; 60, corticosteroid use, organ transplant); <strong>peripheral neuropathy<\/strong> (may be permanent \u2014 discontinue at first symptom); <strong>central nervous system effects<\/strong> (anxiety, confusion, hallucinations, seizures); and <strong>aortic aneurysm \/ dissection<\/strong> (relative risk ~2.0, especially in older adults with hypertension, atherosclerosis, or known aneurysm). The 2016 FDA review concluded that for uncomplicated UTI, sinusitis, and acute bronchitis the risks may outweigh benefits \u2014 reserve fluoroquinolones for indications without alternatives. Stop the drug at the first sign of tendon pain, paresthesia, or neuropsychiatric change.<\/p>\n<\/div>\n<\/div>\n<h2 id=\"side-effects\">Side effects<\/h2>\n<ul>\n<li><strong>GI:<\/strong> nausea, diarrhoea (5\u201310%), abdominal pain.<\/li>\n<li><strong>CNS:<\/strong> headache, dizziness, insomnia, vivid dreams; less commonly anxiety, confusion, depression, hallucinations, seizures (lower the seizure threshold \u2014 caution in epilepsy).<\/li>\n<li><strong>Tendon injury:<\/strong> Achilles tendinitis or rupture (most common in patients &gt; 60 on corticosteroids).<\/li>\n<li><strong>Peripheral neuropathy:<\/strong> can be permanent; presents as burning \/ tingling \/ numbness in feet or hands.<\/li>\n<li><strong>QT prolongation:<\/strong> moxifloxacin highest, then sparfloxacin, then levofloxacin \/ gemifloxacin \/ ciprofloxacin (modest).<\/li>\n<li><strong>Glucose dysregulation:<\/strong> hypoglycaemia (especially with sulfonylureas) and hyperglycaemia reported.<\/li>\n<li><strong>Photosensitivity:<\/strong> increased sunburn risk \u2014 strongest with sparfloxacin \/ lomefloxacin; moderate with ciprofloxacin \/ ofloxacin \/ moxifloxacin.<\/li>\n<li><strong>Aortic aneurysm \/ dissection:<\/strong> emerging signal in older adults.<\/li>\n<li><strong>C. difficile colitis.<\/strong> Fluoroquinolones are a leading driver \u2014 be alert to new diarrhoea.<\/li>\n<\/ul>\n<h2 id=\"contraindications\">Contraindications<\/h2>\n<ul>\n<li>Known fluoroquinolone hypersensitivity.<\/li>\n<li>History of fluoroquinolone-related tendon injury.<\/li>\n<li>Children &amp; adolescents (relative \u2014 use only when no alternative; quinolones cause cartilage damage in juvenile animal models).<\/li>\n<li>Pregnancy and breastfeeding (relative \u2014 use only when no alternative).<\/li>\n<li>Concurrent QT-prolonging drugs in a high-risk patient (especially moxifloxacin).<\/li>\n<li>Myasthenia gravis (may worsen).<\/li>\n<\/ul>\n<h2 id=\"interactions\">Drug interactions<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:14px;\">\n<caption style=\"text-align:left;font-weight:bold;margin-bottom:6px;\">Selected interactions<\/caption>\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Drug<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Effect<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Action<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Antacids \/ iron \/ zinc \/ dairy \/ sucralfate<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Chelation reduces absorption by up to 80%<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Take G-Cin 2 hours BEFORE or 6 hours AFTER<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Warfarin<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">INR rise \u2014 sometimes substantial<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Check INR within 3\u20135 days; counsel<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Sulfonylureas \/ insulin<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Hypoglycaemia risk<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Monitor capillary glucose; counsel<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">NSAIDs<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">May lower seizure threshold<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Caution in patients with seizure history<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Theophylline<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Cipro &amp; ofloxacin raise theophylline levels<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Monitor theophylline level; consider alternative<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Methotrexate<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Increased levels and toxicity<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Hold methotrexate or monitor<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Class IA \/ III antiarrhythmics<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Additive QT prolongation<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Avoid combination (especially moxifloxacin)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Tizanidine<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Severe hypotension and sedation (cipro is a strong CYP1A2 inhibitor)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Absolute contraindication<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 id=\"pregnancy\">Pregnancy &amp; Breastfeeding<\/h3>\n<p>Fluoroquinolones are <strong>category C<\/strong>. Animal data show cartilage damage; human data have not consistently shown teratogenicity but the safety margin is narrow. Avoid in pregnancy unless no alternative exists. In breastfeeding, low milk transfer occurs but most authorities consider short courses compatible \u2014 alternatives are usually preferred.<\/p>\n<h3 id=\"storage\">Storage<\/h3>\n<p>Store below 25 \u00b0C, away from direct sunlight and moisture. Keep in original packaging. Keep out of reach of children. Discard any unused tablets after the printed expiry date \u2014 degraded antibiotics can lose potency or release breakdown products.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:6px;\"><strong style=\"color:#a94442;\">\u26a0 Antibiotic resistance \u2014 please use responsibly<\/strong><\/p>\n<div style=\"margin-top:6px;font-size:14px;line-height:1.55;\">\n<p style=\"margin:0;\">This medicine is only effective against bacterial infections. Do not use it for viral illnesses (common cold, most sore throats, flu, COVID-19), do not stop early when you feel better, and do not save leftovers for future infections. Misuse drives drug-resistant bacteria like MRSA, ESBL, and CRE \u2014 the WHO ranks antimicrobial resistance among the top 10 global public-health threats.<\/p>\n<\/div>\n<\/div>\n<h2 id=\"faqs\">Frequently Asked Questions<\/h2>\n<h3>Should I take G-Cin on an empty stomach?<\/h3>\n<p>Food does not significantly reduce fluoroquinolone absorption \u2014 but dairy, antacids, iron, zinc, magnesium, and calcium supplements can chelate the drug and dramatically reduce absorption. Separate any of these by 2 hours before or 6 hours after the dose.<\/p>\n<h3>I am taking my multivitamin \u2014 when can I take G-Cin?<\/h3>\n<p>Multivitamins typically contain iron, zinc, calcium, and magnesium \u2014 all of which chelate fluoroquinolones. Take the antibiotic 2 hours BEFORE the multivitamin or 6 hours AFTER it.<\/p>\n<h3>Why are fluoroquinolones avoided for simple infections now?<\/h3>\n<p>The 2016 FDA review concluded the risk profile (tendon, neuropathy, neuropsychiatric, aortic) outweighs benefit for uncomplicated UTI, sinusitis, and acute bronchitis when narrow alternatives are available. Reserve fluoroquinolones for resistant pathogens, complicated UTI\/pyelonephritis, prostatitis, and CAP requiring atypical cover.<\/p>\n<h3>I have noticed pain in my Achilles tendon \u2014 what should I do?<\/h3>\n<p>Stop the antibiotic and contact your prescriber the same day. Tendon rupture can occur even after the drug is stopped. Avoid heavy exercise during the course and for 2\u20134 weeks after \u2014 particularly if you are over 60 or taking corticosteroids.<\/p>\n<h3>Will it interact with my warfarin?<\/h3>\n<p>Yes \u2014 INR can rise meaningfully. Check INR within 3\u20135 days and counsel on bleeding signs (gum bleeding, easy bruising, dark stools, blood in urine). Adjust warfarin dose only on physician advice.<\/p>\n<h3>Can I drive on this medicine?<\/h3>\n<p>Most patients can drive normally. If you experience dizziness, vivid dreams, drowsiness, or difficulty concentrating, do not drive until they resolve.<\/p>\n<h3>Why did my doctor say &#8220;no fluoroquinolones for diabetes&#8221;?<\/h3>\n<p>Fluoroquinolones can trigger both hypo- and hyperglycaemia \u2014 especially in patients on sulfonylureas (gliclazide, glimepiride, glibenclamide). The risk is highest with gemifloxacin and gatifloxacin. Monitor capillary glucose closely if alternatives are unavailable.<\/p>\n<h3>Can I take it if I have epilepsy?<\/h3>\n<p>Fluoroquinolones lower the seizure threshold. Use cautiously \u2014 and only if alternatives are unavailable \u2014 under specialist guidance. Concurrent NSAIDs amplify the risk.<\/p>\n<h3>Will it cover Pseudomonas?<\/h3>\n<p>Ciprofloxacin and levofloxacin have meaningful Pseudomonas activity (subject to local susceptibility). Moxifloxacin does NOT \u2014 never use moxifloxacin for Pseudomonas.<\/p>\n<h3>Are fluoroquinolones safe for my child?<\/h3>\n<p>Generally avoided in growing children due to animal data on cartilage damage and recent post-marketing musculoskeletal signal in humans. Reserve for cystic fibrosis exacerbations, MDR pathogens, complicated UTI when alternatives have failed.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Other Antibiotics &amp; Anti-Infective Medications<\/h2>\n<ul>\n<li><a href=\"\/levomac\/\">Levomac (Levofloxacin) \u2014 respiratory fluoroquinolone<\/a><\/li>\n<li><a href=\"\/cifran\/\">Cifran (Ciprofloxacin) \u2014 UTI \/ GI \/ Pseudomonas cover<\/a><\/li>\n<li><a href=\"\/moxif\/\">Moxif (Moxifloxacin) \u2014 broad respiratory cover with anaerobic activity<\/a><\/li>\n<li><a href=\"\/azee\/\">Azee (Azithromycin) \u2014 atypical-pathogen alternative<\/a><\/li>\n<li><a href=\"\/augmentin\/\">Augmentin (Amoxicillin + Clavulanic acid) \u2014 beta-lactam alternative<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:22px 0 0;border-radius:6px;font-size:13px;color:#555;\"><strong>Medical Disclaimer:<\/strong> The information on this page is provided for educational purposes and does not replace a consultation with a qualified clinician. Antibiotic resistance is a serious global health issue \u2014 use antibiotics only for confirmed bacterial infections, complete the full prescribed course, and never share or save leftover doses. Always check for personal allergies, drug interactions, and dose adjustments before starting therapy.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u2705 Enhances Immune System<br \/>\n\u2705 Promotes Digestive Health<br \/>\n\u2705 Supports Liver Function<br \/>\n\u2705 Boosts Energy Levels<br \/>\n\u2705 Improves Skin Health<\/p>\n","protected":false},"featured_media":52563,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3484,3141,3342],"product_tag":[],"class_list":{"0":"post-52562","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-antibiotics","7":"product_cat-category-overview","8":"product_cat-general-health","10":"first","11":"outofstock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product\/52562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/comments?post=52562"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/media\/52563"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/media?parent=52562"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_brand?post=52562"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_cat?post=52562"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_tag?post=52562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}