{"id":58603,"date":"2024-02-27T18:46:43","date_gmt":"2024-02-27T18:46:43","guid":{"rendered":"https:\/\/medsname.com\/olanzoop\/"},"modified":"2026-04-30T10:24:11","modified_gmt":"2026-04-30T10:24:11","slug":"olanzoop","status":"publish","type":"product","link":"https:\/\/medsbase.com\/sv\/product\/olanzoop\/","title":{"rendered":"Olanzoop"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 Snabbt svar<\/h3>\n<p style=\"margin-bottom:0;\">Olanzoop (Olanzapine 5 \/ 10 mg) is an atypical antipsychotic for schizophrenia, bipolar mania and maintenance, treatment-resistant depression (with fluoxetine), and acute agitation. The most robust antipsychotic effect of the atypicals \u2014 but the heaviest metabolic burden.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Vad du f\u00e5r med MedsBase:<\/strong> WHO-GMP-certifierad tillverkare \u00b7 Diskret f\u00f6rpackning \u00b7 V\u00e4rldsvid leverans \u00b7 1 400+ verifierade <a href=\"https:\/\/medsbase.com\/sv\/reviews\/\">kundrecensioner<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Varje best\u00e4llning omfattas av v\u00e5r <a href=\"https:\/\/medsbase.com\/sv\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 om din f\u00f6rs\u00e4ndelse inte anl\u00e4nder inom 20 arbetsdagar, skickar vi om den.<\/p>\n<h3>Varf\u00f6r best\u00e4lla fr\u00e5n MedsBase<\/h3>\n<p>Olanzoop at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our <a href=\"https:\/\/medsbase.com\/sv\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a> \u2014 20 arbetsdagar leveranstid eller vi skickar om utan extra kostnad \u2014 och kvalificerar sig f\u00f6r v\u00e5rt <a href=\"https:\/\/medsbase.com\/sv\/loyalty-points\/\">kundlojalitetsprogram<\/a>. V\u00e4rldsomsp\u00e4nnande leverans \u00e4r tillg\u00e4nglig till de flesta destinationer.<\/p>\n<h2>What Olanzoop is and how it works<\/h2>\n<p>Olanzoop is an olanzapine tablet supplied by Cipla. Available strengths: <strong>5 \/ 10 mg<\/strong>. Olanzapine is a thienobenzodiazepine atypical antipsychotic with strong D2 antagonism, strong 5-HT2A antagonism, and substantial H1 (sedation, weight gain), M1 (anticholinergic), and \u03b11 (orthostasis) blockade. The H1+M1 receptor profile is responsible both for its calming\/sedative effect (useful in acute agitation) and for its metabolic burden.<\/p>\n<h2>Indikationer och dosering<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indikation<\/th>\n<th>Startdos<\/th>\n<th>M\u00e5lgrupp<\/th>\n<th>Max<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Schizofreni (vuxen)<\/td>\n<td>5\u201310 mg OD<\/td>\n<td>10\u201320 mg en g\u00e5ng dagligen<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Schizofreni (ungdomar \u2265 13 \u00e5r)<\/td>\n<td>2.5\u20135 mg OD<\/td>\n<td>10 mg OD<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Bipol\u00e4r mani (vuxna)<\/td>\n<td>10\u201315 mg en g\u00e5ng dagligen<\/td>\n<td>10\u201320 mg en g\u00e5ng dagligen<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Acute agitation (IM)<\/td>\n<td>10 mg IM<\/td>\n<td>\u2014<\/td>\n<td>3 doser\/24h<\/td>\n<\/tr>\n<tr>\n<td>Treatment-resistant depression (with fluoxetine)<\/td>\n<td>5 mg + 20 mg fluoxetine<\/td>\n<td>5\u201318 mg<\/td>\n<td>18 mg<\/td>\n<\/tr>\n<tr>\n<td>\u00c4ldre vuxna<\/td>\n<td>2.5\u20135 mg OD<\/td>\n<td>5\u201310 mg OD<\/td>\n<td>efter tolerans<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Viktiga s\u00e4kerhets\u00f6verv\u00e4ganden<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>FDA svart l\u00e5da \u2013 demensrelaterad psykos<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Alla atypiska antipsykotiska l\u00e4kemedel b\u00e4r en FDA svart l\u00e5da-varning f\u00f6r \u00f6kad d\u00f6dlighet (fr\u00e4mst kardiovaskul\u00e4r och infektionsrelaterad) n\u00e4r de anv\u00e4nds f\u00f6r att behandla beteendest\u00f6rningar hos \u00e4ldre med demens. <strong>Atypiska antipsykotika \u00e4r inte godk\u00e4nda f\u00f6r demensrelaterad psykos eller agitation<\/strong>. Anv\u00e4ndning i denna population \u00e4r off-label, sista utv\u00e4g, tidsbegr\u00e4nsad och kr\u00e4ver explicit risk-nyttosamtal.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Heaviest metabolic burden of the atypicals<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Olanzapine produces the most weight gain (typically 4\u201310 kg in the first 6 months, sometimes far more), the most insulin resistance, and the most lipid disturbance of any commonly-used antipsychotic. Patients can develop type 2 diabetes within months of initiation. <strong>Mandatory monitoring: weight at every visit; fasting glucose \/ HbA1c and fasting lipids at baseline, 12 weeks, then 6-monthly.<\/strong> Counsel about diet and exercise from initiation.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Sedation and anticholinergic burden<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Strong sedation in the first 1\u20132 weeks. Anticholinergic effects (dry mouth, constipation, urinary hesitancy) are universal. Both lessen but do not disappear.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Olanzapine + benzodiazepine IM \u2014 caution<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Combining IM olanzapine with parenteral benzodiazepines has produced cases of severe hypotension, respiratory depression, and death. If both are clinically necessary in acute agitation, separate by \u2265 1 hour and monitor closely.<\/p>\n<\/div>\n<h2>Vanliga biverkningar<\/h2>\n<ul>\n<li><strong>Vikt\u00f6kning och metabolt syndrom<\/strong> \u2014 the dominant long-term concern.<\/li>\n<li><strong>Sedering<\/strong> \u2014 universal at initiation.<\/li>\n<li><strong>Orthostatisk hypotoni<\/strong> \u2014 common at initiation; titrate slowly in older adults.<\/li>\n<li><strong>Antikolinerg<\/strong> \u2014 dry mouth, constipation, urinary hesitancy.<\/li>\n<li><strong>Akathisia, EPS<\/strong> \u2014 less common than risperidone, more common than aripiprazole.<\/li>\n<li><strong>Prolaktin<\/strong> \u2014 modest rise; less than risperidone.<\/li>\n<li><strong>Hepatic<\/strong> \u2014 transient AST\/ALT rises common.<\/li>\n<\/ul>\n<h2>L\u00e4kemedelsinteraktioner<\/h2>\n<ul>\n<li><strong>CYP1A2-h\u00e4mmare<\/strong> (fluvoxamine, ciprofloxacin) \u2014 raise olanzapine levels markedly.<\/li>\n<li><strong>R\u00f6kning<\/strong> \u2014 induces CYP1A2; smokers have lower levels and need higher doses; smoking cessation can produce toxicity.<\/li>\n<li><strong>Karbamazepin<\/strong> \u2014 strong CYP1A2 induction; raises olanzapine clearance.<\/li>\n<li><strong>CNS-depressiva medel<\/strong> \u2014 additiv sedering.<\/li>\n<li><strong>Antikolinergika<\/strong> \u2014 additiv belastning.<\/li>\n<\/ul>\n<h2>Graviditet, amning, pediatrisk anv\u00e4ndning<\/h2>\n<p>Pregnancy: limited data; weigh against untreated illness; late-pregnancy exposure can produce neonatal EPS or withdrawal. Breastfeeding: passes into milk; usually requires alternative or close monitoring. Paediatric: licensed from 13 (schizophrenia, bipolar).<\/p>\n<h2>F\u00f6rvaring<\/h2>\n<p>F\u00f6rvara vid 15\u201330 \u00b0C i originalf\u00f6rpackning.<\/p>\n<h2 id=\"faqs\">Vanliga fr\u00e5gor<\/h2>\n<h3>Why does Olanzoop cause so much weight gain?<\/h3>\n<p>Olanzapine&rsquo;s combined H1 antihistamine, 5-HT2C antagonism, and other receptor effects produce strong appetite stimulation, slowed satiety, and shifted carbohydrate preference. Weight gain is dose-related but real even at low doses. Counselling about diet and exercise from week 1, plus regular weight monitoring, is mandatory.<\/p>\n<h3>How is Olanzoop different from risperidone or aripiprazole?<\/h3>\n<p>Olanzapine has the strongest acute antipsychotic effect and the fastest calming action \u2014 useful in acute agitation. The trade-off is the heaviest metabolic burden. Risperidone is more efficacious for some positive symptoms but raises prolactin substantially. Aripiprazole is metabolically cleanest but produces more akathisia.<\/p>\n<h3>Should I monitor my blood sugar on Olanzoop?<\/h3>\n<p>Yes \u2014 fasting glucose or HbA1c at baseline, 12 weeks, and then 6-monthly. Olanzapine can produce diabetes within months of initiation, sometimes presenting with diabetic ketoacidosis. Don&rsquo;t skip the monitoring.<\/p>\n<h3>Can Olanzoop be used long-term?<\/h3>\n<p>Yes \u2014 particularly for schizophrenia maintenance where olanzapine often outperforms other atypicals on relapse rate. The metabolic burden is the main reason long-term use requires careful weight, glucose, and lipid monitoring, plus active management of cardiometabolic risk.<\/p>\n<h3>How long until Olanzoop works?<\/h3>\n<p>Calming effect within 1\u20132 hours of the first oral dose. Antipsychotic effect builds over 1\u20132 weeks; full antipsychotic and mood-stabilising effect at 4\u20136 weeks.<\/p>\n<h3>What about driving on Olanzoop?<\/h3>\n<p>Avoid driving in the first 1\u20132 weeks of titration. Most patients on stable doses drive normally, but the sedation can be persistent at higher doses.<\/p>\n<h3>Is the orodispersible form different?<\/h3>\n<p>Yes \u2014 orodispersible (ODT) versions of olanzapine exist (Zyprexa Zydis, Olimelt) and dissolve on the tongue without water. Bioequivalent to standard tablets but useful in adherence-uncertain or dysphagia patients.<\/p>\n<h3>Can Olanzoop be combined with fluoxetine?<\/h3>\n<p>Yes \u2014 the olanzapine-fluoxetine combination (OFC, Symbyax) is FDA-approved for treatment-resistant depression and bipolar depression. The fluoxetine partly addresses olanzapine&rsquo;s lack of antidepressant effect; olanzapine adds a strong mood-stabilising component.<\/p>\n<h3>Why does smoking matter?<\/h3>\n<p>Smoking strongly induces CYP1A2, which is olanzapine&rsquo;s main metabolic enzyme. Smokers metabolise olanzapine faster and need higher doses; abrupt cessation of smoking (e.g. hospital admission) can produce olanzapine toxicity if the dose isn&rsquo;t adjusted. Tell the prescriber if smoking status changes.<\/p>\n<h3>Can Olanzoop be stopped abruptly?<\/h3>\n<p>Generally not \u2014 taper over 2\u20134 weeks. Abrupt cessation can produce cholinergic rebound (nausea, sweating, insomnia) and an antipsychotic relapse. Never stop without prescriber agreement.<\/p>\n<h2>Andra l\u00e4kemedel f\u00f6r psykisk h\u00e4lsa<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/sv\/aripicon\/\">Aripicon (Aripiprazol \u2014 D2-partiell agonist)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/olanzap\/\">Olanzap (Olanzapin \u2014 kraftfull antipsykotikum)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/risdone\/\">Risdone (Risperidon)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/seroquit\/\">Seroquit (Kvetiapin \u2014 bipol\u00e4r depression)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/atlura\/\">Atlura (Lurasidon \u2014 metaboliskt s\u00e4kert)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>Medicinsk ansvarsfriskrivning.<\/strong> Denna sida \u00e4r informativ och ers\u00e4tter inte individuell medicinsk r\u00e5dgivning. Farmakoterapi f\u00f6r psykisk h\u00e4lsa b\u00f6r inledas, \u00f6vervakas och justeras under ledning av en kvalificerad l\u00e4kare. Om du eller n\u00e5gon du k\u00e4nner befinner sig i en suicidkris, kontakta omedelbart lokal akuthj\u00e4lp eller ring din lands sj\u00e4lvmordsf\u00f6rebyggande hj\u00e4lplinje (USA\/Kanada: 988; Storbritannien: Samaritans 116 123; internationell lista: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Olanzoop (Olanzapine 5\/10 mg) \u2014 thienobenzodiazepine atypical for schizophrenia and bipolar mania. mandatory weight, glucose and lipid monitoring.<\/p>","protected":false},"featured_media":58604,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4527,4528],"class_list":{"0":"post-58603","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-olanzapine","10":"product_tag-olanzoop","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product\/58603","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/comments?post=58603"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/media\/58604"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/media?parent=58603"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_brand?post=58603"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_cat?post=58603"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_tag?post=58603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}