{"id":58967,"date":"2024-02-28T05:36:03","date_gmt":"2024-02-28T05:36:03","guid":{"rendered":"https:\/\/medsname.com\/pregastar\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"pregastar","status":"publish","type":"product","link":"https:\/\/medsbase.com\/sv\/product\/pregastar\/","title":{"rendered":"Pregastar 75 mg (Pregabalin) \u2014 Behandling av neuropatisk sm\u00e4rta och \u00e5ngest"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;font-size:18px;color:#1a1a1a;\">Quick Answer<\/h3>\n<p><strong>Pregastar 75 mg<\/strong> inneh\u00e5ller <strong>pregabalin<\/strong>, an alpha-2-delta calcium-channel ligand licensed for neuropathic pain (diabetic neuropathy, post-herpetic neuralgia, central neuropathic pain), generalised anxiety disorder, fibromyalgia, and as an adjunct in partial-onset seizures. The 75 mg capsule is the standard starting dose: 75 mg twice daily, increasing to 150 mg twice daily after 3\u20137 days if tolerated. Pregabalin reaches peak effect within 1 hour and has 90%+ bioavailability \u2014 far more predictable than gabapentin.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Vad du f\u00e5r med MedsBase:<\/strong> WHO-GMP-certifierad tillverkare \u00b7 Diskret f\u00f6rpackning \u00b7 V\u00e4rldsvid leverans \u00b7 1 400+ verifierade <a href=\"https:\/\/medsbase.com\/sv\/reviews\/\">kundrecensioner<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Varje best\u00e4llning omfattas av v\u00e5r <a href=\"https:\/\/medsbase.com\/sv\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 om din f\u00f6rs\u00e4ndelse inte anl\u00e4nder inom 20 arbetsdagar, skickar vi om den.<\/p>\n<h3>Varf\u00f6r best\u00e4lla fr\u00e5n MedsBase<\/h3>\n<p>V\u00e5ra generiska l\u00e4kemedel kommer fr\u00e5n WHO-GMP-certifierade tillverkare och skickas v\u00e4rldsvidt i diskreta, enkla f\u00f6rpackningar \u2014 inget l\u00e4kemedelsnamn p\u00e5 f\u00f6rs\u00e4ndelsens utsida. Kortbetalningar hanteras via en reglerad betalningsprocessor (kontoutdrag visar en reglerad kortbetalningsprocessor \u2014 aldrig \u201cMedsBase\u201d eller n\u00e5got l\u00e4kemedelsnamn). Krypto och SEPA-bank\u00f6verf\u00f6ring accepteras ocks\u00e5. Varje best\u00e4llning backas upp av v\u00e5r Reshipment Assurance Policy.<\/p>\n<h2>What Is Pregastar 75?<\/h2>\n<p>Pregastar 75 is an Indian-manufactured generic of <strong>pregabalin<\/strong>, a structural analogue of GABA. Despite that structural similarity, pregabalin does not bind GABA-A or GABA-B receptors and does not act as a GABA mimic. Instead, it binds the <strong>alpha-2-delta-1 subunit of voltage-gated calcium channels<\/strong> in the central nervous system, which reduces the calcium-dependent release of excitatory neurotransmitters (glutamate, noradrenaline, substance P) at hyperexcitable nerve terminals. This is the core mechanism that explains pregabalin&#8217;s effect on neuropathic pain and anxiety alike.<\/p>\n<h2>Why Pregabalin Over Gabapentin?<\/h2>\n<table>\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th>Property<\/th>\n<th>Pregabalin (Pregastar)<\/th>\n<th>Gabapentin<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Bioavailability<\/td>\n<td>\u226590%, dose-linear<\/td>\n<td>Saturable, falls from 60% to 33% as dose rises<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Time to peak<\/td>\n<td>1 timme<\/td>\n<td>2\u20133 hours<\/td>\n<\/tr>\n<tr>\n<td>Daily dose splits<\/td>\n<td>Twice daily (rarely TDS)<\/td>\n<td>Tre g\u00e5nger dagligen<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Typical effective dose<\/td>\n<td>150\u2013600 mg\/day<\/td>\n<td>1800\u20133600 mg\/day<\/td>\n<\/tr>\n<tr>\n<td>Onset of relief<\/td>\n<td>Often within 1 week<\/td>\n<td>2\u20134 weeks of titration<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Anxiolytic licence<\/td>\n<td>Yes (GAD)<\/td>\n<td>No (off-label only)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Indikationer<\/h2>\n<ul>\n<li><strong>Peripheral neuropathic pain<\/strong> \u2014 diabetic neuropathy, post-herpetic neuralgia, post-traumatic nerve injury<\/li>\n<li><strong>Central neuropathic pain<\/strong> \u2014 spinal cord injury, multiple sclerosis<\/li>\n<li><strong>Generalised anxiety disorder (GAD)<\/strong><\/li>\n<li><strong>Fibromyalgi<\/strong> (FDA approved indication; mixed European licensing)<\/li>\n<li><strong>Adjunctive therapy in partial-onset seizures<\/strong> in adults<\/li>\n<\/ul>\n<h2>Dosering &amp; Administrering<\/h2>\n<table>\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th>Indikation<\/th>\n<th>Startdos<\/th>\n<th>Titrering<\/th>\n<th>Effective range<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Neuropatisk sm\u00e4rta<\/td>\n<td>75 mg twice daily<\/td>\n<td>To 150 mg BD after 3\u20137 days<\/td>\n<td>300\u2013600 mg\/day<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Generalised anxiety<\/td>\n<td>75 mg twice daily<\/td>\n<td>To 150\u2013300 mg BD<\/td>\n<td>150\u2013600 mg\/day<\/td>\n<\/tr>\n<tr>\n<td>Fibromyalgi<\/td>\n<td>75 mg twice daily<\/td>\n<td>Escalate to 150 mg BD then 225 mg BD<\/td>\n<td>300\u2013450 mg\/day<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Partial-onset seizures (adjunct)<\/td>\n<td>75 mg twice daily<\/td>\n<td>Escalate weekly<\/td>\n<td>150\u2013600 mg\/day<\/td>\n<\/tr>\n<tr>\n<td>Nedsatt njurfunktion (CrCl 30\u201360)<\/td>\n<td>Halvera dosen<\/td>\n<td>Slower<\/td>\n<td>Adjust to renal function<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Renal impairment (CrCl 15\u201330)<\/td>\n<td>25\u201375 mg\/day<\/td>\n<td>Cautious<\/td>\n<td>Specialistr\u00e5dgivning<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Hur man tar:<\/strong> swallow whole, with or without food. Pregabalin can be taken at the same time daily for best plasma stability. Doses are usually morning and evening with at least 8 hours between them.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>Withdrawal and discontinuation<\/strong> Stopping pregabalin suddenly \u2014 particularly after long-term use \u2014 can cause insomnia, anxiety, headache, sweating, nausea, and rebound pain. Always taper over at least 1 week (longer for higher doses or longer treatment courses). Reduce by 25\u201350% per week.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>Misuse and dependence<\/strong> Pregabalin has documented abuse potential, particularly in patients with a history of substance misuse and when combined with opioids. The combination increases overdose mortality risk significantly. Pregabalin is a Schedule V controlled substance in the United States and a Schedule 3 (Class C) controlled drug in the United Kingdom.<\/div>\n<h2>Vanliga biverkningar<\/h2>\n<ul>\n<li>Dizziness (\u224830%)<\/li>\n<li>Drowsiness, sedation (\u224820%)<\/li>\n<li>Peripheral oedema (mild ankle swelling)<\/li>\n<li>Weight gain (dose-related, average 2\u20134 kg over 12 weeks)<\/li>\n<li>Torr mun<\/li>\n<li>Blurred vision, diplopia<\/li>\n<li>Mild ataxia or unsteadiness<\/li>\n<li>Mood change \u2014 increased appetite or euphoria<\/li>\n<\/ul>\n<h2>Serious Side Effects<\/h2>\n<ul>\n<li>Severe drowsiness or respiratory depression (especially with opioids)<\/li>\n<li>Suicidal thoughts (class warning across all anti-epileptics)<\/li>\n<li>Severe allergic reaction \u2014 angioedema, rash, blistering<\/li>\n<li>Heart failure exacerbation in susceptible patients<\/li>\n<li>Visual changes (rarely)<\/li>\n<li>Rhabdomyolysis (rare)<\/li>\n<\/ul>\n<h2>Kontraindikationer<\/h2>\n<ul>\n<li>Known hypersensitivity to pregabalin<\/li>\n<li>Severe renal failure without dose adjustment<\/li>\n<li>Galactose intolerance \/ lactase deficiency (capsule contains lactose)<\/li>\n<\/ul>\n<p><strong>F\u00f6rsiktighet:<\/strong> elderly, history of opioid dependence, depression, severe heart failure, pregnancy, breastfeeding.<\/p>\n<h2>L\u00e4kemedelsinteraktioner<\/h2>\n<ul>\n<li><strong>Opioids<\/strong> \u2014 markedly increased risk of fatal respiratory depression<\/li>\n<li><strong>Benzodiazepines, alcohol, sleep aids<\/strong> \u2014 additive CNS depression<\/li>\n<li><strong>Thiazolidinediones<\/strong> (pioglitazone, rosiglitazone) \u2014 additive peripheral oedema and heart-failure risk<\/li>\n<li><strong>ACE-h\u00e4mmare<\/strong> \u2014 increased angioedema risk reported<\/li>\n<\/ul>\n<h2>F\u00f6rvaring<\/h2>\n<p>Store below 25 \u00b0C in a dry place, away from direct sunlight. Keep in original blister packaging. Keep out of reach of children. Do not use after the printed expiry date.<\/p>\n<h2 id=\"faqs\">Vanliga fr\u00e5gor<\/h2>\n<h3>Is Pregastar 75 the same as Lyrica?<\/h3>\n<p>Yes \u2014 both contain pregabalin as the active ingredient. Pregastar 75 is a WHO-GMP certified Indian generic of Lyrica 75 mg. Mechanism, dosing, and clinical effect are identical at the same milligram dose.<\/p>\n<h3>How quickly does Pregastar work for nerve pain?<\/h3>\n<p>Pregabalin&#8217;s anti-pain effect builds over the first 7\u201314 days. Many patients notice meaningful relief within the first week \u2014 faster than gabapentin, which typically takes 2\u20134 weeks. If 600 mg\/day for 4 weeks gives no benefit, an alternative class is appropriate.<\/p>\n<h3>What is the maximum daily dose of pregabalin?<\/h3>\n<p>The licensed maximum is 600 mg\/day, divided into two or three doses. Doses above 300 mg\/day require careful renal dose calculation in patients with reduced kidney function.<\/p>\n<h3>Does pregabalin cause weight gain?<\/h3>\n<p>Yes \u2014 average gain is 2\u20134 kg over 12 weeks of treatment. Increased appetite and fluid retention both contribute. Weight gain is dose-dependent and usually plateaus.<\/p>\n<h3>Can I drink alcohol on Pregastar?<\/h3>\n<p>No. The combination amplifies sedation, dizziness, slowed breathing, and impaired coordination. The risk extends beyond the day of drinking \u2014 pregabalin&#8217;s half-life means residual effects last 24+ hours.<\/p>\n<h3>Is Pregastar safe to take with my opioid pain medication?<\/h3>\n<p>Combination requires caution. Pregabalin and opioids both depress the central nervous system and have been linked to higher rates of fatal respiratory depression when combined. Use the lowest effective dose of each, monitor for excessive sedation, and never start both at the same time.<\/p>\n<h3>Is pregabalin a controlled substance?<\/h3>\n<p>Yes \u2014 it is Schedule V in the United States and a Class C \/ Schedule 3 controlled drug in the United Kingdom. This reflects documented abuse potential, particularly in patients with a substance-misuse history.<\/p>\n<h3>Can I take Pregastar in pregnancy?<\/h3>\n<p>European regulators recommend avoiding pregabalin in pregnancy unless clearly necessary, after observational data suggested a small increase in major malformations. Discuss any planned or current pregnancy with your prescriber before continuing.<\/p>\n<h3>How is Pregastar different from gabapentin?<\/h3>\n<p>Same molecular target (alpha-2-delta calcium-channel subunit) but pregabalin has linear, predictable absorption and works at far lower milligram doses (150\u2013600 mg vs. 1800\u20133600 mg). It is also licensed for generalised anxiety disorder, which gabapentin is not.<\/p>\n<h3>Will pregabalin help my anxiety?<\/h3>\n<p>Yes \u2014 pregabalin is licensed for generalised anxiety disorder (GAD) in many countries. Onset of anxiolytic effect is typically within 1 week, faster than SSRIs. It is not first-line for panic disorder or PTSD.<\/p>\n<h3>Can I drive while taking Pregastar?<\/h3>\n<p>Caution is essential \u2014 particularly in the first 1\u20132 weeks and after any dose increase. Dizziness, drowsiness, and impaired vision are common. Do not drive until you know how it affects you, and review driving regulations in your jurisdiction.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Medicinsk ansvarsfriskrivning:<\/strong> Denna sida \u00e4r utbildande och ers\u00e4tter inte professionell medicinsk r\u00e5dgivning. Konsultera alltid en kvalificerad v\u00e5rdgivare innan du b\u00f6rjar, slutar eller \u00e4ndrar n\u00e5got l\u00e4kemedel, s\u00e4rskilt om du har andra medicinska tillst\u00e5nd, tar andra receptbelagda l\u00e4kemedel, \u00e4r gravid eller ammar, eller \u00e4r \u00f6ver 65 \u00e5r.<\/div>\n<p class=\"medsbase-link-boost-2026-04-30\" data-marker=\"mb-link-boost-gabasign\">For patients on pregabalin who need a lower-cost first-line gabapentinoid, <a href='\/sv\/gabasign\/'>Gabasign (gabapentin 100\/300\/400\/600\/800 mg)<\/a> covers the same neuropathic-pain indications at a more accessible price point \u2014 gabapentin is the WHO-Essential-Medicines-listed gabapentinoid and remains preferred for diabetic peripheral neuropathy and post-herpetic neuralgia.<\/p>\n<p data-mb-link-target=\"gabasign\" data-mb-anchor-variant=\"v2\" style=\"margin-top:1em;font-size:0.95em;color:#444;border-left:3px solid #2c7cb0;padding:0.5em 0.75em;background:#f4f8fb;\"><strong>Se \u00e4ven:<\/strong> <a href=\"https:\/\/medsbase.com\/sv\/gabasign\/\"><strong>this gabapentin generic<\/strong><\/a> \u2014 Ciplas generiska gabapentin \u2014 samma FDA-godk\u00e4nda molekyl, full dosintervall fr\u00e5n 300 mg startdos till 600 mg underh\u00e5llsdos.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Relaterade alternativ<\/h3>\n<p>Andra produkter inom <strong>Kroniska tillst\u00e5nd<\/strong> som kunder \u00e4ven tittar p\u00e5:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/sv\/celkeran\/\">Celkeran<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/amlip\/\">Amlip<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/cardipin-retard\/\">Cardipin Retard<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/ondrea\/\">Ondrea<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/loratin\/\">Loratin<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Lindrar nervsm\u00e4rta<br \/>\n\u2705 Treats neuropathic conditions<br \/>\n\u2705 Reduces seizures<br \/>\n\u2705 Alleviates anxiety<br \/>\n\u2705 Improves sleep quality<\/p>\n<p>Pregastar 75 contains Pregabalin.<\/p>","protected":false},"featured_media":58968,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3985],"product_tag":[4602,4603],"class_list":{"0":"post-58967","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-neuropathic-pain-medication","9":"product_tag-pregabalin","10":"product_tag-pregastar","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product\/58967","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/comments?post=58967"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/media\/58968"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/media?parent=58967"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_brand?post=58967"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_cat?post=58967"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_tag?post=58967"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}