{"id":59010,"date":"2024-02-28T05:37:50","date_gmt":"2024-02-28T05:37:50","guid":{"rendered":"https:\/\/medsname.com\/avomine\/"},"modified":"2026-04-30T10:24:05","modified_gmt":"2026-04-30T10:24:05","slug":"avomine","status":"publish","type":"product","link":"https:\/\/medsbase.com\/sv\/product\/avomine\/","title":{"rendered":"Avomine"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Avomine?<\/h3>\n<p style=\"margin:0;\"><strong>Avomine<\/strong> inneh\u00e5ller <strong>promethazine theoclate 25 mg<\/strong>, a first-generation H1 antihistamine with antiemetic, anticholinergic, and sedative properties. It is the established first-line agent for <strong>\u00e5ksjuka<\/strong>, <strong>vestibular nausea<\/strong>, och <strong>vertigo<\/strong>, and is also used for sedation and as an adjunct in allergy and pregnancy-related nausea (jurisdiction-dependent). Take <strong>30&ndash;60 minutes before travel<\/strong> for motion-sickness prophylaxis. Manufactured by Wockhardt under WHO-GMP standards.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>Varf\u00f6r best\u00e4lla fr\u00e5n MedsBase:<\/strong> \u2714 <strong>WHO-GMP-certifierad tillverkare<\/strong> \u2714 Diskret f\u00f6rpackning \u2714 V\u00e4rldsvid leverans \u2714 <a href=\"https:\/\/medsbase.com\/sv\/reviews\/\">Verifierade kundrecensioner (1 400+ kunder)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Varje best\u00e4llning omfattas av v\u00e5r <a href=\"https:\/\/medsbase.com\/sv\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 om din f\u00f6rs\u00e4ndelse inte anl\u00e4nder inom 20 arbetsdagar, skickar vi om den.<\/p>\n<h3>Varf\u00f6r best\u00e4lla fr\u00e5n MedsBase<\/h3>\n<p>V\u00e5ra generiska l\u00e4kemedel kommer fr\u00e5n WHO-GMP-certifierade tillverkare och skickas v\u00e4rldsvidt i diskreta, enkla f\u00f6rpackningar \u2014 inget l\u00e4kemedelsnamn p\u00e5 f\u00f6rs\u00e4ndelsens utsida. Kortbetalningar hanteras via en reglerad betalningsprocessor (kontoutdrag visar en reglerad kortbetalningsprocessor \u2014 aldrig \u201cMedsBase\u201d eller n\u00e5got l\u00e4kemedelsnamn). Krypto och SEPA-bank\u00f6verf\u00f6ring accepteras ocks\u00e5. Varje best\u00e4llning backas upp av v\u00e5r Reshipment Assurance Policy.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#9888;&#65039; Strong sedation &mdash; no driving or machinery.<\/strong> {$brand} causes pronounced drowsiness in most users. Do not drive, operate machinery, or perform tasks requiring alertness for at least 24 hours after a dose. Avoid alcohol, opioids, benzodiazepines, and other CNS depressants &mdash; combination causes profound sedation and respiratory depression. Promethazine is contraindicated in <strong>children under 2 years<\/strong> (risk of fatal respiratory depression) and used cautiously in 2&ndash;5 year olds.<\/div>\n<h2 class=\"wp-block-heading\">When promethazine is the right antiemetic<\/h2>\n<p>Promethazine is the <strong>go-to drug for motion sickness<\/strong> &mdash; sea, air, car, and amusement-park motion. It is also effective for <strong>vestibular vertigo<\/strong> (acute labyrinthitis, vestibular neuritis, Meniere&rsquo;s acute attacks), and as a sedating adjunct in allergic reactions or anxiety-related nausea. It is <strong>not first-line for chemotherapy-induced nausea<\/strong> (use ondansetron\/granisetron instead) and <strong>not first-line for nausea-vomiting of pregnancy<\/strong> in most modern guidelines (NVP first-line is doxylamine+B6 &mdash; Doxinate, Pregnidoxin NU). Some jurisdictions still use promethazine for hyperemesis gravidarum after first-line failure.<\/p>\n<h3 class=\"wp-block-heading\">Varf\u00f6r best\u00e4lla fr\u00e5n MedsBase<\/h3>\n<p>Avomine is supplied from a <strong>WHO-GMP-certifierad tillverkare<\/strong>. Varje best\u00e4llning skickas diskret \u00f6ver hela v\u00e4rlden och omfattas av v\u00e5r <a href=\"https:\/\/medsbase.com\/sv\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. Promethazine has been the global standard for motion sickness for decades and remains a useful sedating antiemetic when histaminergic\/cholinergic vestibular nausea is the dominant problem.<\/p>\n<h2 class=\"wp-block-heading\">Verkningsmekanism<\/h2>\n<p>Promethazine is a phenothiazine-derived antihistamine. It blocks <strong>H1 histamine receptors<\/strong> (the antihistamine effect that reduces motion-induced vestibular signalling and gives sedation), <strong>muskariniska acetylkolinreceptorer<\/strong> (the anticholinergic effect that further suppresses vestibular and gut motility-driven emesis), and <strong>D2 dopamine receptors<\/strong> (a mild antiemetic effect at the chemoreceptor trigger zone). The unique value of promethazine in motion sickness is the combined H1 + anticholinergic blockade &mdash; the vestibular system depends on both pathways. The same combined blockade also explains its strong sedative and dry-mouth profile.<\/p>\n<h2 class=\"wp-block-heading\">Indikationer<\/h2>\n<ul>\n<li><strong>Motion sickness:<\/strong> sea, air, car, train; especially when other agents (cinnarizine, hyoscine patch) have failed or are unavailable.<\/li>\n<li><strong>Vestibular vertigo:<\/strong> acute labyrinthitis, vestibular neuritis, Meniere&rsquo;s acute attacks.<\/li>\n<li><strong>Allergic reactions<\/strong> (urticaria, hay fever) where sedation is helpful or non-sedating antihistamines have failed.<\/li>\n<li><strong>Pre-medication for anaesthesia<\/strong> (sedation + antiemetic + drying of secretions).<\/li>\n<li><strong>S\u00f6mnl\u00f6shet<\/strong> short-term occasional use.<\/li>\n<li><strong>Hyperemesis gravidarum<\/strong> (jurisdiction-dependent, after first-line doxylamine+B6 failure).<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dos<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;\">Indikation<\/th>\n<th style=\"padding:8px;text-align:left;\">Dos<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Motion sickness (adult)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">25 mg the night before, repeat 25 mg morning of travel; or 25 mg 1&ndash;2 h pre-travel; max 75 mg\/day<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Vestibular vertigo (adult)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">25 mg every 8&ndash;12 h during acute episode; taper after 2&ndash;3 days (long-term use slows vestibular compensation)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Children 5&ndash;10 y<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">12.5 mg the night before travel and again the morning of travel<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Children 2&ndash;5 y<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Use only if essential under medical supervision; 6.25 mg twice daily maximum<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Children &lt; 2 y<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">CONTRAINDICATED &mdash; risk of fatal respiratory depression<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Older adults (&gt; 65)<\/td>\n<td style=\"padding:8px;\">Use cautiously &mdash; high anticholinergic burden; risk of confusion, falls, urinary retention<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Biverkningar<\/h2>\n<ul>\n<li><strong>Mycket vanligt:<\/strong> sedation, dry mouth, blurred vision, urinary hesitancy, constipation<\/li>\n<li><strong>Vanligt:<\/strong> dizziness, hypotension on standing, palpitation, mild confusion (especially older adults)<\/li>\n<li><strong>Mindre vanliga:<\/strong> photosensitivity, rash, paradoxical excitation in children, extrapyramidal reactions (low frequency vs other phenothiazines)<\/li>\n<li><strong>S\u00e4llsynta men allvarliga:<\/strong> agranulocytosis, neuroleptic malignant syndrome (very rare), severe respiratory depression in young children, seizures in overdose<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">L\u00e4kemedelsinteraktioner<\/h2>\n<ul>\n<li><strong>CNS-depressiva medel<\/strong> (alcohol, opioids, benzodiazepines, gabapentinoids, sleep medication): additive sedation and respiratory depression &mdash; avoid combination.<\/li>\n<li><strong>Antikolinergika<\/strong> (TCAs, oxybutynin, atropine, hyoscine patch, antipsychotics): additive dry mouth, urinary retention, cognitive impairment &mdash; especially in older adults.<\/li>\n<li><strong>MAO inhibitors:<\/strong> may prolong and intensify sedation &mdash; avoid combination.<\/li>\n<li><strong>Adrenaline (epinephrine):<\/strong> promethazine may reverse the pressor effect (use noradrenaline if vasopressor needed during anaphylaxis on promethazine).<\/li>\n<li><strong>Pregnancy test interference:<\/strong> may cause false positive\/negative immunological pregnancy tests.<\/li>\n<\/ul>\n<h2 id=\"faqs\">Vanliga fr\u00e5gor<\/h2>\n<h3 class=\"wp-block-heading\">How long before travel should I take Avomine?<\/h3>\n<p>For best motion-sickness protection, take 25 mg the <strong>night before travel<\/strong> and a second 25 mg dose 1&ndash;2 hours before departure. Once the journey is underway and you are already nauseated, prevention is much harder &mdash; take the dose proactively.<\/p>\n<h3 class=\"wp-block-heading\">Will Avomine make me sleepy?<\/h3>\n<p>Yes &mdash; pronounced drowsiness is the dominant side effect. Do not drive, fly an aircraft, scuba dive, or operate machinery for 24 hours after a dose. Many users find this useful for long-haul flights but it is dangerous before active tasks.<\/p>\n<h3 class=\"wp-block-heading\">Can Avomine be used in pregnancy?<\/h3>\n<p>Promethazine has been used historically for hyperemesis gravidarum but is no longer first-line in most modern guidelines. First-line for nausea-vomiting of pregnancy (NVP) is <strong>doxylamine + B6<\/strong> (Doxinate, Pregnidoxin NU); ondansetron, metoclopramide, and promethazine are reserved for refractory cases under specialist supervision.<\/p>\n<h3 class=\"wp-block-heading\">Can children take Avomine?<\/h3>\n<p><strong>Children under 2 years must NOT take promethazine<\/strong> &mdash; risk of fatal respiratory depression. For ages 2&ndash;5 use only if essential under medical supervision. Standard motion-sickness dosing starts from age 5 with 12.5 mg the night before and morning of travel.<\/p>\n<h3 class=\"wp-block-heading\">What is the difference between Avomine and ondansetron?<\/h3>\n<p>Avomine is a sedating H1 antihistamine + anticholinergic &mdash; ideal for <strong>motion sickness and vestibular vertigo<\/strong> where the histaminergic and cholinergic pathways are dominant. Ondansetron is a 5-HT3 antagonist &mdash; ideal for <strong>chemo, radiation, surgery, severe gastroenteritis<\/strong> where the serotonin pathway is dominant. They are not interchangeable.<\/p>\n<h3 class=\"wp-block-heading\">Is Avomine addictive?<\/h3>\n<p>No, promethazine is not a controlled substance and does not cause physical dependence. However, the strong sedation makes it occasionally misused for sleep or to potentiate opioids &mdash; the latter is dangerous because of respiratory depression.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol with Avomine?<\/h3>\n<p>No &mdash; combination causes profound sedation and respiratory depression. Avoid alcohol, sleeping pills, and opioids while on promethazine.<\/p>\n<h3 class=\"wp-block-heading\">Vad h\u00e4nder om jag gl\u00f6mmer en dos?<\/h3>\n<p>Promethazine is usually used for prevention &mdash; take the next dose at the next planned time. If you miss the pre-travel dose, taking it once travel-induced nausea has already started is less effective; an ODT 5-HT3 (Ondem MD) or a cinnarizine alternative may give better breakthrough control.<\/p>\n<h3 class=\"wp-block-heading\">How does Avomine differ from cinnarizine and meclozine?<\/h3>\n<p>All three are anti-vertigo\/motion-sickness antihistamines. <strong>Cinnarizine<\/strong> has additional calcium-channel blocking action (useful in Meniere&rsquo;s) and is less sedating. <strong>Meclozine<\/strong> is intermediate &mdash; less sedating than promethazine, longer-acting than cinnarizine. <strong>Promethazine<\/strong> is the most strongly sedating and is preferred when sedation is a benefit (long flights, severe vertigo).<\/p>\n<h3 class=\"wp-block-heading\">How is Avomine stored?<\/h3>\n<p>Store tablets at room temperature (below 25&deg;C), protected from light and moisture. Keep out of reach of children &mdash; accidental paediatric ingestion can cause severe respiratory depression.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Andra behandlingar mot illam\u00e5ende<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/sv\/stemetil-md\/\">Stemetil MD (prochlorperazine &mdash; vestibular nausea ODT)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/dompewal-tablet\/\">Dompewal (domperidone &mdash; gastric-emptying nausea)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/ondem\/\">Ondem (ondansetron &mdash; chemo\/PONV)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/doxinate\/\">Doxinate (doxylamin + B6 \u2014 illam\u00e5ende under graviditet)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/metopar\/\">Metopar (paracetamol + metoklopramid \u2014 illam\u00e5ende vid migr\u00e4n)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/nausea-treatment\/\"><strong>Bl\u00e4ddra bland alla behandlingar mot illam\u00e5ende<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Medicinsk ansvarsfriskrivning.<\/strong> Denna sida \u00e4r endast avsedd f\u00f6r informations\u00e4ndam\u00e5l och ers\u00e4tter inte medicinsk r\u00e5dgivning fr\u00e5n en kvalificerad v\u00e5rdgivare. Kontinuerligt kr\u00e4kningar, blod i spyorna, sv\u00e5r buksm\u00e4rta, tecken p\u00e5 uttorkning, misst\u00e4nkta graviditetskomplikationer eller kemoterapirelaterade symptom kr\u00e4ver utv\u00e4rdering av en l\u00e4kare.<\/div>","protected":false},"excerpt":{"rendered":"<p>Avomine (Promethazine theoclate 25 mg) \u2014 sedating H1 antihistamine + anticholinergic for motion sickness, vestibular vertigo, and Meniere&#8217;s acute attacks.<\/p>","protected":false},"featured_media":59011,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3543],"product_tag":[4612,4613],"class_list":{"0":"post-59010","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-nausea-treatment","9":"product_tag-avomine","10":"product_tag-promethazine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product\/59010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/comments?post=59010"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/media\/59011"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/media?parent=59010"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_brand?post=59010"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_cat?post=59010"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_tag?post=59010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}