{"id":59919,"date":"2024-02-28T06:23:55","date_gmt":"2024-02-28T06:23:55","guid":{"rendered":"https:\/\/medsname.com\/ondem-md\/"},"modified":"2026-04-30T10:23:53","modified_gmt":"2026-04-30T10:23:53","slug":"ondem-md","status":"publish","type":"product","link":"https:\/\/medsbase.com\/sv\/product\/ondem-md\/","title":{"rendered":"Ondem MD"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Ondem MD?<\/h3>\n<p style=\"margin:0;\"><strong>Ondem MD<\/strong> \u00e4r en <strong>orally disintegrating tablet (ODT\/MD)<\/strong> av <strong>ondansetron 4 mg \/ 8 mg<\/strong>, a selective serotonin <strong>5-HT3 receptor antagonist<\/strong>. It is the most-used antiemetic worldwide and works against the strong serotonergic emetic stimulus generated by chemotherapy, radiation, surgery, gastroenteritis, and migraine. Manufactured by Alkem under WHO-GMP standards. Onset within 30 minutes orally and 8&ndash;12 hour duration; usually given 30&ndash;60 minutes before chemo or as needed for breakthrough nausea.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>Varf\u00f6r best\u00e4lla fr\u00e5n MedsBase:<\/strong> \u2714 <strong>WHO-GMP-certifierad tillverkare<\/strong> \u2714 Diskret f\u00f6rpackning \u2714 V\u00e4rldsvid leverans \u2714 <a href=\"https:\/\/medsbase.com\/sv\/reviews\/\">Verifierade kundrecensioner (1 400+ kunder)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Varje best\u00e4llning omfattas av v\u00e5r <a href=\"https:\/\/medsbase.com\/sv\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 om din f\u00f6rs\u00e4ndelse inte anl\u00e4nder inom 20 arbetsdagar, skickar vi om den.<\/p>\n<h3>Varf\u00f6r best\u00e4lla fr\u00e5n MedsBase<\/h3>\n<p>V\u00e5ra generiska l\u00e4kemedel kommer fr\u00e5n WHO-GMP-certifierade tillverkare och skickas v\u00e4rldsvidt i diskreta, enkla f\u00f6rpackningar \u2014 inget l\u00e4kemedelsnamn p\u00e5 f\u00f6rs\u00e4ndelsens utsida. Kortbetalningar hanteras via en reglerad betalningsprocessor (kontoutdrag visar en reglerad kortbetalningsprocessor \u2014 aldrig \u201cMedsBase\u201d eller n\u00e5got l\u00e4kemedelsnamn). Krypto och SEPA-bank\u00f6verf\u00f6ring accepteras ocks\u00e5. Varje best\u00e4llning backas upp av v\u00e5r Reshipment Assurance Policy.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#9888;&#65039; Ondansetron QT-prolongation FDA dose cap.<\/strong> A single IV dose &gt; 16 mg has been associated with QT prolongation and torsades-de-pointes. Maximum single dose is 16 mg IV (oral 24 mg single dose has a slightly different cap). Avoid in <strong>congenital long-QT<\/strong>, hypokalaemia, hypomagnesaemia, or with other QT-prolonging drugs (azithromycin, citalopram, methadone, hydroxychloroquine, amiodarone, fluoroquinolones, antipsychotics). Apomorphine is an absolute contraindication (severe hypotension).<\/div>\n<h2 class=\"wp-block-heading\">When ondansetron is the right antiemetic<\/h2>\n<p>Ondansetron is the <strong>first-line antiemetic for serotonin-driven nausea<\/strong> &mdash; chemotherapy-induced nausea and vomiting (CINV), post-operative nausea and vomiting (PONV), radiation-induced nausea, and severe gastroenteritis. It is <strong>less useful for motion sickness and vestibular nausea<\/strong> (where the dominant pathway is histaminergic and cholinergic &mdash; promethazine\/Avomine, cinnarizine, and meclozine work better) and <strong>not first-line for nausea-vomiting of pregnancy<\/strong> (NVP first-line is doxylamine + B6; ondansetron is reserved for refractory hyperemesis gravidarum after considering a small first-trimester cardiac\/cleft-palate signal in observational studies).<\/p>\n<h3 class=\"wp-block-heading\">Varf\u00f6r best\u00e4lla fr\u00e5n MedsBase<\/h3>\n<p>Ondem MD is supplied from a <strong>WHO-GMP-certifierad tillverkare<\/strong>. Varje best\u00e4llning skickas diskret \u00f6ver hela v\u00e4rlden och omfattas av v\u00e5r <a href=\"https:\/\/medsbase.com\/sv\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. Ondansetron is the global standard for serotonin-driven emesis with millions of doses delivered safely each year. Orally disintegrating tablet (ODT\/MD) formulation is convenient when active vomiting prevents reliable swallowing.<\/p>\n<h2 class=\"wp-block-heading\">Verkningsmekanism<\/h2>\n<p>Chemotherapy, radiation, and surgery damage gut enterochromaffin cells, which release massive amounts of <strong>serotonin (5-HT)<\/strong>. The serotonin binds 5-HT3 receptors on vagal afferents and on the chemoreceptor trigger zone (area postrema), which signal the medullary vomiting centre. Ondansetron is a highly selective antagonist at the 5-HT3 receptor &mdash; it blocks this signal at both peripheral and central sites without affecting D2, H1, muscarinic, or alpha-adrenergic receptors. That selectivity explains its clean side-effect profile: minimal sedation, no extrapyramidal reactions, no anticholinergic burden.<\/p>\n<h2 class=\"wp-block-heading\">Indikationer<\/h2>\n<ul>\n<li><strong>CINV:<\/strong> moderately or highly emetogenic chemotherapy (cisplatin, anthracyclines, cyclophosphamide regimens) &mdash; usually with dexamethasone &plusmn; aprepitant for highly emetogenic regimens.<\/li>\n<li><strong>Str\u00e5lning-inducerad illam\u00e5ende:<\/strong> total kroppsbestr\u00e5lning, h\u00f6g dos abdominal str\u00e5lning.<\/li>\n<li><strong>Postoperativ illam\u00e5ende och kr\u00e4kningar (PONV):<\/strong> single 4 mg dose at induction or end of surgery.<\/li>\n<li><strong>Severe gastroenteritis:<\/strong> dehydration risk in children\/adults.<\/li>\n<li><strong>Migraine-associated nausea:<\/strong> often with sumatriptan or other triptans.<\/li>\n<li><strong>Refractory hyperemesis gravidarum:<\/strong> after first-line doxylamine+B6 (Doxinate, Pregnidoxin NU) and metoclopramide have failed; specialist supervision recommended.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dos<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;\">Indikation<\/th>\n<th style=\"padding:8px;text-align:left;\">Dos<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">CINV (adult)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">8 mg 30 min before chemo, then 8 mg every 8&ndash;12 h for up to 5 days<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">PONV (adult)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">4 mg single dose, IV at induction or oral 1 h pre-op<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Severe gastroenteritis (adult)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">4&ndash;8 mg every 8 h as needed (max 24 mg\/day)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Paediatric (4&ndash;11 y, gastro)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">4 mg every 8 h (8&ndash;15 kg: 2 mg; 15&ndash;30 kg: 4 mg; &gt;30 kg: 4&ndash;8 mg)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Sv\u00e5r leversvikt<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Maximum 8 mg\/day (Child-Pugh C)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Single-dose maximum<\/td>\n<td style=\"padding:8px;\">16 mg IV; 24 mg oral &mdash; do not exceed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Place the ODT on a dry tongue; it dissolves in 10&ndash;30 seconds with saliva. Do not push through the foil &mdash; peel back. No water needed, useful for active vomiting.<\/p>\n<h2 class=\"wp-block-heading\">Biverkningar<\/h2>\n<ul>\n<li><strong>Vanliga (&gt; 10%):<\/strong> headache, constipation (the most clinically meaningful side effect &mdash; pre-empt with hydration and stool softener if multi-day course)<\/li>\n<li><strong>Vanliga (1\u201310%):<\/strong> mild flushing, fatigue, transient AST\/ALT rise, dizziness, hot flushes after IV<\/li>\n<li><strong>Mindre vanliga:<\/strong> bradycardia, hypotension, myalgia<\/li>\n<li><strong>S\u00e4llsynta men allvarliga:<\/strong> QT prolongation\/torsades, serotonin syndrome (with SSRIs\/SNRIs\/triptans\/MAOIs), severe hypersensitivity, transient blindness (very rare, with rapid IV)<\/li>\n<li><strong>Ovanliga:<\/strong> extrapyramidal reactions (rare with ondansetron unlike older antiemetics)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">L\u00e4kemedelsinteraktioner<\/h2>\n<ul>\n<li><strong>Apomorphine:<\/strong> ABSOLUTE contraindication &mdash; severe hypotension and loss of consciousness reported.<\/li>\n<li><strong>Andra QT-f\u00f6rl\u00e4ngande l\u00e4kemedel<\/strong> (azithromycin, clarithromycin, citalopram, escitalopram, methadone, amiodarone, sotalol, fluoroquinolones, hydroxychloroquine, antipsychotics): avoid combination or monitor ECG.<\/li>\n<li><strong>Serotonerga l\u00e4kemedel<\/strong> (SSRIs, SNRIs, MAOIs, triptans, tramadol, fentanyl, linezolid, methylene blue): rare serotonin syndrome reported &mdash; counsel patients to recognise tremor\/agitation\/clonus\/hyperthermia.<\/li>\n<li><strong>Tramadol:<\/strong> ondansetron may reduce tramadol analgesic effect (5-HT3 blockade interferes with descending pain inhibition).<\/li>\n<li><strong>Starka CYP3A4-inducerare<\/strong> (rifampicin, phenytoin, carbamazepine): can lower ondansetron levels and reduce efficacy.<\/li>\n<\/ul>\n<h2 id=\"faqs\">Vanliga fr\u00e5gor<\/h2>\n<h3 class=\"wp-block-heading\">How quickly does Ondem MD work?<\/h3>\n<p>Ondansetron ODTs reach therapeutic plasma levels in about 30 minutes after dissolution. Onset of antiemetic effect is similar to swallowed tablets; the ODT advantage is reliability when vomiting is active.<\/p>\n<h3 class=\"wp-block-heading\">Is Ondem MD safe in pregnancy?<\/h3>\n<p>Ondansetron is reserved for <strong>refractory hyperemesis gravidarum<\/strong> after doxylamine+B6 (Doxinate, Pregnidoxin NU), pyridoxine, and metoclopramide have failed. Some observational studies suggest a small first-trimester cardiac and cleft-palate signal; use should be discussed with a clinician.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Ondem MD for motion sickness?<\/h3>\n<p>Ondansetron works on the serotonin pathway and is <strong>not effective for motion sickness<\/strong>, which is histaminergic\/cholinergic. Use promethazine (Avomine), cinnarizine, meclozine, or a hyoscine patch instead.<\/p>\n<h3 class=\"wp-block-heading\">How is Ondem MD different from metoclopramide or domperidone?<\/h3>\n<p>Metoclopramide and domperidone are <strong>D2 antagonists<\/strong> &mdash; they speed gastric emptying and treat dyspepsia\/regurgitation\/gastroparesis nausea. Ondansetron is a <strong>5-HT3 antagonist<\/strong> &mdash; better for chemo, radiation, surgery, severe gastroenteritis, and migraine nausea. Ondansetron is more expensive but cleaner (no extrapyramidal reactions, no hyperprolactinaemia).<\/p>\n<h3 class=\"wp-block-heading\">Does Ondem MD cause drowsiness?<\/h3>\n<p>No. Unlike promethazine, prochlorperazine, and metoclopramide, ondansetron does not cause sedation or confusion and is preferred for ambulatory or driving patients.<\/p>\n<h3 class=\"wp-block-heading\">What is the maximum dose?<\/h3>\n<p>Maximum single oral dose is 24 mg; maximum single IV dose is 16 mg (FDA cap). Total daily dose typically 24 mg\/day; in severe hepatic impairment cap at 8 mg\/day.<\/p>\n<h3 class=\"wp-block-heading\">Can I take it with my SSRI antidepressant?<\/h3>\n<p>Short-term combinations are usually safe but counsel patients to recognise serotonin syndrome (tremor, agitation, hyperreflexia, clonus, fever). Long-term concurrent use is generally avoided when an alternative antiemetic is available.<\/p>\n<h3 class=\"wp-block-heading\">\u00c4r f\u00f6rstoppning ett problem?<\/h3>\n<p>Yes &mdash; ondansetron causes constipation in up to 1 in 10 users (more on multi-day chemo courses). Maintain hydration, fibre, and a stimulant laxative (senna\/bisacodyl) prophylactically during chemo cycles.<\/p>\n<h3 class=\"wp-block-heading\">Can Ondem MD be used in children?<\/h3>\n<p>Yes &mdash; weight-based dosing is well established for paediatric gastroenteritis (8&ndash;15 kg = 2 mg, 15&ndash;30 kg = 4 mg, &gt;30 kg = 4&ndash;8 mg every 8 h). The ODT formulation is particularly useful for children who cannot swallow tablets.<\/p>\n<h3 class=\"wp-block-heading\">How is Ondem MD stored?<\/h3>\n<p>Store at room temperature (below 30&deg;C), protect from light and moisture, keep out of reach of children. Keep ODT blisters sealed until use; do not refrigerate.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Andra behandlingar mot illam\u00e5ende<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/sv\/ondem-injection\/\">Ondem Injection (ondansetron 2 mg\/ml IV\/IM)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/granicip\/\">Granicip (granisetron &mdash; longer-acting 5-HT3)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/dompewal-tablet\/\">Dompewal (domperidone &mdash; D2 antagonist for regurgitation)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/stemetil-md\/\">Stemetil MD (prochlorperazine ODT &mdash; vestibular nausea)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/avomine\/\">Avomine (promethazine &mdash; motion sickness)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/nausea-treatment\/\"><strong>Bl\u00e4ddra bland alla behandlingar mot illam\u00e5ende<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Medicinsk ansvarsfriskrivning.<\/strong> Denna sida \u00e4r endast avsedd f\u00f6r informations\u00e4ndam\u00e5l och ers\u00e4tter inte medicinsk r\u00e5dgivning fr\u00e5n en kvalificerad v\u00e5rdgivare. Kontinuerligt kr\u00e4kningar, blod i spyorna, sv\u00e5r buksm\u00e4rta, tecken p\u00e5 uttorkning, misst\u00e4nkta graviditetskomplikationer eller kemoterapirelaterade symptom kr\u00e4ver utv\u00e4rdering av en l\u00e4kare.<\/div>","protected":false},"excerpt":{"rendered":"<p>Ondem MD (Ondansetron 4 mg \/ 8 mg orally disintegrating) \u2014 selective 5-HT3 antagonist for chemo, radiation, and PONV. Dissolves on the tongue without water.<\/p>","protected":false},"featured_media":59920,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3543],"product_tag":[3613,4767],"class_list":{"0":"post-59919","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-nausea-treatment","9":"product_tag-ondansetron","10":"product_tag-ondem-md","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product\/59919","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/comments?post=59919"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/media\/59920"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/media?parent=59919"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_brand?post=59919"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_cat?post=59919"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_tag?post=59919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}