{"id":61596,"date":"2024-03-03T06:01:14","date_gmt":"2024-03-03T06:01:14","guid":{"rendered":"https:\/\/medsname.com\/bicalumutide\/"},"modified":"2026-04-30T10:23:34","modified_gmt":"2026-04-30T10:23:34","slug":"bicalumutide","status":"publish","type":"product","link":"https:\/\/medsbase.com\/sv\/product\/bicalumutide\/","title":{"rendered":"Bicalumutide"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Bicalumutide?<\/h3>\n<p style=\"margin:0;\"><strong>Bicalumutide<\/strong> \u00e4r ett tablettpreparat fr\u00e5n Cipla som inneh\u00e5ller <strong>bicalutamide 50 mg<\/strong> \u2014 en icke-steroid <strong>androgenreceptorantagonist (antiandrogen)<\/strong> anv\u00e4nds f\u00f6r <strong>avancerad eller metastaserad prostatacancer<\/strong>. Standardroll: kombineras med en <strong>LHRH-agonist<\/strong> (goserelin, leuprorelin) f\u00f6r kombinerad androgenblockad (CAB). Standarddos: <strong>50 mg once daily (with LHRH agonist) or 150 mg once daily (monotherapy)<\/strong>. Main side effects: gynaecomastia and breast tenderness (common), hot flushes, hepatotoxicity (mandatory LFT monitoring), reduced libido, rare interstitial pneumonitis. <strong>Obligatoriskt: basv\u00e4rden + m\u00e5natliga leverprover under de f\u00f6rsta 4 m\u00e5naderna, d\u00e4refter periodiskt.<\/strong><\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Vad du f\u00e5r med MedsBase:<\/strong> WHO-GMP-certifierad tillverkare \u00b7 Diskret f\u00f6rpackning \u00b7 V\u00e4rldsvid leverans \u00b7 1 400+ verifierade <a href=\"https:\/\/medsbase.com\/sv\/reviews\/\">kundrecensioner<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Varje best\u00e4llning omfattas av v\u00e5r <a href=\"https:\/\/medsbase.com\/sv\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 om din f\u00f6rs\u00e4ndelse inte anl\u00e4nder inom 20 arbetsdagar, skickar vi om den.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Specialist\u00f6vervakning kr\u00e4vs.<\/strong> Cancerl\u00e4kemedel m\u00e5ste ordineras av en behandlande onkolog med bekr\u00e4ftad diagnos, baslinjestagering och definierad behandlingsplan. Starta, avsluta, \u00e4ndra dos eller anv\u00e4nd cancerl\u00e4kemedel aldrig utanf\u00f6r en onkologledd v\u00e5rdplan. De flesta cancerl\u00e4kemedel kr\u00e4ver regelbundna blodprovskontroller (FBC, leverfunktion, njurfunktion), \u00e4r absolut kontraindicerade under graviditet och har betydande l\u00e4kemedelsinteraktioner.<\/div>\n<h2 class=\"wp-block-heading\">What Is Bicalumutide?<\/h2>\n<p>Bicalumutide is an oral tablet from Cipla containing <strong>bicalutamide 50 mg<\/strong>. Bicalutamide is a non-steroidal anti-androgen that competitively blocks the androgen receptor in prostate cancer cells, inhibiting the proliferative effect of testosterone and dihydrotestosterone (DHT). It is used in <strong>avancerad eller metastaserad prostatacancer<\/strong>, n\u00e4stan alltid i kombination med en LHRH-agonist (goserelin, leuprorelin, triptorelin) f\u00f6r <strong>kombinerad androgenblockad (CAB)<\/strong>.<\/p>\n<h2 class=\"wp-block-heading\">How Does Bicalumutide Work?<\/h2>\n<p>Prostate cancer growth is driven by androgen-receptor signalling. Standard androgen deprivation therapy (ADT) suppresses ovarian androgen production through LHRH agonists. However, the adrenal glands continue to produce ~10% of total body androgens, and the residual signal is enough to drive disease progression in many patients. Bicalumutide blocks the androgen receptor itself, so the residual adrenal androgens cannot signal &mdash; producing more complete androgen blockade.<\/p>\n<ul>\n<li><strong>Kompetitiv androgenreceptorantagonist<\/strong> \u2013 binder till AR och f\u00f6rhindrar att testosteron\/DHT aktiverar den.<\/li>\n<li><strong>Long half-life (~6 days)<\/strong> &mdash; once-daily oral dosing.<\/li>\n<li><strong>Anv\u00e4nds f\u00f6r att f\u00f6rhindra \u201ctum\u00f6rflare\u201d<\/strong> n\u00e4r LHRH-agonistterapi p\u00e5b\u00f6rjas \u2013 den initiala LHRH-inducerade testosteron\u00f6kningen kan tillf\u00e4lligt f\u00f6rv\u00e4rra sjukdomen, och f\u00f6rbehandling med antiandrogen blockerar detta.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Anv\u00e4ndningsomr\u00e5den och indikationer<\/h2>\n<ul>\n<li><strong>Kombinerad androgenblockad (CAB)<\/strong> vid avancerad eller metastaserad prostatacancer (med LHRH-agonist)<\/li>\n<li><strong>F\u00f6rebyggande av tum\u00f6rflare<\/strong> vid initiering av LHRH-agonist (2\u20134 veckor f\u00f6re behandling)<\/li>\n<li><strong>Monotherapy 150 mg\/day<\/strong> in locally advanced non-metastatic prostate cancer (alternative to LHRH agonist for patients prioritising sexual function preservation)<\/li>\n<li><strong>Efter biokemisk \u00e5terkomst<\/strong> som en del av intermittenta eller kontinuerliga androgenblockeringsregimer<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Bicalumutide Dosage and How to Take<\/h2>\n<p>Standarddos: <strong>50 mg once daily (with LHRH agonist) or 150 mg once daily (monotherapy)<\/strong>.<\/p>\n<ol>\n<li><strong>En g\u00e5ng dagligen vid samma tid varje dag.<\/strong> Med eller utan mat.<\/li>\n<li><strong>Sv\u00e4lj hela med vatten.<\/strong><\/li>\n<li><strong>Obligatorisk \u00f6vervakning:<\/strong> baslinjev\u00e4rden f\u00f6r levertester (AST, ALT) och PSA. Upprepa levertester <strong>m\u00e5nadsvis under de f\u00f6rsta 4 m\u00e5naderna<\/strong>, sedan var 3\u20136 m\u00e5nader. PSA var 3:e m\u00e5nad. Avbryt och utred om AST\/ALT &gt; 3\u00d7 \u00f6vre normalgr\u00e4nsen.<\/li>\n<li><strong>F\u00f6rebyggande av tum\u00f6rfl\u00e4rr f\u00f6re LHRH-agonistbehandling:<\/strong> start Bicalumutide 2&ndash;4 weeks before LHRH agonist initiation, continue for at least 1 month after.<\/li>\n<li><strong>Avbryt inte utan onkologens instruktion.<\/strong><\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Side Effects of Bicalumutide<\/h2>\n<p><strong>Vanligt:<\/strong><\/p>\n<ul>\n<li>Gynekomasti och br\u00f6st\u00f6mhet (40\u201370% vid monoterapi; mindre vid CAB)<\/li>\n<li>Hettflimmer<\/li>\n<li>Nedsatt libido och erektil dysfunktion<\/li>\n<li>Tr\u00f6tthet, asteni<\/li>\n<li>Diarr\u00e9 (s\u00e4rskilt vid flutamid)<\/li>\n<li>Mild magbesv\u00e4r<\/li>\n<\/ul>\n<p><strong>Viktigt \u2014 krav p\u00e5 \u00f6vervakning:<\/strong><\/p>\n<ul>\n<li><strong>Hepatotoxicitet<\/strong> \u2014 kan vara allvarlig och of\u00f6ruts\u00e4gbar. Avbryt omedelbart vid gulsot, m\u00f6rk urin, sv\u00e5r tr\u00f6tthet eller AST\/ALT &gt; 3\u00d7 ULN. De flesta fall intr\u00e4ffar inom de f\u00f6rsta 4 m\u00e5naderna.<\/li>\n<li>Rare interstitial pneumonitis &mdash; new-onset cough, dyspnoea<\/li>\n<\/ul>\n<p><strong>S\u00e4llsynt:<\/strong> hemolytisk anemi, fotok\u00e4nslighet, sv\u00e5ra hudreaktioner.<\/p>\n<h2 class=\"wp-block-heading\">Varningar och f\u00f6rsiktighets\u00e5tg\u00e4rder<\/h2>\n<ul>\n<li><strong>Graviditet och amning:<\/strong> inte till\u00e4mpligt (endast f\u00f6r m\u00e4n) men antiandrogener \u00e4r fosterfarliga om de tas av misstag under graviditet.<\/li>\n<li><strong>Leversfunktion:<\/strong> obligatoriska m\u00e5natliga leverprover under de f\u00f6rsta 4 m\u00e5naderna. Avbryt vid AST\/ALT &gt; 3\u00d7 ULN.<\/li>\n<li><strong>Diabetes:<\/strong> kan f\u00f6rs\u00e4mra glykemisk kontroll.<\/li>\n<li><strong>Kardiovaskul\u00e4rt:<\/strong> ADT i allm\u00e4nhet \u00e4r associerad med \u00f6kad risk f\u00f6r hj\u00e4rt-k\u00e4rlh\u00e4ndelser. Optimera modifierbara riskfaktorer.<\/li>\n<li><strong>Profylax mot gynekomasti:<\/strong> l\u00e5gdos tamoxifen 10\u201320 mg\/dag eller profylaktisk br\u00f6ststr\u00e5lning minskar incidensen (specialist).<\/li>\n<li><strong>K\u00f6rning:<\/strong> f\u00f6rsiktighet \u2014 tr\u00f6tthet och yrsel kan p\u00e5verka k\u00f6rf\u00f6rm\u00e5gan.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">L\u00e4kemedelsinteraktioner<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombinera med<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Effekt<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Vad man ska g\u00f6ra<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Warfarin och andra kumarinantikoagulantia<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Signifikant INR-h\u00f6jning \u2014 \u00f6kad bl\u00f6dningsrisk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kontrollera INR varje vecka initialt. Minska warfarindosen med 30\u201350%.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">CYP3A4 inhibitors (minor effect)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Raise bicalutamide levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u00d6vervakning f\u00f6r hepatotoxicitet.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">LHRH-agonister (goserelin, leuprorelin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standardkombination \u2014 kombinerad androgenblockad<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standard CAB-schema.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Alkohol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additiv levertoxicitet<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Begr\u00e4nsa alkoholintag under behandlingen.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">F\u00f6rvaring<\/h2>\n<ul>\n<li>F\u00f6rvara vid rumstemperatur, 15\u201325\u00b0C, i originalblister.<\/li>\n<li>H\u00e5ll utom r\u00e4ckh\u00e5ll f\u00f6r barn, kvinnor och husdjur \u2014 antiandrogener \u00e4r fostertoxiska.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Relaterade alternativ p\u00e5 MedsBase<\/h2>\n<p>Andra onkologiska l\u00e4kemedel som finns i lager tillsammans med denna produkt:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/sv\/bdenza\/\"><strong>Bdenza (enzalutamid 40 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/cytomid\/\"><strong>Cytomid (flutamid 250 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/sv\/anti-cancer-medication\/\">Bl\u00e4ddra bland alla cancerl\u00e4kemedel \u2192<\/a><\/p>\n<h2 id=\"faqs\">Vanliga fr\u00e5gor<\/h2>\n<h3 class=\"wp-block-heading\">Why is Bicalumutide usually combined with an LHRH agonist?<\/h3>\n<p>LHRH agonists (goserelin, leuprorelin) suppress testicular androgen production, but the adrenal glands continue producing ~10% of body androgens that can drive prostate cancer growth. Bicalumutide blocks the androgen receptor itself, so adrenal androgens cannot signal. The combination is called <strong>kombinerad androgenblockad (CAB)<\/strong> och ger djupare androgenh\u00e4mning \u00e4n LHRH-agonist ensam vid avancerad sjukdom.<\/p>\n<h3 class=\"wp-block-heading\">What is &ldquo;tumour flare&rdquo; and why does Bicalumutide prevent it?<\/h3>\n<p>When LHRH agonist therapy starts, the pituitary is initially stimulated and testosterone surges for 1&ndash;2 weeks before downregulation kicks in. In patients with significant disease burden (bone metastases, urinary obstruction, spinal cord compression risk), this transient testosterone surge can worsen symptoms acutely. Starting Bicalumutide 2&ndash;4 weeks before the LHRH agonist blocks the receptor and prevents the flare.<\/p>\n<h3 class=\"wp-block-heading\">Hur hanteras gynekomasti?<\/h3>\n<p>Br\u00f6st\u00f6mhet och gynekomasti drabbar 40\u201370% av patienter p\u00e5 bikalutamidmonoterapi vid h\u00f6gre doser. Profylaxalternativ: <strong>l\u00e5gdos tamoxifen 10\u201320 mg\/dag<\/strong> (mest bevis) eller <strong>profylaktisk br\u00f6ststr\u00e5lbehandling<\/strong> som en enda dos p\u00e5 8\u201312 Gy innan p\u00e5b\u00f6rjad antiandrogenbehandling. Diskutera med onkologen innan start om kosmetiska bekymmer \u00e4r betydande.<\/p>\n<h3 class=\"wp-block-heading\">Vilka blodprov beh\u00f6ver jag?<\/h3>\n<p><strong>Obligatoriskt:<\/strong> baslinjeprov f\u00f6r levern (AST, ALT) och PSA. Sedan levertester <strong>m\u00e5nadsvis under de f\u00f6rsta 4 m\u00e5naderna<\/strong>, then every 3&ndash;6 months. PSA every 3 months. Stop Bicalumutide immediately and contact your oncologist if AST\/ALT &gt; 3&times; ULN, or for any jaundice, dark urine or severe fatigue.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Bicalumutide?<\/h3>\n<p>Limit alcohol &mdash; both alcohol and bicalutamide are hepatotoxic and the combination amplifies the risk of severe drug-induced liver injury. Occasional small amounts are usually tolerable; heavy or daily drinking should be avoided throughout treatment.<\/p>\n<h3 class=\"wp-block-heading\">Bicalumutide vs flutamide vs enzalutamide &mdash; what is the difference?<\/h3>\n<p>All three are oral anti-androgens for prostate cancer. <strong>Bicalutamide:<\/strong> once-daily, well-tolerated, standard first-generation choice. <strong>Flutamide:<\/strong> three-times-daily, more diarrhoea and hepatotoxicity risk &mdash; largely replaced by bicalutamide. <strong>Enzalutamide:<\/strong> second-generation, more potent, used for castration-resistant disease (after CAB has failed) &mdash; see <a href=\"https:\/\/medsbase.com\/sv\/bdenza\/\">Bdenza<\/a>.<\/p>\n<h3 class=\"wp-block-heading\">Will Bicalumutide affect my heart?<\/h3>\n<p>Antiandrogen monoterapi har minimal direkt kardiovaskul\u00e4r effekt, men den bredare androgenblockerande terapin (LHRH-agonist + antiandrogen) \u00e4r associerad med \u00f6kad risk f\u00f6r kardiovaskul\u00e4ra h\u00e4ndelser inklusive hj\u00e4rtinfarkt och stroke. Optimera kardiovaskul\u00e4ra riskfaktorer: blodtryckskontroll, statin vid hyperlipidemi, r\u00f6kavv\u00e4njning, motion, viktkontroll.<\/p>\n<h3 class=\"wp-block-heading\">Can I stop Bicalumutide if PSA stays low?<\/h3>\n<p>Diskutera med din onkolog. I vissa intermittenta CAB-protokoll pausas CAB n\u00e4r PSA \u00e4r undertryckt under en tr\u00f6skelniv\u00e5 och \u00e5terupptas n\u00e4r PSA stiger \u2014 detta kan minska biverkningar utan att kompromissa med \u00f6verlevnad. Avbryt aldrig ensidigt \u2014 PSA-\u00f6vervakning och tidpunkt f\u00f6r \u00e5terstart \u00e4r avg\u00f6rande.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 Krypterad kassaprocess<\/strong> \u00b7 <strong>\ud83d\udcb3 Verifierad betalningsprocessor<\/strong> \u00b7 <strong>\ud83d\ude9a V\u00e4rldsomsp\u00e4nnande leverans<\/strong> \u00b7 <strong>\u2b50 4.9\/5 fr\u00e5n 1 400+ kunder<\/strong>\n<\/div>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Varf\u00f6r best\u00e4lla fr\u00e5n MedsBase<\/h3>\n<p>Varje sats h\u00e4rstammar fr\u00e5n en <strong>WHO-GMP-certifierad tillverkare<\/strong>. Best\u00e4llningar skickas i enkel, om\u00e4rkt f\u00f6rpackning fr\u00e5n v\u00e5ra uppfyllningspartners och t\u00e4cks av v\u00e5r <a href=\"\/sv\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a>: om ett paket inte anl\u00e4nder inom 20 arbetsdagar skickar vi en gratis omleverans, inga fr\u00e5gor st\u00e4lls.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Relaterade alternativ<\/h3>\n<p>Andra produkter inom <strong>Kroniska tillst\u00e5nd<\/strong> som kunder \u00e4ven tittar p\u00e5:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/sv\/riborea\/\">Riborea<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/bacloheal\/\">Bacloheal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/amlode\/\">Amlode<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/nicerbium\/\">Nicerbium<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/lipril-h\/\">Lipril-H<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Behandlar prostatacancer<br \/>\n\u2705 Blocks male hormones<br \/>\n\u2705 Bromsar tum\u00f6rtillv\u00e4xt<br \/>\n\u2705 F\u00f6rb\u00e4ttrar \u00f6verlevnadsgraden<br \/>\n\u2705 Reduces cancer symptoms<\/p>\n<p>Bicalumutide contains Bicalutamide.<\/p>","protected":false},"featured_media":61597,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3614,3141,3223,3342],"product_tag":[5066,5067],"class_list":{"0":"post-61596","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-bladder-prostate","8":"product_cat-category-overview","9":"product_cat-chronic-conditions","10":"product_cat-general-health","11":"product_tag-bicalumutide","12":"product_tag-bicalutamide","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product\/61596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/comments?post=61596"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/media\/61597"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/media?parent=61596"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_brand?post=61596"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_cat?post=61596"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_tag?post=61596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}