{"id":61761,"date":"2024-03-06T09:41:53","date_gmt":"2024-03-06T09:41:53","guid":{"rendered":"https:\/\/medsname.com\/temotero\/"},"modified":"2026-04-30T10:23:32","modified_gmt":"2026-04-30T10:23:32","slug":"temotero","status":"publish","type":"product","link":"https:\/\/medsbase.com\/sv\/product\/temotero\/","title":{"rendered":"Temotero"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Temotero?<\/h3>\n<p style=\"margin:0;\"><strong>Temotero<\/strong> is an oral capsule from Glenmark containing <strong>temozolomide<\/strong> p\u00e5 <strong>20 mg and 100 mg<\/strong> &mdash; an oral alkylating cytotoxic agent and the standard chemotherapy for <strong>glioblastoma multiforme (GBM)<\/strong> och <strong>anaplastic astrocytoma<\/strong>. Standard regimen: <strong>concurrent<\/strong> with radiotherapy (75 mg\/m&sup2; daily for 6 weeks), then <strong>maintenance<\/strong> 150&ndash;200 mg\/m&sup2; daily for days 1&ndash;5 of each 28-day cycle for 6 cycles (Stupp protocol). <strong>Ta p\u00e5 fastande mage<\/strong> at the same time each day, with antiemetic (ondansetron) 1 hour before. Mandatory: <strong>PCP-profilaxi<\/strong> with co-trimoxazole during radiotherapy phase. FBC weekly during concurrent phase, then before each maintenance cycle.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Vad du f\u00e5r med MedsBase:<\/strong> WHO-GMP-certifierad tillverkare \u00b7 Diskret f\u00f6rpackning \u00b7 V\u00e4rldsvid leverans \u00b7 1 400+ verifierade <a href=\"https:\/\/medsbase.com\/sv\/reviews\/\">kundrecensioner<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Varje best\u00e4llning omfattas av v\u00e5r <a href=\"https:\/\/medsbase.com\/sv\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 om din f\u00f6rs\u00e4ndelse inte anl\u00e4nder inom 20 arbetsdagar, skickar vi om den.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Specialist\u00f6vervakning kr\u00e4vs.<\/strong> Cancerl\u00e4kemedel m\u00e5ste ordineras av en behandlande onkolog med bekr\u00e4ftad diagnos, baslinjestagering och definierad behandlingsplan. Starta, avsluta, \u00e4ndra dos eller anv\u00e4nd cancerl\u00e4kemedel aldrig utanf\u00f6r en onkologledd v\u00e5rdplan. De flesta cancerl\u00e4kemedel kr\u00e4ver regelbundna blodprovskontroller (FBC, leverfunktion, njurfunktion), \u00e4r absolut kontraindicerade under graviditet och har betydande l\u00e4kemedelsinteraktioner.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 Krypterad kassaprocess<\/strong> \u00b7 <strong>\ud83d\udcb3 Verifierad betalningsprocessor<\/strong> \u00b7 <strong>\ud83d\ude9a V\u00e4rldsomsp\u00e4nnande leverans<\/strong> \u00b7 <strong>\u2b50 4.9\/5 fr\u00e5n 1 400+ kunder<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Temotero?<\/h2>\n<p>Temotero is an oral capsule from Glenmark containing <strong>temozolomide<\/strong> (20 mg and 100 mg). Temozolomide is an oral alkylating cytotoxic agent of the imidazotetrazine class. It crosses the blood-brain barrier (CSF concentration ~30% of plasma) and is the only oral cytotoxic with proven survival benefit in glioblastoma multiforme. Standard combination with radiotherapy (the &ldquo;Stupp protocol&rdquo;, 2005) extended median GBM survival from 12 months to 15 months and 2-year survival from 11% to 27%.<\/p>\n<h2 class=\"wp-block-heading\">Anv\u00e4ndningsomr\u00e5den och indikationer<\/h2>\n<ul>\n<li><strong>Newly-diagnosed glioblastoma multiforme (GBM)<\/strong> &mdash; concurrent with radiotherapy then maintenance (Stupp protocol)<\/li>\n<li><strong>Anaplastic astrocytoma<\/strong> after recurrence<\/li>\n<li><strong>Recurrent high-grade glioma<\/strong><\/li>\n<li><strong>Off-label:<\/strong> melanoma brain metastases, neuroendocrine tumours<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosage (Stupp protocol)<\/h2>\n<ul>\n<li><strong>Concurrent phase:<\/strong> 75 mg\/m&sup2;\/day continuously during 6 weeks of radiotherapy (total ~42 days)<\/li>\n<li><strong>4-week break<\/strong> after radiotherapy completion<\/li>\n<li><strong>Underh\u00e5llsfas:<\/strong> 150 mg\/m&sup2;\/day for days 1&ndash;5 of a 28-day cycle (cycle 1); escalate to 200 mg\/m&sup2;\/day if tolerated for cycles 2&ndash;6 (total 6 cycles, with newer evidence supporting up to 12 cycles in younger MGMT-methylated patients)<\/li>\n<\/ul>\n<ol>\n<li><strong>Take on an empty stomach at the same time each day<\/strong> &mdash; food slows absorption and reduces peak concentration. Most patients take it at bedtime, &ge; 2 hours after the last meal.<\/li>\n<li><strong>Antiemetic:<\/strong> ondansetron 8 mg orally 1 hour before each temozolomide dose, especially during the maintenance phase 5-day pulse.<\/li>\n<li>Swallow capsules whole with water. Do NOT open or chew &mdash; powder is cytotoxic.<\/li>\n<li><strong>PCP-profilaxi<\/strong> with co-trimoxazole 480 mg three times weekly during the concurrent phase &mdash; lymphopenia risk. Continue until CD4 &gt; 200 cells\/&micro;L.<\/li>\n<li><strong>Obligatorisk \u00f6vervakning:<\/strong> FBC weekly during concurrent phase; before each maintenance cycle (day 22 of previous cycle and day 1 of each new cycle); LFTs monthly. Hold cycle for ANC &lt; 1,500\/&micro;L or platelets &lt; 100,000\/&micro;L.<\/li>\n<li>If a dose is vomited within 1 hour, do NOT re-dose. Resume next day per schedule.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Biverkningar<\/h2>\n<p><strong>Vanligt:<\/strong> nausea, vomiting (mostly preventable with ondansetron), fatigue, anorexia, constipation, headache, alopecia.<\/p>\n<p><strong>Viktigt:<\/strong><\/p>\n<ul>\n<li><strong>Myelosuppression<\/strong> &mdash; especially thrombocytopenia (the dose-limiting toxicity); lymphopenia with PCP risk<\/li>\n<li><strong>Pneumocystis jirovecii-pneumoni<\/strong> &mdash; lymphopenia-driven; mandatory prophylaxis during concurrent phase<\/li>\n<li>Hepatotoxicity, including rare reactivation of hepatitis B<\/li>\n<li>Severe skin reactions including SJS\/TEN (rare)<\/li>\n<li>Secondary myelodysplastic syndrome \/ acute leukaemia (rare, long-term)<\/li>\n<li>Severe lymphopenia &gt; 6 months<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Varningar<\/h2>\n<ul>\n<li><strong>Graviditet:<\/strong> teratogenic. Reliable contraception throughout treatment + 6 months after.<\/li>\n<li><strong>Amning:<\/strong> Undvik.<\/li>\n<li><strong>Sv\u00e5r leversvikt:<\/strong> Undvik.<\/li>\n<li><strong>Hepatitis B carrier status:<\/strong> screen and consider antiviral prophylaxis &mdash; reactivation risk.<\/li>\n<li><strong>Levande vacciner:<\/strong> Kontraindikerat.<\/li>\n<li><strong>Severe lymphopenia \/ CD4 &lt; 200:<\/strong> continue PCP prophylaxis until lymphocyte recovery.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">L\u00e4kemedelsinteraktioner<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombinera med<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Effekt<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Vad man ska g\u00f6ra<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Levande vacciner<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Spridd infektion<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kontraindikerat.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Andra myelosuppressiva l\u00e4kemedel<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additiv benm\u00e4rgssuppression<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Specialist\u00f6vervakning.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Valproic acid<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Mildly reduces temozolomide clearance<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">No dose adjustment usually needed.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Co-trimoxazole (PCP prophylaxis)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standard combination<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Continue throughout concurrent phase.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">F\u00f6rvaring<\/h2>\n<ul>\n<li>Rumstemperatur, 15\u201330\u00b0C, originalblisterf\u00f6rpackning.<\/li>\n<li>Out of reach of children, women of childbearing potential, and pets &mdash; cytotoxic powder.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Relaterade alternativ p\u00e5 MedsBase<\/h2>\n<p>Andra onkologiska l\u00e4kemedel som finns i lager tillsammans med denna produkt:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/sv\/endoxan\/\"><strong>Endoxan (cyklofosfamid 50 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/celkeran\/\"><strong>Celkeran (chlorambucil 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/temozol-20\/\"><strong>Temozol (temozolomid 20 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/lomoother\/\"><strong>Lomoother (lomustin 40 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/endace\/\"><strong>Endace (megestrol 40 \/ 160 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/sv\/anti-cancer-medication\/\">Bl\u00e4ddra bland alla cancerl\u00e4kemedel \u2192<\/a><\/p>\n<h2 id=\"faqs\">Vanliga fr\u00e5gor<\/h2>\n<h3 class=\"wp-block-heading\">What is the Stupp protocol?<\/h3>\n<p>The Stupp protocol (2005) is the standard combined chemoradiotherapy regimen for newly-diagnosed glioblastoma multiforme: <strong>radiotherapy (60 Gy in 30 fractions) + concurrent temozolomide (75 mg\/m&sup2;\/day) for 6 weeks, then 4-week break, then maintenance temozolomide (150&ndash;200 mg\/m&sup2;\/day for days 1&ndash;5 of each 28-day cycle) for 6 cycles<\/strong>. The protocol extended median survival from 12 to 15 months and remains the global standard in 2026.<\/p>\n<h3 class=\"wp-block-heading\">Why must I take Temotero on an empty stomach?<\/h3>\n<p>Food slows temozolomide absorption and reduces peak plasma concentration. For consistent dosing, take temozolomide at the same time each day with no food for at least 2 hours before. Most patients take it at bedtime &ge; 2 hours after the last meal. Take ondansetron 8 mg orally 1 hour before each dose to prevent nausea.<\/p>\n<h3 class=\"wp-block-heading\">Why do I need PCP prophylaxis?<\/h3>\n<p>The continuous 6-week concurrent phase causes prolonged lymphopenia &mdash; particularly low CD4 counts &mdash; that creates a real risk of <strong>Pneumocystis jirovecii pneumonia (PCP)<\/strong>, a potentially fatal opportunistic infection. Standard prophylaxis: <strong>co-trimoxazole 480 mg three times weekly<\/strong> throughout concurrent phase, continued until CD4 recovery (often takes 6+ months).<\/p>\n<h3 class=\"wp-block-heading\">What does &ldquo;MGMT methylation&rdquo; mean for my treatment?<\/h3>\n<p>MGMT (O6-methylguanine-DNA methyltransferase) is a DNA repair enzyme that undoes temozolomide&#39;s alkylation damage. <strong>MGMT-methylated<\/strong> tumours have low MGMT expression &mdash; they cannot repair the damage, so respond much better to temozolomide. <strong>MGMT-unmethylated<\/strong> tumours have high MGMT expression and are relatively temozolomide-resistant. MGMT status is determined on the surgical biopsy and influences treatment intensity (longer maintenance, more aggressive regimens) and prognosis.<\/p>\n<h3 class=\"wp-block-heading\">Vilka blodprov beh\u00f6ver jag?<\/h3>\n<p>FBC weekly during the concurrent radiotherapy phase. Before each maintenance cycle: FBC on day 22 of the previous cycle and day 1 of the new cycle. LFTs monthly. Hold cycle for ANC &lt; 1,500\/&micro;L or platelets &lt; 100,000\/&micro;L &mdash; thrombocytopenia is the dose-limiting toxicity.<\/p>\n<h3 class=\"wp-block-heading\">What if I vomit a dose?<\/h3>\n<p>If you vomit within 1 hour of taking Temotero, do NOT re-dose &mdash; the safety risk of double-dosing is greater than the modest loss of efficacy from one missed dose. Resume the next dose at the scheduled time. Speak to your oncology team about pre-medication adjustment if vomiting recurs.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Temotero?<\/h3>\n<p>Avoid during active treatment. Both alcohol and temozolomide are hepatotoxic, and alcohol increases nausea. Even after treatment finishes, limit alcohol given the hepatic and bone marrow recovery period.<\/p>\n<h3 class=\"wp-block-heading\">Will Temotero cure my brain tumour?<\/h3>\n<p>Glioblastoma multiforme remains one of the most aggressive cancers. The Stupp protocol is the established standard and improves median survival, but cure is uncommon at present. Specific situations carry better prognosis: younger age, MGMT methylation, complete surgical resection, IDH mutation. Discuss prognosis honestly with your neuro-oncologist &mdash; treatment goals depend on individual disease characteristics.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Varf\u00f6r best\u00e4lla fr\u00e5n MedsBase<\/h3>\n<p>Varje sats h\u00e4rstammar fr\u00e5n en <strong>WHO-GMP-certifierad tillverkare<\/strong>. Best\u00e4llningar skickas i enkel, om\u00e4rkt f\u00f6rpackning fr\u00e5n v\u00e5ra uppfyllningspartners och t\u00e4cks av v\u00e5r <a href=\"\/sv\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a>: om ett paket inte anl\u00e4nder inom 20 arbetsdagar skickar vi en gratis omleverans, inga fr\u00e5gor st\u00e4lls.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Relaterade l\u00e4kemedel mot cancer<\/h3>\n<p>Andra onkologiska l\u00e4kemedel som finns i lager tillsammans med denna produkt:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/sv\/temozol-20\/\">Temozol 20 (temozolomid 20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/lomoother\/\">Lomoother (lomustin 40 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/endoxan\/\">Endoxan (cyklofosfamid 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/hydrosar\/\">Hydrosar (hydroxyurea 500 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/sv\/folitrax\/\">Folitrax (metotrexat 2,5\/7,5\/10 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Fights brain tumors<br \/>\n\u2705 Bromsar tum\u00f6rtillv\u00e4xt<br \/>\n\u2705 \u00d6verlevnadsgraden \u00f6kar<br \/>\n\u2705 Oral chemotherapy option<br \/>\n\u2705 Well-tolerated treatment<\/p>\n<p>Temotero contains Temozolomide.<\/p>","protected":false},"featured_media":61762,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[5085,4915],"class_list":{"0":"post-61761","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-temotero","10":"product_tag-temozolomide","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product\/61761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/comments?post=61761"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/media\/61762"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/media?parent=61761"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_brand?post=61761"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_cat?post=61761"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/sv\/wp-json\/wp\/v2\/product_tag?post=61761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}