{"id":70754,"date":"2026-05-12T10:43:33","date_gmt":"2026-05-12T10:43:33","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=70754"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"mazdutide","status":"publish","type":"product","link":"https:\/\/medsbase.com\/sv\/product\/mazdutide\/","title":{"rendered":"Mazdutide"},"content":{"rendered":"

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Quick Answer \u2014 What is Mazdutide?<\/h3>\n

Mazdutide<\/strong> (developmental codes IBI362 \/ LY3305677) is a long-acting dual GLP-1 and glucagon receptor co-agonist peptide developed by Innovent Biologics (in-licensed from Eli Lilly). It is the first dual GLP-1\/glucagon agonist to reach Phase 3 trials in obesity and type 2 diabetes, with the glucagon component adding an energy-expenditure mechanism beyond what GLP-1-only and GLP-1\/GIP-dual peptides produce. Plasma half-life supports once-weekly dosing. Supplied in 5\u00a0mg and 10\u00a0mg lyophilized vials for laboratory research use only.<\/p>\n<\/div>\n

Vad du f\u00e5r med MedsBase:<\/strong> Forskningsgrad av liofiliserade peptider \u00b7 HPLC \u226599% renhet (COA p\u00e5 beg\u00e4ran) \u00b7 Diskret temperaturstabil f\u00f6rpackning \u00b7 Peptidbud \u00f6ver hela v\u00e4rlden \u00b7 1 400+ verifierade kundrecensioner<\/a><\/div>\n

\ud83d\udce6 Varje best\u00e4llning omfattas av v\u00e5r Reshipment Assurance Policy<\/strong><\/a> \u2014 om din f\u00f6rs\u00e4ndelse inte anl\u00e4nder inom 20 arbetsdagar, skickar vi om den.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikation<\/th>\nDetalj<\/th>\n<\/tr>\n<\/thead>\n
CAS-nummer<\/strong><\/td>\n2376247-09-1 (mazdutide; commonly cited)<\/td>\n<\/tr>\n
Typ<\/strong><\/td>\nLong-acting dual GLP-1 \/ glucagon receptor co-agonist (acylated synthetic peptide; Innovent IBI362 \/ Eli Lilly LY3305677; oxyntomodulin-derived scaffold)<\/td>\n<\/tr>\n
Molekylvikt<\/strong><\/td>\n~4,865 Da (with fatty-acid acylation; published mature form)<\/td>\n<\/tr>\n
Structure<\/strong><\/td>\nSynthetic peptide based on the natural oxyntomodulin scaffold (the endogenous dual GLP-1\/glucagon agonist), with engineered substitutions for DPP-4 resistance and a fatty-diacid acyl tether attached at a lysine residue via a \u03b3-Glu linker. The acyl chain drives reversible serum-albumin binding that produces the extended weekly half-life.<\/td>\n<\/tr>\n
Form<\/strong><\/td>\nLiofiliserat pulver (vitt till vittaktigt)<\/td>\n<\/tr>\n
Renhet<\/strong><\/td>\n\u226599 % (HPLC-verifierat, COA p\u00e5 beg\u00e4ran)<\/td>\n<\/tr>\n
F\u00f6rvaring<\/strong><\/td>\nLyofiliserat: 2\u20138 \u00b0C (kylsk\u00e5p) f\u00f6r arbetslager; \u221220 \u00b0C f\u00f6r l\u00e5ngtidslagring av o\u00f6ppnade flaskor. Rekonstituerat: 2\u20138 \u00b0C, anv\u00e4nd inom ~30 dagar. Skydda fr\u00e5n ljus. Frys inte upp och tina den rekonstituerade l\u00f6sningen.<\/td>\n<\/tr>\n
L\u00f6slighet<\/strong><\/td>\nBacteriostatic water (recommended) or sterile water for shorter use windows. Acylated peptides may dissolve more slowly \u2014 allow extra equilibration time.<\/td>\n<\/tr>\n
Forskningsanv\u00e4ndning<\/strong><\/td>\nEndast f\u00f6r laboratorieforskning. Ej avsedd f\u00f6r diagnostiskt eller terapeutiskt bruk p\u00e5 m\u00e4nniskor eller djur.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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What Is Mazdutide?<\/h2>\n

Mazdutide<\/strong> is a long-acting synthetic dual GLP-1 and glucagon receptor co-agonist developed under the developmental codes IBI362 (Innovent Biologics, in-licensed from Eli Lilly LY3305677). It is one of the most advanced compounds in the renewed wave of oxyntomodulin-derived dual-agonist pharmacology \u2014 an approach distinct from both the GLP-1-only programme (semaglutide) and the GLP-1\/GIP dual-agonist programme (tirzepatide). The structural inspiration is oxyntomodulin itself, a 37-amino-acid product of preproglucagon processing in intestinal L-cells that natively activates both the GLP-1 and glucagon receptors. Endogenous oxyntomodulin has very short pharmacokinetics; mazdutide engineers around this with a fatty-acid acyl tether at a lysine residue that drives reversible serum-albumin binding and extends the plasma half-life sufficiently for once-weekly subcutaneous administration in clinical research.<\/p>\n

Mazdutide has a mature molecular weight of approximately 4,865\u00a0Da including the acyl modification. The structural scaffold preserves the dual-receptor pharmacology of oxyntomodulin while engineered substitutions confer resistance to DPP-4-mediated proteolytic cleavage that would otherwise produce rapid clearance. Mazdutide is the lead Chinese metabolic peptide programme, with Phase 3 trials (GLORY-1 in obesity, DREAMS-1 and DREAMS-2 in type 2 diabetes) reporting body-weight reductions of approximately 15\u201317% at the highest dose tier over 48 weeks. Outside China, mazdutide is inte godk\u00e4nt<\/strong> by the FDA, EMA, MHRA, or any other major Western regulator. In China, mazdutide has been approved by the NMPA under its initial commercial brand \u2014 making it one of the first dual-agonist incretin peptides to receive regulatory clearance for human use anywhere. The research-grade mazdutide sold here is supplied endast f\u00f6r laboratorieforsknings\u00e4ndam\u00e5l<\/strong> and is not intended for human or veterinary administration. For the triple-agonist comparator that adds GIP on top of the same GLP-1\/glucagon combination, see our Retatrutid<\/a> product page.<\/p>\n

Mechanism of Action \u2014 Dual GLP-1 \/ Glucagon Receptor Co-Agonism<\/h2>\n

What makes mazdutide mechanistically distinctive among current dual-agonist metabolic peptides is that it pairs the canonical GLP-1 satiety \/ glycaemic axis with the glucagon receptor energy-expenditure axis<\/strong> \u2014 not the GIP receptor axis used by tirzepatide. The dual-receptor profile produces complementary effects across three principal compartments documented in published research:<\/p>\n