✓ Medically reviewed by · Last reviewed: May 2026
Pharmacy Researcher · 8 years experience
Pharmacy researcher with 8 years reviewing clinical drug information, generic formulation equivalence, and international pharmaceutical standards. Focuses on patient-facing accuracy in medication education.
Quick Answer
- Dapoxetine is the only SSRI developed specifically for premature ejaculation (PE). Clinical trials show it extends ejaculatory delay by 2–3× versus placebo.
- Available standalone (Duralast, Vriligy) or as an ED+PE combo with sildenafil (Super P-Force) or tadalafil (Tadapox).
- Standard doses: 30mg (starting dose) and 60mg (maintenance). Take 1–3 hours before sexual activity.
- No prescription needed at MedsBase. All brands are WHO-GMP certified. Discreet worldwide shipping.
Premature ejaculation affects an estimated 20–30% of men at some point in their lives, making it the most common male sexual complaint worldwide. Unlike SSRIs prescribed off-label for PE — which take weeks to build up and cause persistent sexual side effects — dapoxetine is engineered to act fast, work in hours, and clear your system by the next day.
This guide covers everything you need to know about buying dapoxetine online: how it works, which dose to start on, the difference between standalone products and combination tablets, and where to order with confidence.
What Is Dapoxetine?
Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) designed specifically for on-demand treatment of premature ejaculation. It was developed after researchers observed that SSRIs used for depression — sertraline, paroxetine, fluoxetine — consistently delayed ejaculation as a side effect. Dapoxetine was engineered to maximise that specific effect while minimising the long half-life that makes other SSRIs unsuitable for as-needed use.
Key pharmacological properties that distinguish dapoxetine from other SSRIs:
- Rapid absorption: Peak plasma concentration reached in approximately 1–2 hours after oral dosing.
- Short half-life (~1.5 hours): Clears the body within 24 hours — no accumulation, no next-day sexual blunting.
- On-demand dosing: Take only when needed, unlike daily SSRIs that require weeks of continuous use.
- Ejaculatory selectivity: Acts centrally on serotonergic pathways in the spinal cord that modulate ejaculatory threshold.
Dapoxetine is approved in more than 60 countries across Europe, Asia, Latin America, and Australasia. It is sold under brand names including Priligy (Janssen), Duralast (Sun Pharma), Vriligy (Sunrise Remedies), and Kutub, among others.
How Dapoxetine Works for Premature Ejaculation
In the pivotal Phase III trials, men taking dapoxetine 60mg reported an intravaginal ejaculatory latency time (IELT) increase from a median of 0.9 minutes at baseline to 3.1 minutes — a 3.5× improvement. Patient-reported satisfaction scores for ejaculatory control and sexual satisfaction improved significantly versus placebo in all three key measures.
Ejaculation is a reflex mediated by the sympathetic nervous system and modulated by serotonin (5-HT) levels in the central nervous system. Low serotonergic activity in the lateral paragigantocellular nucleus and spinal ejaculatory generator is associated with reduced ejaculatory latency.
Dapoxetine inhibits the serotonin transporter (SERT), preventing serotonin reuptake at the synapse. The resulting increase in synaptic 5-HT raises the ejaculatory threshold — meaning greater stimulation is required before the ejaculatory reflex fires. Because dapoxetine acts centrally rather than peripherally, it does not significantly affect penile sensitivity or erection quality at standard doses.
Dapoxetine 30mg vs 60mg: Which Dose Is Right?
| Parameter | 30mg | 60mg |
|---|---|---|
| Starting recommendation | ✅ Yes — all new users | Not recommended for first use |
| Upgrade to 60mg when | — | 30mg effect is insufficient after 3+ uses |
| Median IELT improvement | 2.5× over baseline | 3.5× over baseline |
| Side effect frequency | Lower (nausea ~11%) | Slightly higher (nausea ~22%) |
| Maximum dose per 24 hours | 30mg | 60mg |
| Timing before activity | 1–3 hours | 1–3 hours |
Practical rule: Start at 30mg for the first 2–3 occasions. If control is still unsatisfactory, step up to 60mg. Never exceed 60mg in a 24-hour window. Take with a full glass of water to reduce nausea risk, and avoid alcohol on the same day.
Dapoxetine Alone vs Dapoxetine + ED Medication: Which Do You Need?
The choice between standalone dapoxetine and a combination product comes down to one question: do you have erectile dysfunction as well as premature ejaculation?
- PE only, no ED: Standalone dapoxetine is the cleaner option. Lower risk of drug interactions, fewer cardiovascular considerations, and you take only what you need.
- Both PE and ED: A dapoxetine + PDE5 inhibitor combination is the more practical choice — one tablet addresses both conditions simultaneously. This is why products like Super P-Force (sildenafil + dapoxetine) account for the majority of dapoxetine sales globally.
- ED only, no PE: Do not take dapoxetine. Use sildenafil, tadalafil, or vardenafil alone. See our ED pills comparison guide for a full breakdown.
All Dapoxetine Products Available at MedsBase
Standalone Dapoxetine
| Product | Dapoxetine Dose | Manufacturer | Starting From |
|---|---|---|---|
| Duralast | 30mg / 60mg | Sun Pharma (WHO-GMP) | $30 |
| Vriligy | 60mg | Sunrise Remedies (WHO-GMP) | $19 |
Duralast (Sun Pharma) is the most widely prescribed dapoxetine brand in its originating market and is bioequivalent to Priligy. Available in both 30mg and 60mg, making it ideal for new users who want to start conservatively. Vriligy provides a 60mg dose at a lower price point and suits users who have already established their tolerance at 30mg.
Dapoxetine + Sildenafil Combinations (ED + PE)
| Product | Sildenafil | Dapoxetine | Form | From |
|---|---|---|---|---|
| Super P-Force | 100mg | 60mg | Tablet | $8.50 |
| Super P-Force Oral Jelly | 100mg | 60mg | Oral jelly — faster onset | $16.50 |
| Extra Super P-Force | 200mg | 60mg | Tablet — high-dose ED | $12.50 |
| Suhagra Force | 50mg | 30mg | Tablet — lower doses | $22.50 |
Super P-Force is the most popular dapoxetine combination product worldwide. The 100mg sildenafil handles erectile function (onset 30–60 min, duration 4–6 hours) while 60mg dapoxetine extends ejaculatory control. Taking them in a single tablet means one dose window covers both effects.
The oral jelly version absorbs faster — useful if 60 minutes feels too long to wait. Read our Super P-Force Oral Jelly guide for a detailed onset comparison.
Extra Super P-Force doubles the sildenafil component to 200mg for men who have found 100mg sildenafil insufficient on its own.
Dapoxetine + Tadalafil Combinations
| Product | Tadalafil | Dapoxetine | Duration advantage | From |
|---|---|---|---|---|
| Tadapox | 20mg | 60mg | Up to 36-hour ED window | $17 |
| Extra Super Tadarise | 40mg | 60mg | High-dose tadalafil + PE | $18 |
Tadalafil’s 36-hour duration makes it the preferred PDE5 inhibitor for men who want a longer window of opportunity. Tadapox combines standard-dose tadalafil with full-dose dapoxetine — the choice for men who find the 4–6 hour sildenafil window too short or who prefer the lower sensitivity to food timing that tadalafil offers.
Avanafil + Dapoxetine
| Product | Avanafil | Dapoxetine | Onset advantage | From |
|---|---|---|---|---|
| Extra Super Avana | 200mg | 60mg | Fastest-onset PDE5 (15–30 min) | $39 |
Avanafil has the fastest onset of any PDE5 inhibitor — as little as 15 minutes in some men. Extra Super Avana pairs 200mg avanafil with 60mg dapoxetine for men who need both speed and ejaculatory control.
Side Effects and Safety Considerations
Dapoxetine can cause orthostatic hypotension (dizziness on standing) in some users, particularly after the first dose. Do not stand up quickly after taking it. Avoid alcohol — it significantly worsens this risk. Do not combine dapoxetine with other SSRIs, SNRIs, MAOIs, or thioridazine. Allow at least 14 days after stopping an MAOI before taking dapoxetine.
The most frequently reported side effects of dapoxetine in clinical trials:
- Nausea: Most common — affects approximately 11% (30mg) to 22% (60mg). Taking with food reduces severity.
- Headache: 5–9% of users, typically mild and transient.
- Dizziness / light-headedness: 3–6% — most common shortly after dosing. Sit or lie down if it occurs.
- Diarrhoea: 3–4%.
- Insomnia: Less than 2% — typically only if taken in the evening and the short half-life extends into sleep time.
The majority of side effects are mild, dose-dependent, and resolve without intervention. Serious adverse events (syncope) occur in less than 0.06% of uses and are almost always associated with alcohol co-ingestion or pre-existing cardiovascular conditions.
Dapoxetine is not suitable for men with: significant cardiac disease, moderate or severe hepatic impairment, hypomania/mania history, or those taking medications that interact with SSRIs. Men with mild hepatic impairment should limit to 30mg.
How to Buy Dapoxetine Online at MedsBase
Men who experience PE consistently, who have already tried behavioural techniques without satisfactory results, and who want an evidence-based on-demand solution. If PE is situational or new, consider whether lifestyle factors (anxiety, relationship stress, overstimulation) are the primary driver before starting any medication.
MedsBase stocks the full range of WHO-GMP certified dapoxetine brands. All products ship discreetly — outer packaging carries no indication of contents or sender identity. No prescription is required to order.
Step 1 — Choose your product type:
- PE only → Duralast 30mg to start; step up to Vriligy 60mg if needed
- PE + ED → Super P-Force (sildenafil) or Tadapox (tadalafil, 36-hour window)
- PE + ED, prefer fastest onset → Extra Super Avana (avanafil, 15 min)
Step 2 — Check your other medications. If you take any SSRI, SNRI, or MAOI for any condition, do not combine with dapoxetine without medical guidance.
Step 3 — Start at 30mg. Regardless of which product you choose, begin at the lowest available dose. Assess tolerability and effect over 2–3 uses before considering a step-up.
Frequently Asked Questions
Can I buy dapoxetine online without a prescription?
Yes. Dapoxetine is available without a prescription at MedsBase. All brands supplied are manufactured at WHO-GMP certified facilities. No prior consultation is required to place an order.
What is the difference between dapoxetine 30mg and 60mg?
30mg is the recommended starting dose for all new users. It produces a meaningful improvement in ejaculatory control with a lower rate of nausea and dizziness. 60mg delivers a stronger effect — approximately 3.5× improvement in IELT versus placebo — and is appropriate for men who found 30mg insufficient after several uses. Never take more than 60mg in a 24-hour period.
How long does dapoxetine take to work?
Dapoxetine reaches peak plasma concentration in approximately 1–2 hours after swallowing. Most men notice its effect within 1–3 hours of dosing. Take it 1–3 hours before planned sexual activity. Do not take it more than 3 hours in advance as its active window narrows beyond that point.
Is dapoxetine the same as an antidepressant?
Dapoxetine belongs to the same drug class as SSRIs used for depression, but it is not an antidepressant. Its pharmacokinetic profile — rapid onset, very short half-life (~1.5 hours), and on-demand dosing — makes it pharmacologically distinct from daily antidepressants like fluoxetine or sertraline, which accumulate over weeks. You will not experience mood-related effects from dapoxetine used as directed.
What is Super P-Force and how does it differ from dapoxetine alone?
Super P-Force combines 100mg sildenafil (the active ingredient in Viagra) with 60mg dapoxetine in one tablet. It is designed for men who experience both erectile dysfunction and premature ejaculation simultaneously. Dapoxetine alone has no effect on erectile function — if erection quality is not an issue, standalone dapoxetine (Duralast) is the simpler, lower-risk option.
Can I take dapoxetine with alcohol?
No. Alcohol substantially increases the risk of dizziness, orthostatic hypotension, and fainting when combined with dapoxetine. Both substances lower blood pressure and the combination can cause syncope (sudden loss of consciousness). Avoid alcohol on the day you take dapoxetine.
How is dapoxetine shipped from MedsBase?
All orders are shipped in plain, discreet packaging with no indication of contents or sender. MedsBase ships worldwide. Orders are processed from WHO-GMP certified fulfilment partners. Every order includes our Reshipment Assurance — if your parcel does not arrive, we reship at no additional cost.
Related guides: Super P-Force Oral Jelly — mechanism and dosing · Malegra DXT (sildenafil + duloxetine) vs dapoxetine combos · Best ED pills online — full comparison
Written by
Sophie ChenPharmaceutical Content Researcher · 8 years experience
Sophie Chen is a pharmaceutical content researcher with 8 years covering generic medication access and clinical pharmacology. She specialises in international regulatory frameworks, bioequivalence standards, and patient-facing education on therapeutic drug classes. She is not a clinician.