Super Vidalista (Tadalafil 20 mg + Dapoxetine 60 mg): The Long-Acting ED + PE Combo Compared to Super P-Force

✓ Medically reviewed by  ·  Last reviewed: May 2026

Morgan Ellis

Pharmacy Researcher · 8 years experience

Pharmacy researcher with 8 years reviewing clinical drug information, generic formulation equivalence, and international pharmaceutical standards. Focuses on patient-facing accuracy in medication education.

If you have ever tried Super P-Force and found the four-hour sildenafil window too tight — or you live with both ED and PE and want fewer pills, not more — Super Vidalista is the combo that most directly addresses both problems in one tablet, on a longer clock. This guide explains the mechanism, the dosing, what the “20+60 mg” numbers actually mean, how it stacks up against the rest of the ED+PE combo family at MedsBase, and the specific edge cases (alpha-blockers, nitrates, alcohol, food) that change how you should take it.

The two molecules — what each does, and why combining them works

Most men over 40 who present with ED have at least some component of premature ejaculation, and most men presenting with PE under 60 have at least some erection-quality concern. The two problems share neurovascular pathways, anxiety circuits, and PDE5/serotonin biology — treating just one often unmasks the other. That is the clinical rationale for the combo class.

Tadalafil 20 mg — the “weekend pill” PDE5 inhibitor

Tadalafil is a selective PDE5 inhibitor. PDE5 (phosphodiesterase type 5) is the enzyme that breaks down cyclic GMP in the smooth muscle of the corpus cavernosum. cGMP is what keeps the penile arteries relaxed and the venous outflow restricted — the two-step that holds an erection. Block PDE5 and cGMP accumulates, but only at the moment when sexual stimulation triggers nitric-oxide release. Tadalafil does not produce erections without stimulus; it amplifies the response to one.

The defining feature of tadalafil versus sildenafil and vardenafil is half-life. Sildenafil clears in roughly 4 hours and is effectively gone by hour 6. Tadalafil has a 17.5-hour half-life and stays clinically active for 24–36 hours. That window is why the 20 mg dose is sometimes nicknamed the “weekend pill” — a single Friday-evening dose can support sexual activity into Sunday morning. Onset is slightly slower than sildenafil (typically 30–60 minutes versus 30–45 minutes), but the trade-off is dramatic spontaneity once the drug is on board.

If you want a deeper read on how tadalafil dosing schedules differ, see Daily Tadalafil 5 mg vs On-Demand 20 mg. Super Vidalista sits firmly on the on-demand side of that decision — the dapoxetine component is not safe to take daily, so the tadalafil in this combo is always episodic.

Dapoxetine 60 mg — the SSRI that was actually designed for PE

Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) developed specifically for on-demand premature ejaculation. Unlike sertraline, paroxetine, or fluoxetine — antidepressant SSRIs sometimes used off-label for PE — dapoxetine reaches peak plasma concentration in about 1–2 hours and falls by half within 1.3–1.5 hours. It enters and leaves the system fast enough to be dosed only on the days you need it.

Mechanism: serotonin in the lateral paragigantocellular nucleus and along the ascending spinal tract modulates ejaculatory threshold. Boosting synaptic serotonin (by blocking SERT) raises the threshold — the man needs more sustained stimulation before the reflex fires. Clinical trials (the original ALPS programme that supported European approval) showed dapoxetine 60 mg roughly tripled intravaginal ejaculatory latency time (IELT) from a 0.9-minute baseline to about 3.2 minutes, with patient-reported satisfaction climbing in parallel.

The 60 mg dose is the higher of the two licensed strengths (30 mg and 60 mg). It produces a larger IELT effect than the 30 mg dose, at the cost of slightly more nausea and dizziness. Most men who tolerate it find the 60 mg version meaningfully better. If you are dapoxetine-naive, consider trying a 30 mg-equivalent product like Poxet or Duralast first to gauge tolerance — you can also halve a Super Vidalista tablet for the first dose, accepting that the tadalafil dose will then be 10 mg.

Super Vidalista vs the rest of the ED+PE combo family

MedsBase carries five branded ED+PE combos. They differ on three axes: which PDE5 inhibitor is used, which SSRI is used, and how long the erectile-window lasts. Choose by deciding which axis matters most for you.

What this table tells you: Super Vidalista is the only product on MedsBase that pairs the long-acting tadalafil window with the short-acting, PE-licensed dapoxetine. Every other combo uses sildenafil on the ED side, with various SSRI or SNRI choices on the PE side. If you value the 24–36-hour erectile-response window — for weekends away, unpredictable opportunities, or simply not wanting to schedule sex 45 minutes in advance — Super Vidalista is the differentiated choice.

If you do not need that long a window, sildenafil-based combos may produce a sharper, more on-off response that some men prefer. The full sildenafil/tadalafil/vardenafil discussion is in Cialis vs Viagra: Brand-by-Brand Comparison.

How to take Super Vidalista — timing, food, and the 24-hour rule

The right timing reflects the fact that the dapoxetine peak and the tadalafil onset don’t coincide perfectly — dapoxetine hits its plasma maximum at 1–2 hours, tadalafil at about 2 hours. Splitting the difference works in practice.

• Take 1 hour to 3 hours before sex. Earlier than that and dapoxetine is on the way down by the time of activity; later and tadalafil is still climbing.
• One tablet per 24-hour period — do not double-dose. Tadalafil is on board for a full day; redosing within 24 hours stacks without adding benefit and adds side-effect risk.
• Swallow with a full glass of water (about 250 mL). Dapoxetine specifically requires this to reduce orthostatic syncope risk — the drug can cause a transient blood-pressure drop on standing in the first hour.
• Food matters less than for sildenafil. Tadalafil absorption is unaffected by meals, and dapoxetine’s absorption rate slows slightly with food but final exposure is similar. A light meal beforehand is fine; a heavy fatty meal is not optimal but not disabling.
• Alcohol: keep it under two standard drinks. Dapoxetine plus alcohol meaningfully increases dizziness and syncope risk. Tadalafil plus alcohol can drop blood pressure further. The combination amplifies both. The European label specifically warns against the combination at higher alcohol intakes.

Do not chew the tablet (the dapoxetine is bitter), do not crush it, and do not stand up suddenly within the first hour after dosing — sit on the edge of the bed for 30 seconds before rising if you took it lying down.

Side effects — what is dose-related, what is class-related

Side effects fall into three buckets: PDE5-inhibitor-class effects (mostly tadalafil), SSRI effects (dapoxetine), and combination-specific effects (the orthostatic interaction).

PDE5-inhibitor side effects (tadalafil)

• Headache (~14% of users at 20 mg) — usually mild, peaks at 1–2 hours, settles within 6–8 hours. Ibuprofen or paracetamol is fine.
• Back and muscle pain (~6%) — tadalafil-specific, thought to relate to PDE11 inhibition. Typically appears 12–24 hours after dose and lasts a day. A warm shower and an NSAID help.
• Flushing (~3%) — vasodilation in the face. Usually transient.
• Nasal congestion (~5%) — mucosal vasodilation. Saline spray is the gentle option; avoid pseudoephedrine, which competes pharmacologically.
• Dyspepsia / reflux (~10%) — gentle lower-oesophageal-sphincter relaxation. Eating earlier and avoiding lying flat for 60 minutes helps.

Dapoxetine side effects (SSRI)

• Nausea (~22% at 60 mg) — this is the most common reason men stop the drug. Taking it with a small carbohydrate snack reduces it.
• Dizziness (~11%) — especially in the first hour. The water-and-stay-seated rule above mitigates it.
• Headache (separate from the tadalafil headache and additive).
• Insomnia — can occur if you take a late-evening dose.
• Diarrhoea — usually mild.

Combination-specific effects

The most clinically relevant interaction is orthostatic hypotension — a blood-pressure drop on standing — in the first hour. Tadalafil mildly vasodilates; dapoxetine modestly drops standing BP via central serotonergic effects; alcohol amplifies both. The combination is well-tolerated by men with normal autonomic function but is the reason older men with diabetic autonomic neuropathy or those on antihypertensives should test the drug on a low-risk evening before relying on it.

Drug interactions that change the dose

Several common medications change the effective exposure to tadalafil or dapoxetine and warrant dose reduction or avoidance.

• Strong CYP3A4 inhibitors (clarithromycin, itraconazole, ketoconazole, ritonavir, grapefruit juice in large quantities) raise tadalafil exposure. Halve the tablet, or avoid.
• CYP3A4 inducers (rifampicin, carbamazepine, phenytoin, St John’s wort) lower tadalafil exposure — the drug may simply not work well.
• Thioridazine, pimozide, antipsychotics with QT prolongation — do not combine with dapoxetine.
• Linezolid, methylene blue — MAO-inhibitor-like effects, do not combine.
• Tramadol — serotonergic, do not combine.
• Other PDE5 inhibitors (sildenafil, vardenafil, avanafil) — do not stack on the same day.

How it compares to taking the two drugs separately

You could, in principle, take a 20 mg tadalafil tablet (e.g. Vidalista) and a 60 mg dapoxetine tablet (e.g. Poxet) at the same time. The pharmacological outcome is broadly equivalent. The arguments for the fixed-dose combo are practical:

• One swallow, not two — meaningful for men whose anxiety around the situation already makes pill-rituals awkward.
• Predictable timing — both drugs are absorbed from the same tablet, so the lag between the two is fixed and known.
• Per-encounter cost is typically lower than two separate brand-name tablets.
• Pack discipline — one bottle, one strip, one inventory.

The arguments against the combo — and for taking the two separately — come up if you want to titrate the dapoxetine dose down to 30 mg (start lower if you are sensitive to SSRI nausea), or if you want tadalafil daily 5 mg plus on-demand dapoxetine (a regimen the combo cannot deliver because the dapoxetine cannot be taken daily).

What you get when you order from MedsBase

Super Vidalista at MedsBase is manufactured by Centurion Laboratories (WHO-GMP certified) and ships in 10-, 30-, 60-, 90- and 180-tablet packs. Larger packs lower the per-tablet price meaningfully — the 180-tablet pack works out cheaper per dose than buying tadalafil and dapoxetine separately at most prescription pharmacies. We list current prices on the Super Vidalista product page.

📦 Every order is covered by our Reshipment Assurance Policy — if your parcel does not arrive within 20 business days, we reship at no cost.

If you are paying by card, the statement descriptor is the on-ramp processor (a regulated card-payment processor) — never “MedsBase” or any pharmacy-related label. We explain this in the credit card payment guide.

Frequently asked questions

How long does Super Vidalista last?

The tadalafil component supports erectile response for 24–36 hours after dosing. The dapoxetine component is active for the single sexual encounter (3–5 hours). You can have sex more than once during the 24–36-hour window, but the PE-delay effect is only present for the first encounter.

Can I take Super Vidalista every day?

No. Dapoxetine is licensed only for on-demand use and is not safe to take daily — chronic dosing has not been studied and is not approved in any jurisdiction. If you want a daily regimen, separate the drugs: tadalafil 5 mg daily plus dapoxetine 60 mg only on the days you need PE control. See Daily Tadalafil 5 mg vs On-Demand 20 mg for the daily-versus-on-demand trade-off.

Will it work the first time?

The PDE5 inhibitor (tadalafil) is dose-effective from the first tablet for most men — 70–80% see a clear erection-quality improvement. The dapoxetine effect on ejaculatory latency is also evident from dose one; men often report the largest IELT gain on doses three to six as they relax into the experience.

What if 60 mg of dapoxetine is too much?

Split the tablet. You will then receive 10 mg tadalafil + 30 mg dapoxetine, which is closer to a starting dose. Tadalafil 10 mg still produces a meaningful effect in most men and runs for a similar window. If you find the half-tablet tolerable but ineffective, the full Super Vidalista may suit you better.

Can I drink alcohol with it?

Up to two standard drinks is the practical ceiling. Above that, both the dapoxetine and the tadalafil components amplify alcohol’s blood-pressure drop, raising syncope risk. Skip alcohol entirely on the night of your first dose to gauge your personal response.

Is it stronger than Super P-Force?

Not exactly — the PE-delay component (dapoxetine 60 mg) is identical between Super Vidalista and Super P-Force. The difference is the ED component: tadalafil 20 mg gives a longer window than sildenafil 100 mg, but sildenafil produces a slightly sharper peak response. “Stronger” depends on what you measure.

How does it compare to Malegra DXT or Malegra FXT?

Malegra DXT pairs sildenafil with duloxetine (an SNRI, longer-acting); Malegra FXT pairs sildenafil with fluoxetine (a long-acting SSRI). Both use sildenafil, so the ED window is 4–5 hours. Super Vidalista is the only combo that uses tadalafil. Detailed reads: Malegra DXT guide · Malegra FXT guide.

Do I need a prescription?

You can order Super Vidalista from MedsBase without a prescription — we ship to most countries. That said, the contraindication list above is real: if you are on nitrates, MAOIs, other SSRIs, strong CYP3A4 inhibitors, or have unstable cardiac or hepatic disease, do not take this drug, and speak to a clinician.

What if I have only ED, not PE?

Use plain tadalafil — a Vidalista 20 mg tablet gives the same erectile-response window without the dapoxetine load. Dapoxetine is only useful if PE is a problem; layering it onto an ED-only treatment adds side-effect risk for no clinical gain.

For the broader decision framework on choosing between ED treatments, see our pillar guide: Best Medicine for Erectile Dysfunction Without Side Effects. For PE-specific options without the ED component, see the premature ejaculation treatment category.

Written by

Sophie Chen

Pharmaceutical Content Researcher · 8 years experience

Sophie Chen is a pharmaceutical content researcher with 8 years covering generic medication access and clinical pharmacology. She specialises in international regulatory frameworks, bioequivalence standards, and patient-facing education on therapeutic drug classes. She is not a clinician.