✓ Medically reviewed by · Last reviewed: May 2026
Pharmacy Researcher · 8 years experience
Pharmacy researcher with 8 years reviewing clinical drug information, generic formulation equivalence, and international pharmaceutical standards. Focuses on patient-facing accuracy in medication education.
Key Takeaways
- Hynidase Injection contains hyaluronidase, an enzyme that breaks down hyaluronic acid in connective tissue to allow faster, wider spread of co-injected substances.
- It is used in four main settings: regional anaesthesia (spreading the block), hypodermoclysis (subcutaneous fluid delivery), ophthalmic surgery prep, and cosmetic-adjacent adjuvant procedures.
- Hynidase is manufactured by Bharat Serums & Vaccines, a WHO-GMP certified Indian manufacturer, and is not a controlled substance in most jurisdictions.
- Standard doses range from 150 IU to 1500 IU depending on application — always co-administered with the primary substance, never given as a standalone systemic agent.
- You can order Hynidase Injection online through MedsBase without a prescription — shipped worldwide in discreet, plain packaging.
If you are searching for where to buy Hynidase online or order Hynidase Injection, you likely already know what hyaluronidase does — perhaps you have used it in clinical practice, for subcutaneous hydration, or in the context of regional anaesthesia. This guide covers what Hynidase is, its four main applications, dosing considerations, and how to order it reliably from an international pharmacy that ships worldwide.
What Is Hynidase Injection?
Hynidase is a pharmaceutical-grade hyaluronidase injection manufactured by Bharat Serums & Vaccines Ltd, a WHO-GMP certified Indian manufacturer. The active ingredient — hyaluronidase — is a naturally occurring enzyme (specifically, a glycosidase) that catalyses the hydrolysis of hyaluronic acid, the high-molecular-weight glycosaminoglycan that forms the viscous matrix of connective tissue and the vitreous of the eye.
By degrading hyaluronic acid, Hynidase temporarily increases the permeability of tissue barriers. This makes subcutaneous and intramuscular fluid compartments more permeable, allowing co-injected substances — local anaesthetics, IV fluids, other drugs — to spread and be absorbed significantly faster and over a broader area than they would without the enzyme.
The effect is transient. Tissue permeability returns to baseline as endogenous hyaluronic acid is resynthesised, typically within 24–72 hours. Hynidase itself has no direct pharmacological effect on the tissue: it is an adjuvant, not a therapeutic agent in isolation.
What Is Hynidase Used For?
1. Regional Anaesthesia — Spreading the Block
The oldest and most widely documented use of hyaluronidase is as a spreading factor in regional and local anaesthesia. When added to a local anaesthetic solution (lidocaine, bupivacaine, ropivacaine), hyaluronidase accelerates diffusion through the connective tissue plane, producing:
- Faster onset of the block (reduction of 3–8 minutes in some protocols)
- More even spread across the targeted anatomical territory
- Reduced injection volume needed for equivalent coverage
This is particularly relevant in peribulbar and retrobulbar ophthalmic blocks, where the confined orbital space makes complete, predictable spread critical. Multiple randomised controlled trials have confirmed that hyaluronidase significantly improves akinesia completeness in ophthalmic regional anaesthesia.
2. Hypodermoclysis — Subcutaneous Fluid Delivery
Hypodermoclysis (clysis) is the infusion of fluids directly into the subcutaneous space — a well-established alternative to IV hydration in elderly, paediatric, and palliative patients where venous access is difficult or undesirable. Without hyaluronidase, clysis is limited to slow infusion rates and small volumes.
With Hynidase added to the infusion site, subcutaneous tissue accepts fluids at significantly higher rates (up to 1 litre per hour per site, compared with 30–100 ml/hour without enzyme). This makes clysis a viable, comfortable alternative to IV access in:
- Dehydration management in elderly care and palliative settings
- Paediatric rehydration when IV cannulation has failed
- Post-operative fluid maintenance in patients with poor veins
Hynidase is infiltrated at the clysis site (typically 150–1500 IU) before or at the start of the infusion.
3. Drug Dispersion — Enhancing Absorption of Subcutaneous Injections
Beyond large-volume fluids, hyaluronidase is used to accelerate absorption and spread of specific drugs administered subcutaneously — most notably in oncology (where subcutaneous formulations of trastuzumab and rituximab use recombinant hyaluronidase) and in IV extravasation management (limiting tissue injury when vesicant drugs leak from a vein).
4. Cosmetic-Adjacent Applications
In dermatology and aesthetic medicine, hyaluronidase is used to disperse hyaluronic acid-based dermal fillers — either to correct uneven results, dissolve vascular complications, or reverse over-correction. While dedicated high-concentration formulations exist for this purpose, Hynidase is one of the accessible preparations used in clinical practice in this context.
Hynidase Dosing by Application
| Application | Typical Dose | Administration |
|---|---|---|
| Regional / local anaesthesia | 150–1500 IU added to anaesthetic solution | Mixed into injection, administered with LA |
| Hypodermoclysis | 1500 IU at clysis site | Injected subcutaneously at infusion site before or during infusion |
| Ophthalmic block | 15–150 IU in anaesthetic mix | Mixed with LA, peribulbar or retrobulbar route |
| IV extravasation | 150–1500 IU | Infiltrated around extravasation site promptly |
Doses above 1500 IU per application carry increased risk of systemic effects. In patients with an inflammatory condition or where the skin over the proposed injection site is infected, Hynidase should not be injected directly into the affected area.
Is Hynidase a Controlled Substance?
Hyaluronidase is not a controlled or scheduled substance in the UK, EU, US, Australia, or most other jurisdictions. It does not have abuse potential, is not a narcotic, and is not subject to the prescribing restrictions that apply to opioids or benzodiazepines. In many countries it is classified similarly to other biological adjuvants and is available without a formal prescription through international suppliers.
Hynidase is a pharmaceutical-grade preparation manufactured by Bharat Serums & Vaccines to WHO-GMP standards. It is not a compounded or research-chemical product.
Where to Buy Hynidase Online
Hynidase Injection is available to order at MedsBase — an international online pharmacy that stocks it from the Bharat Serums & Vaccines production run. Orders are shipped worldwide in plain, discreet packaging with no medication name on the exterior of the parcel. Standard pack sizes available; bulk pricing tiers apply for higher-volume hypodermoclysis or clinical use.
Payment options: card (processed through a regulated processor — statement shows a regulated card-payment processor, never “MedsBase” or any medication name), cryptocurrency (Plisio gateway), or SEPA bank transfer.
Shipping: Worldwide. Every order is covered by MedsBase’s Reshipment Assurance Policy — if a parcel does not arrive within 20 business days, it is reshipped.
Frequently Asked Questions
Can I buy hyaluronidase without a prescription?
In most jurisdictions, yes. Hyaluronidase is not a controlled drug. MedsBase supplies Hynidase Injection internationally without requiring a prescription. If your country has specific importation rules for injectables, check local customs regulations before ordering.
What is the difference between Hynidase and recombinant hyaluronidase (rHuPH20)?
Hynidase contains bovine-derived hyaluronidase. rHuPH20 (Halozyme ENHANZE, used in subcutaneous oncology formulations) is recombinant human hyaluronidase with a longer duration of action. For clinical adjuvant use in anaesthesia and hypodermoclysis, bovine hyaluronidase (Hynidase) is the standard and widely published preparation.
How quickly does hyaluronidase work?
Tissue permeability increases within 5–15 minutes of injection. The spreading effect on a co-administered substance begins almost immediately, which is why anaesthetic onset is faster when hyaluronidase is included in the block mixture.
How long does the effect last?
The tissue permeability effect is temporary — typically 24–72 hours — as endogenous hyaluronic acid synthesis restores the matrix. There is no permanent change to connective tissue structure.
Can hyaluronidase cause an allergic reaction?
Allergy to bovine-derived hyaluronidase is rare (estimated <0.1% of patients) but possible. A skin-prick test is advisable before first use in patients with known hypersensitivity to bee stings (cross-reactivity with hyaluronidase present in bee venom). Do not use in patients with known hyaluronidase allergy.
Is Hynidase the same as Wydase or Hyalase?
They are all hyaluronidase preparations. Wydase (Wyeth, US) was discontinued in the early 2000s. Hyalase is the UK brand (CP Pharmaceuticals). Hynidase is Bharat Serums’ equivalent — same active enzyme, same IU dosing system. They are interchangeable for most applications.
WHO-GMP manufacturer · Discreet packaging · Worldwide shipping · Reshipment Assurance Policy
Written by
Sophie ChenPharmaceutical Content Researcher · 8 years experience
Sophie Chen is a pharmaceutical content researcher with 8 years covering generic medication access and clinical pharmacology. She specialises in international regulatory frameworks, bioequivalence standards, and patient-facing education on therapeutic drug classes. She is not a clinician.