Hydrea
Hydrea (Hydroxyurea 500 mg) — BMS ribonucleotide reductase inhibitor for chronic myeloid leukaemia, polycythaemia vera, essential thrombocythaemia, sickle cell disease.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
Quick Answer
Hydrea — Hydroxyurea 500 mg (Bristol Myers Squibb). Ribonucleotide reductase inhibitor for chronic myeloid leukaemia (older first-line, now second-line after BCR-ABL TKIs), polycythaemia vera, essential thrombocythaemia, sickle cell disease, refractory cytoreduction.
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⚠️ Specialist-supervised cancer therapy — this medication is started, monitored, and stopped by an oncologist or haematologist. Dosing depends on tumour type, stage, body surface area, organ function, and concomitant therapy. Self-treatment is not appropriate; the information below is educational and supports informed conversations with your specialist.
Cumulative myelosuppression — weekly FBC initially. Cutaneous side effects: leg ulcers (especially ankles), nail/skin pigmentation, secondary skin cancers (squamous cell). Avoid in pregnancy (teratogenic) and breastfeeding.
Frequently Asked Questions
When is this used?
Ribonucleotide reductase inhibitor for chronic myeloid leukaemia (older first-line, now second-line after BCR-ABL TKIs), polycythaemia vera, essential thrombocythaemia, sickle cell disease, refractory cytoreduction. Specific protocols are oncologist-determined.
Side effects?
Class-typical: myelosuppression, nausea, alopecia, mucositis, fatigue. Specific toxicities depend on the drug — see safety boxes above.
Drug interactions?
Cancer chemotherapy has multiple critical interactions. Always disclose all medications including herbals and supplements. Anticoagulants, anticonvulsants, antibiotics, antifungals, and antivirals all need review.
Pregnancy?
Cytotoxic chemotherapy is teratogenic. Effective contraception during and for 6 months after for both partners.
Monitoring?
Specialist-determined — typically FBC, renal/liver function, electrolytes before each cycle. Drug-specific tests (echocardiogram for anthracyclines, audiometry for cisplatin, etc.).
What if I miss a dose?
Oral cytotoxics: skip the missed dose, do not double up, contact your oncology team. IV: dosing is strictly scheduled — discuss any delay or missed cycle with the specialist.
Storage?
Oral cytotoxics: at room temperature, away from children, in original blister. Hand washing after handling tablets. Pregnant household members should not handle broken tablets.
Vaccines?
Live vaccines are contraindicated during chemotherapy. Inactivated vaccines (annual influenza, pneumococcal) are recommended. Coordinate with oncology for timing.
Long-term complications?
Class-dependent: secondary malignancy, infertility, cardiotoxicity, neuropathy. Discuss with oncology — fertility preservation may be relevant before starting.
When is treatment finished?
Determined by tumour response, treatment intent (curative vs palliative), and toxicity. Imaging and clinical assessment guide ongoing therapy.
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More options in Anti Cancer Medication
Ranked by recent MedsBase order volume — what other customers in this category are picking.
| Strength | 500 mg |
|---|---|
| Quantity | 30 Capsule/s, 60 Capsule/s, 90 Capsule/s |
| Pharma Form | Capsule/s |
| Manufacturer | Sarabhai Chemicals |
| Treatment | Resistant chronic myeloid leukemia |
| Generic Brand | Hydroxyurea |
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