⚡ Quick Answer — What is Maxiflo Inhaler?
Maxiflo Inhaler is a combination preventer (controller) inhaler for asthma and COPD, containing fluticasone propionate (an inhaled corticosteroid that reduces airway inflammation) plus formoterol (a long-acting β2 agonist that holds the airways open for 12 hours). Each dose delivers fluticasone 125/250 mcg + formoterol 6 mcg per actuation, manufactured by Cipla at WHO-GMP certified facilities — the same active drugs as international brand Flutiform. Maxiflo Inhaler is taken twice daily, every day, even when symptoms are absent. Where licensed, the formoterol component allows {$brand} to be used as both maintenance and reliever therapy (SMART/MART regime). Rinse mouth and gargle after every dose to prevent oral thrush and hoarseness.
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What Is Maxiflo Inhaler?
Maxiflo Inhaler is an Indian-manufactured pressurised metered-dose inhaler (HFA pMDI) combining fluticasone propionate + formoterol. The international brand of this combination is Flutiform. Combination ICS-LABA inhalers deliver superior asthma and COPD control compared to either component alone, with a single device improving adherence and reducing the risk of using LABA monotherapy (which carries a black-box warning for asthma death without concomitant ICS).
How Does Maxiflo Inhaler Work?
The two active ingredients work on different mechanisms in parallel:
- fluticasone propionate (inhaled corticosteroid): suppresses inflammatory cytokines, reduces eosinophil and lymphocyte infiltration, stabilises airway mucosa, restores β2 receptor responsiveness. Effect builds over 1–2 weeks of consistent dosing.
- formoterol (long-acting β2 agonist): activates bronchial smooth muscle β2 receptors, raising cyclic AMP and producing sustained bronchodilation lasting 12 hours (formoterol has 1–3 minute onset; salmeterol 15–30 minute onset).
- Synergy: the corticosteroid restores β2 receptor expression and prevents tachyphylaxis to LABA; the LABA improves smooth-muscle relaxation that ICS alone does not address. Combined, they reduce exacerbations more than either component alone at equivalent doses.
Uses and Indications
- Persistent asthma not controlled by ICS alone — first-line ICS-LABA combination
- Asthma maintenance therapy — twice daily, every day, regardless of symptoms
- COPD with frequent exacerbations, especially with elevated blood eosinophil count (≥300/µL) or asthma overlap
- Asthma-COPD overlap syndrome (ACOS)
- SMART / MART regime (single inhaler maintenance and reliever therapy) — formoterol-containing combinations only
Maxiflo Inhaler Dosage
| Patient | Dose | Frequency |
|---|---|---|
| Adults — moderate asthma | 2 inhalations (125/6) | Twice daily |
| Adults — severe asthma | 2 inhalations (250/6) | Twice daily |
| Children >12 yr | 2 inhalations (125/6) | Twice daily |
How to Use Maxiflo Inhaler Properly
- Shake the inhaler well; remove the cap.
- Breathe out fully away from the device.
- Seal lips around the mouthpiece.
- Press the canister at the start of a slow deep breath (3–5 seconds).
- Hold breath 10 seconds, then breathe out gently.
- Wait 30 seconds before second puff if needed.
- Rinse mouth, gargle, and spit out after every dose.
- Use a spacer for children, the elderly, and during acute illness.
Side Effects of Maxiflo Inhaler
Common (mostly local from ICS, plus some β2 effects from LABA):
- Oral thrush (white candidal plaques in mouth or throat)
- Hoarse voice / dysphonia
- Mild tremor (LABA effect; less than with high-dose SABA)
- Palpitations or heart rate increase (≤10 bpm at standard dose)
- Headache
- Throat irritation, mild cough on inhalation
Less common:
- Mild reduction in growth velocity in children at high doses
- Easy bruising at high cumulative ICS doses
- Hypokalaemia at high LABA doses (with diuretics, theophylline, oral steroids)
- Pneumonia in COPD users (slight ICS-related increase)
- Adrenal suppression with high doses or strong CYP3A4 inhibitor co-prescription
Serious (stop and seek emergency help):
- Severe allergic reaction / anaphylaxis
- Paradoxical bronchospasm
- Severe palpitations, chest pain, irregular heartbeat
- Adrenal crisis during illness or surgery
Warnings and Precautions
- Use every day, even when you feel well. The benefit accumulates over 1–2 weeks; symptoms return within days of stopping.
- Never use the LABA component alone in asthma — LABA without ICS carries a higher risk of severe asthma death. {$brand} contains both components, so this is not an issue with this product.
- {$brand} is not a rescue inhaler (unless used as part of an explicitly prescribed SMART/MART regime — formoterol component only).
- Rinse mouth, gargle, and spit out after every dose; brush teeth before bed.
- COPD users: ICS slightly raises pneumonia risk — ensure ICS adds value (eosinophilic phenotype, frequent exacerbations).
- Strong CYP3A4 inhibitors (ritonavir, ketoconazole, itraconazole, clarithromycin) raise systemic exposure of both components — avoid prolonged co-prescription.
- Pregnancy and breastfeeding: Budesonide-formoterol has the most pregnancy data; uncontrolled asthma is far more dangerous than the medication.
- Cardiovascular disease: use cautiously in severe coronary artery disease, arrhythmias, hyperthyroidism, severe heart failure.
Contraindications
- Known hypersensitivity to fluticasone propionate, formoterol, or any formulation excipient
- Untreated active fungal, bacterial, mycobacterial (TB), or viral respiratory infection
- Severe hypersensitivity to lactose or milk proteins (DPI formulations contain lactose)
- Acute asthma attack — use additional reliever inhaler if attack persists
Drug Interactions
| Interacting drug | Effect | What to do |
|---|---|---|
| Strong CYP3A4 inhibitors (ritonavir, ketoconazole, itraconazole, clarithromycin) | Raise systemic ICS exposure → adrenal suppression / Cushing risk | Avoid; monitor cortisol if essential |
| Non-selective beta-blockers (propranolol, timolol drops) | Block LABA effect — risk of severe bronchospasm | Avoid; switch to cardioselective if essential |
| Loop or thiazide diuretics | Additive hypokalaemia from LABA | Monitor potassium with high doses |
| Theophylline / aminophylline | Additive tachycardia and hypokalaemia | Monitor heart rate and potassium |
| MAOIs and tricyclic antidepressants | Potentiate LABA cardiovascular effects | Caution — monitor BP/HR |
Storage
- Store below 25°C, protected from direct sunlight and heat.
- Do not refrigerate. Do not freeze.
- Do not puncture the canister; even an empty canister can explode if heated.
- Keep out of reach of children. Use within the expiry date printed on the canister.
Related Alternatives on MedsBase
- Budecort Inhaler — budesonide ICS preventer
- Asthalin Inhaler — salbutamol reliever
- Tiova Inhaler — tiotropium LAMA for COPD
- Montair — montelukast LTRA add-on
- Duolin Inhaler — salbutamol + ipratropium combo reliever
Frequently Asked Questions
How is Maxiflo different from Seroflo?
Both contain fluticasone (the same ICS) but pair it with different LABAs. Seroflo uses salmeterol (slow onset, no SMART option). Maxiflo uses formoterol (1–3 minute onset, can be used in SMART/MART regime where licensed). The fluticasone-formoterol pair is also sold as Flutiform internationally.
Can Maxiflo be used as a SMART/MART reliever?
In some markets, fluticasone-formoterol combinations are licensed for SMART/MART. Discuss with your prescriber. Note SMART is most established for budesonide-formoterol (Foracort, Symbicort).
How fast does Maxiflo start to work?
Formoterol component begins bronchodilation in 1–3 minutes. Fluticasone preventer effect builds over 1–2 weeks of consistent twice-daily use.
Why must I rinse my mouth?
Inhaled steroid that deposits in the mouth can cause oral thrush and hoarseness. Rinse, gargle, spit out after every dose.
Is Maxiflo safe in pregnancy?
Fluticasone has reassuring observational pregnancy data. Budesonide is the most data-supported ICS in pregnancy; some prescribers prefer it.
Can children use Maxiflo?
Use age-appropriate strength under medical guidance. Inhaler with spacer is preferred for children under 12.
How does Maxiflo compare with Foracort?
Foracort = budesonide + formoterol. Maxiflo = fluticasone + formoterol. Both have fast LABA onset. Choice often comes down to prescriber familiarity, individual response, and price.
How long does a Maxiflo Inhaler last?
120-actuation canister = 60 days at twice-daily dosing. Track usage or check the dose counter if fitted.
Should I rinse with water or use a special mouthwash?
Plain water is sufficient. The goal is mechanical removal of drug residue from mouth and pharynx. Spit out — do not swallow.

































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