Puretrig 5000IU Injection

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Puretrig 5000IU Injection is a pharmaceutical-grade human chorionic gonadotropin (hCG) preparation used in clinical fertility medicine, andrology, and reproductive endocrinology. Each vial contains 5,000 IU of hCG supplied as a sterile, lyophilised (freeze-dried) powder, together with a diluent ampoule for reconstitution. Routes of administration are subcutaneous (SC) or intramuscular (IM), depending on the indication and prescriber preference.

hCG is a naturally occurring glycoprotein hormone, produced in pregnancy by the placenta. Pharmaceutically, its action mirrors that of luteinising hormone (LH), making it the first-line agent used to induce final follicular maturation and ovulation in women, and to stimulate Leydig cells to produce testosterone in men.

What Is Puretrig 5000IU?

Puretrig is one of several clinically equivalent hCG brands sold internationally — similar to HUCOG 5000IU, Eutrig HP 5000IU, and ZyHCG HP 10000IU. All contain the same active hormone at different strengths. The 5,000 IU strength of Puretrig is the sweet spot for ovulation triggering, IVF triggering, and multi-week male-fertility or TRT-adjunct protocols.

Puretrig is prescribed for:

• Ovulation induction in anovulatory women (often after clomiphene or letrozole priming)
• Final egg-maturation “trigger” injection in IVF and IUI cycles (timed ~34–36 hours before egg retrieval or insemination)
• Male hypogonadism — particularly secondary (hypogonadotropic) hypogonadism where the pituitary fails to stimulate the testes
• Testicular-function preservation during testosterone replacement therapy (TRT) — to prevent testicular atrophy and maintain spermatogenesis
• Male infertility from low intratesticular testosterone or low-LH states
• Cryptorchidism (undescended testes) in prepubertal boys — an older paediatric indication, now less common

How Does Puretrig Work?

hCG and LH share the same receptor — the LH/CG receptor — which is expressed on:

• Granulosa and theca cells of the ovary (in women)
• Leydig cells of the testis (in men)

Because hCG binds the LH receptor with high affinity and has a much longer half-life than native LH (~30 hours vs ~30 minutes), a single 5,000 IU dose can drive days of sustained receptor activation.

In women:

• After follicular growth has been primed by FSH (endogenous or via drugs like letrozole or gonadotropins), Puretrig delivers an LH-like surge
• This triggers the final maturation of the ovum and ovulation roughly 34–40 hours later
• In IVF, ovulation is intentionally timed so that oocyte retrieval can be performed just before release

In men:

• Puretrig stimulates Leydig cells to produce testosterone and supports intratesticular testosterone levels that are essential for spermatogenesis
• In secondary hypogonadism, hCG can fully restore endogenous testosterone without requiring exogenous testosterone
• In TRT patients, hCG is co-administered to prevent the testicular shrinkage and loss of sperm production that exogenous testosterone alone causes

Uses and Indications

• Ovulation induction — after clomiphene, letrozole, or injectable FSH priming
• IVF / IUI trigger injection — timed 34–36 hours before retrieval or insemination
• Male hypogonadotropic hypogonadism — to restore testosterone and spermatogenesis
• TRT adjunct therapy — co-administered to preserve testicular volume and fertility
• Post-cycle recovery in anabolic-steroid users — off-label; used alongside SERMs (clomiphene, tamoxifen) to restart HPG axis
• Cryptorchidism — selected paediatric cases, under specialist supervision

Puretrig Dosage and Administration

How to Reconstitute and Inject Puretrig

1. Clean hands and surface. Alcohol-swab the rubber stopper of both the Puretrig vial and the diluent ampoule
2. Draw the diluent. Using a sterile syringe, withdraw the sterile water or saline from the diluent ampoule (typically 1 mL for a 5,000 IU vial)
3. Inject diluent into the powder vial. Aim for the glass wall, not the powder. Let the diluent dissolve the powder fully — swirl gently, do not shake (frothing denatures the protein)
4. Draw the reconstituted solution into a new sterile syringe. The solution should be clear and colourless
5. Select a site. Subcutaneous: outer thigh or lower abdomen. Intramuscular: gluteus or deltoid
6. Swab the skin, inject slowly, withdraw the needle, press the site briefly
7. Dispose of syringes safely in a sharps bin
8. Reconstituted solution must be used immediately or refrigerated (2–8 °C) and used within 30 days — check your specific prescribing information

Sterile diluent is available on site as Sterile Water for Injection 10 mL for patients who need a replacement ampoule.

Side Effects of Puretrig

Puretrig is generally well tolerated. Side effects are dose-dependent and often mild.

Seek urgent medical attention if you experience severe pelvic pain, rapid weight gain, shortness of breath, dark urine, severe nausea and vomiting, or calf / chest pain — these can be early signs of OHSS or thromboembolism.

Warnings and Precautions

• Ovarian Hyperstimulation Syndrome (OHSS) — a potentially serious complication of ovulation induction. Symptoms: pelvic pain, bloating, ascites, reduced urine output, shortness of breath, weight gain. Risk is higher in women with PCOS, high baseline oestradiol, or large numbers of follicles
• Multiple pregnancy — higher rate of twins, triplets, or higher-order multiples after ovulation induction, particularly when combined with injectable FSH
• Thromboembolic events — the hormonal milieu after hCG triggering slightly elevates risk of venous and arterial thrombosis. Hydrate well and report any calf or chest symptoms promptly
• Ovarian torsion — enlarged ovaries after stimulation can twist on their stalk. Sudden severe unilateral pelvic pain requires urgent gynaecological review
• Ectopic pregnancy — can occur after any fertility treatment; monitor early pregnancy with serum hCG and early ultrasound
• Gynaecomastia in men — aromatisation of testosterone raises oestrogen; managed with dose adjustment, anastrozole, or tamoxifen
• Pregnancy tests — hCG is the hormone pregnancy tests measure. Home urine tests can be falsely positive for up to 10 days after a trigger injection. Use blood tests or wait ≥10 days
• Storage — reconstituted hCG is a protein and denatures with heat, freezing, or vigorous shaking

Contraindications — Who Should NOT Take Puretrig

• Confirmed or suspected pregnancy (except as a trigger in assisted reproduction)
• Known or suspected hormone-dependent tumours — prostate, breast, ovarian, testicular, uterine, or pituitary
• Precocious puberty in children
• Undiagnosed abnormal uterine bleeding
• Primary ovarian or testicular failure — hCG will not work where the target organ is non-responsive
• Active thromboembolic disorder
• Hypersensitivity to hCG or any excipient
• Severe cardiac, renal, or hepatic disease

Drug Interactions

Always share a full list of prescription and non-prescription medications, including performance-enhancing drugs, with your prescriber before starting Puretrig.

What to Do in Case of Overdose

Overdose is uncommon with hCG. In women, the main risk is a more severe OHSS. In men, excessive aromatisation can cause marked gynaecomastia and water retention. Management is supportive — dose reduction, fluid monitoring, and anastrozole or tamoxifen if oestrogenic symptoms are prominent. Seek medical advice urgently if you suspect an overdose.

Storage Instructions

• Store unopened vials in a refrigerator at 2–8 °C, protected from light. Do not freeze
• Some manufacturers permit short-term room-temperature storage — check the blister/leaflet for your specific batch
• Once reconstituted, the solution must be used immediately or refrigerated and discarded within 30 days
• Protect from direct light and heat
• Keep out of reach of children and pets
• Dispose of unused vials and used syringes via a pharmacy take-back scheme or sharps bin

Related Alternatives on MedsBase

Looking for related hCG or fertility treatment options?

• HUCOG 5000IU Injection — Bharat Serums hCG 5000IU
• HUCOG 10000IU Injection — 10,000 IU strength for higher-dose protocols
• ZyHCG HP 10000IU Injection — Zydus Cadila high-purity hCG
• Eutrig HP 5000IU Injection — high-purity 5000 IU alternative
• Clomisign — clomiphene citrate for ovulation induction and male PCT
• Qualifol 75IU — recombinant FSH for follicle priming
• Sterile Water for Injection 10 mL — replacement diluent
• Browse all Fertility treatments →

Frequently Asked Questions

What is Puretrig used for?

Puretrig is an injectable human chorionic gonadotropin (hCG). It is used to trigger ovulation in female fertility treatment, to raise testosterone and sperm production in men with hypogonadism, and to preserve testicular function during testosterone replacement therapy (TRT).

Does Puretrig help with weight loss?

No — despite marketing claims for the “hCG diet” in the 2010s, hCG has no FDA-approved role in weight loss, and controlled trials have failed to show any effect on fat mass beyond placebo. Puretrig should be used only for its licensed fertility and endocrine indications.

How fast does Puretrig work?

For ovulation triggering, the LH-equivalent surge from Puretrig produces ovulation within 34–40 hours. In men, testosterone begins rising within days; steady-state response in hypogonadism protocols is usually reached over 6–12 weeks.

Can I self-inject Puretrig?

Many patients do — subcutaneous injections into the outer thigh or lower abdomen are straightforward after a quick training session. For the first IVF trigger, most clinics will either administer the injection or supervise the first one to ensure correct timing.

What is the difference between Puretrig, HUCOG, ZyHCG, and Eutrig HP?

All contain the same active hormone (hCG) and are clinically equivalent at equivalent doses. Differences are brand, manufacturer, and minor formulation / excipient choices. Use what your prescriber recommends or what is consistently stocked.

Will Puretrig make a pregnancy test show positive?

Yes — home urine pregnancy tests can read falsely positive for up to 10 days after a trigger injection, because they measure hCG. For an accurate early-pregnancy test after a trigger, use serum hCG measured by a clinic laboratory, not a home urine test.

Does Puretrig prevent testicular shrinkage on TRT?

Yes — this is one of its most important modern uses. A typical TRT-adjunct regimen is 500–1,500 IU hCG two or three times per week alongside a testosterone ester. It preserves testicular volume, maintains spermatogenesis, and supports intratesticular steroid production that exogenous testosterone alone suppresses.

Can Puretrig be used during post-cycle therapy (PCT) after anabolic-steroid use?

Off-label, yes — hCG is commonly used alongside SERMs like clomiphene or tamoxifen to restart the HPG axis after anabolic-steroid cycles. Clinical evidence is limited and professional supervision is strongly recommended.

What is OHSS and how serious is it?

Ovarian Hyperstimulation Syndrome (OHSS) is a rare but potentially serious complication of hCG triggering in women, characterised by enlarged ovaries, fluid shifts, and in severe cases respiratory and renal compromise. Mild OHSS is common and self-limiting. Severe OHSS requires hospitalisation. Hydrate well, report symptoms early, and follow your clinic’s monitoring protocol.

How long does a reconstituted Puretrig vial last?

Use immediately when possible. If refrigerated at 2–8 °C, the reconstituted solution is generally stable for up to 30 days — check your specific product insert. Discard any solution that becomes cloudy or discoloured.

Does Puretrig require a prescription?

Yes — hCG is a specialist-supervised medication. Use under the direction of a qualified clinician (reproductive endocrinologist, fertility specialist, or andrologist) who can tailor dose and timing to your specific protocol.

Puretrig 5000IU is one of two highly purified hCG injections we carry; Eutrig HP 5000IU (highly purified human chorionic gonadotropin) is the Bharat Serums sibling option — identical dose and indication, useful when one brand goes out of stock or supplier preference matters.

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