Trental 400

✅ Improved blood circulation
✅ Reduced leg pain
✅ Enhanced tissue oxygenation
✅ Alleviates claudication symptoms
✅ Enhanced walking ability

Trental 400 contains Pentoxifylline.

Product Overview

Trental 400 is a medication containing the active ingredient Pentoxifylline, formulated as prolonged-release tablets. Pentoxifylline belongs to a class of drugs known as hemorrheologic agents, which improve blood flow by decreasing its viscosity. Trental 400 is designed to enhance blood circulation in individuals with peripheral vascular diseases, such as intermittent claudication, where blood flow to the extremities is compromised. By improving blood flow, Trental 400 helps reduce symptoms such as leg pain and cramping, allowing individuals to engage in daily activities more comfortably.


Trental 400 is primarily used to alleviate symptoms associated with peripheral vascular diseases, including intermittent claudication. Intermittent claudication is characterized by pain, cramping, or weakness in the legs during physical activity due to inadequate blood flow to the muscles. Trental 400 helps improve blood circulation to the affected areas, reducing pain and discomfort and increasing walking distance before symptoms occur.

How to Use

To use Trental 400, follow the instructions provided by your healthcare provider carefully. Typically, the recommended dosage is one tablet taken orally three times daily with meals. Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as it is formulated for prolonged release. It is essential to take Trental 400 consistently at the same times each day to maintain therapeutic levels in the body.

How it Works

Trental 400 works by increasing blood flow to the peripheral tissues through its vasodilatory and rheological properties. Pentoxifylline, the active ingredient, inhibits phosphodiesterase activity, leading to increased levels of cyclic adenosine monophosphate (cAMP) in vascular smooth muscle cells. This results in relaxation of the smooth muscle, dilation of blood vessels, and improved blood flow to the extremities. Additionally, Trental 400 reduces blood viscosity, enhancing microcirculation and oxygen delivery to tissues.

Dosage and Administration

The typical dosage of Trental 400 is one prolonged-release tablet (400 mg) taken orally three times daily with meals. Your healthcare provider may adjust the dosage based on your individual response to treatment and the severity of your symptoms. It is important to follow your doctor’s instructions regarding dosage and administration to achieve optimal therapeutic outcomes.


Trental 400 offers several benefits for individuals with peripheral vascular diseases, including relief from leg pain, cramping, and weakness associated with intermittent claudication. By improving blood flow to the extremities, Trental 400 helps increase walking distance and physical activity tolerance, enhancing overall quality of life for affected individuals. Additionally, its prolonged-release formulation ensures sustained therapeutic effects throughout the day.

Common Side Effects

Common side effects of Trental 400 may include gastrointestinal upset, such as nausea, vomiting, diarrhea, or abdominal discomfort. Some individuals may also experience headache, dizziness, flushing, or palpitations. These side effects are usually mild and transient, resolving with continued use. If you experience severe or persistent side effects, consult your healthcare provider for further evaluation.


Before using Trental 400, inform your healthcare provider of any existing medical conditions, allergies, or medications you may be taking, especially anticoagulants or antiplatelet drugs. Trental 400 may increase the risk of bleeding, particularly in individuals with bleeding disorders or those taking blood-thinning medications. Pregnant or breastfeeding women should consult their doctor before using Trental 400.

Storage Information

Store Trental 400 prolonged-release tablets at room temperature away from moisture, heat, and light. Keep the medication out of reach of children and pets. Do not store Trental 400 in the bathroom or near the kitchen sink, where it may be exposed to moisture. Check the expiration date on the packaging and discard any expired or unused tablets properly.


Our sole intention is to ensure that its consumers get information that is expert-reviewed, accurate, and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions, or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


400 mg


30 Tablet/s, 60 Tablet/s, 90 Tablet/s, 180 Tablet/s


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