Avana
✅ Enhances erectile function
✅ Improves sexual performance
✅ Increases blood flow
✅ Treats erectile dysfunction
✅ Enhances sexual satisfaction
Avana contains Avanafil.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is Avana?
Avana contains avanafil and is used for erectile dysfunction. Available in 50 / 100 / 200 mg. Clinical effect lasts around 4 to 5 hours (onset as fast as 15 minutes). Manufactured by Sunrise Remedies.
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Avana is an avanafil tablet for the treatment of erectile dysfunction. Avanafil is the fastest-onset PDE5 inhibitor currently on the market — effects can begin within 15 minutes, well ahead of sildenafil, tadalafil, or vardenafil.
Manufactured by Sunrise Remedies, Avana contains the same active ingredient as Menarini’s branded Stendra® (or Spedra® in Europe) at a lower price. It is a second-generation PDE5 inhibitor designed to deliver the response of its predecessors with less side-effect burden and more flexible timing.
What Is Avana?
Avana is a prescription PDE5 inhibitor, FDA-approved in 2012, with a clinical profile optimized for rapid onset and a cleaner side-effect profile. It is highly selective for PDE5 over PDE6 (the retinal enzyme) and PDE11, which is thought to explain its lower rate of visual and musculoskeletal side effects.
Avana is used for:
- Erectile dysfunction of any cause
- Men who need rapid onset — avanafil can work in as little as 15 minutes
- Men who have had side effects with other PDE5 inhibitors — often tolerated when sildenafil or tadalafil aren’t
How Does Avana Work?
Avanafil shares the core PDE5-inhibition mechanism with other drugs in its class:
- Sexual stimulation releases nitric oxide in penile tissue
- NO activates guanylate cyclase, raising cyclic GMP
- cGMP relaxes arterial smooth muscle, increasing inflow and trapping blood in the erectile bodies
- PDE5 normally degrades cGMP, ending the erection
- Avanafil blocks PDE5, prolonging the response
What distinguishes avanafil is its pharmacokinetic profile: time to peak plasma ~30–45 minutes, and meaningful effect within 15 minutes in many patients. Its half-life is about 5 hours, so the clinical window is 4–5 hours.
Avanafil is highly selective for PDE5 versus PDE6 and PDE11 — which is why visual side effects (blue tinge, photosensitivity seen with sildenafil) and muscle aches (common with tadalafil) are less frequent.
Uses and Indications
- Erectile dysfunction — first-line PDE5 option, FDA-approved since 2012
- Men needing rapid, on-demand response
- Men intolerant of other PDE5 inhibitors
Avana Dosage and Administration
| Scenario | Recommended Dose | Frequency / Timing |
|---|---|---|
| ED — starter dose | 100 mg | 15–30 min before activity; max 1 dose / 24 h |
| ED — lower sensitivity | 50 mg | For men with side effects at 100 mg |
| ED — inadequate response | 200 mg | Maximum single dose; step up after 2–3 adequate 100 mg trials |
| Elderly (65+) | Standard dose | No routine reduction unless organ impairment |
| Mild–moderate hepatic impairment | 50 mg | Use with caution |
| Severe renal or hepatic impairment | Not recommended | Avoid |
| Maximum daily dose | 200 mg | On-demand only — not licensed for daily dosing |
How to Take Avana Properly
- Swallow whole with water — can be taken with or without food (though a heavy meal may slow onset slightly)
- Allow 15–30 minutes before intended activity — one of avanafil’s strongest selling points
- Do not exceed one dose per 24 hours
- Avoid grapefruit juice
- Limit alcohol to 1–2 drinks
Side Effects of Avana
Avanafil has one of the cleanest side-effect profiles in the PDE5 class.
| Severity | Side Effect |
|---|---|
| Common | Headache, facial flushing, nasal congestion |
| Less common than with sildenafil | Visual disturbance (rare — avanafil has low PDE6 activity), musculoskeletal pain |
| Uncommon | Dizziness, dyspepsia, back pain, palpitations |
| Rare | Priapism, sudden vision loss (NAION), sudden hearing loss |
Warnings and Precautions
- Cardiovascular fitness for sex — sexual activity places cardiac demand on the heart. Men with active angina, recent MI (within 90 days), uncontrolled arrhythmia, or severe heart failure should have a cardiac assessment before starting a PDE5 inhibitor
- Blood pressure — PDE5 inhibitors cause mild, transient reductions in BP; use with caution if taking multiple antihypertensives
- Priapism — higher risk in men with sickle-cell disease, multiple myeloma, or leukaemia; seek urgent care if an erection lasts more than 4 hours
- Vision — discontinue and seek review if sudden visual changes occur; rare cases of non-arteritic anterior ischaemic optic neuropathy (NAION) have been reported
- Hearing — rare reports of sudden sensorineural hearing loss — stop and consult a doctor if affected
- Alcohol — significant alcohol intake combined with any PDE5 inhibitor can compound dizziness, headache, and low blood pressure
- Grapefruit juice — inhibits CYP3A4 and can raise blood levels
Contraindications — Who Should NOT Take This Medication
- Concurrent use of any nitrate — GTN, isosorbide mono/dinitrate, nicorandil, amyl nitrite (“poppers”)
- Concurrent use of guanylate cyclase stimulators such as riociguat
- Recent heart attack (within 90 days), unstable angina, or angina during intercourse
- NYHA Class II or greater heart failure within the last 6 months
- Uncontrolled arrhythmia, hypotension (BP <90/50) or uncontrolled hypertension (BP >170/100)
- Stroke within the last 6 months
- Known non-arteritic anterior ischaemic optic neuropathy (NAION) in one or both eyes
- Severe hepatic impairment (Child-Pugh C)
- Hypersensitivity to the active ingredient or any excipient
Drug Interactions
| Drug / Class | Interaction |
|---|---|
| Nitrates (GTN, ISMN, ISDN, amyl nitrite/”poppers”) | Absolute contraindication — severe, potentially fatal hypotension |
| Alpha-blockers (doxazosin, tamsulosin, alfuzosin) | Additive blood-pressure lowering — stabilise alpha-blocker dose first, start at lowest PDE5 dose |
| CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, clarithromycin) | Raise PDE5 plasma levels — reduce dose or avoid combination |
| CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, St John’s wort) | Lower PDE5 plasma levels — efficacy may be reduced |
| Riociguat and other sGC stimulators | Contraindicated — severe hypotension risk |
| Other PDE5 inhibitors | Do not combine — additive side effects without extra efficacy |
| Antihypertensives | Small additive BP reduction — usually clinically insignificant |
| Grapefruit juice | Inhibits CYP3A4 — avoid large or regular intake |
Always share a full list of your current medications, including over-the-counter products, recreational drugs, and herbal supplements, with your prescriber before starting this medication.
What to Do in Case of Overdose
Symptoms of a PDE5 overdose include severe headache, marked hypotension, dizziness, back or muscle pain, and prolonged erection. Management is supportive, with fluid resuscitation and cardiac monitoring. Contact your local poisons service or emergency department immediately if an overdose is suspected.
Storage Instructions
- Store below 30 °C in a dry place, away from direct sunlight
- Keep in the original blister packaging until use
- Keep out of reach of children and pets
- Do not use after the expiry date printed on the pack
- Dispose of unused tablets via a pharmacy take-back scheme where available
Related Alternatives on MedsBase
Looking for related ED or sexual-health treatment options?
- Modula — tadalafil 5 mg, ideal for once-daily low-dose therapy
- Vidalista — Centurion Labs tadalafil, 2.5 to 80 mg
- Tadacip — Cipla tadalafil 20 mg
- Megalis — Macleods tadalafil 10 mg / 20 mg
- Suhagra — Cipla sildenafil 25/50/100 mg
- Browse all Erectile Dysfunction treatments →
Frequently Asked Questions
How fast does Avana work?
Avanafil is the fastest-onset PDE5 inhibitor — effects can begin within 15 minutes and are usually reliable by 30 minutes. This is significantly faster than sildenafil, tadalafil, or vardenafil.
How long does Avana last?
The clinical window is about 4–5 hours. Half-life is ~5 hours.
Why would I choose Avana over sildenafil?
Three reasons: (1) speed — 15-min onset, (2) selectivity — far fewer visual side effects than sildenafil, (3) timing flexibility — food has less impact on absorption than with sildenafil.
Can I take Avana with food?
Yes — food has less impact than with sildenafil. A heavy meal may slightly delay onset, but the effect is modest.
Can I take Avana every day?
No — avanafil is on-demand only. For a once-daily schedule, tadalafil 5 mg (e.g. Modula) is the licensed option.
Is Avana safer than older PDE5 inhibitors?
Avanafil has a cleaner side-effect profile thanks to its high PDE5 selectivity, but the class-wide contraindications (nitrates, recent MI, unstable angina) still apply.
Does Avana work for men who failed sildenafil?
Some non-responders do respond to avanafil. If sildenafil has been given 2–3 adequate trials with no effect, switching is worth trying — avanafil, tadalafil, and vardenafil each have distinct receptor-binding profiles.
Can I drink alcohol with Avana?
Limit to 1–2 drinks. Heavy alcohol adds to vasodilation and dizziness.
Is Avana safe with heart conditions?
Contraindicated with any nitrate, within 90 days of MI, or in unstable angina. Discuss your cardiac status with a doctor before starting.
What’s the maximum dose of Avana?
200 mg on-demand. Most men respond well to the 100 mg starter dose — step up only after 2–3 adequate 100 mg trials with a clear response gap.
See also: Malegra FXT — Sunrise Remedies dual ED+PE tablet pairing sildenafil 100 mg with fluoxetine 40 mg in one daily dose.
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