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Ca Atra

Ca Atra (All-trans Retinoic Acid 10 mg) — Cipla differentiating agent for acute promyelocytic leukaemia (APL). Combined with anthracycline or arsenic trioxide for near-curative response.

Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience  · Last reviewed: May 2026

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Ca Atra — All-trans Retinoic Acid (Tretinoin) 10 mg (Cipla Inc). Differentiating agent for acute promyelocytic leukaemia (APL) — combined with anthracycline or arsenic trioxide gives near-curative remission rates. Specialist haematology supervision.

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⚠️ Specialist-supervised cancer therapy — this medication is started, monitored, and stopped by an oncologist or haematologist. Dosing depends on tumour type, stage, body surface area, organ function, and concomitant therapy. Self-treatment is not appropriate; the information below is educational and supports informed conversations with your specialist.

Differentiation syndrome (APL syndrome)
Differentiation syndrome (formerly retinoic acid syndrome) — fever, dyspnoea, weight gain, peripheral oedema, hypotension, pleural/pericardial effusion. Occurs days 5-21 of induction. Treat immediately with high-dose dexamethasone. Mortality rate ~10% if unrecognised. Mandatory haematology monitoring.

Frequently Asked Questions

When is this used?

Differentiating agent for acute promyelocytic leukaemia (APL) — combined with anthracycline or arsenic trioxide gives near-curative remission rates. Specialist haematology supervision. Specific protocols are oncologist-determined.

Side effects?

Class-typical: myelosuppression, nausea, alopecia, mucositis, fatigue. Specific toxicities depend on the drug — see safety boxes above.

Drug interactions?

Cancer chemotherapy has multiple critical interactions. Always disclose all medications including herbals and supplements. Anticoagulants, anticonvulsants, antibiotics, antifungals, and antivirals all need review.

Pregnancy?

Cytotoxic chemotherapy is teratogenic. Effective contraception during and for 6 months after for both partners.

Monitoring?

Specialist-determined — typically FBC, renal/liver function, electrolytes before each cycle. Drug-specific tests (echocardiogram for anthracyclines, audiometry for cisplatin, etc.).

What if I miss a dose?

Oral cytotoxics: skip the missed dose, do not double up, contact your oncology team. IV: dosing is strictly scheduled — discuss any delay or missed cycle with the specialist.

Storage?

Oral cytotoxics: at room temperature, away from children, in original blister. Hand washing after handling tablets. Pregnant household members should not handle broken tablets.

Vaccines?

Live vaccines are contraindicated during chemotherapy. Inactivated vaccines (annual influenza, pneumococcal) are recommended. Coordinate with oncology for timing.

Long-term complications?

Class-dependent: secondary malignancy, infertility, cardiotoxicity, neuropathy. Discuss with oncology — fertility preservation may be relevant before starting.

When is treatment finished?

Determined by tumour response, treatment intent (curative vs palliative), and toxicity. Imaging and clinical assessment guide ongoing therapy.

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Medical Disclaimer: Cancer therapy is highly individualised. Specific drug, dose, schedule, monitoring, and supportive care must be determined by a qualified oncologist or haematologist based on tumour biology, staging, comorbidities, and goals of care. This information is educational; it does not substitute for professional medical advice.

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Strength

10 mg

Quantity

100 Capsule/s, 200 Capsule/s, 300 Capsule/s

Pharma Form

Soft Gelatin Capsules

Manufacturer

Jenome Biophar

Treatment

Acute promyelocytic leukemia

Generic Brand

Tretinoin (All-trans Retinoic Acid)

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