Hansepran

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Why order from MedsBase

Our generic medications are sourced from WHO-GMP certified manufacturers and shipped worldwide in discreet, plain packaging — no medication name on the parcel exterior. Card payments are routed through a regulated processor (statement descriptors include a regulated card-payment processor — never “MedsBase” or any medication name). Crypto and SEPA bank transfer are also accepted. Every order is backed by our Reshipment Assurance Policy.

Why order from MedsBase

Choosing Hansepran from MedsBase:

• WHO-GMP certified manufacturer — sourced from a regulated facility, finished pack with batch number and expiry.
• Discreet packaging — plain envelope, no medication name on the outside.
• Worldwide shipping with Reshipment Assurance — if your parcel does not arrive within 20 business days we re-ship at no cost (subject to policy terms).
• Loyalty points — 1 point per $1 spent (excludes peptides); 100 points = $5 off.

What Hansepran is and how it works

Hansepran is a combination pack containing dapsone 100 mg + clofazimine 50 mg + rifampicin 600 mg (combination pack) — the WHO-recommended Multi-Drug Therapy (MDT) for multibacillary (MB) leprosy. Three drugs work in combination to prevent resistance:

• Rifampicin — a bactericidal antibiotic that kills 99.99% of Mycobacterium leprae with the first dose. The most potent anti-leprosy agent; used once monthly to limit hepatotoxicity.
• Clofazimine — a bacteriostatic phenazine dye that accumulates in macrophages and skin; reduces leprosy reactions; causes orange-red skin pigmentation that is reversible after stopping.
• Dapsone — a sulfone antibiotic that inhibits folate synthesis in M. leprae; daily self-administered.

Manufacturer: WHO-GMP certified manufacturer.

WHO-MB-MDT regimen (12 months)

Important pre-treatment considerations

• G6PD testing — dapsone causes haemolysis in G6PD deficiency. Test before starting; treat with caution if deficient.
• Baseline LFTs and FBC — and monitor at 2 weeks, 1 month, 3 months, then quarterly.
• Pregnancy testing — rifampicin reduces oral contraceptive efficacy; double contraception during therapy.
• Counselling — about expected side effects (orange-red urine and tears from rifampicin, brown-orange skin pigmentation from clofazimine, dapsone-related fatigue).
• Household contact screening — close contacts must be examined and may need single-dose rifampicin chemoprophylaxis (post-exposure).

Side effects

Rifampicin

• Orange-red discolouration of urine, sweat, tears (harmless — counsel patient).
• Hepatotoxicity (1–4%); avoid alcohol; monitor LFTs.
• Reduces oral contraceptive efficacy (potent CYP3A4 inducer).
• Flu-like syndrome with intermittent dosing.

Clofazimine

• Reversible orange-red-brown skin pigmentation, peaks at 6 months, fades over 6–12 months after stopping.
• Dry skin, ichthyosis.
• Gastrointestinal: abdominal pain, nausea, diarrhoea (usually mild).
• Rare: enteropathy with chronic high-dose use (paradoxical bowel obstruction from drug crystals).

Dapsone

• Haemolysis (especially in G6PD deficiency); methaemoglobinaemia.
• Agranulocytosis (rare, 1 in 10,000) — usually in first 6 months; FBC monitoring at 2 weeks, 1 month, then 3-monthly.
• Dapsone hypersensitivity syndrome (rare but serious — fever, lymphadenopathy, hepatitis, eosinophilia at 4–8 weeks).
• Fatigue, headache, photosensitivity.

Leprosy reactions

Type 1 (reversal) reactions — new red painful lesions, nerve pain — and Type 2 (erythema nodosum leprosum) reactions — fever, painful subcutaneous nodules, uveitis — can occur during or after MDT. They require prompt steroid (Type 1) or thalidomide/clofazimine (Type 2) treatment. Patients must report any new symptoms immediately.

Contraindications

• Severe hepatic impairment (rifampicin).
• Severe G6PD deficiency (relative contraindication for dapsone — alternative regimen needed).
• Hypersensitivity to any component.
• Pregnancy: use under specialist supervision (regimen continued with pregnancy precautions, as untreated leprosy is more dangerous than treatment).

Storage

Store below 25 °C, away from direct light. Keep blister pack intact until use.

Frequently Asked Questions

Is leprosy curable?

Yes — completely. WHO-MDT for 12 months cures multibacillary leprosy in over 99% of cases. Early diagnosis and treatment prevent disability.

Why is the treatment 12 months?

M. leprae reproduces extremely slowly (doubling time ~14 days), and viable bacilli can persist for months even after symptoms resolve. The 12-month course ensures elimination and prevents relapse and resistance.

Will my skin pigmentation come back to normal?

Yes. Rifampicin urine/tear discolouration disappears within days of the last dose. Clofazimine skin pigmentation fades over 6–12 months after stopping treatment.

Can I infect my family during treatment?

No — the first dose of rifampicin makes you 99.99% non-infectious within days. Continued MDT eliminates remaining bacilli over the 12-month course.

Why must rifampicin be supervised once monthly?

Rifampicin is the most potent drug; supervised monthly dosing ensures adherence to the most critical component. Self-administered dapsone and clofazimine fill in the daily backbone.

Should my family be tested?

Yes — close household contacts should be examined for early skin or nerve signs. They may be offered single-dose rifampicin post-exposure prophylaxis (per WHO PEP guidelines).

Is WHO-MDT free?

Yes — WHO-MDT is provided free of charge to patients through national leprosy programmes worldwide, funded by international donations. Patients should not pay for the regimen itself, though supplementary care may be charged.

What if I miss doses?

Adherence is critical for cure and to prevent resistance. Single missed doses of dapsone are made up the next day. Missed monthly rifampicin should be taken as soon as possible. Patterns of non-adherence need specialist review and possible regimen extension.

Can I drink alcohol during treatment?

Avoid alcohol — both rifampicin and dapsone cause hepatotoxicity, and alcohol amplifies risk. Limit to occasional small amounts under medical advice.

When can I expect symptoms to resolve?

Skin lesions typically reduce significantly within the first 3 months. Nerve damage may not fully recover — early treatment is key to prevent long-term disability. Regular monitoring continues for 5+ years post-cure.

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