HUCOG 5000IU Injection

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What is HUCOG 5000 IU Injection?

HUCOG 5000 IU Injection contains human chorionic gonadotropin (hCG) — a glycoprotein hormone naturally produced by the placenta during pregnancy. The hCG in HUCOG 5000 IU Injection is purified from the urine of pregnant women and supplied in 5,000 IU vials as a lyophilised (freeze-dried) powder, accompanied by a sterile water diluent for reconstitution immediately before use.

Manufactured by Bharat Serums and Vaccines Ltd (BSV). Pack sizes available at MedsBase: 1, 2, 3, 10 or 30 vials.

Pharmacologically interchangeable with other urinary hCG products globally: Pregnyl (Organon), Choragon (Ferring), Profasi, Ovidac, Lupi-HCG. Recombinant hCG (Ovitrelle / Ovidrel by Merck Serono) is a different production method but pharmacologically equivalent at standard doses.

How hCG works

hCG shares its α-subunit with LH, FSH, and TSH, but its unique β-subunit gives it a much longer half-life than endogenous LH (~36 hours vs ~30 minutes). It binds the LH/CG receptor on:

• Ovarian theca and granulosa cells (in women) — triggering final follicular maturation, ovulation 36-40 hours after the trigger dose, and subsequent corpus luteum formation
• Testicular Leydig cells (in men) — stimulating endogenous testosterone production and supporting spermatogenesis when given over weeks-to-months
• Placenta (in pregnancy) — maintaining corpus luteum progesterone production until placental progesterone takes over at ~10 weeks gestation

The long half-life is what makes hCG useful as an “ovulation trigger” — a single bolus dose mimics the natural LH surge and gives a predictable window for timed intercourse, intrauterine insemination (IUI), or oocyte retrieval for IVF.

Approved clinical uses

In women:

• Ovulation trigger in anovulatory infertility cycles after follicular maturation with clomiphene, letrozole, or injectable gonadotropins (FSH / hMG)
• Final oocyte maturation in IVF / ICSI cycles, given 36 hours before egg retrieval
• Luteal phase support in some assisted-reproduction protocols (less common; progesterone is the standard)

In men:

• Hypogonadotropic hypogonadism — congenital (Kallmann syndrome) or acquired (pituitary disease, post-surgery, post-radiation). hCG restores testosterone and, when combined with FSH or hMG over months, can restore spermatogenesis.
• Cryptorchidism (undescended testes) in pre-pubertal boys — selected cases as an alternative to surgical orchidopexy
• Restoration of fertility after long-term anabolic-androgenic-steroid (AAS) use or testosterone replacement therapy (TRT) — an off-label but well-established endocrinology indication, used to restart Leydig cell testosterone production and preserve testicular volume / spermatogenesis. Standard “post-cycle therapy” (PCT) protocols incorporate hCG with selective oestrogen receptor modulators (clomiphene, tamoxifen).
• Adjunct to TRT to maintain fertility and testicular volume during ongoing testosterone replacement — some endocrinologists co-prescribe hCG 250-500 IU 2-3×/week alongside testosterone for men who wish to preserve fertility

How to reconstitute & inject HUCOG 5000 IU Injection

HUCOG 5000 IU Injection arrives as two vials: a vial of lyophilised hCG powder and a vial of sterile water for injection (the diluent). Reconstitute immediately before use:

1. Wash hands thoroughly
2. Wipe both vial tops with an alcohol swab and allow to dry
3. Using a sterile syringe with a drawing-up needle, withdraw the entire diluent volume from the water vial (typically 1 mL)
4. Inject the diluent slowly down the inside wall of the powder vial — do not aim directly at the powder pellet (causes foaming)
5. Roll the vial gently between your palms until fully dissolved — do NOT shake (denatures protein, may reduce potency)
6. The reconstituted solution should be clear and colourless. Do not use if cloudy or particulate.
7. Withdraw the prescribed dose with a fresh insulin syringe (for SC) or a 23-25 G needle (for IM)
8. Inject as directed by your prescriber: subcutaneously into the abdomen or thigh (most common — less painful, equivalent absorption) OR intramuscularly into the deltoid or gluteal muscle
9. Discard syringe and needle into a sharps container

Some protocols dilute the reconstituted hCG further to allow micro-doses (e.g. 250-500 IU 2-3×/week for fertility preservation on TRT). For example, reconstituting one 5,000 IU vial in 5 mL of sterile bacteriostatic water gives 1,000 IU/mL, allowing 0.25 mL = 250 IU per dose. Store the diluted solution refrigerated and use within 30 days; bacteriostatic water (containing 0.9% benzyl alcohol) is required for multi-dose use, NOT plain sterile water.

Dosing by indication

Doses below are typical — your endocrinologist or fertility specialist will tailor to your specific situation:

Children: dosing is paediatric-specialist territory only. Do not self-dose hCG in children.

Side effects & safety

Common (1 in 100):

• Local injection-site reactions (pain, redness, swelling, mild bruising)
• Headache
• Fatigue / mood changes
• Mild fluid retention
• In men: gynaecomastia (breast tenderness or swelling) from hCG-driven aromatisation of testosterone to oestradiol — an aromatase inhibitor (anastrozole) is sometimes added in protocols where this is a problem

Less common but important:

• Ovarian hyperstimulation syndrome (OHSS) in women — see dedicated section below; this is the most serious adverse effect
• Multiple pregnancy — ovulation-induction with hCG carries a 5-12% twin rate and a small triplet/higher-order rate
• Thromboembolism — rare but real; particular caution in women with thrombophilia or prior VTE
• Hypersensitivity reactions (rash, urticaria, anaphylaxis)
• Premature epiphyseal closure if used inappropriately in pre-pubertal boys

OHSS warning — women undergoing fertility treatment

Ovarian hyperstimulation syndrome (OHSS) is the most serious risk of hCG-triggered ovulation in fertility cycles. It results from VEGF-mediated capillary leak after multiple-follicle ovulation, causing fluid shifts, ascites, and (in severe cases) pleural effusion, oliguria, thromboembolism and electrolyte disturbance.

Risk factors: young age, low BMI, polycystic ovary syndrome (PCOS), high antral follicle count, high oestradiol on the trigger day (>3,500 pg/mL), large number of follicles (>15-20).

Symptoms to watch for in the 1-2 weeks after a trigger shot:

• Mild OHSS: abdominal bloating, mild pelvic discomfort, mild nausea
• Moderate OHSS: significant abdominal distension, ascites visible on ultrasound, weight gain >2 kg, vomiting
• Severe OHSS — SEEK URGENT MEDICAL CARE: rapid weight gain >1 kg/day, breathlessness, severe abdominal pain, reduced urine output, calf pain or swelling (DVT), chest pain

Modern fertility centres mitigate OHSS risk through pre-trigger oestradiol monitoring, GnRH-agonist trigger protocols (instead of hCG) in high-risk patients, “freeze-all” embryo strategies to avoid pregnancy in the same cycle as the trigger, and cabergoline prophylaxis. If you are at high risk, your fertility specialist will discuss alternatives.

Contraindications & warnings

Do not use HUCOG 5000 IU Injection if you have:

• Known or suspected hormone-dependent cancer (breast, prostate, ovary, endometrium)
• Undiagnosed abnormal vaginal bleeding
• Active thromboembolic disease
• Pregnancy (women)
• Premature puberty (when used in cryptorchidism context)
• Pituitary or hypothalamic tumour
• Hypersensitivity to hCG, urinary protein products, or any excipient

Use with caution if you have:

• Cardiac, renal or hepatic disease
• Migraine, asthma, epilepsy — fluid retention may exacerbate
• History of DVT/PE or thrombophilia
• Untreated thyroid or adrenal dysfunction

Drug interactions

• Anticoagulants (warfarin, DOACs, heparin) — increased VTE risk with hCG fluid shifts; close monitoring required
• Other gonadotropins (FSH, hMG) — combined use is part of standard protocols but increases OHSS and multi-pregnancy risk
• Aromatase inhibitors (anastrozole, letrozole) — sometimes co-administered in male protocols to manage hCG-driven oestradiol
• SERMs (clomiphene, tamoxifen) — commonly co-administered in PCT and HPG-axis-restart protocols
• Anabolic-androgenic steroids and exogenous testosterone — suppress endogenous LH/FSH; hCG is sometimes added as a “Leydig cell preservation” strategy

Storage & reconstitution shelf life

Unopened (lyophilised) vials: store at 2-25°C in the original carton, protected from light. Refer to the patient information leaflet for the specific temperature range applicable to your batch — some hCG preparations are room-temperature stable, others require refrigeration.

Reconstituted with plain sterile water: use immediately — discard any unused portion. Plain sterile water is single-use only.

Reconstituted with bacteriostatic water (for multi-dose use, e.g. micro-dose protocols): refrigerate at 2-8°C and use within 30 days. Mark the vial with the reconstitution date.

How HUCOG 5000 IU Injection compares to other hCG brands

All urinary hCG products contain the same active hormone and are pharmacologically interchangeable at equivalent IU doses. Brand differences come down to manufacturer, formulation excipients, vial design, and price:

• Eutrig HP — Bharat Serums, highly purified urinary hCG, 5,000 IU vial
• HUCOG 5000 — Bharat Serums, urinary hCG, 5,000 IU vial
• HUCOG 10000 / ZyHCG HP 10000 — same active, 10,000 IU vial format for higher single doses (ovulation trigger, IVF)
• Pregnyl, Choragon, Profasi — international branded urinary hCG, same active
• Ovitrelle / Ovidrel (choriogonadotropin alfa) — recombinant hCG; pharmacologically equivalent at standard ovulation-trigger doses (250 mcg recombinant ≈ 5,000 IU urinary)

Other relevant pages: Clomisign (Clomiphene 50 mg) for the SERM commonly paired with hCG in fertility and PCT protocols.

Frequently Asked Questions

When do I take HUCOG 5000 IU Injection for ovulation in a clomiphene cycle?

Your fertility specialist will time the trigger using ultrasound monitoring of your follicle size. The standard timing is when the dominant follicle reaches 18-20 mm in diameter, typically days 10-14 of a clomiphene-stimulated cycle. Ovulation occurs 36-40 hours after the hCG injection — intercourse, IUI, or oocyte retrieval is timed accordingly.

Subcutaneous or intramuscular — which is better?

For most indications, subcutaneous (SC) injection into the abdomen or thigh is now standard — equivalent absorption, less painful than IM, and easier to self-administer. IM is sometimes used for higher single doses (10,000 IU ovulation trigger) or per specialist preference. Follow your prescriber’s instruction.

Can I use HUCOG 5000 IU Injection for weight loss?

No. The “hCG diet” promoted in the 1950s by Dr Albert Simeons and various commercial programmes since has been repeatedly debunked. Multiple controlled trials have shown that hCG provides no weight-loss benefit over the very-low-calorie diet (500 kcal/day) the protocols mandate — and the diet itself is dangerous. The FDA has issued warnings against over-the-counter “homeopathic hCG” products and against medical hCG-for-weight-loss protocols. Do not use hCG for weight loss.

How does hCG help men recover testosterone after AAS or TRT?

Long-term exogenous testosterone or anabolic-androgenic steroid use suppresses pituitary LH and FSH secretion (negative feedback), which in turn shuts down endogenous Leydig cell testosterone production and spermatogenesis — causing testicular atrophy and post-cycle hypogonadism. hCG mimics LH and directly stimulates the Leydig cells, “waking up” testosterone production and helping preserve testicular volume. Combined with a SERM (clomiphene or tamoxifen) to restore the upstream pituitary axis, hCG forms the backbone of the post-cycle therapy (PCT) protocol that endocrinologists use to manage iatrogenic hypogonadism.

What is OHSS and how do I know if I have it?

Ovarian hyperstimulation syndrome is a fluid-shift disorder that can follow hCG-triggered ovulation in fertility cycles. Mild symptoms (bloating, mild pelvic discomfort) are common and self-limiting. SEEK URGENT MEDICAL CARE if you develop rapid weight gain (>1 kg/day), severe abdominal pain, breathlessness, reduced urine output, calf pain or swelling, or chest pain. See the OHSS section above for full details.

How long after the trigger shot until ovulation?

Ovulation typically occurs 36-40 hours after an hCG trigger dose. Timed intercourse is generally recommended at 24 and 36 hours after the injection. IUI is timed to 24-36 hours; oocyte retrieval for IVF is timed to 35-36 hours.

Will HUCOG 5000 IU Injection show up on a pregnancy test?

Yes — pregnancy tests detect hCG, so an injection of pharmaceutical hCG will produce a positive urine pregnancy test for approximately 7-14 days afterwards. This is why fertility cycles use blood beta-hCG tests timed at 14+ days after the trigger to confirm pregnancy — by then, residual injected hCG has cleared and any positive result is from implantation.

How should I store the vials?

Unopened lyophilised vials should be stored according to the patient information leaflet supplied with your batch — some hCG preparations are room-temperature stable up to 25°C, others require refrigeration. Always protect from light. Reconstituted hCG with plain sterile water must be used immediately; with bacteriostatic water, it can be refrigerated and used over 30 days.

Can I self-administer HUCOG 5000 IU Injection?

Subcutaneous self-injection is straightforward and is taught by every fertility clinic and endocrinologist. Intramuscular injection is harder to self-administer well and is often given by a partner or nurse. Whichever route you use, the injection should be prescribed by a qualified clinician with a clear treatment plan and follow-up.

Where can I order HUCOG 5000 IU Injection online?

You can order HUCOG 5000 IU Injection from MedsBase in pack sizes of 1, 2, 3, 10 or 30 vials. Orders ship worldwide with discreet packaging. HUCOG 5000 IU Injection is specialist-supervised worldwide — please ensure you have a valid medical indication and clinician supervision before ordering.

Patients already familiar with HUCOG 5000IU Injection (urinary hCG) sometimes compare formulations when switching to a different manufacturer’s trigger shot, making Puretrig 5000IU Injection (hCG 5000IU) a straightforward like-for-like alternative in the same ovulation-induction protocol.

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