Lomoother
✅ Brain tumor treatment
✅ Chemotherapy drug
✅ Slows tumor growth
✅ Alkylating agent
✅ Oral medication
Lomoother contains Lomustine.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is Lomoother?
Lomoother is an oral capsule from Beacon Pharmaceuticals containing lomustine (CCNU) 40 mg — a nitrosourea alkylating agent that crosses the blood-brain barrier. Used for recurrent or refractory primary brain tumours (high-grade glioma, ependymoma) and as part of older Hodgkin lymphoma combination regimens. Standard adult monotherapy dose: 100–130 mg/m² orally as a single dose every 6 weeks — the 6-week interval is mandatory because nadir is delayed (4–6 weeks) and recovery slow. Mandatory: FBC at baseline, weekly between cycles, and on day 42 before next dose. Cumulative dose limit ~1,000 mg/m² because of cumulative myelotoxicity and pulmonary fibrosis risk. Pregnancy contraindication; offer fertility preservation.
📦 Every order is covered by our Reshipment Assurance Policy — if your parcel does not arrive within 20 business days, we reship it.
What Is Lomoother?
Lomoother is an oral capsule from Beacon Pharmaceuticals containing lomustine (CCNU) 40 mg. Lomustine is a nitrosourea alkylating agent that crosses the blood-brain barrier (CSF concentration ~30–50% of plasma), making it one of the few oral cytotoxics with meaningful CNS penetration. Used in primary brain tumours, particularly recurrent high-grade glioma after temozolomide failure.
Uses and Indications
- Recurrent or refractory glioblastoma multiforme after temozolomide
- Anaplastic astrocytoma, anaplastic oligodendroglioma (PCV regimen)
- Hodgkin lymphoma (older CCNU-containing combinations)
- Brain metastases (selected)
Dosage and How to Take
- Standard: 100–130 mg/m² PO as a SINGLE dose every 6 weeks
- PCV regimen (oligodendroglioma): 110 mg/m² day 1 + procarbazine + vincristine, every 6 weeks
- Take as a single oral dose at bedtime, on an empty stomach (no food 2 hours before or 2 hours after).
- Antiemetic (ondansetron 8 mg) 1 hour before dose.
- Swallow capsules whole with water. Do NOT open.
- Mandatory 6-week interval between doses — nadir is delayed (typically week 4–6), recovery slow. Dosing more frequently than every 6 weeks risks cumulative pancytopenia.
- Mandatory monitoring: FBC at baseline, weekly throughout the cycle, and on day 42 before next dose. LFTs and renal function monthly. PFTs (DLCO) baseline and if dyspnoea.
- Cumulative dose limit ~1,000 mg/m² over the lifetime — cumulative myelotoxicity and pulmonary fibrosis become rate-limiting.
Side Effects
Common: nausea (significant), vomiting, anorexia.
Important:
- Delayed cumulative myelosuppression — thrombocytopenia and leucopenia at week 4–6, recovery slow
- Pulmonary fibrosis at high cumulative dose — mandatory PFTs if dyspnoea
- Hepatotoxicity
- Renal toxicity
- Secondary leukaemia (long-term, dose-related)
- Permanent infertility (gonadotoxic)
- Confusion, lethargy, ataxia (high doses)
Warnings
- Pregnancy: teratogenic; strict contraception throughout + 6 months after.
- Breastfeeding: avoid.
- Pre-existing pulmonary disease: baseline DLCO; avoid in severe.
- Severe hepatic / renal impairment: reduce dose.
- Live vaccines: contraindicated.
- Cumulative dose tracking — specialist responsibility.
Drug Interactions
| Combine with | Effect | What to do |
|---|---|---|
| Other myelosuppressives | Additive prolonged pancytopenia | Specialist supervision. |
| Cimetidine | Increases lomustine marrow toxicity | Use ranitidine or famotidine instead. |
| Live vaccines | Disseminated infection | Contraindicated. |
Storage
- Refrigerate at 2–8°C.
- Out of reach of children, women of childbearing potential, pets.
Related Alternatives on MedsBase
Other oncology medications stocked alongside this product:
- Endoxan (cyclophosphamide 50 mg)
- Celkeran (chlorambucil 2 / 5 mg)
- Temotero (temozolomide 20 / 100 mg)
- Temozol (temozolomide 20 mg)
- Endace (megestrol 40 / 160 mg)
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Frequently Asked Questions
Why must doses be 6 weeks apart?
Lomustine causes delayed cumulative myelosuppression. The blood count nadir typically occurs at week 4–6 after a dose, with slow recovery thereafter. Dosing more frequently than every 6 weeks stacks the marrow toxicity and risks severe pancytopenia. The 6-week interval is rigid — even if you feel well, do not dose-advance without specialist instruction.
Why is there a cumulative dose limit?
Cumulative pulmonary fibrosis and persistent thrombocytopenia become limiting at total exposure above ~1,000 mg/m² (lifetime). Specialists track cumulative dose and stop or extend the interval as the limit is approached. Tell every doctor about every previous chemotherapy course.
Can I take Lomoother with food?
No — take on an empty stomach (no food for 2 hours before or 2 hours after). Most patients take the dose at bedtime ≥ 2 hours after dinner. Pre-medicate with ondansetron 8 mg about 1 hour before to prevent the significant nausea and vomiting characteristic of nitrosoureas.
What blood tests do I need?
FBC at baseline, weekly between cycles, and on day 42 before each next dose. LFTs and renal function monthly. PFTs (with DLCO) at baseline and any time you develop new dyspnoea or persistent dry cough.
Will Lomoother work for my brain tumour?
Lomustine has a long history in primary brain tumours. In recurrent glioblastoma after temozolomide failure, lomustine produces modest disease-control benefit in some patients. In oligodendroglioma, the PCV regimen (procarbazine + lomustine + vincristine) has documented overall survival benefit when combined with radiotherapy in 1p/19q co-deleted disease. Discuss expected benefit specific to your tumour with the neuro-oncologist.
Why must Lomoother be refrigerated?
Lomustine is heat-sensitive and degrades at room temperature, especially in warmer climates. Refrigeration (2–8°C) preserves potency. Keep in original blister.
Caregivers handling Lomoother?
Wear gloves when handling capsules and patient body fluids in the first 48 hours after a dose. Wash hands afterwards. Pregnant caregivers should avoid handling.
Can I have live vaccines?
No — contraindicated during lomustine and for at least 6 months after the last dose. Inactivated vaccines safe and recommended.
Why order from MedsBase
Every batch is sourced from a WHO-GMP certified manufacturer. Orders are dispatched in plain, unbranded packaging from our fulfilment partners and covered by our Reshipment Assurance Policy: if a parcel does not arrive within 20 business days we send a free reshipment, no questions asked.
Related Anti-Cancer Medications
Other oncology medications stocked alongside this product:
- Endoxan (cyclophosphamide 50 mg)
- Celkeran (chlorambucil 2 mg)
- Temozol 20 (temozolomide 20 mg)
- Temotero (temozolomide 100/250 mg)
- Hydrosar (hydroxyurea 500 mg)
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Ranked by recent MedsBase order volume — what other customers in this category are picking.
| Strength | 40 mg |
|---|---|
| Quantity | 1 Bottle/s, 2 Bottle/s, 3 Bottle/s, 6 Bottle/s |
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