Lupimeb
Lupimeb (mebendazole 100 mg chewable, Lupin) — benzimidazole anthelmintic for pinworm, roundworm, hookworm, and whipworm. Single-dose for pinworm; 3-day course for roundworm and whipworm.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
Quick Answer — What is Lupimeb?
Lupimeb is an oral mebendazole 100 mg chewable tablet from Lupin. Mebendazole is a WHO Essential Medicine for pinworm, roundworm, hookworm, and whipworm. Standard adult dose: 100 mg as a single dose for pinworm, repeat in 2 weeks. For mixed infection or whipworm: 100 mg twice daily for 3 days.
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Why order from MedsBase
Our generic medications are sourced from WHO-GMP certified manufacturers and shipped worldwide in discreet, plain packaging — no medication name on the parcel exterior. Card payments are routed through a regulated processor (statement descriptors include a regulated card-payment processor — never “MedsBase” or any medication name). Crypto and SEPA bank transfer are also accepted. Every order is backed by our Reshipment Assurance Policy.
What is Lupimeb?
Lupimeb is mebendazole 100 mg chewable from Lupin. Mebendazole was the first benzimidazole anthelmintic in routine human use and remains a WHO Essential Medicine. Albendazole has overtaken it as first-line in most settings, but mebendazole has a niche role: it is preferred in patients with concurrent moderate-to-severe hepatic impairment (less hepatic metabolism) and is the agent of choice in some paediatric whipworm protocols.
Mechanism of action
Mebendazole binds β-tubulin in parasite cells, preventing microtubule polymerisation. This blocks parasite glucose uptake and depletes glycogen stores — the worm starves over 2–3 days. Mebendazole’s oral bioavailability is very low (< 10%), which is therapeutically useful: high concentrations stay in the gut lumen where intestinal worms live, with minimal systemic exposure.
Lupimeb indications and dose
| Indication | Dose | Schedule |
|---|---|---|
| Pinworm (Enterobius) | 100 mg | Single dose, repeat at 2 weeks |
| Roundworm (Ascaris) | 100 mg BID | For 3 days |
| Hookworm (Ancylostoma, Necator) | 100 mg BID | For 3 days |
| Whipworm (Trichuris) | 100 mg BID | For 3 days; may extend to 5–7 days for heavy load |
| Mixed nematode infection | 100 mg BID | For 3 days |
Tablets can be chewed, swallowed whole, or crushed and mixed with food.
Side effects
- Common: mild abdominal pain, transient diarrhoea, flatulence as worms pass
- Less common: headache, dizziness, mild rash
- Rare: reversible neutropenia (high-dose long courses), elevated transaminases, alopecia (very rare)
- Very rare: Stevens-Johnson syndrome, toxic epidermal necrolysis
Drug interactions
- Cimetidine — raises mebendazole plasma levels modestly; clinically relevant only in long courses for tissue parasites
- Phenytoin, carbamazepine, rifampicin — reduce mebendazole levels (CYP induction)
- Metronidazole — case reports of Stevens-Johnson syndrome with concurrent use; avoid if possible
Contraindications
- Hypersensitivity to mebendazole or other benzimidazoles
- Children < 1 year
- First trimester of pregnancy
- Severe hepatic impairment
Storage
Store Lupimeb below 30°C in the original blister, away from light and moisture.
Why order from MedsBase
Lupimeb is supplied from a WHO-GMP certified manufacturer, packaged discreetly, and shipped worldwide. Every order is covered by our Reshipment Assurance Policy — you never wear the cost of a lost parcel.
Frequently Asked Questions
Can I just take one tablet?
For pinworm, yes — one 100 mg dose, then a second at 2 weeks. For roundworm, hookworm, whipworm, or mixed infection, the standard course is 100 mg twice daily for 3 days.
Do I need to fast before Lupimeb?
No. Mebendazole works locally in the gut lumen and absorption is intentionally low. Take with or without food.
Can my child chew Lupimeb?
Yes — the tablet is designed to be chewed, swallowed whole, or crushed into food. Chewing is fine for children old enough to spit out anything they dislike (typically age 4+).
How is mebendazole different from albendazole?
Both are benzimidazoles with the same mechanism. Albendazole has higher systemic absorption (better for tissue-dwelling parasites like echinococcus), while mebendazole stays mostly in the gut lumen (preferred for some paediatric protocols and patients with hepatic impairment). For routine intestinal nematodes, both work.
Will Lupimeb treat tapeworm?
Mebendazole has activity against some intestinal cestodes (Hymenolepis nana) but is NOT first-line for tapeworm. Use niclosamide or praziquantel for confirmed Taenia infection.
How long until the worms are gone?
Adult worms are paralysed within 24–48 hours and pass in faeces over the following 3–5 days. Visible worms in stool are normal and a sign the drug is working. Itching and other symptoms resolve within 1–2 weeks.
Is Lupimeb safe in pregnancy?
Avoid in the first trimester. After week 13, mebendazole is acceptable for moderate-to-heavy worm burden — discuss with a clinician.
Can I drink alcohol with Lupimeb?
There is no specific alcohol interaction. Heavy alcohol use stresses the liver, and if the worm load is heavy enough to cause transient transaminase rise, abstaining for the treatment course is prudent.
Does Lupimeb treat lice or scabies?
No. Mebendazole has no activity against ectoparasites — use ivermectin or permethrin for scabies and pediculicide shampoos or oral ivermectin for lice.
Should I retest after treatment?
For routine pinworm or hookworm in an immunocompetent person with symptom resolution, no follow-up testing is needed. Persistent eosinophilia, weight loss, or recurring symptoms warrant repeat stool ova-and-parasite testing 2–4 weeks after treatment.
Patients seeking extended parasite coverage beyond Lupimeb (mebendazole 100 mg) may consider Wormentel (fenbendazole 222 / 500 mg) as a fenbendazole alternative in the same benzimidazole class but with a broader organism spectrum covering Giardia, tapeworm, and Trichinella.
Other Antiparasitic Medications
- Mebex (mebendazole 100 mg)
- Lupimeb (mebendazole 100 mg)
- ABD 400 (albendazole 400 mg)
- Nemocid (pyrantel pamoate)
- Iverheal (ivermectin)
More options in Threadworm Treatment
Ranked by recent MedsBase order volume — what other customers in this category are picking.
| Strength | 100 mg |
|---|---|
| Quantity | 30 Tablet/s, 60 Tablet/s, 90 Tablet/s, 180 Tablet/s, 420 Tablet/s, 840 Tablet/s |
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