ONOFF-400
✅ Bacterial infection treatment
✅ Broad-spectrum antibiotic
✅ Fast-acting formula
✅ Minimal side effects
✅ Convenient dosage
ONOFF-400 contains Ofloxacin.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is ONOFF-400?
ONOFF-400 is a fixed-dose combination for mixed aerobic-anaerobic GI infections. Take with food. Manufactured under WHO-GMP standards.
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Product Overview
ONOFF-400 is a medication containing the active ingredient Ofloxacin. It belongs to the class of antibiotics known as fluoroquinolones, which are effective against a wide range of bacterial infections. ONOFF-400 works by inhibiting the enzymes necessary for bacterial DNA replication, thus preventing the growth and spread of bacteria in the body. It is available in tablet form and is typically prescribed by healthcare professionals for the treatment of various bacterial infections.
Uses
ONOFF-400 is prescribed for the treatment of bacterial infections such as urinary tract infections, respiratory tract infections, skin infections, and certain sexually transmitted diseases like gonorrhea. It is also used in the prevention of anthrax infection after exposure. Your healthcare provider will determine the appropriate use of ONOFF-400 based on the specific type and severity of the bacterial infection.
How to Use
ONOFF-400 tablets are taken orally with a full glass of water, usually with or without food, as directed by your doctor. It is important to follow the dosage instructions provided by your healthcare provider. Do not crush or chew the tablets, swallow them whole. If you have difficulty swallowing the tablets, consult your doctor for alternative options.
How it Works
ONOFF-400 works by inhibiting the activity of bacterial DNA gyrase and topoisomerase IV enzymes, which are essential for bacterial DNA replication, transcription, repair, and recombination. By interfering with these processes, ONOFF-400 prevents the growth and spread of bacteria, ultimately leading to their death.
Dosage and Administration
The dosage of ONOFF-400 varies depending on the type and severity of the infection being treated, as well as the patient’s age, weight, and overall health condition. It is typically taken twice daily, with or without food. Follow your doctor’s instructions carefully and complete the full course of treatment even if you start to feel better.
Benefits
The benefits of ONOFF-400 include its effectiveness in treating a wide range of bacterial infections, its convenient oral tablet form, and its relatively low risk of serious side effects when used as directed by a healthcare professional. It provides rapid relief from symptoms and helps to eliminate bacterial infections from the body.
Common Side Effects
Common side effects of ONOFF-400 may include nausea, diarrhea, dizziness, headache, and abdominal pain. These side effects are usually mild and temporary, but if they persist or worsen, contact your doctor promptly. In rare cases, ONOFF-400 may cause serious side effects such as tendon rupture, allergic reactions, and nerve damage.
Warnings
Before using ONOFF-400, inform your doctor about any medical conditions you have, especially kidney disease, liver disease, or myasthenia gravis. Avoid taking ONOFF-400 if you have a history of hypersensitivity to fluoroquinolones or any of its components. Use caution when driving or operating machinery, as ONOFF-400 may cause dizziness or drowsiness.
Storage Information
Store ONOFF-400 tablets at room temperature away from moisture and heat. Keep the medication out of reach of children and pets. Do not use ONOFF-400 after the expiration date printed on the packaging. Properly discard any unused medication.
Disclaimer:
Our sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Frequently Asked Questions
Why is ONOFF-400 a fixed-dose combination?
ONOFF-400 combines a fluoroquinolone (broad gram-negative + atypical cover) with a nitroimidazole (anaerobic cover) to treat mixed aerobic/anaerobic infections in a single tablet — most commonly intra-abdominal, pelvic, gynaecological, dental, and infected diabetic-foot infections.
Can I drink alcohol while taking ONOFF-400?
No. The nitroimidazole component (ornidazole or metronidazole) can produce a disulfiram-like reaction with alcohol — flushing, nausea, vomiting, palpitations, and headache. Avoid all alcohol during the course AND for 48 hours after the last dose, including mouthwash and cough syrup.
Should I separate ONOFF-400 from antacids and supplements?
Yes. The fluoroquinolone fraction binds aluminium/magnesium antacids, sucralfate, iron, zinc, calcium, and dairy. Take ONOFF-400 at least 2 hours before or 6 hours after any of these.
Is ONOFF-400 safe in pregnancy?
ONOFF-400 is generally avoided in pregnancy. The fluoroquinolone fraction has a theoretical arthropathy signal in the foetus, and metronidazole is avoided in the first trimester. Specialist supervision required for any pregnancy use.
What are the most common side effects?
Nausea, metallic taste (from the nitroimidazole), abdominal discomfort, dizziness, and a transient skin rash. Rarer but serious: tendon pain (stop and seek review), seizures, peripheral neuropathy with prolonged use of either component, and Clostridioides difficile colitis.
How long is a typical course of ONOFF-400?
5–7 days is typical for routine intra-abdominal or gynaecological infection. Severe, complicated, or specialist-managed infections may run longer. Complete the prescribed course even if symptoms resolve early.
Other Anti-Infective Medications
- Cipmox — amoxicillin
- Clavam Dry Syrup — amoxicillin + clavulanate
- Cetil — cefuroxime
- Cefoprox — cefpodoxime
- Taxim-O DT — cefixime
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| Strength | 400 mg |
|---|---|
| Quantity | 30 Tablet/s, 60 Tablet/s, 90 Tablet/s, 180 Tablet/s |
ONOFF-400
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