Tadapox
✅ Enhances erections
✅ Delays ejaculation
✅ Improves sexual satisfaction
✅ Treats erectile dysfunction
✅ Enhances sexual performance
Tadapox contains Tadalafil and Dapoxetine.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is Tadapox?
Tadapox contains tadalafil 20 mg + dapoxetine 60 mg and is used for erectile dysfunction with premature ejaculation. Available in tadalafil 20 mg + dapoxetine 60 mg. Clinical effect lasts around up to 36 hours for ED; 3–5 hours for PE. Manufactured by Sunrise Remedies.
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Tadapox is a dual-action tablet combining tadalafil 20 mg (a long-acting PDE5 inhibitor for erectile dysfunction) and dapoxetine 60 mg (a short-acting SSRI for premature ejaculation). It is designed for men who have both ED and PE — a co-existing pattern reported in an estimated 30–40% of men with sexual-function complaints.
Manufactured by Sunrise Remedies, Tadapox offers the convenience of one tablet instead of two, with fixed-ratio dosing that has been clinically studied as a combination approach.
What Is Tadapox?
Tadapox is a combination tablet containing:
- Tadalafil 20 mg — a PDE5 inhibitor that improves erectile response to sexual stimulation; effects can last up to 36 hours
- Dapoxetine 60 mg — a short-acting SSRI that extends intravaginal ejaculatory latency time by 2–3×
It is used on-demand before intercourse and is specifically indicated for men with co-existing ED and PE.
How Does Tadapox Work?
The two components act on different physiological pathways:
- Tadalafil blocks PDE5, prolonging cyclic GMP activity and smooth-muscle relaxation in penile arteries — this enables and sustains an erection when sexual stimulation occurs
- Dapoxetine blocks the serotonin transporter centrally, delaying the ejaculatory reflex and extending IELT
Together, Tadapox addresses both the erectile and ejaculatory components of male sexual response in a single dose. Tadalafil reaches peak in ~2 hours and covers up to 36 hours; dapoxetine reaches peak in ~1 hour and covers 3–5 hours.
Uses and Indications
- Combined ED and premature ejaculation — the primary indication
- ED where extra control is desired — for men without formal PE but who want longer-lasting intimacy
Tadapox Dosage and Administration
| Scenario | Recommended Dose | Frequency / Timing |
|---|---|---|
| ED + PE — standard | 1 tablet (tadalafil 20 mg + dapoxetine 60 mg) | 1–3 hours before intercourse; max 1 tablet / 24 h |
| Dose-sensitive / elderly | Half tablet if scored, or switch to lower-strength components separately | Titrate under medical guidance |
| Mild hepatic impairment | Half tablet maximum | Caution — both components cleared hepatically |
| Moderate–severe hepatic impairment | Contraindicated | Dapoxetine component unsafe |
| Severe renal impairment | Not recommended | Both components require renal clearance |
| Age >64 | Not recommended | Dapoxetine safety unproven above 64 |
| Maximum daily dose | 1 tablet per 24 hours | Do not stack with additional tadalafil or dapoxetine |
How to Take Tadapox Properly
- Swallow whole with a full glass of water — reduces dapoxetine-related dizziness and syncope risk
- Take 1–3 hours before intended activity — the dapoxetine component is timing-sensitive
- Can be taken with or without food (tadalafil is food-independent; dapoxetine is too)
- Do not take more than one tablet per 24 hours
- Avoid alcohol — compounds dapoxetine’s BP-lowering and dizziness effects
- Do not combine with additional tadalafil, sildenafil, or dapoxetine
Side Effects of Tadapox
Side effects combine those of the two components.
| Component / Severity | Side Effect |
|---|---|
| Tadalafil — common | Headache, indigestion, back pain, muscle aches, flushing, nasal congestion |
| Dapoxetine — common | Nausea, dizziness, headache, dry mouth, fatigue, insomnia |
| Combined — uncommon | Syncope, orthostatic hypotension, palpitations, blurred vision |
| Rare | Priapism, NAION (sudden vision loss), sudden hearing loss, serotonin syndrome (with other serotonergic drugs) |
Syncope warning: dapoxetine can cause fainting, particularly in the first hour. Take with water, sit or lie down if lightheaded, and avoid driving or hazardous activity for 24 hours after dosing.
Warnings and Precautions
- Cardiovascular fitness for sex — sexual activity places cardiac demand on the heart. Men with active angina, recent MI (within 90 days), uncontrolled arrhythmia, or severe heart failure should have a cardiac assessment before starting a PDE5 inhibitor
- Blood pressure — PDE5 inhibitors cause mild, transient reductions in BP; use with caution if taking multiple antihypertensives
- Priapism — higher risk in men with sickle-cell disease, multiple myeloma, or leukaemia; seek urgent care if an erection lasts more than 4 hours
- Vision — discontinue and seek review if sudden visual changes occur; rare cases of non-arteritic anterior ischaemic optic neuropathy (NAION) have been reported
- Hearing — rare reports of sudden sensorineural hearing loss — stop and consult a doctor if affected
- Alcohol — significant alcohol intake combined with any PDE5 inhibitor can compound dizziness, headache, and low blood pressure
- Grapefruit juice — inhibits CYP3A4 and can raise blood levels
Contraindications — Who Should NOT Take This Medication
- Concurrent use of any nitrate — GTN, isosorbide mono/dinitrate, nicorandil, amyl nitrite (“poppers”)
- Concurrent use of guanylate cyclase stimulators such as riociguat
- Recent heart attack (within 90 days), unstable angina, or angina during intercourse
- NYHA Class II or greater heart failure within the last 6 months
- Uncontrolled arrhythmia, hypotension (BP <90/50) or uncontrolled hypertension (BP >170/100)
- Stroke within the last 6 months
- Known non-arteritic anterior ischaemic optic neuropathy (NAION) in one or both eyes
- Severe hepatic impairment (Child-Pugh C)
- Hypersensitivity to the active ingredient or any excipient
Drug Interactions
| Drug / Class | Interaction |
|---|---|
| Nitrates (GTN, ISMN, ISDN, amyl nitrite/”poppers”) | Absolute contraindication — severe, potentially fatal hypotension |
| Alpha-blockers (doxazosin, tamsulosin, alfuzosin) | Additive blood-pressure lowering — stabilise alpha-blocker dose first, start at lowest PDE5 dose |
| CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, clarithromycin) | Raise PDE5 plasma levels — reduce dose or avoid combination |
| CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, St John’s wort) | Lower PDE5 plasma levels — efficacy may be reduced |
| Riociguat and other sGC stimulators | Contraindicated — severe hypotension risk |
| Other PDE5 inhibitors | Do not combine — additive side effects without extra efficacy |
| Antihypertensives | Small additive BP reduction — usually clinically insignificant |
| Grapefruit juice | Inhibits CYP3A4 — avoid large or regular intake |
Always share a full list of your current medications, including over-the-counter products, recreational drugs, and herbal supplements, with your prescriber before starting this medication.
What to Do in Case of Overdose
Symptoms of a PDE5 overdose include severe headache, marked hypotension, dizziness, back or muscle pain, and prolonged erection. Management is supportive, with fluid resuscitation and cardiac monitoring. Contact your local poisons service or emergency department immediately if an overdose is suspected.
Storage Instructions
- Store below 30 °C in a dry place, away from direct sunlight
- Keep in the original blister packaging until use
- Keep out of reach of children and pets
- Do not use after the expiry date printed on the pack
- Dispose of unused tablets via a pharmacy take-back scheme where available
Related Alternatives on MedsBase
Looking for related ED or sexual-health treatment options?
- Modula — tadalafil 5 mg, ideal for once-daily low-dose therapy
- Vidalista — Centurion Labs tadalafil, 2.5 to 80 mg
- Tadacip — Cipla tadalafil 20 mg
- Megalis — Macleods tadalafil 10 mg / 20 mg
- Suhagra — Cipla sildenafil 25/50/100 mg
- Browse all Erectile Dysfunction treatments →
Frequently Asked Questions
Who should take Tadapox?
Tadapox is designed for men with both erectile dysfunction and premature ejaculation — a co-occurring pattern reported in roughly 30–40% of men seeking sexual-health treatment. If you only have ED, a pure PDE5 inhibitor is simpler and cleaner.
How fast does Tadapox work?
Plan 1–3 hours before intended activity. Dapoxetine’s peak is at ~1 hour; tadalafil’s is at ~2 hours. The tadalafil window extends up to 36 hours afterward, but the dapoxetine (PE-delay) window is only 3–5 hours.
Can I take Tadapox every day?
No — it is on-demand only, maximum one tablet per 24 hours. For daily dosing, consider a separate low-dose tadalafil (Modula 5 mg) if you only need ongoing ED cover.
Can I drink alcohol with Tadapox?
Avoid alcohol. The dapoxetine component sharply increases the risk of fainting and dizziness when combined with alcohol.
Can I combine Tadapox with another PDE5 inhibitor?
No — never stack PDE5 inhibitors. Tadapox already contains 20 mg tadalafil, which is a full on-demand dose.
Is Tadapox safe for men with heart conditions?
Combination tablets require extra caution. Contraindicated with nitrates, within 90 days of MI, or in unstable angina/heart failure. The dapoxetine component also adds orthostatic-hypotension risk. Always clear with a doctor first.
What about age limits?
Not recommended for men over 64 — dapoxetine safety data above that age is insufficient.
Can I split Tadapox tablets?
Only if the tablets are scored. Check your blister. If not scored, request a lower-strength separate-component option rather than splitting an unscored combination tablet.
What if I only need ED treatment?
Use a pure tadalafil product like Modula, Vidalista, Tadacip, or Megalis. You will pay less and carry none of the dapoxetine-related side effects.
What if Tadapox doesn’t work?
Review timing (dapoxetine is peak at 1 h, not later), alcohol, hydration. If ED response is inadequate, consider a higher on-demand tadalafil dose separately. If PE response is inadequate, behavioural therapy and topical anaesthetics can supplement pharmacological treatment.
Patients comparing tadalafil-plus-dapoxetine combination tablets often weigh Cipla’s Tadapox (tadalafil 20 mg + dapoxetine 60 mg) against Sunrise Remedies’s equivalent Super Tadarise (tadalafil 20 mg + dapoxetine 60 mg) — both deliver the same active doses, with the choice usually coming down to manufacturer preference and stock availability.
Tadapox combines tadalafil with dapoxetine for couples wanting long-acting, on-demand cover, but for a fluoxetine-based daily-use alternative that targets ejaculatory latency over weeks, Malegra FXT (sildenafil 100 / fluoxetine 40 mg) swaps the SSRI class and shortens the erection window.
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| Strength | 20+60 mg |
|---|---|
| Quantity | 10 Tablet/s, 30 Tablet/s, 60 Tablet/s, 90 Tablet/s, 180 Tablet/s |
2 reviews for Tadapox
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| 4 star | 0% | |
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