✅ Acne control
✅ Oil reduction
✅ Skin rejuvenation
✅ Pore cleansing
✅ Scar fading

Signatret contains Isotretinoin.

Product Overview

Signatret is a medication containing the active ingredient Isotretinoin, a powerful retinoid derived from vitamin A. It is specifically formulated to treat severe nodular acne that has not responded to other treatments. Signatret works by targeting the underlying causes of acne, including excess sebum production, inflammation, and the formation of comedones (clogged pores). Available in oral capsule form, Signatret offers a comprehensive solution for individuals struggling with severe acne, providing long-lasting improvement in skin clarity and texture.


Signatret is indicated for the treatment of severe nodular acne, a debilitating form of acne characterized by large, painful nodules beneath the skin’s surface. It is reserved for cases where other acne treatments have failed to provide adequate relief. Signatret works by reducing sebum production, preventing clogged pores, and decreasing inflammation, resulting in significant improvement in acne symptoms and prevention of scarring.

How to Use

Signatret should be taken orally with food to enhance absorption and minimize gastrointestinal side effects. The dosage is determined by your healthcare provider based on factors such as the severity of acne, body weight, and response to treatment. Typically, Signatret is taken once or twice daily for a period of several months. It’s crucial to follow the prescribed dosage and schedule provided by your doctor and to avoid doubling up on doses if one is missed. Consistent use of Signatret is essential for optimal therapeutic outcomes.

How it Works

Isotretinoin, the active ingredient in Signatret, works by targeting multiple factors involved in acne formation. It reduces sebum production, which helps prevent pores from becoming clogged and forming acne lesions. Additionally, Isotretinoin decreases inflammation in the skin and promotes cell turnover, leading to the resolution of existing acne lesions and the prevention of new ones. By addressing these underlying mechanisms, Signatret provides comprehensive treatment for severe nodular acne, resulting in clearer, smoother skin.

Dosage and Administration

The dosage of Signatret varies depending on the severity of acne and individual patient response. It is typically started at a low dose and gradually increased over time to minimize side effects. The usual recommended dose ranges from 0.5 to 1 mg per kilogram of body weight per day, divided into two doses taken with meals. Treatment with Signatret may last for several months, and improvement in acne symptoms is usually seen within the first few weeks of therapy. It’s important to follow your doctor’s instructions carefully and not exceed the prescribed dosage to minimize the risk of side effects.


Signatret offers significant benefits in the treatment of severe nodular acne by providing long-lasting improvement in acne symptoms and preventing scarring. Its unique mechanism of action targets multiple factors involved in acne formation, including sebum production, pore-clogging, and inflammation, resulting in clearer, smoother skin. Signatret’s oral capsule formulation provides convenience and ease of administration, allowing for effective acne management with once or twice daily dosing.

Common Side Effects

Common side effects of Signatret may include dry skin, chapped lips, dry eyes, nosebleeds, joint pain, and muscle stiffness. These side effects are usually mild and transient, resolving with continued use or dose adjustment. However, Signatret may also cause more serious side effects such as liver toxicity, increased intracranial pressure, and mood changes, requiring close monitoring by your healthcare provider. It’s important to report any unusual or persistent side effects to your doctor promptly.


Signatret is associated with several important warnings, including the risk of severe birth defects if taken during pregnancy. Female patients of childbearing age must use two forms of contraception and undergo regular pregnancy testing before, during, and after treatment with Signatret to prevent pregnancy-related complications. Additionally, Signatret may increase the risk of depression, suicidal thoughts, and psychiatric disorders, particularly in patients with a history of mental health issues. It’s important to discuss the potential risks and benefits of Signatret with your healthcare provider before starting treatment.

Storage Information

Signatret should be stored at room temperature away from light and moisture. Keep the medication out of reach of children and pets. Do not store Signatret in the bathroom or near the kitchen sink, where it may be exposed to moisture. Proper storage helps maintain the effectiveness and safety of the medication, ensuring optimal therapeutic outcomes.


Our sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Additional Information


20 mg


30 Capsule/s, 60 Capsule/s, 90 Capsule/s, 180 Capsule/s


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