Inmecin-R
✅ Relieves Inflammation
✅ Eases Pain
✅ Reduces Swelling
✅ Treats Arthritis
✅ Manages Gout
Inmecin-R contains Indomethacin.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is Inmecin-R?
Inmecin-R is a 75 mg sustained-release indomethacin capsule, a convenient once- or twice-daily form of one of the most potent non-selective NSAIDs in clinical use. It is used for chronic inflammatory arthritis, particularly rheumatoid arthritis, ankylosing spondylitis, and prolonged gout management. Typical adult dose is one 75 mg SR capsule once or twice daily with food. Indomethacin has a stronger CNS and GI profile than ibuprofen — use the lowest effective dose for the shortest reasonable time.
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Inmecin-R 75 mg is a sustained-release (SR) oral capsule of indomethacin. The SR formulation spreads the release of the 75 mg dose over 8–12 hours, giving steadier blood levels and simpler once- or twice-daily dosing than the immediate-release 25/50 mg capsule (Inmecin), which must be taken three times a day.
Inmecin-R is typically chosen when a patient needs chronic indomethacin therapy for an inflammatory spondyloarthropathy, chronic gout, or persistent inflammatory arthritis, and adherence to TDS dosing is difficult. The total daily dose of 75–150 mg is similar to that used with immediate-release indomethacin.
What Is Inmecin-R Used For?
- Rheumatoid arthritis — symptom control in ongoing inflammatory flares
- Ankylosing spondylitis — preferred first-line NSAID in many guidelines; can reduce radiographic progression when used regularly
- Chronic gout — inter-crisis management
- Osteoarthritis with marked inflammatory component
- Psoriatic arthritis, reactive arthritis
- Pericarditis — maintenance phase alongside colchicine
How Does Indomethacin Work?
Indomethacin is a non-selective NSAID — it blocks both COX-1 (which maintains stomach lining, platelet function, and kidney perfusion) and COX-2 (which is upregulated at sites of inflammation). This broad action explains both its strong anti-inflammatory effect and its well-known gastrointestinal and renal side-effect profile.
The therapeutic chain of events is the same for every NSAID:
- Tissue injury or inflammation releases phospholipids from cell membranes
- Phospholipase A₂ converts them to arachidonic acid
- Cyclooxygenase (COX-1/COX-2) converts arachidonic acid to prostaglandins — the molecules responsible for pain, swelling, and fever
- Indomethacin blocks the COX enzymes, so less prostaglandin is produced, so there is less pain and inflammation
Because prostaglandins also protect the stomach lining, regulate kidney blood flow, and influence platelet function, the same mechanism that relieves pain is also responsible for the main NSAID side effects: stomach irritation, fluid retention, high blood pressure, and (in some individuals) kidney stress.
Inmecin-R Dosing
- Ankylosing spondylitis, rheumatoid arthritis: 75 mg SR once daily to start; may increase to 75 mg twice daily (total 150 mg) if needed.
- Osteoarthritis, chronic gout maintenance: 75 mg SR once daily.
- Elderly patients: start at 75 mg SR once daily and titrate slowly.
Swallow the SR capsule whole with water, with or after food. Do not open, crush, or chew — this destroys the sustained-release action and converts a 12-hour dose into an immediate burst, raising both GI and CNS risk.
Once-daily dosing is usually taken in the morning with breakfast. Twice-daily dosing should be spaced about 12 hours apart (e.g. 8 a.m. and 8 p.m., both with food).
GI safety — read this before the first dose. Every NSAID, including Inmecin-R, carries a real risk of gastritis, peptic ulcer, and upper-GI bleeding. The risk is highest in patients over 65, in those with prior ulcer disease, and in anyone also taking low-dose aspirin, corticosteroids, SSRIs, or anticoagulants. Take Inmecin-R with food, use the lowest effective dose for the shortest reasonable time, and ask your doctor about co-prescribing a proton pump inhibitor (omeprazole, pantoprazole) if you need it for more than 2–4 weeks.
Who Should Not Take Inmecin-R?
- Known hypersensitivity to Indomethacin or any NSAID
- Active or recurrent peptic ulcer, GI bleed, or GI perforation
- Asthma, urticaria, or rhinitis precipitated by aspirin or another NSAID (“aspirin-exacerbated respiratory disease”)
- Severe heart failure (NYHA class IV)
- Severe hepatic impairment (Child–Pugh C)
- Severe renal impairment (CrCl < 30 mL/min)
- Third trimester of pregnancy (risk of premature ductus arteriosus closure and oligohydramnios)
- Recent coronary artery bypass graft surgery (CABG) — absolute contraindication for all NSAIDs
Indomethacin-specific cautions:
- History of seizures or epilepsy
- Depression, psychosis, or history of hallucinations
- Parkinson’s disease
- Elderly — higher rate of CNS side effects
Cardiovascular risk
All NSAIDs (except low-dose aspirin) carry some increase in the risk of heart attack and stroke, and can worsen heart failure. The risk is dose- and duration-dependent and is generally highest with COX-2 selective agents and with diclofenac. Patients with established ischaemic heart disease, peripheral arterial disease, stroke, or uncontrolled hypertension should use non-selective NSAIDs (ibuprofen or naproxen) at the lowest effective dose, or use paracetamol instead where possible.
Renal (kidney) safety
NSAIDs reduce renal prostaglandin production, which can cause salt and water retention, raise blood pressure, and — in vulnerable patients — cause acute kidney injury. High-risk groups are the elderly, patients on ACE inhibitors/ARBs plus diuretics (the “triple whammy”), anyone dehydrated (vomiting, diarrhoea, heat, heavy exercise), and those with pre-existing CKD. Stop the NSAID and seek medical review if you develop reduced urine output, swelling, or unexplained weight gain.
Side Effects of Inmecin-R
The SR formulation does not eliminate indomethacin’s characteristic side effects — it smooths out plasma peaks but the total daily exposure is similar.
- Very common: headache, dizziness, dyspepsia, nausea
- Common: abdominal pain, diarrhoea or constipation, drowsiness, tinnitus, rash, fluid retention, raised BP
- Uncommon: peptic ulcer, GI bleed, acute kidney injury, hepatotoxicity, depression, confusion
- Rare: Stevens-Johnson syndrome, aseptic meningitis, blood dyscrasias
Ordering & Delivery
MedsBase offers worldwide shipping on every order. Orders are dispatched in discreet packaging and arrive in branded manufacturer packs. If your preferred strength or pack size is out of stock, contact customer support for an ETA.
Medical disclaimer. The information on this page is provided for general education only. It is not a substitute for advice from your own doctor or pharmacist. NSAIDs have well-documented gastrointestinal, cardiovascular, and renal risks — please talk to a qualified healthcare professional before starting, stopping, or changing therapy, especially if you have a history of ulcer disease, heart disease, kidney disease, asthma, or are pregnant.
Frequently Asked Questions
What is Inmecin-R used for?
Inmecin-R (indomethacin 75 mg SR) is used for chronic inflammatory conditions — rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, osteoarthritis with significant inflammation, and chronic gout maintenance.
How is Inmecin-R different from Inmecin?
Same molecule (indomethacin), different formulation. Inmecin-R 75 mg is sustained release, dosed once or twice daily. Inmecin 25/50 mg is immediate release, dosed three times a day. SR is more convenient for chronic therapy.
Is Inmecin-R good for acute gout flares?
Indomethacin is first-line for acute gout, but the immediate-release form (Inmecin 50 mg TDS) is usually preferred for rapid symptom control in the first 48–72 hours. Inmecin-R is more appropriate for chronic gout maintenance or when a patient is already on SR therapy.
Can I open the Inmecin-R capsule?
No. The sustained-release pellets inside the capsule rely on an intact coating to release gradually. Opening, crushing, or chewing causes an immediate-release dump of 75 mg, which greatly increases side-effect risk.
How long does Inmecin-R take to work?
Pain relief typically starts within 1–2 hours of the first dose; maximum anti-inflammatory benefit builds over 1–2 weeks of regular dosing.
Can I take Inmecin-R with food?
Always take it with food or milk. Never on an empty stomach — gastric irritation is the most common reason patients drop out.
Is Inmecin-R safe long-term?
In ankylosing spondylitis, regular NSAID therapy (including indomethacin SR) may slow radiographic progression. Long-term use should be paired with a proton pump inhibitor for GI protection and regular monitoring of blood pressure, kidney function, and liver enzymes.
Can I drink alcohol on Inmecin-R?
Avoid alcohol or limit to occasional light use. Alcohol increases GI bleed risk with any NSAID and can worsen dizziness and drowsiness.
Is Inmecin-R safe in pregnancy?
No — contraindicated in the third trimester (risk of premature ductus arteriosus closure). Avoid in early pregnancy unless specifically supervised.
What drug interactions should I know about?
Lithium (levels rise), methotrexate (toxicity), ACE inhibitors + diuretics (kidney injury), anticoagulants and SSRIs (bleed risk), antihypertensives (blood-pressure effects blunted). Share your full medication list with your prescriber.
Can I drive on Inmecin-R?
Test your own response first. Dizziness or drowsiness are common in the first few days; do not drive until you know how it affects you.
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| Strength | 75 mg |
|---|---|
| Quantity | 30 Capsule/s, 60 Capsule/s, 90 Capsule/s, 180 Capsule/s |
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