Nise Gel
✅ Fast pain relief
✅ Soothes inflammation
✅ Convenient topical application
✅ Reduces swelling
✅ Improves mobility
Nise Gel contains Nimesulide.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is Nise Gel?
Nise Gel is a nimesulide 1% topical gel used for the localised relief of musculoskeletal and soft-tissue pain. Apply a thin layer 2 to 3 times daily to the painful area for up to 14 days. Topical nimesulide works mostly at the site of application, which means it provides strong local anti-inflammatory action with very low systemic exposure — important, because oral nimesulide is hepatotoxicity-restricted in many countries.
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Nise Gel 1% (30 g) is a topical preparation of nimesulide, a preferential COX-2 NSAID widely used in Asia, South America, and parts of Europe. While oral nimesulide has been associated with rare but serious hepatotoxicity and is therefore restricted to short courses in many jurisdictions, the topical form delivers the drug directly to inflamed tissue with minimal systemic absorption — which is why topical nimesulide remains in common use for musculoskeletal pain.
Topical nimesulide is chosen when a localised anti-inflammatory is needed and the patient prefers a lighter formulation than a diclofenac gel, or where nimesulide’s local tolerability profile is clinically preferable.
What Is Nise Gel Used For?
- Acute musculoskeletal injuries — sprains, strains, pulled muscles
- Osteoarthritis of hand, knee, or ankle
- Tendonitis, tenosynovitis, bursitis
- Periarthritis of the shoulder
- Low back pain with a localised component
- Post-traumatic inflammation of superficial soft tissues
- Mild neuralgia (short courses, as adjunct)
How Does Nise Gel Work?
Nimesulide preferentially blocks the COX-2 enzyme at sites of inflammation, reducing prostaglandin-mediated pain and swelling. In addition, nimesulide has documented effects on neutrophil activation and oxidative stress, which contribute to its anti-inflammatory action. Topical application delivers therapeutic local concentrations with systemic absorption of usually less than 10%.
How to Apply Nise Gel
- Wash your hands and the skin area with mild soap and water; dry thoroughly.
- Squeeze a small ribbon (about the size of a cherry for a single knee, a grape for a wrist or elbow) onto the painful area.
- Gently rub in until absorbed — this usually takes 30–60 seconds.
- Wash your hands with soap and water after application (unless you are treating your hands).
- Do not cover the area with an occlusive dressing (cling film, tight bandage, waterproof plaster) unless your doctor specifically recommends it — occlusion increases systemic absorption.
- Keep the gel away from broken skin, eyes, lips, and mucous membranes.
How often: 2 to 3 times daily. Maximum in 24 hours: about 5 g (roughly the size of a large walnut). Treatment courses are usually 7–14 days; longer use should be reviewed by a doctor.
Safety notes for Nise Gel. Topical NSAIDs are not risk-free. Although systemic absorption is low (typically 5–10% of an equivalent oral dose), large treatment areas, occlusive dressings, broken skin, or long-duration use can push absorption into a range that matters — particularly in people with kidney disease, heart failure, prior peptic ulcers, or late pregnancy. Do not combine Nise Gel with an oral NSAID unless your doctor has specifically recommended it.
Who Should Not Use Nise Gel?
- Known hypersensitivity to the active ingredient or to any NSAID
- A history of asthma, urticaria, or angioedema triggered by aspirin or an NSAID
- Broken skin, open wounds, infected skin, or active eczema at the application site
- Children under 12 years (topical NSAID use should be specialist-guided)
- Third trimester of pregnancy (NSAID class effect on fetal ductus arteriosus)
Use with caution if you are already taking an oral NSAID, low-dose aspirin, or if you have severe kidney or liver disease.
Nimesulide-specific caution: although systemic exposure from topical nimesulide is low, use the lowest effective dose and avoid long treatment courses in patients with pre-existing liver disease.
Common Side Effects
Most users tolerate topical NSAID gels well. Effects are usually mild and local.
- Common: skin irritation at the application site — tingling, mild burning, redness, or dryness
- Uncommon: contact dermatitis, pruritus, rash extending beyond the application area
- Rare: photosensitivity (especially with piroxicam gel), severe skin reactions, systemic NSAID effects in heavy long-term use
Stop the gel and contact your doctor if you develop a widespread rash, blistering, skin peeling, mouth ulcers, or any signs of a systemic NSAID effect (indigestion, ankle swelling, unusual bruising).
Ordering & Delivery
MedsBase offers worldwide shipping on every order. Orders are dispatched in discreet packaging and arrive in branded manufacturer packs. If your preferred pack size is out of stock, contact customer support for an ETA.
Medical disclaimer. The information on this page is provided for general education only. It is not a substitute for advice from your own doctor or pharmacist. Talk to a qualified healthcare professional before starting, stopping, or changing therapy, especially if you have a history of ulcer disease, heart disease, kidney disease, asthma, liver disease, or are pregnant.
Frequently Asked Questions
What is Nise Gel used for?
Nise Gel (nimesulide 1%) is used for localised musculoskeletal and soft-tissue pain — sprains, strains, tendonitis, bursitis, and small-joint osteoarthritis.
Is topical nimesulide safer than oral nimesulide?
Yes. Oral nimesulide has rare but documented hepatotoxicity and is restricted to short courses in several countries. Topical nimesulide keeps systemic absorption very low (typically < 10% of oral bioavailability), which greatly reduces the hepatic risk while preserving local anti-inflammatory benefit.
How long does Nise Gel take to work?
Many users feel local relief within 1–2 hours of the first application. Full anti-inflammatory benefit builds over 3–5 days of regular use.
How often should I apply Nise Gel?
Two to three times daily, with at least 5 hours between applications. Do not exceed 5 g per application or about 15 g per day.
Can I use Nise Gel with an oral NSAID?
Usually not. Combining topical and oral NSAIDs does not double the local effect but does add systemic exposure. Discuss with your doctor before combining.
Can I apply Nise Gel under a bandage?
Avoid occlusive dressings, which increase absorption. A loose breathable covering is acceptable.
How long can I use Nise Gel?
Usually up to 14 days. Longer use should be reviewed by a doctor.
Is Nise Gel safe in pregnancy?
Avoid in the third trimester. Use in early pregnancy only on medical advice.
Can children use Nise Gel?
Not recommended under 12 years without medical advice.
Does Nise Gel leave a residue or smell?
It is a clear, fast-absorbing gel with a mild scent. It should dry within 2–3 minutes.
What should I do if the skin becomes irritated?
Mild tingling or redness is common and usually settles. If irritation spreads or persists, stop the gel and contact your doctor.
See also: Lox 2% Jelly — Neon Labs lidocaine 2% topical gel for haemorrhoids, urinary catheterisation, premature ejaculation and minor procedures.
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| Strength | 30 g |
|---|---|
| Quantity | 1 Tube/s, 2 Tube/s, 3 Tube/s, 6 Tube/s |
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