Trajenta Duo
✅ Dual-action control
✅ Regulates blood sugar
✅ Combines two medications
✅ Improves insulin sensitivity
✅ Manages type 2 diabetes
Trajenta Duo contains Linagliptin & Metformin.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is Trajenta Duo?
Trajenta Duo is a fixed-dose combination tablet of linagliptin (2.5 mg) and metformin (500 mg or 1000 mg) for type 2 diabetes. It pairs complementary mechanisms: metformin reduces hepatic glucose production and improves insulin sensitivity, while linagliptin (a DPP-4 inhibitor) raises incretin hormones to stimulate glucose-dependent insulin release and suppress glucagon. Expected HbA1c reduction: 1.5–2.0 points. Weight-neutral and very low hypoglycaemia risk as a combination. Usual dose: one tablet twice daily with meals. Main side effects are metformin GI upset in the first 1–2 weeks. The linagliptin component needs no renal dose adjustment; the metformin component follows standard rules — avoid if eGFR < 30. Avoid in type 1 diabetes, DKA, eGFR < 30, and severe hepatic impairment.
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What Is Trajenta Duo?
Trajenta Duo is a fixed-dose combination oral antidiabetic tablet containing linagliptin (2.5 mg) and metformin hydrochloride (500 mg or 1000 mg), manufactured by Boehringer Ingelheim. Available in packs of 30, 60, 90 or 180 tablets. It is used when monotherapy with either component is not enough, or as initial combination therapy when HbA1c is substantially above target.
How Does Trajenta Duo Work?
Trajenta Duo combines two complementary mechanisms that do not overlap:
- Metformin — activates AMP-activated protein kinase (AMPK) in the liver, reducing hepatic glucose production. Also improves peripheral insulin sensitivity in muscle and fat. Does not stimulate insulin release — so no hypoglycaemia on its own.
- linagliptin — a DPP-4 inhibitor (“gliptin”). Blocks the enzyme that breaks down GLP-1 and GIP, raising active incretin levels. This stimulates glucose-dependent insulin release and suppresses glucagon — only when blood glucose is elevated.
Because neither component stimulates insulin release independent of blood glucose, the combination has a very low hypoglycaemia risk. Typical HbA1c reduction: 1.5–2.0 percentage points. Weight effect: neutral or slightly weight-reducing (from metformin).
Dosage and Administration
Usual dose: one tablet twice daily, with breakfast and dinner. Dose is individualised based on prior therapy, HbA1c target, and renal function.
- Take with food — improves metformin tolerability.
- Miss a dose? Skip it — take the next at the normal time.
- Renal dosing: The linagliptin component needs no renal dose adjustment; the metformin component follows standard rules — avoid if eGFR < 30.
- Hold for IV contrast, surgery, or acute illness with dehydration.
- Check vitamin B12 annually on long-term metformin.
Side Effects
From metformin (usually first 1–2 weeks):
- Diarrhoea, nausea, abdominal cramps, flatulence, metallic taste, loss of appetite
From the DPP-4 inhibitor:
- Upper respiratory infection, nasopharyngitis, headache
- Rare pancreatitis, severe arthralgia, bullous pemphigoid
Uncommon but serious:
- Lactic acidosis from metformin — very rare; almost always with AKI, sepsis, or hypoxia
- Vitamin B12 deficiency (long-term metformin)
- Acute pancreatitis — stop if severe abdominal pain
Drug Interactions
- Sulfonylureas, insulin, meglitinides — additive glucose-lowering; doses of these may need reduction to avoid hypoglycaemia.
- IV iodinated contrast — hold Trajenta Duo pre- and post-procedure if eGFR < 60.
- Cationic drugs (cimetidine, dolutegravir, ranolazine) — raise metformin levels.
- Carbonic anhydrase inhibitors (acetazolamide, topiramate) — additive acidosis risk.
- Strong CYP3A4 inhibitors — may raise saxagliptin levels (not relevant for sitagliptin/linagliptin/vildagliptin).
- Corticosteroids, thiazides, beta-2 agonists — may raise blood glucose.
Who Should Not Take Trajenta Duo?
- Type 1 diabetes mellitus or diabetic ketoacidosis
- Severe renal impairment (eGFR < 30)
- Severe hepatic impairment
- Acute illness with tissue-hypoxia risk
- History of hypersensitivity to either component
- History of pancreatitis (relative)
- Pregnancy and breastfeeding
- Before and 48 hours after IV iodinated contrast if eGFR < 60
Storage
Store Trajenta Duo below 30°C in a dry place, in the original blister pack. Keep out of reach of children.
Frequently Asked Questions
Is Trajenta Duo the same as taking Trajenta and metformin separately?
Clinically, yes — same molecules at the same doses. The fixed-dose combination improves adherence, reduces pill burden, and typically costs less than the two components bought separately. The trade-off is less dose flexibility.
Will Trajenta Duo cause hypoglycaemia?
On its own, very rarely. Neither DPP-4 inhibitors nor metformin stimulates insulin release independent of glucose. Hypoglycaemia becomes a concern only when Trajenta Duo is combined with a sulfonylurea, meglitinide, or insulin.
Will I gain weight on Trajenta Duo?
No. The combination is weight-neutral or slightly weight-reducing, which is a major reason it is preferred over sulfonylurea-based combinations in overweight patients.
How long before Trajenta Duo starts working?
Fasting glucose starts to fall within a week. Maximal HbA1c effect is at 12 weeks. If HbA1c has not fallen by at least 0.5% after 3 months at the target dose, additional therapy may be needed.
Can I drink alcohol while taking Trajenta Duo?
Moderate alcohol with food is usually safe. Avoid binge drinking — it raises lactic acidosis risk (metformin) and can impair liver function.
Where can I buy Trajenta Duo online?
You can order Trajenta Duo (Linagliptin 2.5 mg + Metformin 500/1000 mg (twice daily)) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide, with discreet packaging and genuine WHO-GMP certified manufacturer stock.
Related Diabetes Medications
- Januvia — Sitagliptin monotherapy
- Trajenta — Linagliptin monotherapy
- Glycomet SR — Metformin sustained-release
- Jardiance — Empagliflozin (SGLT-2 alternative)
- Forxiga — Dapagliflozin (SGLT-2 alternative)
- Browse all Diabetes Medications
Patients discontinuing the linagliptin component of Trajenta Duo while continuing metformin may transition directly to Glycomet SR (metformin hydrochloride 500–1000 mg SR), available in the same 500 mg and 1000 mg SR strengths as the original combination tablet.
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| Strength | 2.5mg/500mg, 2.5mg/1000mg |
|---|---|
| Quantity | 30 Tablet/s, 60 Tablet/s, 90 Tablet/s, 180 Tablet/s |
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