Hepcinat LP
✅ Treats Hepatitis C
✅ High success rate
✅ Shortens treatment duration
✅ Lowers risk of liver damage
✅ Improves liver function
Hepcinat LP contains Ledipasvir + Sofosbuvir.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
Quick Answer — Hepcinat LP (Sofosbuvir 400 mg + Ledipasvir 90 mg)
- Active ingredients: sofosbuvir 400 mg + ledipasvir 90 mg, fixed-dose combination tablet, taken once daily.
- Indication: chronic hepatitis C virus (HCV) infection, genotypes 1, 4, 5 and 6 in adults — the generic of Harvoni (Gilead).
- Mechanism: sofosbuvir is an NS5B nucleotide polymerase inhibitor; ledipasvir is an NS5A inhibitor. The combination targets two essential HCV proteins simultaneously.
- Cure rate: 94–99% sustained virologic response (SVR12) across most regimens — functional HCV cure in 12 weeks for treatment-naive non-cirrhotic patients.
- Treatment is curative, not chronic suppression. Once SVR12 is achieved (HCV RNA undetectable 12 weeks post-treatment), HCV is eradicated and tablets stop.
- Take with care alongside: amiodarone (bradycardia risk — usually contraindicated), strong CYP/P-gp inducers (rifampicin, St John’s wort, anticonvulsants — reduce DAA exposure), and acid-reducers (PPIs — lower ledipasvir absorption; separate by >= 12 hours where possible).
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What Is Hepcinat LP?
Hepcinat LP is a fixed-dose combination tablet containing Ledipasvir 90 mg and Sofosbuvir 400 mg, manufactured by Natco Pharma — one of India’s largest specialty pharmaceutical companies. It is a direct-acting antiviral (DAA) treatment for chronic hepatitis C virus (HCV) infection, offering cure rates exceeding 95% in most patient populations.
Hepcinat LP is a generic equivalent of Harvoni (Gilead Sciences), which revolutionized hepatitis C treatment when it launched in 2014 at a cost of $94,500 per course in the United States. Hepcinat LP delivers the same clinical outcomes at a fraction of the cost, making a hepatitis C cure accessible to patients worldwide.
What Does Hepcinat LP Treat?
Hepcinat LP is approved for the treatment of chronic hepatitis C in adults with the following genotypes:
| HCV Genotype | Treatment Duration | Cure Rate (SVR12) | Notes |
|---|---|---|---|
| Genotype 1 | 12 weeks (8 weeks in select patients) | 97–99% | Most common genotype in the US and Europe |
| Genotype 4 | 12 weeks | 93–95% | Common in Egypt and the Middle East |
| Genotype 5 | 12 weeks | 95%+ | Primarily found in South Africa |
| Genotype 6 | 12 weeks | 96%+ | Common in Southeast Asia |
8-week treatment may be sufficient for treatment-naive genotype 1 patients without cirrhosis and with a baseline HCV RNA level below 6 million IU/mL.
For genotypes 2 and 3, a Sofosbuvir + Velpatasvir combination such as Velasof or Velpanat is recommended instead, as these cover all HCV genotypes.
How Hepcinat LP Works
Hepcinat LP combines two direct-acting antivirals that target different stages of the hepatitis C replication cycle:
- Sofosbuvir (400 mg) — A nucleotide analog NS5B polymerase inhibitor. It gets incorporated into the viral RNA chain during replication, causing premature chain termination. This blocks the virus from copying itself.
- Ledipasvir (90 mg) — An NS5A inhibitor that blocks a protein essential for both viral replication and assembly of new virus particles. By targeting NS5A, Ledipasvir prevents the virus from multiplying and releasing new copies into the bloodstream.
By attacking HCV at two different points simultaneously, Hepcinat LP achieves rapid viral suppression and prevents the development of drug-resistant strains — a problem that plagued earlier single-agent hepatitis C treatments.
Dosage and How to Take Hepcinat LP
- Take one tablet once daily, with or without food.
- Swallow the tablet whole with water — do not crush, break, or chew.
- Take Hepcinat LP at the same time each day for consistent drug levels.
- If you miss a dose, take it as soon as you remember on the same day. If it is already the next day, skip the missed dose and continue with your regular schedule.
- Do not stop treatment early, even if you feel well. Completing the full course is essential to prevent viral relapse.
Treatment Duration
| Patient Type | Duration | Tablets Needed | Price at MedsBase |
|---|---|---|---|
| Treatment-naive, no cirrhosis, low viral load | 8 weeks | 56 tablets (2 packs) | $999 |
| Treatment-naive, no cirrhosis | 12 weeks | 84 tablets (3 packs) | $1,428 |
| Treatment-naive with compensated cirrhosis | 12 weeks | 84 tablets | $1,428 |
| Treatment-experienced, no cirrhosis | 12 weeks | 84 tablets | $1,428 |
| Treatment-experienced with compensated cirrhosis | 24 weeks | 168 tablets (6 packs) | Contact us |
What Is SVR12 (Sustained Virologic Response)?
SVR12 means the hepatitis C virus is undetectable in your blood 12 weeks after completing treatment. Achieving SVR12 is considered a functional cure — over 99% of patients who reach SVR12 remain virus-free permanently. Your doctor will order a blood test (HCV RNA PCR) at 12 weeks post-treatment to confirm cure.
Side Effects
Hepcinat LP is one of the best-tolerated hepatitis C treatments available. Most patients complete the full course with minimal or no side effects.
Common Side Effects
- Fatigue (reported in ~15% of patients)
- Headache (~11%)
- Nausea (~7%)
- Insomnia
- Diarrhea
These are generally mild and do not require treatment discontinuation.
Serious Side Effects (Rare)
- Bradycardia (slow heart rate) — Reported when taken with amiodarone. This combination is contraindicated.
- Hepatitis B reactivation — Patients co-infected with HBV must be monitored, as suppressing HCV can trigger HBV flare-ups.
Important Drug Interactions
- Amiodarone — Do NOT take with Hepcinat LP. Can cause life-threatening bradycardia.
- Rifampin, carbamazepine, phenytoin, St. John’s wort — Strong P-gp inducers that significantly reduce Sofosbuvir and Ledipasvir levels, potentially causing treatment failure.
- Proton pump inhibitors (omeprazole, esomeprazole) — Reduce Ledipasvir absorption. If necessary, take a PPI at a dose not exceeding 20 mg, at least 2 hours before Hepcinat LP.
- Antacids (Tums, Maalox) — Separate by at least 4 hours from Hepcinat LP.
- Rosuvastatin — Levels may increase; limit to 10 mg/day.
- HIV antiretrovirals — Tenofovir levels may increase when combined with certain HIV regimens. Renal monitoring is recommended. Products like Tenvir AF (TAF-based) are preferred over TDF-based regimens.
Warnings and Precautions
- Hepatitis B co-infection: All patients should be tested for HBV before starting treatment. HBV reactivation can cause serious liver injury or death.
- Decompensated cirrhosis: Hepcinat LP is not recommended for patients with decompensated liver disease (Child-Pugh B or C). A regimen containing Sofosbuvir + Velpatasvir + Voxilaprevir may be considered instead.
- Kidney impairment: No dose adjustment needed for mild to moderate kidney impairment. Not recommended for severe renal impairment (eGFR < 30 mL/min).
- Pregnancy: Not enough data to confirm safety. Avoid unless clearly necessary.
Hepcinat LP vs Other Hepatitis C Treatments
MedsBase offers several hepatitis C medications. Here’s how they compare:
| Product | Active Ingredients | Genotypes Covered | Price (12-week course) |
|---|---|---|---|
| Hepcinat LP | Ledipasvir 90 mg + Sofosbuvir 400 mg | 1, 4, 5, 6 | $1,428 |
| Ledifos | Ledipasvir 90 mg + Sofosbuvir 400 mg | 1, 4, 5, 6 | Check price |
| Hepcvir L | Ledipasvir 90 mg + Sofosbuvir 400 mg | 1, 4, 5, 6 | Check price |
| MyHep LVIR | Ledipasvir 90 mg + Sofosbuvir 400 mg | 1, 4, 5, 6 | Check price |
| Velasof | Velpatasvir 100 mg + Sofosbuvir 400 mg | All (1–6) | Check price |
| Velpanat | Velpatasvir 100 mg + Sofosbuvir 400 mg | All (1–6) | Check price |
| MyHep All | Velpatasvir 100 mg + Sofosbuvir 400 mg | All (1–6) | Check price |
Which should you choose? If you know your HCV genotype is 1, 4, 5, or 6, Hepcinat LP is a proven and cost-effective choice. If you are unsure of your genotype, a pan-genotypic option like Velasof or Velpanat covers all genotypes and eliminates the need for genotyping tests.
Storage
Store at room temperature (20–25°C / 68–77°F). Protect from moisture and direct sunlight. Keep out of reach of children. Do not use after the expiration date on the packaging.
Frequently Asked Questions
What is the cure rate of Hepcinat LP?
Clinical trials and real-world studies show cure rates (SVR12) of 95–99% for hepatitis C genotype 1 patients. Cure rates for genotypes 4, 5, and 6 are similarly high, typically exceeding 93%.
Is Hepcinat LP the same as Harvoni?
Yes. Hepcinat LP is a generic version of Harvoni, containing the same active ingredients (Ledipasvir 90 mg + Sofosbuvir 400 mg) in the same doses. It is manufactured by Natco Pharma under a voluntary license from Gilead Sciences and is bioequivalent to the branded product.
How long do I need to take Hepcinat LP?
Most patients take Hepcinat LP for 12 weeks (84 days). Some treatment-naive patients without cirrhosis and with low viral loads may qualify for an 8-week course. Treatment-experienced patients with cirrhosis may need 24 weeks. Your doctor will determine the appropriate duration.
Can Hepcinat LP cure all types of hepatitis C?
Hepcinat LP is most effective for HCV genotypes 1, 4, 5, and 6. For genotypes 2 and 3, a Sofosbuvir + Velpatasvir combination (such as Velasof) is recommended instead.
What tests do I need before starting Hepcinat LP?
Before starting treatment, your doctor should order: HCV genotype test, HCV viral load (RNA PCR), hepatitis B surface antigen test, liver function tests, and a kidney function test (eGFR). If cirrhosis is suspected, a FibroScan or liver biopsy may be recommended.
Can I take Hepcinat LP if I have cirrhosis?
Yes — Hepcinat LP is effective for patients with compensated cirrhosis (Child-Pugh A). A 12-week course is recommended. However, it is not recommended for decompensated cirrhosis (Child-Pugh B or C), which requires specialist management.
Can I take Hepcinat LP with HIV medications?
Hepcinat LP can be used with most HIV antiretroviral regimens. However, Tenofovir disoproxil fumarate (TDF) levels may increase when combined with Ledipasvir, so renal function should be monitored. TAF-based regimens such as Tenvir AF are generally preferred.
Do I need a prescription to buy Hepcinat LP?
At MedsBase, you can order Hepcinat LP online without a prescription. We offer discreet packaging and worldwide shipping. We strongly recommend consulting a hepatologist or gastroenterologist before starting treatment to determine the correct duration and monitor your response.
Disclaimer
Our sole intention is to ensure that its consumers get information that is expert-reviewed, accurate, and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions, or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
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More options in Hepatitis Medication
Ranked by recent MedsBase order volume — what other customers in this category are picking.
| Strength | 90 mg + 400 mg |
|---|---|
| Quantity | 28 Tablet/s, 56 Tablet/s, 84 Tablet/s |
| Pharma Form | Tablet/s |
| Manufacturer | Natco Pharma |
| Treatment | Hepatitis C |
| Generic Brand | Ledipasvir & Sofosbuvir |
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