Doxolin
✅ Asthma symptom management
✅ Convenient tablet format
✅ Easy administration
✅ Enhanced respiratory comfort
Contains Doxofylline
✓ Medicinsk gennemgået af Morgan Ellis — Apoteksforsker · 8 års erfaring · Sidst gennemgået: maj 2026
⚡ Quick Answer — What is Doxolin?
Doxolin indeholder doxofylline, en methylxanthine bronchodilator with anti-inflammatory effects, used as add-on therapy for chronic asthma and COPD. Doxofylline is a newer methylxanthine with similar efficacy to theophylline but a wider safety margin — fewer cardiac, GI, and CNS side effects. No routine drug-level monitoring required. Dose is 400 mg once or twice daily. Each tablet contains 400 mg, fremstillet af Zydus Cadila at WHO-GMP certified facilities.
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What Is Doxolin?
Doxolin is an oral methylxanthine bronchodilator. Methylxanthines are derived from natural alkaloids (theophylline is the dimethylxanthine present in tea). Their use has declined since the 1990s as inhaled β2-agonists and corticosteroids became first-line — but they retain a role as third-line add-on therapy in difficult asthma and COPD.
How Does Doxolin Work?
- Phosphodiesterase inhibition (PDE3, PDE4) — raises cyclic AMP in airway smooth muscle and inflammatory cells; net result is bronchodilation and reduced mediator release.
- Adenosine receptor antagonism — blocks adenosine-mediated bronchoconstriction and mast-cell mediator release.
- HDAC2 activation (theophylline at low serum levels 5–10 mg/L) — restores corticosteroid responsiveness in COPD and severe asthma where steroid resistance is partly mediated by reduced HDAC2.
- Diaphragm contractility — methylxanthines reduce diaphragm fatigue, useful in COPD with severe airflow limitation.
— det forstærker den normale fysiologiske respons snarere end at udløse en kunstigt.
- Severe chronic asthma — add-on to high-dose ICS-LABA where additional bronchodilation is needed
- COPD maintenance — add-on to LAMA-LABA or triple therapy
- Nocturnal asthma — sustained-release formulation provides overnight bronchodilation
- Apnoea of prematurity (theophylline) — neonatal use
- Theophylline-intolerant patients — better-tolerated alternative
Doxolin Dosage
| Patient | Dosis | Hyppighed |
|---|---|---|
| Adults — initial | 200 mg | Three times daily — first 7 days |
| Adults — maintenance | 400 mg | Once or twice daily |
| Elderly / liver disease | Halve dose | Once or twice daily |
Side Effects of Doxolin
- Nausea, vomiting, dyspepsia
- Hovedpine
- Tremor
- Insomnia, restlessness
- Mild palpitations (less than theophylline)
- Mild hypokalaemia at high doses
Serious — stop and seek help:
- Severe palpitations or arrhythmia
- Persistent vomiting
- Alvorlig allergisk reaktion
Advarsler og forholdsregler
- No routine blood-level monitoring — wider safety margin than theophylline.
- Many drug interactions — see interactions table. Most metabolised by CYP1A2; many inhibitors and inducers shift levels significantly.
- Smoking induces CYP1A2 and lowers theophylline levels by ~50% — re-titrate at smoking cessation.
- Cardiac disease: use cautiously in arrhythmias, heart failure, severe hypertension.
- Hyperthyroidism: increased clearance plus exaggerated adrenergic effects.
- Graviditet og amning: generally avoided; use only if benefit clear.
- Liver disease: reduce dose — methylxanthines are hepatically metabolised.
Kontraindikationer
- Hypersensitivity to doxofylline or other xanthines (caffeine, theobromine)
- Active peptic ulcer disease
- Uncontrolled tachyarrhythmias
- Severe heart failure (NYHA IV)
Lægemiddelinteraktioner
| Interacting drug | Effekt | Hvad skal der gøres |
|---|---|---|
| Ciprofloxacin, erythromycin, clarithromycin, fluvoxamine | Inhibit CYP1A2 → raise theophylline levels → toxicity (nausea, arrhythmia, seizures) | Avoid or reduce theophylline dose 50%; check serum levels |
| Cimetidine, allopurinol | Raise theophylline levels | Reduce dose; monitor levels |
| Phenytoin, carbamazepine, rifampicin | Induce CYP — lower levels | Higher dose may be needed |
| Smoking | Induces CYP1A2 — lower levels | Re-titrate dose at smoking cessation |
| β-agonists, diuretics | Additive hypokalaemia | Monitor potassium |
Opbevaring
- Store below 25°C in a cool, dry place away from direct sunlight.
- Keep in original packaging until use to protect from moisture and light.
- Do not use after the expiry date printed on the strip.
- Keep out of reach of children.
Relaterede alternativer på MedsBase
- Asthalin Inhaler — salbutamol reliever
- Budecort Inhaler — budesonide ICS preventer
- Foracort Inhaler — budesonide + formoterol ICS-LABA
- Tiova Inhaler — tiotropium LAMA for COPD
- Montair — montelukast LTRA tablet
Ofte stillede spørgsmål
How is doxofylline different from theophylline?
Doxofylline is a newer methylxanthine (introduced in the 1990s) with similar bronchodilator efficacy and a wider safety margin. Cardiac, GI, and CNS side effects are less common; routine blood-level monitoring is not required; and it has fewer drug interactions.
Why prefer doxofylline over theophylline?
Better tolerability, simpler dosing (no level monitoring), fewer interactions. Particularly useful in elderly patients and those who could not tolerate theophylline.
How fast does Doxolin work?
Bronchodilation begins within 1 hour; full effect over days.
Is Doxolin a reliever?
No — it is a controller. Keep a SABA (Asthalin, Levolin) for acute attacks.
Can I take Doxolin with my ICS?
Yes — doxofylline is typically added on top of ICS or ICS-LABA when additional bronchodilation is needed.
What are the common side effects?
Nausea, mild headache, tremor, insomnia. Generally milder than theophylline at equivalent bronchodilation.
Is Doxolin safe in pregnancy?
Limited data; inhaled therapy is preferred.
Can children take Doxolin?
Use with caution; specialist supervision recommended in paediatric use.
How does Doxolin compare to roflumilast (Rofaday)?
Both are oral non-bronchodilator-class agents with anti-inflammatory effects. Roflumilast is specifically for severe COPD with chronic bronchitis. Doxofylline has broader use across asthma and COPD as an add-on bronchodilator.
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| Styrke | 400 mg |
|---|---|
| Antal | 30 tablet(ter), 60 tablet(ter), 90 tablet(ter) |
| Farmaceutisk form | Tablet/s |
| Producent | Zydus Cadila Pharma |
| Behandling | Asthma prevention, Chronic obstructive pulmonary disease (COPD) |
| Generisk mærke | Levosalbutamol + Ipratropium |
Doxolin
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