Floslo
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✓ Medicinsk gennemgået af Morgan Ellis — Apoteksforsker · 8 års erfaring · Sidst gennemgået: maj 2026
Hurtigt svar
Floslo indeholder solifenacin succinate 5 mg / 10 mg made by Intas Pharma. It is used for overactive bladder (OAB) symptoms — urgency, frequency and urge incontinence. Take exactly as directed by your clinician — do not adjust the dose yourself.
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What Floslo is and how it works
Floslo contains solifenacin succinate, a competitive M3-selective muscarinic receptor antagonist. By blocking M3 receptors on the detrusor (bladder smooth muscle), solifenacin reduces involuntary contractions during the storage phase of bladder filling and damps down urgency, frequency and urge-incontinence episodes.
Solifenacin is licensed for the symptomatic treatment of overactive bladder (OAB) with urinary urgency, frequency and urge incontinence. It is one of the most prescribed antimuscarinics for OAB worldwide due to once-daily dosing and a relatively favourable tolerability profile.
Dosering og indtagelse
| Patientgruppe | Anbefalet dosis |
|---|---|
| Voksne med OAB — startdosis | 5 mg once daily |
| Step-up after 4 weeks if needed | Forøg til 10 mg once daily |
| Alvorlig nyreinsufficiens (eGFR <30) | Cap at 5 mg/day |
| Moderat leversvigt (Child-Pugh B) | Cap at 5 mg/day |
| Svær leversvigt (Child-Pugh C) | Undgå |
| Samtidig stærk CYP3A4-hæmmer | Cap at 5 mg/day |
Swallow whole, with or without food, at the same time each day. Some improvement appears within 1–2 weeks; full effect by 4–6 weeks. Step up to 10 mg only if response at 5 mg is inadequate after 4 weeks — side effects (especially dry mouth and constipation) rise meaningfully at the higher dose.
⚠ Anticholinergic burden — review concurrent medicines
Solifenacin contributes to total anticholinergic load. In older adults, sustained high anticholinergic burden is linked to kognitivt forfald og øget demensrisiko. Audit other anticholinergic medicines (TCAs, sedating antihistamines, oxybutynin, hyoscine, certain Parkinson drugs). Mirabegron (a beta-3 agonist with no anticholinergic effect) is the cleaner alternative if burden is a concern.
Bivirkninger
| Bivirkning | Frequency at 5 mg | Frequency at 10 mg |
|---|---|---|
| Tør mund | ~11% | ~28% |
| Forstoppelse | ~5% | ~13% |
| Sløret syn | ~4% | ~5% |
| Fordøjelsesbesvær / kvalme | ~3% | ~4% |
| Tørre øjne | Almindelige | Almindelige |
| Urinretention | Sjælden | Sjælden |
| QT-forlængelse | Meget sjælden | Avoid in long-QT syndrome |
| Cognitive side effects | Sjælden | Greater in older adults |
| Akut vinkelblok-glaukom | Meget sjælden | Same-day ophthalmology |
Lægemiddelinteraktioner
| Kombination | Effekt | Handling |
|---|---|---|
| Strong CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin, ritonavir) | Solifenacin levels rise | Cap at 5 mg/day |
| Stærke CYP3A4-inducere (rifampicin, phenytoin, carbamazepin) | Virkningstab | Switch to non-CYP3A4 alternative |
| Other anticholinergics | Additive burden | Avoid stacking |
| QT-prolonging drugs (sotalol, amiodarone, citalopram > 20 mg, methadone) | Additive QT effect | Undgå kombination |
| Bisphosphonates | Solifenacin can worsen oesophageal irritation | Take separately, sit upright 30 min after bisphosphonate |
Who should not take Floslo
- Urinretention eller betydelig blæreudløbshindring
- Severe gastrointestinal disease (toxic megacolon, severe ulcerative colitis, paralytic ileus, gastric retention)
- Ukontrolleret snævervinklet glaukom
- Myasthenia gravis
- Svær leversvigt (Child-Pugh C)
- Patients on haemodialysis
- Graviditet / amning (ingen menneskelige data)
Ofte stillede spørgsmål
How is solifenacin different from oxybutynin?
Solifenacin is M3-selective and dosed once daily. Compared with non-selective oxybutynin IR, it has lower rates of dry mouth, constipation and cognitive side effects, and a longer half-life. Oxybutynin transdermal patch closes some of that gap by avoiding first-pass metabolism.
How quickly will I notice an effect?
Most users see fewer urgency episodes within 1–2 weeks. Full benefit by 4–6 weeks. A 3-day bladder diary at baseline and at week 4 is the cleanest way to measure progress.
When should I move to 10 mg?
Only after 4 weeks at 5 mg with insufficient symptom control, on the advice of your prescriber. Side effects rise meaningfully at the higher dose — many users get adequate relief at 5 mg.
Can I take Floslo with an alpha-blocker for combined BPH and OAB?
Yes, this is a recognised pattern in men whose obstruction has been treated but storage symptoms persist. Post-void residual urine must be measured first; significant retention contraindicates an antimuscarinic.
What about combination with mirabegron?
The SYNERGY and BESIDE trials supported solifenacin + mirabegron for refractory OAB. The combination is initiated by a urologist after monotherapy fails.
Why is dry mouth worse at 10 mg?
Salivary glands have M3 receptors. The higher dose blocks more of them. Hydration, sugar-free gum and avoiding caffeine help — or step back to 5 mg if intolerable.
Is solifenacin safe in older adults?
Use cautiously and at the lowest effective dose. Anticholinergic burden, not solifenacin alone, drives the dementia signal. Mirabegron is preferred if burden is high or memory concerns exist.
Can I drink alcohol while taking it?
Modest amounts are usually fine. Alcohol is a bladder irritant; cutting back often helps independently. Avoid combining with sedating drugs because of additive drowsiness.
Hvad hvis jeg glemmer en dosis?
Take it when you remember on the same day. If it is almost time for the next, skip the missed dose — never double up.
Will I have to take it forever?
OAB is usually a chronic condition. Some users can step down or pause once bladder retraining and lifestyle measures take effect. Symptoms typically return within 1–2 weeks of stopping.
Andre blære- og prostata-medicin
- Vesigard (darifenacin XR) — M3-selective antimuscarinic alternative
- Darilong (darifenacin XR) — alternative darifenacin brand
- Urotel XL (tolterodine ER) — once-daily ER antimuscarinic
- Mirago (mirabegron) — beta-3 agonist, no anticholinergic load
- Oxyspas (oxybutynin) — ældre ikke-selektiv antimuskarinerg
Medicinsk ansvarsfraskrivelse. Oplysningerne på denne side er kun til generel undervisning og er ikke en erstatning for rådgivning fra en kvalificeret kliniker. Drøft enhver ny medicin eller dosisændring med din læge eller apoteker, især hvis du er gravid, ammer, har andre medicinske tilstande eller tager andre lægemidler.
Flere muligheder i Blære Prostata
Rangeret efter seneste MedsBase ordrevolumen — hvad andre kunder i denne kategori vælger.
| Styrke | 5 mg, 10 mg |
|---|---|
| Antal | 30 tablet(ter), 60 tablet(ter), 90 tablet(ter) |
| Farmaceutisk form | Tablet/s |
| Producent | Intas Pharma |
| Behandling | Symptomer på overaktiv blære (OAB) |
| Generisk mærke | Solifenacin Succinate |
Floslo
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