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Lenalid

Lenalid (Lenalidomide 5/10/25 mg) — Natco IMiD for multiple myeloma. Pregnancy black-box; mandatory thromboprophylaxis with corticosteroid combinations.

Medicinsk gennemgået af Morgan Ellis — Apoteksforsker · 8 års erfaring  · Sidst gennemgået: maj 2026

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Lenalid — Lenalidomide 5/10/25 mg (Natco Pharma). Immunomodulatory drug (IMiD) for multiple myeloma (newly diagnosed and relapsed/refractory), 5q-myelodysplastic syndrome, and mantle cell lymphoma. Modern IMiD with greater potency and fewer neuropathy/sedation side effects than thalidomide.

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Lenalid ships from a WHO-GMP certified manufacturer in plain packaging, billed through a regulated payment processor (the statement descriptor reads a regulated card-payment processor — never MedsBase or any medication name). Every order carries our 20-business-day Reshipment Assurance.

⚠️ Specialist-supervised cancer therapy — this medication is started, monitored, and stopped by an oncologist or haematologist. Dosing depends on tumour type, stage, body surface area, organ function, and concomitant therapy. Self-treatment is not appropriate; the information below is educational and supports informed conversations with your specialist.

Pregnancy black-box — strict prevention programme
All IMiDs are severely teratogenic (thalidomide most notoriously — phocomelia). Mandatory pregnancy-prevention programme (REMS/iCare equivalent): pregnancy testing before, during, and after; two effective contraceptive methods; counselling for both partners; no blood donation during therapy or for 4 weeks after. Even one dose during pregnancy can cause severe malformations.
VTE risk — thromboprophylaxis
IMiDs carry significantly elevated risk of deep vein thrombosis and pulmonary embolism, especially in combination with corticosteroids or doxorubicin. Mandatory thromboprophylaxis: low-dose aspirin (low-risk), or LMWH/warfarin/DOAC (higher-risk patients). Specialist-determined.
Myelosuppression + monitoring
All IMiDs cause myelosuppression — neutropenia, thrombocytopenia, anaemia. Weekly FBC during initiation; monthly maintenance. Renal dose adjustment (lenalidomide especially — significant renal accumulation).

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When is this used?

Immunomodulatory drug (IMiD) for multiple myeloma (newly diagnosed and relapsed/refractory), 5q-myelodysplastic syndrome, and mantle cell lymphoma. Modern IMiD with greater potency and fewer neuropathy/sedation side effects than thalidomide.

How is it taken?

Once daily, typically in cycles (e.g., 21 days on, 7 days off for lenalidomide). Specific dose and schedule are myeloma-protocol-specific (Rd, RVd, KRd, etc.). Specialist-determined by tumour response and tolerability.

Pregnancy prevention?

Mandatory programme: monthly pregnancy tests, two effective contraceptive methods, partner contraception, counselling. Even one dose during pregnancy causes severe malformations. No blood donation during therapy or for 4 weeks after stopping.

Common side effects?

IMiD class: VTE, fatigue, rash, GI (constipation, diarrhoea), myelosuppression. Lenalidomide: less neuropathy than thalidomide. Pomalidomide: often better tolerated than thalidomide; renal-friendly. Thalidomide: peripheral neuropathy, sedation.

Lægemiddelinteraktioner?

Anticoagulants — adjust based on VTE prophylaxis strategy. Digoxin levels may rise. Erythropoietin agents + IMiD — increased thrombosis risk; use only with mandatory thromboprophylaxis.

Renal monitoring?

Lenalidomide: dose-adjust by CrCl (significant renal accumulation). Pomalidomide: less renal effect but still monitor. Thalidomide: renally cleared metabolite — monitor renal function.

Hvad hvis jeg glemmer en dosis?

Take when you remember if <12 hours late; otherwise skip and resume — do not double up. Notify oncology team if multiple doses missed.

Vaccination?

Inactivated vaccines OK; live vaccines contraindicated during IMiD therapy. Optimise vaccinations before starting if possible.

Long-term complications?

IMiD therapy: secondary primary malignancies (especially with extended use), cumulative VTE risk, neuropathy (thalidomide especially).

When is treatment stopped?

Specialist-determined: response duration, toxicity, planned treatment break, transition to maintenance therapy. IMiD maintenance therapy is now standard in myeloma — typically lenalidomide post-autologous stem cell transplant continued for 2-3 years or until intolerance.

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  • Xbira — abiraterone 250 mg — CYP17 inhibitor for metastatic prostate cancer
  • Zoldria — zoledronic acid IV — for bone metastases and hypercalcaemia
  • Actorise — darbepoetin alfa — for chemotherapy-induced anaemia
Medicinsk ansvarsfraskrivelse: Cancer therapy is highly individualised. Specific drug, dose, schedule, monitoring, and supportive care must be determined by a qualified oncologist or haematologist based on tumour biology, staging, comorbidities, and goals of care. This information is educational; it does not substitute for professional medical advice.

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Styrke

5 mg, 10 mg, 25 mg

Antal

30 kapsler, 60 kapsler, 90 kapsler

Farmaceutisk form

Kapsel(er)

Producent

Natco Pharma

Behandling

Multiple myeloma, Lepra reaction

Generisk mærke

Lenalidomide

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