Levolin

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What Is Levolin?

Levolin is a tablets produceret af Cipla at WHO-GMP certified facilities. Each tablet delivers 1 mg or 2 mg of levosalbutamol. levosalbutamol is on the WHO List of Essential Medicines and is the world’s most-used reliever medication for asthma and reversible airflow obstruction.

Levosalbutamol is the pharmacologically active R-(−)-enantiomer of salbutamol. Standard salbutamol is a 50:50 racemic mixture of R and S isomers; the S-isomer contributes nothing to bronchodilation but may worsen airway hyperreactivity in some patients. By using only the R-isomer, levosalbutamol delivers the same therapeutic effect at half the milligram dose, with potentially less tremor and tachycardia in sensitive patients (especially children and those with cardiovascular comorbidities).

How Does Levolin Work?

levosalbutamol selectively activates beta-2 adrenergic receptors on the smooth muscle that rings the bronchial airways. Receptor activation raises intracellular cyclic AMP, smooth muscle relaxes, and the airway lumen widens — this is bronchodilation. Bronchodilation begins within 15–30 minutter, peaks at 30–90 minutes, and lasts (hurtigere på tom mave), maksimal plasmakoncentration efter 1 time, og varighed af meningsfuld klinisk effekt omkring. levosalbutamol also modestly inhibits mast-cell mediator release, reduces plasma exudation from airway capillaries, and improves mucociliary clearance.

Selectivity is dose-dependent: at therapeutic doses, β2 effects predominate; at higher systemic doses (oral tablets, repeated nebulisation), spillover onto β1 receptors causes tachycardia and palpitations, and onto β2 receptors elsewhere causes tremor and hypokalaemia.

— det forstærker den normale fysiologiske respons snarere end at udløse en kunstigt.

• Acute asthma exacerbations — first-line reliever (rescue) inhaler/nebulisation
• Chronic obstructive pulmonary disease (COPD) — symptomatic relief of acute breathlessness and exercise dyspnoea
• Exercise-induced bronchoconstriction — inhaled 15–30 minutes before exercise
• Bronchospasm with allergen, cold air, or viral exposure
• Anaphylaxis with bronchospasm — adjunct to adrenaline
• Hyperkalaemia (off-label) — nebulised salbutamol drives K⁺ intracellularly

Vigtigt: Levolin is a reliever, not a controller. It does not reduce underlying airway inflammation. Patients using more than the equivalent of one SABA canister per month, or needing a SABA more than three days per week outside of exercise pre-dosing, have poorly-controlled asthma and require step-up to inhaled corticosteroid (ICS) or ICS-LABA combination therapy.

Levolin Dosage

How to Use Levolin Properly

• Swallow with water; food does not significantly affect absorption.
• Space doses at least 4 hours apart.
• Inhaled levosalbutamol is preferred for most patients — fewer systemic side effects.
• Never double up after a missed dose.

Side Effects of Levolin

Common (dose-related, settle within 30–60 minutes):

• Fine tremor, especially of the hands
• Palpitations or increased heart rate (typically 10–20 bpm rise)
• Hovedpine
• Dry mouth, throat irritation
• Muscle cramps
• Hyperactivity or agitation in young children

Mindre almindelige:

• Hypokalaemia — especially with high repeat doses, worsened by theophylline, steroids or loop diuretics
• Mild hyperglycaemia
• Insomnia if dosed late evening
• Possible paradoxical worsening with the R-isomer is rare

Serious (stop and seek emergency help):

• Severe allergic reaction / angio-oedema / anaphylaxis
• Paradoxical bronchospasm — worsening wheeze immediately after dose
• Cardiac arrhythmias (atrial fibrillation, supraventricular tachycardia)
• Severe hypokalaemia with arrhythmia or muscle weakness

Advarsler og forholdsregler

• Frequent {$brand} use = poor asthma control. Needing a reliever more than 3 days per week (excluding exercise pre-dosing) means the underlying disease is not managed. Step up ICS-based controller therapy.
• Carry your reliever with you — many fatal asthma attacks happen when the inhaler is at home or expired.
• Cardiovascular disease: use cautiously in severe coronary artery disease, arrhythmias, hyperthyroidism, or severe heart failure.
• Diabetes: monitor glucose with repeat high doses.
• Graviditet og amning: levosalbutamol is used at the lowest effective dose. Uncontrolled asthma is more dangerous to mother and fetus than the drug itself.
• Severe attack red flags (call emergency services): no relief 10 min after a full dose, peak flow <50% of personal best, difficulty speaking in full sentences, blue lips or drowsiness.

Kontraindikationer

• Known hypersensitivity to levosalbutamol or any formulation excipient
• Tachyarrhythmias (uncontrolled) — relative contraindication
• Phaeochromocytoma — relative contraindication
• Hypertrophic obstructive cardiomyopathy — caution

Lægemiddelinteraktioner

Opbevaring

• Store below 25°C in a cool, dry place away from direct sunlight.
• Keep in original packaging until use to protect from moisture and light.
• Do not use after the expiry date printed on the strip.
• Keep out of reach of children.

Relaterede alternativer på MedsBase

• Asthalin Respules — salbutamol nebuliser solution
• Budecort Inhaler — budesonide ICS preventer
• Foracort Inhaler — budesonide + formoterol ICS-LABA
• Seretide Accuhaler — fluticasone + salmeterol ICS-LABA
• Duolin Inhaler — salbutamol + ipratropium combo reliever

Ofte stillede spørgsmål

Why levosalbutamol tablets when inhalers exist?

Oral tablets are useful for patients who cannot use inhaler devices reliably. The systemic side-effect profile is heavier than inhaled, but lighter than racemic salbutamol tablets at equivalent bronchodilation.

Levolin tablet vs. Asthalin tablet — which is better?

Both work. Levolin (levosalbutamol) uses half the milligram dose for similar bronchodilation and may cause less tremor and palpitations. Asthalin (racemic salbutamol) is well-established and lower-cost.

Will Levolin make me jittery?

Fine tremor and increased heart rate are dose-dependent β2 effects — milder than with racemic salbutamol at equivalent doses, but still present in some people, especially at the 2 mg strength.

Can I take Levolin during pregnancy?

Levosalbutamol is considered low-risk in pregnancy; uncontrolled asthma is more dangerous than the drug. Inhaled is preferred.

How fast does Levolin tablet work?

Onset 15–30 minutes, peak 1–2 hours, duration 4–6 hours.

Can I take Levolin if I have heart disease?

Use with caution. Tachyarrhythmias, severe coronary artery disease, and severe heart failure are relative contraindications. Discuss with your cardiologist.

Is Levolin habit-forming?

No — there is no addiction or tolerance with levosalbutamol. However, frequent use is a marker of poor disease control, not dependence.

Hvad hvis jeg glemmer en dosis?

Take it as soon as you remember unless the next dose is due. Never double up.

Does food affect Levolin tablet?

Food slightly delays absorption but does not reduce total drug exposure.

More options in Asthma/COPD Treatment

Rangeret efter seneste MedsBase ordrevolumen — hvad andre kunder i denne kategori vælger.

Asthalin

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Aerocort Inhaler

US$6.00 – US$14.00Interval de preț: US$6.00 până la US$14.00

Asthalin Respules

US$10.90 – US$27.50Interval de preț: US$10.90 până la US$27.50