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Urimax-F kombinerer tamsulosin 0.4 mg (alpha-blocker for fast urinary symptom relief) with finasteride 5 mg (a type-2 5-alpha-reductase inhibitor that shrinks the prostate over 3–6 months). Dual-MOA therapy for moderate–severe BPH with an enlarged prostate. Once-daily.
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What Is Urimax-F?
Urimax-F is a fixed-dose combination containing tamsulosin 0.4 mg + finasteride 5 mg, two complementary BPH drugs:
- Tamsulosin — selective alpha-1A blocker relaxing prostate and bladder-neck smooth muscle; fast symptomatic relief (days–weeks)
- Finasteride 5 mg — type-2 5-alpha-reductase inhibitor reducing scalp and prostate DHT; shrinks the prostate 20–25% over 6 months
The MTOPS trial showed this combination approach reduced BPH clinical progression by ~66% vs placebo and outperformed either drug alone. Strengths: 0.4 mg tamsulosin + 5 mg finasteride. Fremstillet af Cipla.
Klinisk anvendelse
- Moderate–severe BPH with an enlarged prostate (>30–40 mL)
- Men at risk of acute urinary retention or BPH-related surgery
- Men who plateaued on tamsulosin alone and want progression prevention
Sådan indtages
- Swallow the capsule whole with water. Do not crush, chew, or open — finasteride is teratogenic via skin contact if the capsule is broken.
- Take once daily, 30 minutes after the same meal (breakfast preferred).
- Urinary symptom improvement begins within 1–2 weeks; full prostate-shrinkage effect at 6 months.
- Tell any ophthalmologist before cataract surgery (IFIS risk from tamsulosin).
- Tell any clinician ordering PSA — finasteride halves readings.
Bivirkninger
Tamsulosin-related: dizziness, headache, abnormal ejaculation, rhinitis, asthenia.
Finasteride-related: decreased libido (~1–2%), erectile dysfunction (~1–2%), reduced ejaculate volume, gynecomastia, mood changes, rare persistent post-finasteride syndrome.
Serious rare: orthostatic hypotension, Intraoperative Floppy Iris Syndrome, priapism.
Who Should Not Take Urimax-F
- Women of reproductive age — finasteride is teratogenic. Do not handle broken capsules.
- Men with severe hepatic impairment
- Orthostatic hypotension history
- Planlagt katarakt-/glaukomoperation uden at informere øjenlægen
- Concurrent strong CYP3A4 inhibitors
- Known hypersensitivity to tamsulosin or finasteride
Urimax-F vs Dutas-T — Finasteride vs Dutasteride Combination
Both combinations pair tamsulosin with a 5-ARI; the only difference is the 5-ARI itself. Finasteride blocks type-2 5AR only (~70% DHT suppression). Dutasteride is dual (type-1 + type-2, ~90% DHT suppression). In direct comparison, dutasteride produces slightly greater prostate shrinkage but with slightly higher sexual side-effect incidence. Finasteride is better-studied for hair loss; dutasteride is less commonly prescribed in the US. See our full comparison guide.
Opbevaring
Store at room temperature (15–25 °C / 59–77 °F), away from moisture and direct light. Keep capsules sealed in the blister. Keep away from women of reproductive age.
Ofte stillede spørgsmål
Why a combination tablet?
Tamsulosin and finasteride address BPH through different mechanisms — smooth-muscle relaxation + prostate shrinkage. Combination therapy reduces BPH progression more than either drug alone (MTOPS trial).
How fast will my symptoms improve?
Tamsulosin begins working within 1–2 weeks. Finasteride takes 3–6 months to meaningfully shrink the prostate. Peak combination benefit is seen at 6–12 months.
What if I take Urimax-F for hair loss?
Finasteride 5 mg is the BPH dose — not the hair-loss dose (1 mg). Using 5 mg for hair loss is off-label and exposes you to higher DHT suppression + higher sexual side-effect risk. For hair loss use Finpecia (1 mg) eller Proscalpin (1 mg).
Can I combine Urimax-F with a PDE5 inhibitor?
With caution. Tamsulosin + sildenafil/vardenafil can cause additive hypotension. Tadalafil 5 mg daily is often pragmatic — space doses or discuss with a clinician.
What about PSA?
Finasteride halves PSA — always disclose use before any PSA test. Convention is to double the measured value for interpretation.
Should my partner worry about handling Urimax-F?
Only if capsules are broken or leaking. Intact capsules are safe to handle. Women of reproductive age should not handle broken capsules — finasteride is teratogenic.
Is combination better than monotherapy for everyone?
No — small prostates (<30 mL) often respond well to tamsulosin alone. Combination is strongest for men with larger prostates, elevated PSA, or BPH-progression risk factors.
What if Urimax-F stops working?
Discuss with a clinician. Options: switch to dutasteride-containing combination (Dutas-T), add tadalafil 5 mg daily, consider surgical evaluation (TURP, HoLEP, UroLift).
Relaterede BPH-produkter
- Urimax (Tamsulosin 0.2 mg)
- Urimax-kapsel (Tamsulosin 0,4 mg)
- Tamsuheal (Tamsulosin 0,4 mg)
- Monolosin (Tamsulosin 0,4 mg)
- Dutas-T (Tamsulosin + Dutasteride)
- Nafodil (Naftopidil 50 mg)
- Deetor (Dutasteride 0,5 mg)
⚕️ Medicinsk ansvarsfraskrivelse: Denne information er udelukkende til undervisningsformål og erstatter ikke lægevejledning. Konsulter en kliniker før du påbegynder, stopper eller ændrer medicin. Receptpligtige produkter bør kun anvendes under lægelig opsyn.
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