Galvus is a medication containing Vildagliptin. It is commonly used for Chronic Conditions. Available at affordable prices from MedsBase with worldwide shipping.

What are the side effects of Galvus?

DPP-4 inhibitors are among the best-tolerated oral antidiabetics. Most side effects are mild and similar across the class. Common: Upper respiratory tract infection, nasopharyngitis Headache Mild GI upset — nausea, diarrhoea (less common than with metformin) Uncommon but important: Acute pa...

How can I order Galvus online?

You can order Galvus online from MedsBase with worldwide shipping. We supply WHO-GMP certified generic medications produced by licensed pharmaceutical manufacturers.

Galvus

✅ Helps control blood sugar
✅ Enhances insulin production
✅ Improves glycemic control
✅ Convenient once-daily dosing
✅ Well-tolerated with few side effects

Galvus contains Vildagliptin

SKU: Galvus Kategori: Kategorioversigt, Kroniske tilstande, Diabetes, Diabetesmedicin Tag: Galvus, Vildagliptin

✓ Medicinsk gennemgået af Morgan Ellis — Apoteksforsker · 8 års erfaring · Sidst gennemgået: maj 2026

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⚡ Quick Answer — What is Galvus?

Galvus is a brand of vildagliptin (50 mg), a DPP-4 inhibitor (dipeptidyl peptidase-4 inhibitor, also called a “gliptin”) used for type 2 diabetes. It works by blocking the enzyme DPP-4, which normally breaks down incretin hormones (GLP-1 and GIP). Higher incretin levels stimulate insulin release and suppress glucagon only when blood glucose is high — so DPP-4 inhibitors produce a glucose-dependent effect and do not cause hypoglycaemia as monotherapy. HbA1c reduction: 0.6–0.8 points. Weight-neutral. Once-daily dosing (most gliptins). Twice-daily dosing is the main drawback. Requires baseline and periodic ALT monitoring — rare hepatic adverse events were seen early. Do not use if baseline ALT > 3× ULN. Cardiovascular-neutral in meta-analyses; no dedicated large CV outcome trial. Dose: 50 mg twice daily (morning and evening) — or 50 mg once daily in combination with a sulfonylurea. Reduce to 50 mg once daily if eGFR < 50. Main side effects are mild — upper respiratory symptoms, headache, rare pancreatitis. Avoid in type 1 diabetes and DKA.

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What Is Galvus?

Galvus is an oral antidiabetic medicine containing vildagliptin (50 mg), manufactured by Novartis. Available in packs of 30, 60, 90 or 180 tablets. It is prescribed for adults with type 2 diabetes, usually alongside metformin or as a second- or third-line agent.

vildagliptin belongs to the DPP-4 inhibitor (“gliptin”) class — first approved 2007 in EU (Galvus, Novartis); not approved in US. Gliptins are widely used because they are weight-neutral, have a low hypoglycaemia risk, and can be used across the renal spectrum with appropriate dose adjustment.

How Does Galvus Work?

After meals, the gut releases two incretin hormones — GLP-1 (glucagon-like peptide-1) og GIP (glucose-dependent insulinotropic peptide). These hormones tell the pancreas to release insulin and the liver to suppress glucagon, but they are rapidly broken down by the enzyme dipeptidyl peptidase-4 (DPP-4) within minutes.

vildagliptin blocks DPP-4. This raises active GLP-1 and GIP levels, producing:

Glucose-dependent insulin release from pancreatic beta cells — only when blood glucose is elevated
Suppression of glucagon from alpha cells, reducing hepatic glucose output after meals
Modest slowing of gastric emptying

Because insulin release is glucose-dependent, DPP-4 inhibitors do not cause hypoglycaemia on their own. Typical HbA1c reduction: 0.6–0.8 percentage points. Weight effect: neutral. Blood pressure and lipid effects: neutral.

Dosage and Administration

Standard dose: 50 mg twice daily (morning and evening) — or 50 mg once daily in combination with a sulfonylurea. Reduce to 50 mg once daily if eGFR < 50. Galvus can be taken with or without food.

Once-daily dosing (twice for vildagliptin) — pick a consistent time.
Half-life and excretion: ~3 hours; mixed hepatic (hydrolysis) and renal clearance.
Renal dosing: Reduce to 50 mg once daily if eGFR < 50. Can be used in moderate-to-severe CKD with reduced dose.
No hepatic dose adjustment for most gliptins (vildagliptin needs baseline ALT check).
Miss a dose — skip it; take the next at the usual time. Do not double up.

Side Effects

DPP-4 inhibitors are among the best-tolerated oral antidiabetics. Most side effects are mild and similar across the class.

Common:

Upper respiratory tract infection, nasopharyngitis
Hovedpine
Mild GI upset — nausea, diarrhoea (less common than with metformin)

Uncommon but important:

Acute pancreatitis — rare but documented class effect; stop immediately if severe abdominal pain develops
Severe joint pain (arthralgia) — can occur weeks to months after starting; usually resolves on discontinuation
Hypersensitivity / angioedema — bullous pemphigoid has been reported; stop if blistering skin lesions develop
Saxagliptin specifically: small increase in hospitalisation for heart failure
Vildagliptin specifically: rare hepatic enzyme elevations — monitor ALT

As monotherapy, hypoglycaemia is very rare. When combined with sulfonylureas or insulin, those agents’ doses may need reducing.

Lægemiddelinteraktioner

Sulfonylureas, insulin, meglitinides — additive glucose-lowering. Expect to reduce these doses when adding a gliptin.
Strong CYP3A4/5 inhibitors (ketoconazole, clarithromycin, ritonavir, atazanavir) — raise saxagliptin levels; halve the saxagliptin dose. Minimal effect on sitagliptin, linagliptin, vildagliptin.
Rifampicin — reduces linagliptin levels modestly; effect may be clinically meaningful.
ACE inhibitors — theoretical additive angioedema risk; clinical significance debated.
Digoxin — small rise in peak level with sitagliptin; usually not clinically important.

Who Should Not Take Galvus?

Type 1 diabetes mellitus
Diabetic ketoacidosis
Known hypersensitivity to vildagliptin or other DPP-4 inhibitors
History of pancreatitis (relative — discuss alternatives)
Pregnancy and breastfeeding — data limited; alternatives preferred
Saxagliptin specifically: severe heart failure
Vildagliptin specifically: ALT or AST > 3× upper limit of normal

Storage

Store Galvus below 30°C in a dry place, in the original blister. Keep out of reach of children.

Ofte stillede spørgsmål

Is Galvus the same as vildagliptin?

Yes. Galvus contains the same active ingredient as the originator brand. Bioequivalence is required by regulatory authorities, so clinical effect is the same at the same dose.

Why is vildagliptin twice daily when others are once daily?

Vildagliptin has a shorter plasma half-life (~3 hours) than sitagliptin, linagliptin, or teneligliptin, so twice-daily dosing is needed for 24-hour DPP-4 inhibition. Some patients find this inconvenient. Vildagliptin also requires baseline and periodic liver function tests, which the other gliptins do not.

Will Galvus cause low blood sugar?

On its own, no. DPP-4 inhibitors act in a glucose-dependent manner — they only augment insulin release when blood glucose is high. Hypoglycaemia only becomes a concern when Galvus is combined with a sulfonylurea, meglitinide, or insulin.

Does Galvus cause weight gain?

No — DPP-4 inhibitors are weight-neutral. This is one of the main reasons they are preferred over sulfonylureas in overweight patients.

Can Galvus cause pancreatitis?

Acute pancreatitis is a rare but documented class effect. The absolute risk is small, and large trials (TECOS, CARMELINA, SAVOR) have generally shown no statistically significant excess. Stop immediately and seek medical attention if severe abdominal pain develops — especially pain radiating to the back.

How long does Galvus take to work?

Fasting glucose starts to fall in the first week. Maximal HbA1c effect is at 12 weeks. If HbA1c has not fallen by at least 0.3–0.5% after 3 months, a different second agent (SGLT-2 inhibitor or GLP-1 agonist) should be considered.

Can I stop Galvus suddenly if I don’t feel well?

Yes — DPP-4 inhibitors can be stopped abruptly without rebound hyperglycaemia. If you develop severe abdominal pain, skin blistering, or severe joint pain, stop and contact your doctor.

Where can I buy Galvus online?

You can order Galvus (50 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide, with discreet packaging and genuine WHO-GMP certified manufacturer stock.

Related Diabetes Medications

⚕ Medical Disclaimer. This page is for informational purposes only and does not replace medical advice from a qualified healthcare professional. DPP-4 inhibitors are associated with rare pancreatitis, severe joint pain, and bullous pemphigoid — always use under medical guidance and stop with prompt review if these occur.