Ketosteril

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What Ketosteril is and how it works

Ketosteril contains a fixed mix of ketoanalogues (nitrogen-free analogues of essential amino acids) and a smaller amount of essential amino acids. In CKD, dietary protein restriction reduces uraemic toxin generation but risks malnutrition. The ketoanalogues let the body manufacture amino acids by adding the patient’s own circulating nitrogen waste — so essential nutrition is preserved while urea load and uraemic symptoms (nausea, fatigue, itch) drop.

The combination is designed for use alongside a low-protein diet (typically 0.4–0.6 g/kg/day under dietitian supervision). It is not effective and may even worsen things on a normal-protein diet because excess nitrogen is then loaded back in.

Dosering og indtagelse

Swallow whole with the main meal so the amino acids are available alongside dietary nitrogen sources. Do not crush or chew. Tablets are large; some users prefer to space them through a meal rather than take all at once. Ensure you are also drinking enough water unless your nephrologist has restricted fluids.

Overvågning

• Serum calcium — ketoanalogues contain calcium; check at baseline and every 1–3 months. Stop if hypercalcaemia (> 2.6 mmol/L)
• Serum phosphate, PTH, eGFR, BUN/urea — routine CKD monitoring
• Body weight, MUAC and dietary protein intake — via dietitian to confirm adequate nutrition is maintained
• Albumin, prealbumin — if malnutrition is suspected

Bivirkninger

Lægemiddelinteraktioner

Who should not take Ketosteril

• Hypercalcaemia (corrected serum calcium > 2.6 mmol/L)
• Disorders of amino-acid metabolism (e.g. maple syrup urine disease, hereditary phenylketonuria)
• Patients NOT on a structured low-protein diet (no benefit and possible nitrogen overload)
• Severe galactose intolerance / Lapp lactase deficiency (excipient)
• Hypersensitivity to any constituent

Ofte stillede spørgsmål

Is Ketosteril a treatment for prostate or bladder problems?

Nej. It is a kidney-disease nutritional supplement — ketoanalogues plus essential amino acids — for use with a low-protein diet to delay CKD progression and reduce uraemic symptoms. Bladder/prostate medications are listed in the alternatives panel at the bottom of this page.

How does the low-protein diet plus Ketosteril actually slow CKD?

Less dietary nitrogen means less urea generation; the kidneys handle less waste; glomerular hyperfiltration drops. Adding ketoanalogues lets the body still build essential amino acids using circulating nitrogen waste, so nutritional status stays adequate. Trials show eGFR decline slows in stages 3–5 CKD on a structured protein-restricted diet plus ketoanalogues.

How many tablets per day?

Roughly 1 tablet per 5 kg of body weight per day, divided across the three main meals. A 70 kg adult typically takes 4–5 tablets at each meal (~12–14/day). Your nephrologist or dietitian will fine-tune.

Why with meals?

Ketoanalogues need an immediate source of nitrogen to be converted into essential amino acids. Taking them with meals provides that nitrogen and improves bioavailability.

Will I gain weight or muscle from this?

Ketosteril provides amino-acid building blocks but is not a high-calorie supplement. Maintenance of weight and muscle on a low-protein diet depends on adequate calories overall. A renal dietitian will plan calories around the protein restriction.

What about dialysis — do I still need it?

Most haemodialysis programmes match a more liberal dietary protein intake (1.0–1.2 g/kg/day) to dialysate amino-acid losses. Specialist supervision is needed; do not self-adjust.

Can I stop my phosphate binder?

No. Ketosteril does not bind dietary phosphate. Continue your prescribed binder (sevelamer, calcium acetate, lanthanum) at meal times unless your nephrologist says otherwise.

How is calcium measured and watched?

Corrected serum calcium is checked at baseline and every 1–3 months. If it rises above 2.6 mmol/L, the dose is reduced or stopped. Avoid concurrent calcium supplements unless your specialist directs.

Are there alternatives if I cannot tolerate Ketosteril?

Yes — structured low-protein diets without ketoanalogues, or alpha-keto acid mixtures with different ratios. The decision is individualised; ask your renal dietitian.

What other meds should I separate from this?

Tetracyclines, fluoroquinolones, levothyroxine, oral iron, bisphosphonates and aluminium-containing antacids should be taken at least 2 hours apart from Ketosteril because of calcium chelation.

Andre blære- og prostata-medicin

• Silofast (silodosin) — alpha-blocker for BPH
• Alfusin (alfuzosin 10 mg ER) — alpha-blocker for BPH
• Cystone — herbal urinary support, kidney-stone adjunct
• Urotel XL (tolterodine ER) — for OAB symptoms
• Fosirol 3 g (fosfomycin) — for an acute UTI episode

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