Ledifos
Ledifos (Sofosbuvir + Ledipasvir 400 + 90 mg) — Hetero generic of Harvoni. 12-week fixed-combination tablet for genotypes 1, 4, 5, and 6.
✓ Medicinsk gennemgået af Morgan Ellis — Apoteksforsker · 8 års erfaring · Sidst gennemgået: maj 2026
Hurtigt svar
Ledifos — sofosbuvir 400 mg + ledipasvir 90 mg fixed combination (Hetero Drugs). Single-tablet regimen for chronic hepatitis C genotypes 1, 4, 5, 6 — 12 weeks once-daily oral therapy. Cure rate ≥95%. Generic of Gilead Harvoni.
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Ledifos ships from a WHO-GMP certified manufacturer in plain packaging, billed through a regulated payment processor (the statement descriptor reads a regulated card-payment processor — never MedsBase or any medication name). Every order carries our 20-business-day Reshipment Assurance.
All DAA Hep C therapies carry an FDA black-box warning for hepatitis B virus reactivation in patients co-infected with HCV + HBV (which can be fulminant and fatal). Test for HBsAg and HBV DNA before starting any DAA regimen. If HBV-positive, hepatology must manage co-treatment or prophylactic anti-HBV therapy.
Sådan virker det
Two complementary direct-acting antivirals in one tablet:
- Sofosbuvir — NS5B nucleotide polymerase inhibitor (chain terminator)
- Ledipasvir — NS5A inhibitor (replication and virion assembly)
Combined attack on two essential viral proteins gives a high barrier to resistance. The combination is genotype 1/4/5/6-active. For genotypes 2 and 3, sofosbuvir + velpatasvir or sofosbuvir + daclatasvir are preferred.
Ledipasvir absorption is pH-dependent. Take with food to maximise levels. PPIs (omeprazole, pantoprazole) reduce ledipasvir absorption — take the DAA tablet first thing in the morning before any PPI dose, OR switch to H2 blockers (famotidine) or antacids during therapy. Antacids should be separated by ≥4 hours.
Treatment-duration table
| Population | Regime |
|---|---|
| Genotype 1, 4, 5, 6, treatment-naive, no cirrhosis | 12 weeks one tablet daily |
| Treatment-naive with compensated cirrhosis | 12 weeks (24 weeks if difficult-to-treat profile) |
| Treatment-experienced, no cirrhosis | 12 uger |
| Treatment-experienced with cirrhosis | 12 weeks + ribavirin OR 24 weeks without |
| Decompensated cirrhosis (Child-Pugh B/C) | 12 weeks + ribavirin (specialist hepatology supervision) |
Sustained virologic response at 12 weeks post-treatment (SVR12) is the marker of cure — achieved in ~95-99% of patients across modern DAA regimens.
Vigtige lægemiddelinteraktioner
| Lægemiddel | Effect & action |
|---|---|
| Amiodarone + sofosbuvir | FDA warning — symptomatic bradycardia, deaths reported. Avoid combination. If unavoidable, in-hospital cardiac monitoring required. |
| PPIs (omeprazole, pantoprazole) | Reduce ledipasvir absorption (pH-dependent). Take ledipasvir-containing regimens with food and PPIs ≥4 hours apart, or use H2 blockers/antacids instead. Velpatasvir also pH-sensitive — same advice. |
| Rifampicin, rifabutin | Strong CYP3A4 + P-gp inducers — significantly reduce DAA levels. Avoid combination. |
| Sankthansurt | CYP3A4 induction — reduces DAA levels and risks treatment failure. Avoid throughout therapy. |
| Phenytoin, carbamazepine, oxcarbazepine | Anticonvulsant inducers — significantly reduce DAA levels. Switch to non-inducing antiepileptic (lamotrigine, levetiracetam) before starting Hep C therapy. |
| Statins (rosuvastatin, atorvastatin) | Variable rises in statin levels. Use lowest dose; rosuvastatin generally avoided with sof+vel; atorvastatin acceptable at low dose. |
| Warfarin | INR can fluctuate as the liver recovers during DAA therapy. Monitor INR weekly until stable. |
| HIV antiretrovirals | Tenofovir + ledipasvir — increased tenofovir exposure; monitor renal function. Efavirenz reduces velpatasvir levels — avoid combination. HCV-HIV co-infection always needs ID/hepatology specialist input. |
Ofte stillede spørgsmål
What is the cure rate?
Modern DAA regimens achieve sustained virologic response (SVR12) — undetectable HCV RNA at 12 weeks post-treatment, considered cure — in 95-99% of patients across genotypes. Cirrhosis, prior treatment failure, and HCV/HIV co-infection slightly reduce response rates.
What is SVR12?
Sustained Virologic Response at 12 weeks post-treatment. After completing a 12-week DAA course, HCV RNA is checked at 12 weeks after the last dose. Undetectable = cure. Late relapse beyond SVR12 is <1%.
Will I need a follow-up test?
Yes. HCV RNA at the end of treatment + at 12 weeks post-treatment confirms SVR12. Liver biochemistry and FibroScan/imaging at 6-12 months in cirrhotic patients to assess regression. Even after cure, screen for hepatocellular carcinoma every 6 months if cirrhosis is established.
What about hepatitis B?
All DAAs carry an FDA black-box warning for HBV reactivation in HCV+HBV co-infected patients. Test HBsAg and HBV DNA before starting. If HBV-positive, hepatology must coordinate.
Kan jeg drikke alkohol?
Avoid alcohol throughout treatment and ideally for 6-12 months after. Active alcohol use does not preclude DAA therapy but worsens long-term liver outcomes regardless of HCV status.
Graviditet?
Sofosbuvir is FDA pregnancy category B (no human teratogenicity data; animal data reassuring). Most DAAs lack pregnancy data. Contraception during therapy is standard. Ribavirin (where used as adjunct) is strongly teratogenic — both partners must use contraception during ribavirin therapy and 6 months after.
Bivirkninger?
Modern DAAs are generally well tolerated. Common: fatigue, headache, nausea, insomnia. Less common: rash, diarrhoea. Treatment-limiting side effects are rare.
Generic vs branded — does it matter?
Indian generic DAAs are manufactured under voluntary licences from Gilead (Sovaldi, Harvoni, Epclusa), AbbVie, and BMS. They are bioequivalent and have the same molecule. Multiple real-world studies (CT2, Plus-Asia) show equivalent SVR12 rates to branded products.
Drug interactions to watch?
Most important: amiodarone + sofosbuvir (bradycardia black-box), rifampicin (kills DAA levels), PPIs (reduce ledipasvir/velpatasvir), HIV ARV adjustments needed in co-infection. Always disclose all medications including herbal/OTC.
After cure — can I get HCV again?
Yes. SVR clears the current infection but does not provide future immunity. Re-infection through new exposures (IV drug use, unsafe medical procedures, MSM with HIV co-infection) is possible. Counsel on prevention and offer HCV RNA testing at any new risk exposure.
Se også: this generic Harvoni — Natco’s generic Harvoni — sofosbuvir 400 mg + ledipasvir 90 mg in a single 12-week course for hepatitis C genotypes 1, 4, 5, 6.
Other Hepatitis C Medications
- Velpanat — sofosbuvir + velpatasvir — pan-genotypic alternative including G2 and G3
- Hepcvel — sofosbuvir + velpatasvir — Cipla brand
- Natdac — daclatasvir 30/60 mg — alternative NS5A inhibitor for sofosbuvir partner
- MyHep — sofosbuvir 400 mg monotherapy backbone
- Hepcvir — sofosbuvir 400 mg — Cipla brand
Flere muligheder inden for hepatitismedicin
Rangeret efter seneste MedsBase ordrevolumen — hvad andre kunder i denne kategori vælger.
| Styrke | 90 mg + 400 mg |
|---|---|
| Antal | 28 Tablet/s, 56 Tablet/s, 84 Tablet/s |
| Farmaceutisk form | Tablet/s |
| Producent | Hetero Drugs |
| Behandling | Hepatitis C |
| Generisk mærke | Ledipasvir & Sofosbuv |
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