Metrogyl
✅ Treats bacterial infections
✅ Reduces inflammation
✅ Heals dental abscesses
✅ Prevents post-surgery infections
✅ Effective against parasites
✓ Medicinsk gennemgået af Morgan Ellis — Apoteksforsker · 8 års erfaring · Sidst gennemgået: maj 2026
⚡ Quick Answer — What is Metrogyl?
Metrogyl is a metronidazole tablet (200 mg / 400 mg, Unique Pharma) — a nitroimidazole antibiotic and antiprotozoal. Used for bacterial vaginosis, trichomoniasis, anaerobic infections (intra-abdominal, dental abscess), C. difficile colitis, amoebiasis, and giardiasis. Avoid all alcohol during the course and for 48 hours after — disulfiram-like reaction.
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How Metrogyl works
Metrogyl contains Metronidazole, a 5-nitroimidazole that is reduced inside anaerobic organisms to short-lived radicals which damage bacterial DNA, RNA, and proteins, killing the cell. Nitroimidazoles are bactericidal against obligate anaerobes (Bacteroides fragilis, Clostridium spp., Fusobacterium, Prevotella, Peptostreptococcus) and protozoa (Giardia lamblia, Entamoeba histolytica, Trichomonas vaginalis). They are inactive against aerobes — combination with a Gram-negative agent (cipro / ceftriaxone) is needed for mixed aerobic-anaerobic infection.
Indications & dosing
| Indikation | Dosis | Varighed |
|---|---|---|
| Bacterial vaginosis | 400–500 mg twice daily OR 2 g single dose | 5–7 days |
| Trichomoniasis | 500 mg twice daily OR 2 g single dose | 5–7 days |
| Helicobacter pylori (triple therapy) | 400 mg three times daily | 14 days |
| Anaerobic intra-abdominal infection (with cipro / ceftriaxone) | 500 mg three times daily | 5–14 days |
| Pseudomembranous (C. difficile) colitis — non-severe | 400 mg three times daily | 10–14 days |
| Amoebiasis (intestinal) / liver abscess | 750 mg three times daily | 7–10 days |
| Giardiasis | 2 g single dose × 3 days OR 400 mg three times daily for 5 days | 3–5 days |
| Dental abscess | 400 mg three times daily | 5 days |
Metronidazole and tinidazole inhibit acetaldehyde dehydrogenase. Drinking alcohol during therapy or within 48–72 hours of stopping can produce flushing, severe nausea, vomiting, palpitations, shortness of breath and headache. Avoid all alcohol — including alcohol-containing mouthwash, cough syrups, and topical preparations — during the course and for 48 hours after.
Bivirkninger
- Mave-tarm: metallic taste (very common — almost all patients), nausea, anorexia, dyspepsia.
- CNS: headache, dizziness, ataxia. Cerebellar dysfunction reported with prolonged or high-dose use — discontinue if movement / balance problems.
- Peripheral neuropathy: typically with cumulative dosing > 50 g (long courses, repeat exposure). Discontinue at first symptom — recovery may be incomplete.
- Dark / red-brown urine: harmless metabolite; reverses on stopping.
- Disulfiram-like reaction with alcohol (see warning above).
- Encephalopathy: rare; presents as confusion, ataxia, seizures.
- Pancreatitis: rare.
- Allergiske reaktioner: rash, urticaria; very rarely Stevens-Johnson.
Kontraindikationer
- First trimester of pregnancy (relative); use cautiously throughout pregnancy.
- Active alcohol use within 48 hours of dose.
- Severe hepatic impairment (dose reduction needed).
- Active CNS disease (relative).
Lægemiddelinteraktioner
| Lægemiddel | Effekt | Action |
|---|---|---|
| Alkohol | Disulfiram-like reaction | Avoid all alcohol during course and 48 h after |
| Warfarin | Marked INR rise (CYP2C9 inhibition) | Check INR within 3 days; reduce warfarin dose or switch |
| Lithium | Raises lithium levels — toxicity risk | Monitor lithium level |
| Phenytoin / phenobarbital | Reduce metronidazole levels | May need higher antibiotic dose |
| Cyclosporine / tacrolimus | Levels rise | Monitor levels |
| Disulfiram | Acute psychosis reported | Absolute contraindication if disulfiram in last 2 weeks |
| 5-fluorouracil | Toxicity rises | Avoid combination |
Pregnancy & Breastfeeding
Metronidazole is FDA category B and considered safe in second and third trimesters; first-trimester use is acceptable when bacterial vaginosis or trichomoniasis treatment is clinically necessary, but some guidelines prefer to defer treatment until after the first trimester. Tinidazole is FDA category C with less safety data — avoid in the first trimester. Both transfer to breast milk; many guidelines recommend interrupting breastfeeding for 12–24 hours after a single 2 g dose.
Opbevaring
Store below 25 °C, away from direct sunlight and moisture. Keep in original packaging. Keep out of reach of children. Discard any unused tablets after the printed expiry date — degraded antibiotics can lose potency or release breakdown products.
This medicine is only effective against bacterial infections. Do not use it for viral illnesses (common cold, most sore throats, flu, COVID-19), do not stop early when you feel better, and do not save leftovers for future infections. Misuse drives drug-resistant bacteria like MRSA, ESBL, and CRE — the WHO ranks antimicrobial resistance among the top 10 global public-health threats.
Ofte stillede spørgsmål
Can I drink alcohol with Metrogyl?
No — and not for at least 48 hours after the last dose. The disulfiram-like reaction (flushing, severe nausea, palpitations) can be very uncomfortable.
Why is my urine dark / brownish?
A harmless metronidazole metabolite. It does not signal kidney damage and reverses within a day or two of stopping.
How quickly will it work for trichomoniasis?
A single 2 g dose is curative in > 90% of women. Symptoms typically resolve over 3–5 days. Treat all sexual partners simultaneously to prevent re-infection.
Should I take it with food?
Yes — taking with food substantially reduces GI side effects (nausea, metallic taste). Absorption is unaffected.
Hvad hvis jeg glemmer en dosis?
Take it as soon as you remember. If close to the next scheduled dose, skip and resume. Do not double up — single missed doses rarely affect outcomes.
Why does it cause a metallic taste?
A direct effect of nitroimidazole metabolites on taste-bud receptors. Reverses within a few days of stopping. Sucking on hard candy or flavoured mints during the course can mask it.
Can I use Metrogyl for a UTI?
No — nitroimidazoles are inactive against aerobic Gram-negative rods like E. coli, the main cause of UTI. Use nitrofurantoin / TMP-SMX / cephalosporin / fosfomycin / fluoroquinolone instead.
Will it interact with my contraceptive pill?
Modern evidence does not show a clinically meaningful reduction. Continue your usual schedule — but use additional protection if you experience vomiting or diarrhoea.
I am pregnant — can I take Metrogyl?
Metronidazole is considered safe in second and third trimesters; cautious use in the first trimester is acceptable when treatment is clinically needed. Tinidazole has less safety data and is usually avoided in the first trimester.
Will I need a probiotic?
Optional — Saccharomyces boulardii or a multi-strain Lactobacillus product taken several hours apart from the antibiotic may reduce diarrhoea risk. Stop if any GI symptoms.
Other Antibiotics & Anti-Infective Medications
- Metrogyl (Metronidazole) — anaerobic / protozoal infections
- Tiniba (Tinidazole) — single-dose alternative for trichomonas / amoebiasis
- Cifran (Ciprofloxacin) — combination partner for IBD / abdominal sepsis
- Augmentin (Amoxicillin + Clavulanic acid) — broad-spectrum partner
- Doxt (Doxycycline) — alternative for some STIs
More options in Antibiotics
Rangeret efter seneste MedsBase ordrevolumen — hvad andre kunder i denne kategori vælger.
| Styrke | 200 mg, 400 mg |
|---|---|
| Antal | 30 tablet(ter), 60 tablet(ter), 90 tablet(ter) |
| Farmaceutisk form | Tablet/s |
| Producent | Lekar Pharma Ltd |
| Behandling | Bacterial infections, Parasitic infections |
| Generisk mærke | Metronidazole |
Metrogyl
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