Cendox
Cendox (Doxycycline Hyclate 100 mg, Centurion Lab) — tetracycline antibiotic for cholera adjunct, traveller’s diarrhoea, second-line H. pylori eradication, Q fever and brucellosis. WHO Essential Medicine. Worldwide shipping from MedsBase.
✓ Medicinsk gennemgået af Morgan Ellis — Apoteksforsker · 8 års erfaring · Sidst gennemgået: maj 2026
⚡ Quick Answer — What is Cendox?
Cendox er doxycycline hyclate 100 mg capsule — a tetracycline antibiotic active against a wide range of Gram-positive, Gram-negative, atypical, intracellular, and zoonotic organisms. In a gastro-health context, doxycycline is used for cholera adjunct therapy, traveller’s diarrhoea (especially when invasive E. coli or Vibrio is suspected), Helicobacter pylori second-line eradication, Whipple’s disease, and Q fever. Standarddosis for voksne: 100 mg twice daily for 1–14 days depending on indication. Manufactured by Centurion Lab under WHO-GMP standards.
Hvorfor bestille fra MedsBase
📦 Hver ordre er dækket af vores Reshipment Assurance Policy — hvis din pakke ikke ankommer inden for 20 hverdage, sender vi en erstatning.
Hvorfor bestille fra MedsBase
Cendox is supplied from a WHO-GMP certificeret producent. Hver ordre sendes diskret over hele verden og er dækket af vores Reshipment Assurance Policy — if it does not arrive within 20 business days, we reship at no cost. Doxycycline is on the WHO Essential Medicines List for several indications including cholera, brucellosis, leptospirosis, and Q fever — antibiotics with this safety and spectrum profile are increasingly precious as bacterial resistance widens.
Mekanisme
Doxycycline binds reversibly to the 30S bacterial ribosomal subunit, blocking aminoacyl-tRNA from attaching to the A-site and halting protein synthesis. It is bacteriostatic at usual doses. Unlike older tetracyclines, it has high oral bioavailability (~95 percent) that is only modestly reduced by food, a long half-life (~18 hours) allowing twice-daily dosing, and biliary plus intestinal excretion that minimises renal-dose adjustment.
Gastrointestinale indikationer
- Cholera (Vibrio cholerae): adjunct to oral rehydration, single 300 mg dose or 100 mg twice daily for 3 days
- Traveller’s diarrhoea (suspected ETEC or Vibrio): 100 mg twice daily for 3 days
- H. pylori second-line eradication (after metronidazole/clarithromycin failure): doxycycline 100 mg BD + bismuth + PPI + metronidazole for 14 days
- Whipple’s disease maintenance: 100 mg twice daily long-term (after IV ceftriaxone induction; specialist)
- Q fever (Coxiella burnetii): 100 mg twice daily for 14–21 days (chronic Q fever needs 18 months + hydroxychloroquine)
- Brucellosis: 100 mg twice daily + rifampicin 600–900 mg daily for 6 weeks
Other common uses (cross-category)
- Acne vulgaris (low-dose 50–100 mg/day for 3 months)
- Chlamydia, urethritis, PID (100 mg twice daily for 7–14 days)
- Lyme disease (100 mg twice daily for 14–21 days)
- Malaria prophylaxis (100 mg daily, started 1–2 days before travel)
- Atypical pneumonia (100 mg twice daily for 7–14 days)
- Rosacea, periorificial dermatitis, hidradenitis (sub-antimicrobial 40 mg/day MR)
Dosis
Adults: 100 mg twice daily on day 1 (or 200 mg single first dose), then 100 mg twice daily — or 100 mg once daily for less serious infections. Maximum 200 mg/day. Children > 8 years: 4 mg/kg/day in 1–2 divided doses, max 200 mg/day. Hepatic impairment: dose reduce. CrCl: no reduction needed. Take with a full glass of water and remain upright 30 minutes; can be taken with food (modest reduction in absorption).
Bivirkninger
- GI: nausea, vomiting, diarrhoea, oesophagitis (mostly preventable with upright posture and water)
- Skin: photosensitivity (very common), rash; rare Stevens-Johnson syndrome and DRESS
- Dental: permanent staining if used in children < 8 or pregnancy after 18 weeks
- Hepatotoxicity (rare; LFTs in long courses)
- Benign intracranial hypertension (rare)
- Vaginal candidiasis, oral thrush
- C. difficile-associated diarrhoea (rare)
Lægemiddelinteraktioner
- Antacids, iron, zinc, calcium, dairy products, sucralfate, bismuth, PEG laxatives: chelate doxycycline and reduce absorption — separate by 2 hours before or 6 hours after.
- Warfarin: doxycycline displaces warfarin from albumin and can raise INR — check INR a few days into the course.
- Kombineret p-pille: a small theoretical effect through bowel-flora alteration; for short courses (< 14 days) extra contraception is no longer routinely advised by most modern guidelines.
- Carbamazepine, phenytoin, barbiturater: induce doxycycline metabolism — reduce levels.
- Methotrexat: doxycycline may raise methotrexate levels.
Ofte stillede spørgsmål
Why is it in a gastro category?
Doxycycline is the standard adjunct to oral rehydration in cholera, has a role in suspected invasive traveller’s diarrhoea, and is part of bismuth quadruple therapy for second-line H. pylori eradication. The gut category lists it because of these GI uses.
Can I take it with milk or yoghurt?
Avoid taking it with milk, yoghurt, or calcium-fortified drinks — dairy chelates doxycycline and reduces absorption by 30–50 percent. Separate by 2 hours.
Why must I stay upright after the dose?
Doxycycline can cause severe oesophagitis (chemical burn of the oesophagus) if a tablet lodges there. Take with at least 250 mL water and remain upright (sitting or standing) for 30 minutes.
How careful should I be with sun?
Very. Doxycycline is one of the most photosensitising oral drugs in common use. Sunburn can develop within an hour of moderate sun exposure. Use SPF 50+ daily and reapply, wear long sleeves and a hat, and avoid solariums.
Vil det misfarve mine tænder?
Only if you are pregnant after 18 weeks or under 8 years old. After permanent teeth have erupted (around age 8) the staining risk is gone.
Er det sikkert under graviditet?
No after 18 weeks gestation. Avoid in early pregnancy too unless the indication is severe (e.g. life-threatening Q fever, anthrax) and no alternative exists.
Kan jeg drikke alkohol?
Light alcohol is acceptable. Heavy alcohol increases hepatotoxicity risk and reduces immune response to infection.
Hvad hvis jeg glemmer en dosis?
Take it as soon as you remember unless close to the next dose. Do not double up. Maintaining the dose interval matters more than catching up.
Will it interact with my contraceptive?
For courses under 14 days, modern guidelines no longer routinely recommend extra contraception. Use condoms if you are concerned or if breakthrough bleeding occurs.
Opbevaring
Below 25°C in a dry place. Avoid freezing. Keep capsules in the original blister.
Cendox doxycycline is an effective single agent for chlamydia, Q fever, and Lyme; if you’re using it specifically as doxy-PEP within a broader HIV-prevention regimen, our PrEP Starter Pack (Tenvir-EM + doxycyclin 100 mg) bundles Tenvir-EM with the doxycycline in matched supply tiers.
Andre mave-tarm-medicin
- Ciplox — Ciprofloxacin (alternative for invasive enteric infection)
- Synclar — Clarithromycin (H. pylori first-line)
- Rcifax — Rifaximin (tarmselektiv)
- Rifagut — Rifaximin
- Divaine — Minocycline (related tetracycline)
- Se alle mave-tarm-medicin
Flere muligheder i behandling af klamydia
Rangeret efter seneste MedsBase ordrevolumen — hvad andre kunder i denne kategori vælger.
| Styrke | 100 mg |
|---|---|
| Antal | 30 kapsler, 60 kapsler, 90 kapsler |
| Farmaceutisk form | Kapsel(er) |
| Producent | Centurion Lab |
| Behandling | Mave-tarm-sundhed |
| Generisk mærke | Doxycycline Hyclate |
Cendox
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