Reglan
Reglan (Metoclopramide 10 mg) — central + peripheral D2 antagonist prokinetic and antiemetic. Carries FDA black-box for tardive dyskinesia (12-week max). For nausea, vomiting, gastroparesis, migraine-associated nausea. Worldwide shipping from MedsBase.
✓ Medicinsk gennemgået af Morgan Ellis — Apoteksforsker · 8 års erfaring · Sidst gennemgået: maj 2026
⚡ Quick Answer — What is Reglan?
Reglan is metoclopramide 10 mg — a centrally and peripherally acting dopamine D2 receptor antagonist used as an antiemetic and prokinetic. It accelerates gastric emptying, increases LES tone, and blocks the chemoreceptor trigger zone. Indications include nausea/vomiting (post-operative, chemotherapy adjunct, migraine-associated), gastroparesis, and prevention of aspiration. Standard dose: 10 mg three times daily before meals, for a maximum of 5 days (FDA) or 12 weeks (EMA gastroparesis exception). WHO-GMP certified manufacturer.
📦 Hver ordre er dækket af vores Reshipment Assurance Policy — hvis din pakke ikke ankommer inden for 20 hverdage, sender vi en erstatning.
Hvorfor bestille fra MedsBase
Vores generiske medicin kommer fra WHO-GMP certificerede producenter og sendes verdensomspændende i diskret, neutral emballage — ingen medicinnavn på pakkens ydre. Kortbetalinger håndteres af en reguleret processor (kontoudtogsbeskrivelser inkluderer en reguleret betalingsprocessor — aldrig “MedsBase” eller medicinnavn). Crypto og SEPA bankoverførsel accepteres også. Hver ordre er dækket af vores Reshipment Assurance Policy.
Hvorfor bestille fra MedsBase
Reglan is supplied from a WHO-GMP certified manufacturer. Every order ships discreetly worldwide and is covered by our Reshipment Assurance Policy — if it does not arrive within 20 business days, we reship at no cost. Metoclopramide remains a first-line agent for several niche indications (migraine-associated nausea, post-operative ileus prevention, lactation enhancement) where its central D2 effect is helpful.
Mechanism of action
Metoclopramide blocks dopamine D2 receptors centrally (in the chemoreceptor trigger zone, the nigrostriatum, and the tuberoinfundibular system) and peripherally (gut). At higher doses it also blocks 5-HT3 and stimulates 5-HT4 receptors in the gut, which contributes to its prokinetic effect. CNS penetration distinguishes it from domperidone and explains both its higher antiemetic potency and its extrapyramidal side-effect profile.
Indications
- Nausea and vomiting (chemotherapy-induced, post-operative, migraine-associated)
- Diabetic and idiopathic gastroparesis (12-week max under EMA)
- Aspiration prevention pre-anaesthesia (rapid-sequence induction adjunct)
- Adjunct in radiology to speed barium transit
- Off-label: galactagogue
Dose
Adults: 10 mg up to three times daily, 30 minutes before meals and at bedtime if needed. Maximum cumulative duration: 5 days for nausea/vomiting (FDA), 12 weeks for gastroparesis (EMA, specialist). CrCl < 60: reduce dose 50 percent. Hepatic impairment: reduce dose. Children: avoid < 1 year; restricted use in > 1 year for chemo-induced or post-op nausea, weight-based.
Side effects
- Common: drowsiness, restlessness, fatigue, diarrhoea
- Extrapyramidal: acute dystonia, akathisia, parkinsonism, tardive dyskinesia (BLACK-BOX)
- Hyperprolactinaemia: galactorrhoea, gynaecomastia, menstrual disturbance
- Rare: neuroleptic malignant syndrome, seizures, methaemoglobinaemia (G6PD-deficient infants)
- Cardiac: bradycardia and hypotension after rapid IV push
Drug interactions
- Anticholinergics, opioids: oppose the prokinetic effect.
- Other dopamine antagonists (haloperidol, risperidone, prochlorperazine): additive extrapyramidal risk — avoid stacking.
- MAO inhibitors: hypertensive crisis — avoid.
- SSRIs, SNRIs: serotonin syndrome (rare).
- Levodopa: each blocks the other's effect — do not co-prescribe.
- Digoxin: gastric-emptying acceleration may reduce digoxin absorption.
Ofte stillede spørgsmål
How is Reglan different from domperidone?
Both block D2 receptors. Metoclopramide crosses the blood-brain barrier and is more potent as an antiemetic but causes extrapyramidal side effects (FDA black-box). Domperidone is peripheral-only with minimal EPS but has a QT-prolongation signal.
What does the FDA black-box mean for me?
Use the lowest dose for the shortest time. Tell the prescriber immediately about any involuntary tongue, jaw, lip, or limb movements — these may be early tardive dyskinesia and the drug must be stopped.
Can I take it for travel sickness?
There are better-tolerated alternatives (cinnarizine, hyoscine, antihistamines). Metoclopramide is not first-line for motion sickness because it does not act on the vestibular system.
Is it safe in pregnancy?
Category B in the US. Used in pregnancy for nausea/vomiting and is the second-line after pyridoxine-doxylamine when first-line fails. Discuss with obstetric prescriber.
Can I drive on this?
Drowsiness is common, especially in the first few days. Do not drive or operate machinery until you know how it affects you.
What if I develop a stiff neck or strange jaw movements?
Stop the drug and seek medical help. Acute dystonia is treated with IV anticholinergic (procyclidine or benztropine) and is fully reversible.
Why do I have leaky breasts on this medication?
Metoclopramide raises prolactin via pituitary D2 blockade. The effect is reversible on discontinuation.
Can it interact with my Parkinson’s drugs?
Yes — metoclopramide blocks central D2 receptors and can dramatically worsen Parkinson’s motor symptoms. Avoid in Parkinson’s disease.
Storage
Below 25°C in a dry place. Keep out of reach of children.
What if I miss a dose?
Take it before the next meal, then continue. Do not double up.
Other Gastro Health Medications
- Dompewal — Domperidone (peripheral D2 antagonist)
- Stemetil — Prochlorperazine (antiemetic)
- Doxinate — Doxylamine + B6 (NVP first-line)
- Omez D — Omeprazole + Domperidone SR
- GR8-OD — Pantoprazole + Domperidone SR
- Browse all Gastro Health Medications
More options in Gastro Health
Rangeret efter seneste MedsBase ordrevolumen — hvad andre kunder i denne kategori vælger.
| Styrke | 10 mg |
|---|---|
| Antal | 30 Tablet/s, 60 Tablet/s, 90 Tablet/s, 180 Tablet |
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