Temsunol
Temsunol (Tamsulosin 0.4 mg) — uroselective alpha-1A blocker for BPH urinary symptoms (weak stream, frequency, urgency, hesitancy). Once-daily 30 min after the same meal. Manufactured by Knoll Pharma to WHO-GMP standards.
✓ Medicinsk gennemgået af Morgan Ellis — Apoteksforsker · 8 års erfaring · Sidst gennemgået: maj 2026
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Temsunol — tamsulosin 0.4 mg (Knoll Pharma). Uroselective alpha-1A blocker for benign prostatic hyperplasia (BPH) — relaxes bladder-neck and prostatic smooth muscle to improve urinary flow. One capsule once daily, 30 minutes after the same meal each day.
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- WHO-GMP certificeret producent
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Hvorfor bestille fra MedsBase
Temsunol ships from a WHO-GMP certified manufacturer in plain packaging, billed through a regulated payment processor (the statement descriptor reads a regulated card-payment processor — never MedsBase or any medication name). Every order carries our 20-business-day Reshipment Assurance.
Tamsulosin causes Intraoperative Floppy Iris Syndrome (IFIS) in up to ~90% of treated patients. Tell any ophthalmologist about tamsulosin use BEFORE cataract or glaucoma surgery — even years after stopping. The surgeon needs to know to use intracameral phenylephrine, capsular tension rings, or a different surgical approach.
First dose can cause sudden drop in BP, especially in dehydrated, elderly, or volume-depleted patients. Take the first dose at bedtime to reduce fall risk. Avoid combining with PDE5 inhibitors (sildenafil/tadalafil) within 4 hours.
How tamsulosin works
Tamsulosin is a uroselective alpha-1A adrenoceptor antagonist. The bladder neck and prostatic smooth muscle are densely populated with alpha-1A receptors; blocking them relaxes the dynamic component of bladder outlet obstruction without significantly affecting vascular alpha-1B receptors (which dominate blood vessels). This is why tamsulosin causes less postural hypotension than older non-selective alpha blockers (prazosin, doxazosin).
Tamsulosin treats symptoms only — it does not shrink the prostate. To shrink the gland and reduce long-term progression risk, a 5-alpha-reductase inhibitor (finasteride or dutasteride) is added; combination therapy is superior in glands >30 mL or PSA >1.5 ng/mL (CombAT trial).
Dosering
| Indikation | Dosis | Noter |
|---|---|---|
| BPH urinary symptoms | 0.4 mg once daily | 30 min after the same meal each day |
| Refractory symptoms | 0.8 mg once daily | Specialist-supervised; some markets do not approve this dose |
| Acute urinary retention | 0.4 mg/day × 7-10 days before catheter trial-without-catheter | Improves trial-without-catheter success ~25-30% |
| Distal ureteric stones (off-label) | 0.4 mg/day × 4 weeks | Medical expulsive therapy for stones <10 mm |
Swallow whole — do not crush, chew, or open the capsule. Improvement in flow rate is typically noticed within 1-2 weeks; full benefit at 4-6 weeks.
Bivirkninger
- Common (1-10%): dizziness, headache, retrograde or absent ejaculation (~5-15% — reversible on stopping), nasal congestion (rhinitis), abnormal ejaculation
- Mindre almindelige: orthostatic hypotension, syncope (especially first dose), palpitations, asthenia, decreased libido
- Rare but important: priapism (medical emergency >4 hours), Stevens-Johnson syndrome, IFIS during cataract surgery
Lægemiddelinteraktioner
| Lægemiddel | Effekt |
|---|---|
| Strong CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin) | Up to 3× tamsulosin AUC — avoid combination |
| PDE5-hæmmere (sildenafil, tadalafil, vardenafil) | Additive hypotension — separate by ≥4 hours; tadalafil 5 mg OD has the cleanest profile if combination is needed |
| Other alpha blockers | Do not combine — stacked vasodilation |
| Cimetidin | Modest rise in tamsulosin levels — usually clinically insignificant |
Ofte stillede spørgsmål
When will I notice improvement?
Many men notice better flow within 7-14 days; full effect takes 4-6 weeks. If symptoms have not improved after 6 weeks, discuss with your clinician — combination with a 5-alpha-reductase inhibitor or alternative therapy may be warranted.
Can I take Temsunol on an empty stomach?
Manufacturer guidance is to take it 30 minutes after the same meal every day. Empty-stomach dosing increases peak plasma levels and the risk of orthostatic hypotension.
Will tamsulosin shrink my prostate?
No. Tamsulosin relaxes prostatic smooth muscle and improves urinary flow but does not change gland size. To shrink the prostate, a 5-alpha-reductase inhibitor (finasteride or dutasteride) is needed — often combined with tamsulosin in larger glands.
What about retrograde ejaculation?
About 5-15% of men experience reduced ejaculate volume or retrograde ejaculation (semen passes into the bladder). This is reversible on stopping the drug. It is more common with the 0.8 mg dose. The semen is harmless and reappears in the next urination.
I am having cataract surgery — does this matter?
Yes — tell your ophthalmologist immediately. Tamsulosin causes Intraoperative Floppy Iris Syndrome and the surgical approach needs to change. The effect persists for weeks-to-years after stopping, so do not just pause the drug — the surgeon still needs to know.
Kan jeg drikke alkohol?
Modest alcohol is acceptable but increases dizziness and orthostatic hypotension risk. Avoid alcohol when starting therapy or after a dose increase.
Hvad hvis jeg glemmer en dosis?
Take it when you remember if you are still close to your normal time. If it is nearly time for the next dose, skip the missed dose — do not double up.
Can women take tamsulosin?
Tamsulosin is sometimes used off-label in women for refractory urinary retention or distal ureteric stones (medical expulsive therapy). It is not a first-line female lower urinary tract symptom drug.
Does it interact with my BP medication?
Tamsulosin lowers BP modestly. If you are on multiple antihypertensives (especially other alpha blockers, ACE inhibitors, ARBs, or diuretics), expect a small additional drop. Monitor for postural symptoms; rarely need a dose adjustment of either drug.
Is the once-daily dose enough?
Yes — tamsulosin has a 9-15 hour half-life and once-daily 0.4 mg gives steady symptom control. Splitting the dose adds inconvenience without benefit.
Other BPH & Urinary Medications
- Urimax D — tamsulosin 0.4 mg + dutasteride 0.5 mg fixed combo for prostates >30 mL
- Alfusin — alfuzosin 10 mg — alternative non-selective alpha blocker, slightly different side-effect profile
- Silofast — silodosin 4/8 mg — another uroselective alpha-1A blocker; higher retrograde-ejaculation rate but less BP effect
- Finpecia — finasteride 1 mg — 5ARI for hair loss; 5 mg version for BPH gland shrinkage
- Urotel XL — tolterodine 4 mg ER — for overactive bladder symptoms, NOT for BPH
More options in Alpha Blocker
Rangeret efter seneste MedsBase ordrevolumen — hvad andre kunder i denne kategori vælger.
| Styrke | 0.4 mg |
|---|---|
| Antal | 60 Tablet/s, 120 Tablet/s, 240 Tablet/s |
| Farmaceutisk form | Tablet/s |
| Producent | Knoll Pharma |
| Behandling | Godartet prostataforstørrelse (BPH) |
| Generisk mærke | Tamsulosin |
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