Alfusin D
✅ Treats enlarged prostate
✅ Improves urine flow
✅ Reduces frequent urination
✅ Minimizes bladder obstruction
✅ Alleviates urinary symptoms
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
Quick Answer
Alfusin D contains alfuzosin + dutasteride 10 mg + 0.5 mg made by Cipla Inc. It is used for moderate-to-severe benign prostatic hyperplasia (BPH) where both flow improvement and prostate shrinkage are needed. Take exactly as directed by your clinician — do not adjust the dose yourself.
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What Alfusin D is and how it works
Alfusin D is a combination tablet containing two medicines that target BPH at different mechanisms:
- Alfuzosin 10 mg ER — an alpha-1 adrenoceptor antagonist that relaxes prostate, bladder-neck and urethral smooth muscle, improving flow within days.
- Dutasteride 0.5 mg — a dual 5-alpha-reductase inhibitor that blocks the conversion of testosterone to dihydrotestosterone (DHT). Lower DHT shrinks the prostate by ~25% over 6–12 months and lowers the long-term risk of acute urinary retention and BPH-related surgery.
This dual approach is supported by the CombAT trial (Combination of Avodart and Tamsulosin, 4-year data), which showed superiority of dual therapy over either drug alone for symptom score, flow rate, retention risk and need for surgery in men with prostates >30 mL.
✅ Who benefits most from this combination
Men with moderate-to-severe LUTS (IPSS ≥ 8) AND a prostate volume > 30 mL AND/OR PSA > 1.5 ng/mL. If your gland is small (< 30 mL) the combination adds little over alfuzosin monotherapy.
Dose and how to take it
One tablet once daily, after the same meal each day — usually breakfast or dinner. Swallow whole with water; do not crush, chew or open the tablet (the alfuzosin portion is an ER matrix). Improvement in flow appears within 1–2 weeks (alfuzosin component); prostate shrinkage and the full reduction in retention risk take 6–12 months (dutasteride component). Long-term treatment is usually intended.
⚠ Pregnancy — do not handle if your partner is pregnant or could become pregnant
Dutasteride is absorbed through the skin and can cause genital malformations in male foetuses. Pregnant women and women who could become pregnant must not handle leaking or broken tablets. Do not donate blood while taking dutasteride and for 6 months after stopping — the half-life is ~5 weeks. Use barrier contraception if your partner could become pregnant; semen contains small amounts of dutasteride.
Side effects
| Side effect | Source | Frequency |
|---|---|---|
| Dizziness, light-headedness on standing | Alfuzosin | Common |
| Headache, fatigue | Alfuzosin | Common |
| Decreased libido | Dutasteride | Common (~3–5%) |
| Erectile dysfunction | Dutasteride | Common (~5–7%) |
| Ejaculation disorder (reduced volume) | Both | Common |
| Breast tenderness or enlargement (gynecomastia) | Dutasteride | Uncommon |
| Intraoperative Floppy Iris Syndrome | Alfuzosin | Surgical risk — tell ophthalmologist |
| Mood changes / depressive symptoms | Dutasteride | Uncommon — report if severe |
Drug interactions
| Combination | Effect | Action |
|---|---|---|
| Strong CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin) | Major rise in alfuzosin AND dutasteride levels | Avoid |
| Other alpha-blockers | Additive hypotension | Do not combine |
| PDE-5 inhibitors | Additive hypotension | Stabilise on combo first; introduce cautiously |
| Antihypertensives | Additive BP lowering | Monitor BP, especially in first week |
| Warfarin | No clinically significant interaction | Standard INR monitoring |
Important PSA note
Dutasteride halves serum PSA within 6 months. Your urologist should double the measured PSA before interpreting it for prostate-cancer screening. If your PSA rises above the new (halved) baseline while on treatment, that is a flag for further investigation — do not assume the drug is failing.
Who should not take Alfusin D
- Women, children, adolescents (dutasteride is teratogenic and there is no female indication)
- History of orthostatic hypotension or first-dose syncope
- Severe hepatic impairment
- Concurrent strong CYP3A4 inhibitors
- Known hypersensitivity to alfuzosin, dutasteride, or other 5-alpha-reductase inhibitors (e.g. finasteride)
Frequently Asked Questions
How is this different from alfuzosin alone?
Alfuzosin alone improves flow within days, but does nothing for prostate size. Adding dutasteride shrinks the gland over 6–12 months and reduces long-term retention and surgery risk. The combination is for men whose gland is enlarged, not just symptomatic.
Why must my partner avoid handling the tablets?
Dutasteride is absorbed through skin and can disrupt male foetal development. Whole tablets are coated and safe; broken or leaking tablets must not be touched by women who could be pregnant.
Can I donate blood while on Alfusin D?
No. Dutasteride has a 5-week half-life; do not donate blood during treatment and for 6 months after stopping, to protect potentially pregnant recipients.
Will my PSA reading still be useful?
Yes — your clinician simply doubles the measured value to get an “equivalent” PSA. Any rise above the halved baseline is investigated normally.
How long before I notice an effect?
Flow rate improves within 1–2 weeks (alfuzosin). Symptom score (IPSS) typically drops 4–6 points by 3 months. Prostate shrinkage and the retention-risk benefit accumulate over 6–12 months (dutasteride).
Is sexual side-effect risk additive?
Partly. Each drug independently reduces ejaculate volume; dutasteride adds 3–7% rates of decreased libido and erectile dysfunction. Most are reversible on stopping, though dutasteride effects can persist for weeks after the last dose.
Can I crush or split the tablet?
No. Alfuzosin is in an extended-release matrix; crushing dumps a whole day’s dose at once and causes severe hypotension. Swallow whole.
What happens if I stop taking it?
Alfuzosin’s flow benefit fades within 1–2 weeks. Dutasteride’s prostate-size reduction reverses over 6–12 months. Symptoms typically return.
Can I switch to dutasteride alone later?
Some men whose symptoms are dominated by gland size rather than tone do drop the alpha-blocker after 6–12 months. Discuss the timing with your urologist — do not self-switch.
Is this safe long-term?
Yes — both components are licensed for chronic use. Long-term safety data exists out to 4 years (CombAT) and informally beyond. Annual urology review is recommended.
Other Bladder & Prostate Medications
- Silofast (silodosin) — alpha-blocker monotherapy, more selective
- Alfusin (alfuzosin 10 mg ER) — alpha-blocker alone
- Alfusin Tab (alfuzosin 2.5 mg) — alternative starting dose
- Urotel XL (tolterodine ER) — for storage-symptom-dominant LUTS
- Cystone — herbal urinary support adjunct
Medical disclaimer. The information on this page is for general educational purposes only and is not a substitute for advice from a qualified clinician. Discuss any new medication or dose change with your doctor or pharmacist, especially if you are pregnant, breastfeeding, have other medical conditions, or take other medicines.
More options in Bladder Prostate
Ranked by recent MedsBase order volume — what other customers in this category are picking.
| Strength | 10 mg + 0.5 mg |
|---|---|
| Quantity | 30 Tablet/s, 60 Tablet/s, 90 Tablet/s |
| Pharma Form | Tablet/s |
| Manufacturer | Cipla Inc |
| Treatment | Benign prostatic hyperplasia (BPH) |
| Generic Brand | Alfuzosin + Dutasteride |
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