Asitomycin 500
✅ Treats bacterial infections
✅ Effective against respiratory infections
✅ Fights skin infections
✅ Resolves ear infections
✅ Combats urinary tract infections
Asitomycin contains Azithromycin.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is Asitomycin 500?
Asitomycin 500 is an azithromycin 500 mg tablet — a macrolide antibiotic used for respiratory tract infections, skin and soft-tissue infections, chlamydia and other STIs, otitis media, and Mycoplasma pneumonia. Typical adult regimens are 500 mg once daily for 3 days (the “Z-pack” equivalent) or a single 1 g dose for uncomplicated chlamydia. Take once daily with or without food. Preferred alternative for patients with penicillin allergy.
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Asitomycin 500 is an azithromycin 500 mg tablet — a second-generation macrolide antibiotic derived from erythromycin. Azithromycin has a broad spectrum covering Gram-positive cocci, many Gram-negative respiratory pathogens, atypical organisms (Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella), and the sexually transmitted pathogens Chlamydia trachomatis and Neisseria gonorrhoeae (when combined with ceftriaxone).
Azithromycin’s distinguishing feature is its extraordinarily long tissue half-life (60–70 hours in tissue vs ~11 hours in plasma) — this is why short 3-day and even single-dose regimens can clear infections that would take 7–14 days with traditional antibiotics. It is on the WHO Model List of Essential Medicines and a staple of primary care worldwide.
What Is Asitomycin 500?
Asitomycin is a prescription macrolide antibiotic active against a wide range of bacteria. It binds the 50S subunit of the bacterial ribosome, blocking protein synthesis and arresting bacterial growth. Asitomycin 500 is commonly prescribed for:
- Community-acquired pneumonia — particularly when atypical organisms are suspected
- Acute bacterial bronchitis and COPD exacerbations — when antibiotics are indicated
- Bacterial sinusitis and pharyngitis — penicillin-allergic patients
- Otitis media — alternative where amoxicillin cannot be used
- Chlamydia trachomatis urogenital infection — single 1 g dose historically first-line
- Gonorrhoea (in combination) — with ceftriaxone for uncomplicated genital infection per CDC guidance
- Skin and soft-tissue infections — cellulitis, erysipelas
- Pelvic inflammatory disease — as part of combination therapy
- Traveller’s diarrhoea — first-line in South and Southeast Asia due to fluoroquinolone resistance
- Prophylaxis of Mycobacterium avium complex (MAC) in advanced HIV
How Does Asitomycin 500 Work?
Azithromycin is a bacteriostatic macrolide at therapeutic doses (bactericidal at higher concentrations against some organisms):
- It binds the 23S rRNA of the 50S ribosomal subunit, blocking the exit tunnel through which newly-synthesised peptide chains must pass
- This arrests bacterial protein synthesis without affecting human ribosomes (which are structurally different)
- Azithromycin concentrates intracellularly, particularly in phagocytes that deliver it directly to sites of infection
- Its tissue half-life of 60–70 hours means a 3-day treatment course provides 10 days of effective tissue drug levels — which is why short regimens work for many infections
Asitomycin 500 Dosage and Administration
| Indication | Adult Dose | Duration |
|---|---|---|
| Respiratory tract infection (standard “Z-pack”) | 500 mg on day 1, then 250 mg days 2–5 or 500 mg daily | 3–5 days |
| Chlamydia (uncomplicated urogenital) | 1 g (2 × 500 mg tablets) | Single dose |
| Gonorrhoea | 2 g + ceftriaxone 500 mg IM | Single dose combination |
| Acute otitis media (paediatric) | 30 mg/kg single dose or 10 mg/kg/day × 3 days | As dosed |
| Traveller’s diarrhoea | 500 mg daily OR 1 g single dose | 1–3 days |
| MAC prophylaxis (HIV) | 1,200 mg once weekly | Ongoing |
| Hepatic / renal impairment | Caution in severe impairment | Usually no dose adjustment needed |
How to Take Asitomycin 500 Properly
- Swallow the tablet whole with water — take with or without food (food does not meaningfully affect absorption of the tablet form)
- Take at the same time each day during a multi-day course
- Complete the full prescribed course even if you feel better by day 2
- For single-dose chlamydia therapy, avoid sexual contact for 7 days after the dose to prevent onward transmission (and partner treatment is essential)
- Avoid antacids containing aluminium or magnesium within 2 hours of dosing — they lower absorption
- Stay well hydrated
Side Effects of Asitomycin 500
Azithromycin is generally well tolerated. The most common side effects involve the GI tract and are dose-dependent.
| Severity | Side Effect |
|---|---|
| Common (≥1 in 10) | Diarrhoea, nausea, abdominal pain |
| Common (≥1 in 100) | Vomiting, altered taste, headache, dizziness, vaginal candidiasis, transient rise in liver enzymes |
| Uncommon | Rash, pruritus, fatigue, tinnitus, palpitations |
| Rare but serious | C. difficile colitis, severe hepatotoxicity, Stevens-Johnson syndrome / DRESS, QT prolongation with torsades de pointes, hearing loss with prolonged high-dose use |
Seek urgent medical attention for palpitations or fainting, jaundice, severe watery diarrhoea with blood or fever, or widespread rash with mucous-membrane involvement.
Warnings and Precautions
- QT prolongation. Azithromycin modestly prolongs the QT interval. Avoid or use cautiously in patients with congenital long QT, uncorrected hypokalaemia or hypomagnesaemia, bradycardia, or on other QT-prolonging drugs (amiodarone, sotalol, quinolones, methadone, antipsychotics)
- Hepatic function. Rare cases of severe cholestatic hepatitis reported — avoid in significant hepatic impairment
- Myasthenia gravis. Macrolides can worsen myasthenia — use with caution
- Pregnancy and breastfeeding. Azithromycin is considered safe in both — it has been used in chlamydia therapy during pregnancy for decades
- Resistance. Azithromycin resistance in Streptococcus pneumoniae and Neisseria gonorrhoeae is rising globally; local guidelines now favour ceftriaxone monotherapy for gonorrhoea in many regions
Contraindications — Who Should NOT Take Asitomycin 500
- Known hypersensitivity to azithromycin, erythromycin, or any macrolide
- History of cholestatic jaundice or hepatic dysfunction associated with prior azithromycin
- Congenital long QT syndrome or active QT-prolonging drug combination
Drug Interactions
| Drug / Class | Interaction |
|---|---|
| QT-prolonging drugs (amiodarone, sotalol, quinolones, methadone, haloperidol, citalopram) | Additive QT prolongation — avoid combination |
| Antacids (Al/Mg containing) | Reduce absorption — separate by 2 hours |
| Warfarin | May increase INR — monitor closely |
| Digoxin | Azithromycin may raise digoxin levels — monitor for toxicity |
| Ergot alkaloids | Risk of ergotism — avoid |
| Statins (simvastatin, lovastatin) | Modest rise in statin levels — monitor for myopathy |
| Ciclosporin, tacrolimus | May raise immunosuppressant levels — monitor |
| Alcohol | No direct interaction; moderate intake tolerated |
Storage Instructions
- Store below 25 °C in a dry place, away from direct sunlight
- Keep in the original blister packaging
- Keep out of reach of children
- Do not use after the expiry date
- Dispose of unused tablets via a pharmacy take-back scheme
Related Alternatives on MedsBase
- Azee — Cipla azithromycin, alternative brand
- Mox — amoxicillin, penicillin-class alternative
- Augmentin — amoxicillin + clavulanate for beta-lactamase producers
- Erythromycin — older macrolide
- Ceftum — cefuroxime cephalosporin
- Browse all Antibiotics →
Frequently Asked Questions
What is Asitomycin 500 used for?
Asitomycin 500 is an azithromycin antibiotic used for respiratory tract infections, skin and soft-tissue infections, chlamydia, gonorrhoea (combined with ceftriaxone), otitis media, and Mycoplasma / Legionella pneumonia.
How fast does Asitomycin 500 work?
Most patients notice improvement within 48–72 hours. Because of azithromycin’s very long tissue half-life, a 3-day treatment course gives about 10 days of effective tissue drug levels.
Is Asitomycin 500 the same as a Z-pack?
Essentially yes — the “Z-pack” is a branded 5-day azithromycin regimen (500 mg day 1 + 250 mg days 2–5). Asitomycin 500 provides the same active ingredient at the same strength.
Can I drink alcohol with Asitomycin 500?
Moderate alcohol intake does not meaningfully interact with azithromycin, but heavy drinking while fighting infection slows recovery.
Should I take Asitomycin 500 with food?
Either is fine for tablets. If taking suspension, an empty stomach is preferred. Antacids containing aluminium or magnesium should be separated from the dose by at least 2 hours.
Can Asitomycin 500 treat chlamydia?
Yes — a single 1 g dose (two 500 mg tablets) has been a standard first-line treatment for uncomplicated urogenital chlamydia for many years. Doxycycline 100 mg twice daily for 7 days is now preferred in many guidelines, but azithromycin remains a valid alternative, particularly when adherence is a concern.
I’m allergic to penicillin — can I take Asitomycin?
Yes. Macrolides like azithromycin are not cross-reactive with penicillins and are routinely used in penicillin-allergic patients.
Does Asitomycin treat COVID-19?
No. Randomised trials (PRINCIPLE, RECOVERY) have shown no benefit of azithromycin in COVID-19 outside specific bacterial superinfection scenarios. The FDA, WHO, and NICE recommend against routine use for COVID-19.
Will Asitomycin affect my heart rhythm?
Azithromycin can modestly prolong the QT interval. In patients with pre-existing heart rhythm conditions or on other QT-prolonging drugs, cardiac monitoring and dose consideration are needed. Rare cases of torsades de pointes have been reported.
How long should I wait before taking it again?
A second course can be given whenever clinically indicated. Repeated use within short intervals without a specific indication promotes resistance.
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| Strength | 500 mg |
|---|---|
| Quantity | 9 Tablet/s, 18 Tablet/s, 30 Tablet/s, 60 Tablet/s, 90 Tablet/s, 180 Tablet/s |
Asitomycin 500
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